Full Text Journal Articles by
Author Haibo Zhou

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Establishment of recombineering genome editing system in Paraburkholderia megapolitana empowers activation of silent biosynthetic gene clusters.

Wentao Zheng, Xue Wang, Haibo Zhou, Youming Zhang, Aiying Li, Xiaoying Bian,

The Burkholderiales are an emerging source of bioactive natural products. Their genomes contain a large number of cryptic biosynthetic gene clusters (BGCs), indicating great potential for novel structures. However, the lack of genetic tools for the most of Burkholderiales strains restricts the mining of these cryptic BGCs. We previously discovered ... Read more >>

Microb Biotechnol (Microbial biotechnology)
[2020, 13(2):397-405]

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Identification of Holrhizins E-Q Reveals the Diversity of Nonribosomal Lipopeptides in Paraburkholderia rhizoxinica.

Hanna Chen, Haibo Zhou, Tao Sun, Jiaying Xu, Qiang Tu, Jie Yang, Youming Zhang, Xiaoying Bian,

The products of a nonribosomal peptide synthetase gene, holA, from Paraburkholderia rhizoxinica were investigated using our recently established recombineering technique. Fifteen products, including 13 new linear lipopeptides, holrhizins E-Q (2-8, 10-15), together with the two known holrhizins A and B (1, 9), were detected in the activated mutant, and their ... Read more >>

J. Nat. Prod. (Journal of natural products)
[2020, :]

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Genome Mining and Biosynthesis of Primary Amine-Acylated Desferrioxamines in a Marine Gliding Bacterium.

Zong-Jie Wang, Haibo Zhou, Guannan Zhong, Liujie Huo, Ya-Jie Tang, Youming Zhang, Xiaoying Bian,

Genome mining of Fulvivirga sp. W222 revealed a desferrioxamine-like biosynthetic gene cluster containing an unknown gene fulF that is conserved in many Bacteroidetes species. A series of primary amine-acylated desferrioxamine G1 analogues, fulvivirgamides, were identified, and fulvivirgamides A2, B2, B3, and B4 (1-4) were purified and characterized. The function of ... Read more >>

Org. Lett. (Organic letters)
[2020, 22(3):939-943]

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Spermidine Suppresses Inflammatory DC Function by Activating the FOXO3 Pathway and Counteracts Autoimmunity.

Guanhua Li, Huihua Ding, Xiang Yu, Yao Meng, Jun Li, Qiang Guo, Haibo Zhou, Nan Shen,

Dendritic cells (DCs) function is intimately linked to microenvironment and metabolism. Type I interferons (IFNs) condition dendritic cells to respond to weak self-signals, leading to autoimmunity. However, the metabolic adaption in the process is unclear. Here, we identified spermidine as a critical metabolite impacting the metabolic fitness of DC. First, ... Read more >>

iScience (iScience)
[2020, 23(1):100807]

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Oral Microbiota as Promising Diagnostic Biomarkers for Gastrointestinal Cancer: A Systematic Review.

Yanwei Chen, Xuechen Chen, Haixin Yu, Haibo Zhou, Shu Xu,

Emerging evidence has shown the potential of oral microbiota as a noninvasive diagnostic tool in gastrointestinal (GI) cancer. PubMed, Web of Science, and Embase were systematically searched for eligible studies published until May 31, 2019. Of the 17 included studies published between 2011 and 2019, five kinds of GI cancer, ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2019, 12:11131-11144]

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Static Low-Angle Squatting Reduces the Intra-Articular Inflammatory Cytokines and Improves the Performance of Patients with Knee Osteoarthritis.

Zhihong Zhao, Rui Wang, Yu Guo, Lianxu Chen, Kai Wang, Haibo Zhou, Hongwei Li, Jingbin Zhou,

Osteoarthritis (OA) is one of the major diseases leading to disability, and inflammation plays an important role in the pathogenesis of OA. However, inflammation of OA is multifactorial, chronic, and in low intensity, which makes drug-based immunotherapy difficult. Here, we have designed a novel method of exercise-static low angle squat ... Read more >>

Biomed Res Int (BioMed research international)
[2019, 2019:9617923]

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Double-negative T Cells Inhibit Proliferation and Invasion of Human Pancreatic Cancer Cells in Co-culture.

Yin Lu, Pibo Hu, Haibo Zhou, Zhijian Yang, Y U Sun, Robert M Hoffman, Jiong Chen,

BACKGROUND/AIM:Double-negative T (DNT) cells are phenotypically CD3+CD4-CD8-T cells. This study aimed to investigate the anti-cancer activity of DNT cells against pancreatic cancer cells. MATERIALS AND METHODS:DNT cells were isolated from human peripheral blood. The effect of DNT cells on proliferation and invasion of the human pancreatic cell line Panc-1 was ... Read more >>

Anticancer Res. (Anticancer research)
[2019, 39(11):5911-5918]

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Destin: toolkit for single-cell analysis of chromatin accessibility.

Eugene Urrutia, Li Chen, Haibo Zhou, Yuchao Jiang,

SUMMARY:Single-cell assay of transposase-accessible chromatin followed by sequencing (scATAC-seq) is an emerging new technology for the study of gene regulation with single-cell resolution. The data from scATAC-seq are unique-sparse, binary and highly variable even within the same cell type. As such, neither methods developed for bulk ATAC-seq nor single-cell RNA-seq ... Read more >>

Bioinformatics (Bioinformatics (Oxford, England))
[2019, 35(19):3818-3820]

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Influence of Self-Relevance and Reputational Concerns on Altruistic Moral Decision Making.

Youlong Zhan, Xiao Xiao, Qianbao Tan, Shangming Zhang, Yangyi Ou, Haibo Zhou, Jin Li, Yiping Zhong,

Complex moral decision making may share certain cognitive mechanisms with economic decision making under risk situations. However, it is little known how people weigh gains and losses between self and others during moral decision making under risk situations. The current study adopted the dilemma scenario-priming paradigm to examine how self-relevance ... Read more >>

Front Psychol (Frontiers in psychology)
[2019, 10:2194]

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Analysis of secondary phenotypes in multigroup association studies.

Fan Zhou, Haibo Zhou, Tengfei Li, Hongtu Zhu,

Although case-control association studies have been widely used, they are insufficient for many complex diseases, such as Alzheimer's disease and breast cancer, since these diseases may have multiple subtypes with distinct morphologies and clinical implications. Many multigroup studies, such as the Alzheimer's Disease Neuroimaging Initiative (ADNI), have been undertaken by ... Read more >>

Biometrics (Biometrics)
[2019, :]

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Identification and expression analyses of new genes associated with ciprofloxacin resistance in Vibrio parahaemolyticus.

Haibo Zhou, Ying Liang, Lu Gao, Jianluan Ren, Feng Xue, Dehua Guo, Yuan Jiang, Zhenquan Yang, Lele Lian, Jianjun Dai,

Quinolone-resistant foodborne pathogens have become an important public health concern, however, little is known about the molecular mechanism of ciprofloxacin (CIP) resistance among Vibrio parahaemolyticus isolates. This study aimed to explore new genes implicated in resistance to CIP in genome-wide. CIP susceptibility of six V. parahaemolyticus isolates was analyzed by ... Read more >>

Food Res. Int. (Food research international (Ottawa, Ont.))
[2019, 125:108629]

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Identification and expression analyses of new genes associated with ciprofloxacin resistance in Vibrio parahaemolyticus

Haibo Zhou, Jianjun Dai, Lu Gao, Dehua Guo, Yuan Jiang, Lele Lian, Ying Liang, Jianluan Ren, Feng Xue, Zhenquan Yang,

Quinolone-resistant foodborne pathogens have become an important public health concern, however, little is known about the molecular mechanism of ciprofloxacin (CIP) resistance among Vibrio parahaemolyticus isolates. This study aimed to explore new genes implicated in resistance to CIP in genome-wide. CIP susceptibility of six V. parahaemolyticus isolates was analyzed by ... Read more >>

Food Res. Int. (Food research international (Ottawa, Ont.))
[2019, :Not Available]

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Combined effect between WT1 methylation and Helicobacter pylori infection, smoking, and alcohol consumption on the risk of gastric cancer.

Haibo Zhou, Hongru Sun, Xinyan Liu, Jie Chen, Lei Zhang, Shangqun Lin, Xu Han, Chuang Nie, Yupeng Liu, Wenjing Tian, Yashuang Zhao,

BACKGROUND:Peripheral blood leukocyte DNA methylation status has been proposed to be a surrogate marker for evaluating susceptibility to gastric cancer (GC). Helicobacter pylori (H pylori) infection, smoking, and alcohol consumption are known to induce gene methylation. A case-control study was performed to investigate the interactions between the methylation of two candidate ... Read more >>

Helicobacter (Helicobacter)
[2019, 24(5):e12650]

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A nanohybrid composed of MoS2 quantum dots and MnO2 nanosheets with dual-emission and peroxidase mimicking properties for use in ratiometric fluorometric detection and cellular imaging of glutathione.

Xiao Tang, Xueyi Zeng, Huimei Liu, Yili Yang, Haibo Zhou, Huaihong Cai,

A nanohybrid probe was fabricated from manganese dioxide nanosheets (MnO2 NSs), molybdenum disulfide quantum dots (MoS2 QDs) and o-phenylenediamine (OPD) for ratiometric detection of glutathione (GSH) in aqueous solutions and living cells. The MoS2 QDs act as the fluorescent "turn off-on" units. The MnO2 NSs have 3 functions, viz. (a) ... Read more >>

Mikrochim Acta (Mikrochimica acta)
[2019, 186(8):572]

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Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis.

Changyang Zhou, Yidi Sun, Rui Yan, Yajing Liu, Erwei Zuo, Chan Gu, Linxiao Han, Yu Wei, Xinde Hu, Rong Zeng, Yixue Li, Haibo Zhou, Fan Guo, Hui Yang,

Recently developed DNA base editing methods enable the direct generation of desired point mutations in genomic DNA without generating any double-strand breaks1-3, but the issue of off-target edits has limited the application of these methods. Although several previous studies have evaluated off-target mutations in genomic DNA4-8, it is now clear ... Read more >>

Nature (Nature)
[2019, 571(7764):275-278]

Cited: 9 times

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Nonreceptor tyrosine phosphatase 14 promotes proliferation and migration through regulating phosphorylation of YAP of Hippo signaling pathway in gastric cancer cells.

Xu Han, Tong Sun, Jia Hong, Rongrong Wei, Yingzi Dong, Di Huang, Jie Chen, Xiyun Ren, Haibo Zhou, Wenjing Tian, Yunhe Jia,

BACKGROUND:The Hippo signaling pathway is associated with cell proliferation and organ size, and its transcriptional coactivator Yes-associated protein (YAP), emerges as a crucial oncoprotein in multiple cancers. It was increasingly recognized that nonreceptor tyrosine phosphatase 14 (PTPN14) was relevant to the cell membrane and cytoskeleton, and had a critical effect ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2019, 120(10):17723-17730]

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Surface Acting or Deep Acting, Who Need More Effortful? A Study on Emotional Labor Using Functional Near-Infrared Spectroscopy.

Yongbiao Lu, Wenfeng Wu, Gaoxing Mei, Shouying Zhao, Haibo Zhou, Daling Li, Deng Pan,

Emotional labor is characterized by two main regulation strategies: surface acting and deep acting. However, which strategy consumes more energy? To explore this, we used functional near-infrared spectroscopy (fNIRS) to measure changes in hemoglobin density while participants performed a task requiring them to make the opposite emotional facial expression of ... Read more >>

Front Hum Neurosci (Frontiers in human neuroscience)
[2019, 13:151]

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Advances in biosensors for the detection of ochratoxin A: Bio-receptors, nanomaterials, and their applications.

Yasmin Alhamoud, Danting Yang, Samuel Selorm Fiati Kenston, Guozhen Liu, Linyang Liu, Haibo Zhou, Fatma Ahmed, Jinshun Zhao,

Ochratoxin A (OTA) is a class of mycotoxin mainly produced by the genera Aspergillus and Penicillium. OTA can cause various forms of kidney, liver and brain diseases in both humans and animals although trace amount of OTA is normally present in food. Therefore, development of fast and sensitive detection technique ... Read more >>

Biosens Bioelectron (Biosensors & bioelectronics)
[2019, 141:111418]

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Silver Doped Mesoporous Silica Nanoparticles Based Electrochemical Enzyme-Less Sensor for Determination of H2O2 Released from Live Cells.

Danting Yang, Ning Ni, Lu Cao, Xin Song, Yasmin Alhamoud, Guangxia Yu, Jinshun Zhao, Haibo Zhou,

In this study, a silver doped mesoporous silica nanoparticles-based enzyme-less electrochemical sensor for the determination of hydrogen peroxide (H2O2) released from live cells was constructed for the first time. The presented electrochemical sensor exhibited fast response (2 s) towards the reduction of H2O2 concentration variation at an optimized potential of ... Read more >>

Micromachines (Basel) (Micromachines)
[2019, 10(4):]

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Ferruginol Diterpenoid Selectively Inhibits Human Thyroid Cancer Growth by Inducing Mitochondrial Dependent Apoptosis, Endogenous Reactive Oxygen Species (ROS) Production, Mitochondrial Membrane Potential Loss and Suppression of Mitogen-Activated Protein Kinase (MAPK) and PI3K/AKT Signaling Pathways.

Guoqing Luo, Jingjing Zhou, Guanjie Li, Ningdong Hu, Xu Xia, Haibo Zhou,

BACKGROUND Thyroid cancer causes considerable mortality and morbidity across the globe. Owing to the unavailability of biomarkers and the adverse effects of existing drugs, there is an urgent need to develop efficient chemotherapy for the treatment of thyroid cancers. Plants have served as exceptional source of drugs for the treatment ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2019, 25:2935-2942]

Cited: 1 time

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Inhibition of hepatocellular carcinoma cell proliferation, migration, and invasion by a disintegrin and metalloproteinase-17 inhibitor TNF484.

Changhong Xia, Dongsheng Zhang, Yanmei Li, Jie Chen, Haibo Zhou, Long Nie, Yanyan Sun, Siyan Guo, Jianbiao Cao, Fangzheng Zhou, Junlai Li,

Background:The aim of this study was to test the effect of TNF484 on cell proliferation, migration, and invasion of hepatocellular carcinoma (HCC) cells. Materials and Methods:Various doses (0, 1, 10, 50, and 100 nM) of TNF484 were applied to the HepG2 and Bel7402 cells, and cell proliferation was measured by ... Read more >>

J Res Med Sci (Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences)
[2019, 24:26]

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A Multi-faceted Intervention Aimed at Black-White Disparities in the Treatment of Early Stage Cancers: The ACCURE Pragmatic Quality Improvement trial.

Samuel Cykert, Eugenia Eng, Matthew A Manning, Linda B Robertson, Dwight E Heron, Nora S Jones, Jennifer C Schaal, Alexandra Lightfoot, Haibo Zhou, Christina Yongue, Ziya Gizlice,

BACKGROUND:Reports continue to show that Blacks with curable lung or breast cancer complete treatment less often than similar Whites contributing to worse survival. ACCURE is an intervention trial designed to address this problem. PATIENTS AND METHODS:A pragmatic, quality improvement trial comparing an intervention group to retrospective and concurrent controls. Patients ... Read more >>

J Natl Med Assoc (Journal of the National Medical Association)
[2019, :]

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Long-term Low-Dose Sucrose May Prevent Migraine: Two Double-Blinded Randomized Controlled Pilot Trials.

Ran Yan, Xin Wang, HaiBo Zhou, Xin Li, YanBo Diao, YuHang Xing, YuLan Zhu, XiaoFeng Jiang, JiaMei Sun, ZuoMing Zhang, YaShuang Zhao,

AIMS:To evaluate the efficacy of sucrose in the prevention of migraine attacks. METHODS:Two randomized double-blinded pilot trials were conducted, one in college students and one in adults. Migraineurs were randomized into two groups that each received an oral liquid: for students, sucrose 5 g/day (s-group; n = 12) or glucose ... Read more >>

J Oral Facial Pain Headache (Journal of oral & facial pain and headache)
[2019, 33(2):165–173]

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The glutathione-S-transferase mu-1 null genotype increases wood smoke-induced airway inflammation.

Allison J Burbank, Anusha Vadlamudi, Katherine H Mills, Ethan M Alt, Heather Wells, Haibo Zhou, Neil Alexis, Michelle L Hernandez, David B Peden,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2019, 143(6):2299-2302.e3]

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Gamma tocopherol effect on LPS-induced sputum neutrophilia is not modified by BMI or GSTM1 genotype.

Amika K Sood, Allison J Burbank, Charity G Duran, Kimberly Enders, Haibo Zhou, David B Peden, Michelle L Hernandez,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2019, 143(5):1937-1939]

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