Full Text Journal Articles by
Author Haige Chen

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Urinary Molecular Pathology for Patients with Newly Diagnosed Urothelial Bladder Cancer.

Ruiyun Zhang, Jingyu Zang, Feng Xie, Yue Zhang, Yiqiu Wang, Ying Jing, Yi Zhang, Zhaoxiong Chen, Akezhouli Shahatiaili, Mei-Chun Cai, Zhixin Zhao, Pan Du, Shidong Jia, Guanglei Zhuang, Haige Chen,

<h4>Purpose</h4>Next-generation sequencing (NGS)-based profiling of both urinary tumor DNA (utDNA) and circulating tumor DNA (ctDNA) shows promise for noninvasive detection and surveillance of urothelial bladder cancer (UBC). However, the analytic performance of these assays remains undefined in the real-world setting. Here, we sought to evaluate the concordance between tumor DNA ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001878]

Cited: 0 times

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Immunotherapy in the Treatment of Urothelial Bladder Cancer: Insights From Single-Cell Analysis

Jingyu Zang, Kaiyan Ye, Yang Fei, Ruiyun Zhang, Haige Chen, Guanglei Zhuang,

Urothelial bladder cancer (UBC) is a global challenge of public health with limited therapeutic options. Although the emergence of cancer immunotherapy, most notably immune checkpoint inhibitors, represents a major breakthrough in the past decade, many patients still suffer from unsatisfactory clinical outcome. A thorough understanding of the fundamental cellular and ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:]

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FTO modifies the m6A level of MALAT and promotes bladder cancer progression.

Le Tao, Xingyu Mu, Haige Chen, Di Jin, Ruiyun Zhang, Yuyang Zhao, Jie Fan, Ming Cao, Zhihua Zhou,

<h4>Background</h4>Nearly a half million people around the world are diagnosed with bladder cancer each year, and an incomplete understanding of its pathogenicity and lack of efficient biomarkers having been discovered lead to poor clinical management of bladder cancer. Fat mass and obesity-associated protein (FTO) is a critical player in carcinogenesis. ... Read more >>

Clin Transl Med (Clinical and translational medicine)
[2021, 11(2):e310]

Cited: 2 times

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Co-Expression of Stem Cell and Epithelial Mesenchymal Transition Markers in Circulating Tumor Cells of Bladder Cancer Patients.

Ruiyun Zhang, Jun Xia, Yiqiu Wang, Ming Cao, Di Jin, Wei Xue, Yiran Huang, Haige Chen,

<h4>Objective</h4>Cancer cells with stemness and epithelial-to-mesenchymal transition (EMT) features display enhanced malignant and metastatic potential. This study aimed to introduce a new methodology developed in order to investigate the co-expression of a stemness (OCT4) and EMT markers on single circulating tumor cells (CTCs) of patients with localized urinary bladder cancer ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2020, 13:10739-10748]

Cited: 2 times

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A perioperative management to reduce rate of urinary tract infection for patient underwent radical cystectomy with ileal conduit diversion.

Yiqiu Wang, Wenhao Shen, Xiuqun Yuan, Shahatiaili Akezhouli, Di Jin, Haige Chen,

<h4>Background</h4>Although radical cystectomy, as the standard surgical treatment for muscle-invasive bladder cancer patients, prolongs survival remarkably, there are postoperative complications associated with urinary diversion. This study aimed to explore the antibiotic prophylaxis, according to culture of single J stent and urine from patients underwent urinary diversion (ileal conduit), its capacity ... Read more >>

Int Urol Nephrol (International urology and nephrology)
[2021, 53(3):401-407]

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Survival after radical cystectomy for bladder cancer: Multicenter comparison between minimally invasive and open approaches.

Weibin Xie, Junming Bi, Qiang Wei, Ping Han, Dongkui Song, Lei Shi, Dingwei Ye, Yijun Shen, Xin Gou, Weiyang He, Shaogang Wang, Zheng Liu, Jinhai Fan, Kaijie Wu, Zhiwen Chen, Xiaozhou Zhou, Chuize Kong, Yang Liu, Chunxiao Liu, Abai Xu, Baiye Jin, Guanghou Fu, Wei Xue, Haige Chen, Tiejun Pan, Zhong Tu, Tianxin Lin, Jian Huang,

<h4>Objective</h4>To investigate oncological outcomes in patients with bladder cancer who underwent minimally invasive radical cystectomy (MIRC) or open radical cystectomy (ORC).<h4>Methods</h4>We identified patients with bladder cancer who underwent radical cystectomy (RC) in 13 centers of the Chinese Bladder Cancer Consortium (CBCC). Perioperative outcomes were compared between MIRC and ORC. The ... Read more >>

Asian J Urol (Asian journal of urology)
[2020, 7(3):291-300]

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Aberrantly glycosylated integrin α3β1 is a unique urinary biomarker for the diagnosis of bladder cancer.

Di Jin, Ruiyun Zhang, Haige Chen, Chong Li,

Bladder cancer (BC) is the most common malignancy of the urinary tract. We developed a new and ELISA kit for detecting aberrantly glycosylated integrin α3β1 (AG31) in human urine. We analysed urine samples (n=408) of patients with BC, renal cell carcinoma (RCC), prostate cancer (PC), cystitis, nephritis, and prostatitis from ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12(11):10844-10862]

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Granulocytic myeloid-derived suppressor cells correlate with outcomes undergoing neoadjuvant chemotherapy for bladder cancer.

Guoliang Yang, Mengyao Liu, Qiang Liu, Xuehui Duan, Haige Chen, Lianhua Zhang, Juanjie Bo,

<h4>Objectives</h4>It remains unclear whether the immunologic status of cells in peripheral blood can be used as a prognostic indicator of response to treatment for patients with neoadjuvant chemotherapy (NAC). This study sought to evaluate whether the proportion of granulocytic myeloid-derived suppressor cells (G-MDSCs) and monocytic myeloid-derived suppressor cells could correlate ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(1):5.e17-5.e23]

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Combining DWI radiomics features with transurethral resection promotes the differentiation between muscle-invasive bladder cancer and non-muscle-invasive bladder cancer.

Shuaishuai Xu, Qiuying Yao, Guiqin Liu, Di Jin, Haige Chen, Jianrong Xu, Zhicheng Li, Guangyu Wu,

<h4>Purpose</h4>To investigate the value of radiomics features from diffusion-weighted imaging (DWI) in differentiating muscle-invasive bladder cancer (MIBC) from non-muscle-invasive bladder cancer (NMIBC).<h4>Methods</h4>This retrospective study included 218 pathologically confirmed bladder cancer patients (training set: 131 patients, 86 MIBC; validation set: 87 patients, 55 MIBC) who underwent DWI before biopsy through transurethral ... Read more >>

Eur Radiol (European radiology)
[2020, 30(3):1804-1812]

Cited: 1 time

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Micropipette Aspiration of Single Cells for Both Mechanical and Electrical Characterization.

Huayan Pu, Na Liu, Jiasheng Yu, Yang Yang, Yi Sun, Yan Peng, Shaorong Xie, Jun Luo, Liang Dong, Haige Chen, Yu Sun,

Cellular physical properties have been identified to reflect cell states. Existing techniques are able to characterize either mechanical or electrical properties of a cell. This paper presents a micropipette aspiration technique that enables the characterization of both mechanical (instantaneous elastic modulus, equilibrium elastic modulus, and viscosity), and electrical (specific membrane ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2019, 66(11):3185-3191]

Cited: 3 times

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Comprehensive genomic profiling of neuroendocrine bladder cancer pinpoints molecular origin and potential therapeutics.

Peiye Shen, Ying Jing, Ruiyun Zhang, Mei-Chun Cai, Pengfei Ma, Haige Chen, Guanglei Zhuang,

Neuroendocrine bladder cancer is a relatively rare but often lethal malignancy, with cell of origin, oncogenomic architecture and standard treatment poorly defined. Here we performed comprehensive whole-genome and transcriptome sequencing on a unique cohort of genitourinary neuroendocrine neoplasms, mainly small cell carcinomas of the urinary bladder. The mutational landscape and ... Read more >>

Oncogene (Oncogene)
[2018, 37(22):3039-3044]

Cited: 6 times

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Somatic FGFR3 Mutations Distinguish a Subgroup of Muscle-Invasive Bladder Cancers with Response to Neoadjuvant Chemotherapy.

Zhao Yang, Ruiyun Zhang, Yunxia Ge, Xuying Qin, Xing Kang, Yue Wang, Xu Zhang, Chengli Song, Xiaofang Quan, Haifeng Wang, Haige Chen, Chong Li,

The administration of neoadjuvant chemotherapy (NAC) preceding radical cystectomy benefits overall survival for patients with muscle-invasive bladder cancer (MIBC). However, the relationship between the genetic profiling of MIBC and NAC response remains unclear. Here, a mutation panel of six cancer-associated genes (TSC1, FGFR3, TERT, TP53, PIK3CA and ERBB2) and an ... Read more >>

EBioMedicine (EBioMedicine)
[2018, 35:198-203]

Cited: 6 times

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Prevalence and clonality of synchronous primary carcinomas in the bladder and prostate.

Ying Jing, Ruiyun Zhang, Pengfei Ma, Mei-Chun Cai, Guanglei Zhuang, Haige Chen,

Incidental prostate adenocarcinoma (IPCa) has been frequently discovered during postoperative histopathological evaluation of radical cystoprostatectomy specimens in patients with bladder cancer (BCa). However, there is currently no conclusive study addressing the clinical significance of IPCa and the clonal relatedness of IPCa and BCa. Here, we performed a retrospective single-center review ... Read more >>

J Pathol (The Journal of pathology)
[2018, 244(1):5-10]

Cited: 0 times

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Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells.

Lianhua Zhang, Guoliang Yang, Ruiyun Zhang, Liang Dong, Haige Chen, Juanjie Bo, Wei Xue, Yiran Huang,

Bladder cancer (BC) has become a serious health prob-lem and represents the second most commonly diagnosed urological tumor. Curcumin is a principal active natural component of turmeric and has long been used in Asia as a traditional herbal medicine. Curcumin suppresses cell growth in various types of cancer, including BC, ... Read more >>

Int J Oncol (International journal of oncology)
[2018, 53(2):515-526]

Cited: 10 times

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Phase distribution analysis of tissues based on the off-axis digital holographic hybrid reconstruction algorithm.

Yunyi Lin, Liang Dong, Haige Chen, Sujuan Huang,

Off-axis digital holography (DH) has great potential in histopathology for its high efficiency and precision. Phase distribution, usually extracted by the angular spectrum (AS) algorithm from a digital hologram, reflects important structural information of biological tissues. However, the complex structure of tissues introduces spectrum aliasing of the hologram, making the ... Read more >>

Biomed Opt Express (Biomedical optics express)
[2018, 9(1):1-13]

Cited: 3 times

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Preoperative prognostic nutritional index is a significant predictor of survival in patients with localized upper tract urothelial carcinoma after radical nephroureterectomy.

Jiwei Huang, Yichu Yuan, Yanqing Wang, YongHui Chen, Wen Kong, Wei Xue, Haige Chen, Jin Zhang, Yiran Huang,

<h4>Background</h4>Patient's nutritional and immunological status have a potentially significant role in survival outcome in patients with malignant tumors. We investigated the prognostic value of preoperative prognostic nutritional index (PNI) in patients with localized upper tract urothelial carcinoma (UTUC) undergoing radical nephrouretectomy (RNU).<h4>Patients and methods</h4>A total of 425 patients with nonmetastatic ... Read more >>

Urol Oncol (Urologic oncology)
[2017, 35(12):671.e1-671.e9]

Cited: 14 times

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Depletion of astrocyte elevated gene-1 suppresses tumorigenesis through inhibition of Akt activity in bladder cancer cells.

Lianhua Zhang, Guoliang Yang, Haige Chen, Yiran Huang, Wei Xue, Juanjie Bo,

Astrocyte elevated gene-1 (AEG-1) has been reported to promote tumorigenesis, however the molecular mechanisms by which AEG-1-induced bladder cancer progression has remained elusive. Here, we identified that depletion of AEG-1 in bladder cancer cells suppressed cell growth. Moreover, we observed that down-regulation of AEG-1 induced apoptosis and inhibited cell migration ... Read more >>

Am J Transl Res (American journal of translational research)
[2017, 9(12):5422-5431]

Cited: 1 time

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BCMab1-Ra, a novel immunotoxin that BCMab1 antibody coupled to Ricin A chain, can eliminate bladder tumor.

Chong Li, Ruping Yan, Zhao Yang, Haifeng Wang, Ruiyun Zhang, Haige Chen, Jiansong Wang,

Bladder cancer is one of the most common malignancies. However, there is no ideal therapy to cure bladder cancer so far, especially invasive carcinoma. Here, we developed a new antibody-based drug BCMab1-Ra, which was generated by conjugation of BCMab1 (a new monoclonal antibody that specifically recognized the aberrantly glycosylated Integrin ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(28):46704-46705]

Cited: 5 times

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Correction: Folic acid-functionalized up-conversion nanoparticles: toxicity studies in vivo and in vitro and targeted imaging applications.

Lining Sun, Zuwu Wei, Haige Chen, Jinliang Liu, Jianjian Guo, Ming Cao, Tieqiao Wen, Liyi Shi,

Correction for 'Folic acid-functionalized up-conversion nanoparticles: toxicity studies in vivo and in vitro and targeted imaging applications' by Lining Sun et al., Nanoscale, 2014, 6, 8878-8883. ... Read more >>

Nanoscale (Nanoscale)
[2017, 9(36):13828]

Cited: 0 times

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Preoperative serum pre-albumin as an independent prognostic indicator in patients with localized upper tract urothelial carcinoma after radical nephroureterectomy.

Jiwei Huang, Yanqing Wang, Yichu Yuan, YongHui Chen, Wen Kong, Haige Chen, Jin Zhang, Yiran Huang,

<h4>Purpose</h4>To investigate the prognostic value of preoperative pre-albumin and albumin level in patients with localized upper tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy.<h4>Methods and materials</h4>Between January 2003 and June 2013, we evaluated data on 425 patients with nonmetastatic UTUC (Ta-4N0/+M0) who underwent radical nephroureterectomy at our institution. Low pre-albumin level ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(22):36772-36779]

Cited: 18 times

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Prognostic value of preoperative plasma fibrinogen level and platelet-to-lymphocyte ratio (F-PLR) in patients with localized upper tract urothelial carcinoma.

Jiwei Huang, Yichu Yuan, Yanqing Wang, Jin Zhang, Wen Kong, Haige Chen, Yonghui Chen, Yiran Huang,

<h4>Purpose</h4>Hemostatic factors is thought to have a potentially significant role in progression and metastasis of malignant tumors. We investigated the prognostic value of preoperative plasma fibrinogen level and platelet-to-lymphocyte ratio (PLR) in localized upper tract urothelial carcinoma (UTUC).<h4>Materials and methods</h4>A total of 481 patients who underwent radical nephroureterectomy for localized ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(22):36761-36771]

Cited: 13 times

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SERS measurement of the bladder cancer cells with the nanoparticles.

Di Jin, Haige Chen, Ming Cao, Guoliang Yang, Wei Xue, Yiran Huang,

The surfaced enhanced Raman spectroscopy (SERS) of bladder cancer cells and tissues were measured in this paper. Both depth SERS and map SERS of SCABER bladder cancer cells were measured with confocal Raman microscope using gold nanoparticles as the enhance substrate. We also measured SERS of normal bladder tissue and ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2015, 28(5 Suppl):1853-1856]

Cited: 0 times

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Simultaneous realization of Hg(2+) sensing, magnetic resonance imaging and upconversion luminescence in vitro and in vivo bioimaging based on hollow mesoporous silica coated UCNPs and ruthenium complex.

Xiaoqian Ge, Lining Sun, Binbin Ma, Di Jin, Liang Dong, Liyi Shi, Nan Li, Haige Chen, Wei Huang,

We have constructed a multifunctional nanoprobe with sensing and imaging properties by using hollow mesoporous silica coated upconversion nanoparticles (UCNPs) and Hg(2+) responsive ruthenium (Ru) complex. The Ru complex was loaded into the hollow mesoporous silica and the UCNPs acted as an energy donor, transferring luminescence energy to the Ru ... Read more >>

Nanoscale (Nanoscale)
[2015, 7(33):13877-13887]

Cited: 16 times

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Thyroid-Like Follicular Carcinoma of the Kidney in a Patient with Skull and Meningeal Metastasis: A Unique Case Report and Review of the Literature.

Liang Dong, Jiayu Huang, Luke Huang, Oumin Shi, Qiang Liu, Haige Chen, Wei Xue, Yiran Huang,

Thyroid-like follicular carcinoma of the kidney (TLFCK) is an extremely rare subtype of renal cell carcinoma with close resemblance to the well-differentiated thyroid follicular neoplasms. TLFCK has not been included in the 2004 World Health Organization (WHO) classification due to the limited data available. Only 27 cases have been reported ... Read more >>

Medicine (Baltimore) (Medicine)
[2016, 95(15):e3314]

Cited: 5 times

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Catalpol Inhibited the Proliferation of T24 Human Bladder Cancer Cells by Inducing Apoptosis Through the Blockade of Akt-Mediated Anti-apoptotic Signaling.

Di Jin, Ming Cao, Xin Mu, Guoliang Yang, Wei Xue, Yiran Huang, Haige Chen,

Catalpol is an iridoid glucoside extracted from the traditional Chinese medicinal plant called Rehmannia glutinosa, and it is reported to possess a variety of pharmacological activities. The goal of this research was to explore the effect of catalpol on the human bladder cancer cells T24. The cells were treated for ... Read more >>

Cell Biochem Biophys (Cell biochemistry and biophysics)
[2015, 71(3):1349-1356]

Cited: 13 times

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