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Author Hafiz Muhammad Asif

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α-Glucosidase Inhibitory, Anti-Oxidant, and Anti-Hyperglycemic Effects of Euphorbia nivulia-Ham. in STZ-Induced Diabetic Rats.

Muhammad Younus, Muhammad Mohtasheem Ul Hasan, Khalil Ahmad, Ali Sharif, Hafiz Muhammad Asif, Muhammad Rahil Aslam, Ihsan Ul Haq, Zulfiqar Ahmad,

In this study, we aimed to investigate the antidiabetic effects of Euphorbia nivulia (En), native to Cholistan Desert area of Bahawalpur, Pakistan. First, we performed high-performance liquid chromatography analysis and found that this plant contains ferulic acid, gallic acid, quercetin, benzoic acid, polyphenols, and flavonoids. Then, we performed in vitro ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(3):1559325820939429]

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Early Detection and Assessment of Covid-19.

Hafiz Abdul Sattar Hashmi, Hafiz Muhammad Asif,

Background: Since the Covid-19 global pandemic emerged, developing countries have been facing multiple challenges over its diagnosis. We aimed to establish a relationship between the signs and symptoms of COVID-19 for early detection and assessment to reduce the transmission rate of SARS-Cov-2. Methods: We collected published data on the clinical ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2020, 7:311]

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EARLY DETECTION OF COVID-19

Hafiz Abdul Sattar Hashmi, Hafiz Muhammad Asif,

Abstract Since SARS-Cov-2 epidemic appeared in Wuhan China, it became challenge for health authorities to counter Covid-19 epidemic. Early evaluation of suspects, screening for Covid-19 and management posed challenge to health authorities especially in developing countries which were not ready to cope with it. Early mild symptoms appeared during course ... Read more >>

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Dose-Dependent, Antidepressant, and Anxiolytic Effects of a Traditional Medicinal Plant for the Management of Behavioral Dysfunctions in Animal Models.

Hafiz Muhammad Asif, Abdul Hayee, Muhammad Rahil Aslam, Khalil Ahmad, Abdul Sattar Hashmi,

The present work was carried out to assess the Onosma bracteatum anxiolytic and antidepressant properties. Swiss albino mice (male) were fed orally with hydroalcoholic extract at different doses 50, 100, and 200 mg 1 hour prior to test with the standard diazepam and fluoxetine. Anxiolytic and antidepressant activities were evaluated ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2019, 17(4):1559325819891262]

Cited: 2 times

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From Simplicity to Complexity in Grafting Dawson-Type Polyoxometalates on Porphyrin, Leading to the Formation of New Organic-Inorganic Hybrids for the Investigation of Third-Order Optical Nonlinearities.

Arshad Iqbal, Hafiz Muhammad Asif, Yunshan Zhou, Lijuan Zhang, Ting Wang, Farooq Khurum Shehzad, Xiaoyu Ren,

Four new organic-inorganic hybrids, [N(C4H9)4]5H[{HNC2O(CH2O)3P2V3W15O59}C44N4H29O3] (TPPOH-1POM), [N(C4H9)4]10H2[{HNC2O(CH2O)3P2V3W15O59}2C44N4H28O2] (TPPOH-2POM trans), [N(C4H9)4]10H2[{HNC2O(CH2O)3P2V3W15O59}2C44N4H28O2] (TPPOH-2POM cis), and [N(C4H9)4]15H3[{HNC2O(CH2O)3P2W15V3O59}3C44N4H27O] (TPPOH-3POM), have been synthesized by covalently grafting the Dawson-type polyoxometalate (POM) [N(C4H9)4]5[H4P2W15V3O62] onto new porphyrins N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]-4-[10,15,20-tris(4-hydroxyphenyl)porphyrin-5-yl]benzamide (TPPOH-1Tris), 4,4'-[5,15-bis(4-hydroxyphenyl)porphyrin-10,20-diyl]bis[ N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]benzamide] (TPPOH-2Tris trans), 4,4'-[10,15-bis(4-hydroxyphenyl)porphyrin-5,20-diyl]bis[ N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]benzamide] (TPPOH-2Tris cis). and 4,4',4″-[20-(4-hydroxyphenyl)porphyrin-5,10,15-triyl]tris[ N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]benzamide] (TPPOH-3Tris), respectively, in N, N-dimethylacetamide under nitrogen. The ... Read more >>

Inorg Chem (Inorganic chemistry)
[2019, 58(13):8763-8774]

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Phytochemical screening and antipyretic effects of hydroalcoholic extracts of selected medicinal plants of Rawalakot, Azad Jammu and Kashmir in albino rats.

Mahvish Ajaz, Muhammad Akram, Hafiz Muhammad Asif, Abid Hussain, Syed Muhammad Ali Shah, Imtiaz Mahmood Tahir, Muhammad Daniyal, Fahad Said Khan,

Pyrexia occurs due to infection, malignancy and other diseases. Majority of the antipyretic drugs are synthetic in nature which exerts side effects such as gastric ulcer, hepatic necrosis and renal damage. The antipyretic potential of the hydro-alcoholic extracts of Achillea millefolium, Taraxacum officinale, Salix alba and Trigonella foenum were investigated ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(2):581-592]

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Antihyperglycemic Activity of Hydroalcoholic Extracts of Selective Medicinal Plants Curcuma longa, Lavandula stoechas, Aegle marmelos, and Glycyrrhiza glabra and Their Polyherbal Preparation in Alloxan-Induced Diabetic Mice.

Sodah Bint Mustafa, Muhammad Akram, Hafiz Muhammad Asif, Imran Qayyum, Asif Mehmood Hashmi, Naveed Munir, Fahad Said Khan, Muhammad Riaz, Saeed Ahmad,

Background:Diabetes mellitus is a metabolic disorder associated with relative or absolute insulin deficiency or resistance, characterized by hyperglycemia. Modern prescriptions such as pioglitazone have better therapeutic potential, but its side effects and financial burden for developing countries have motivated the researchers to find alternative natural drugs to compete hyperglycemia in ... Read more >>

(Dose-response : a publication of International Hormesis Society)
[2019, 17(2):1559325819852503]

Cited: 1 time

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Acute and sub acute toxicity study and randomized clinical trial of polyherbal coded drug candicure in the management of acute vulvo-vaginal candidiasis.

Sabira Sultana, Tasneem Qureshi, Hafiz Muhammad Asif, Muhammad Akram, Sultan Ayaz, Syed Muhammad Ali Shah,

Vulvo-Vaginal Candidiasis is common gynecological disorder. Clinical trials are designed to evaluate the effect of medical intervention with allopathic and herbal medicine to treat vulvo-vaginal candidiasis. The toxicity index and the safety profile of test drug were assessed on animals' model. Toxicity study of polyherbal formulation was done in order ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(1(Supplementary)):315-322]

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Covalent Synthesis of Two Hybrids Composed of Dawson-Type Polyoxometalate and Porphyrin with Remarkable Third-Order Optical Nonlinearities Reflecting the Effect of Polyoxometalates.

Hafiz Muhammad Asif, Yunshan Zhou, Lijuan Zhang, Nusrat Shaheen, Di Yang, Jiaqi Li, Yi Long, Arshad Iqbal, Yanqin Li,

Two new porphyrin-polyoxometalate hybrids, namely, [(C4H9)4N]10H2[{COHNC(CH2O)3P2V3W15O59}2C44N4H28]·CH3CN 1, bearing two covalent-bonded Wells-Dawson-type polyoxometalates (POMs), and [(C4H9)4N)]5H[COHNC(CH2O)3P2V3W15O59{C44H29N4}]·CH3CN 2, bearing one covalent-bonded POM, have been synthesized and thoroughly characterized by means of elemental analysis, powder XRD, FT-IR, 1H (31P, 51V) NMR, MALDI-TOF-MS, UV-vis spectra, and cyclic voltammetry measurement. Experimental results demonstrate that while ... Read more >>

Inorg Chem (Inorganic chemistry)
[2017, 56(16):9436-9447]

Cited: 1 time

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Review: Medicinal plants combating against hypertension: A green antihypertensive approach.

Sabira Sultana, Hafiz Muhammad Asif,

Hypertension (HTN) or high blood pressure is a medical condition that accounts 9.4 million deaths all over the world every year. It is leading cause of morbidity and mortality worldwide. It increases the risk of cardiovascular diseases, including heart failure, diffuse atherosclerosis, cognitive impairment and dementia. Clinically, synthetic antihypertensive drugs ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2017, 30(6):2311-2319]

Cited: 1 time

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Antipyretic effects of hydro-methanol extract of Melia azedarach Linn. seeds and Cucumis melo Linn. seeds in experimental rabbits.

Sabira Sultana, Naveed Akhtar, Hafiz Muhammad Asif,

To investigate the antipyretic activity of hydro-methanol extract of Melia azedarach Linn. (HMEMA) seeds and Cucumis melo Linn. (HMECM) seeds in experimental animals. Baker's yeast was used to induce fever in rabbits which were divided into six groups. The animal groups were thereafter administered distilled water (control), paracetamol (reference standard, ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2017, 30(4):1257-1261]

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Hepatoprotective evaluation of aqueous-ethanolic extract of Capparis decidua (Stems) in paracetamol induced hepatotoxicity in experimental rabbits.

Jalilur Rehman, Naveed Akhtar, Hafiz Muhammad Asif, Sabira Sultana, Mukhtiar Ahmad,

Liver diseases are the most common ailment all over the world mostly caused by viruses, toxic chemicals, excessive intake of alcohol, high doses of paracetamol, carbon tetrachloride, chemotherapeutic agents and peroxides oil, etc. There is a great need to assess the scientific basis for the medicinal plants that are claimed ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2017, 30(2):507-511]

Cited: 2 times

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Clinical study on the efficacy of Amoebex (coded herbal drug) compared with Metronidazole for the treatment of Amoebic dysentery.

Syed MuhammadAli Shah, Khan Usmanghani, Naveed Akhtar, Muhammad Akram, Hafiz Muhammad Asif, Muhammad Mohtasheemul Hasan,

Amoebiasisis an infectious disease, which originated with the single-celled parasitic protozoan Entamoeba histolytica. The parasitic amoeba infects the liver and intestine and may cause mild diarrhea and serious dysentery with bloody and mucoid stool. A study was conducted to evaluate the efficacy of Amoebex (400mg), a herbal formulation for the ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2016, 29(6):2005-2014]

Cited: 2 times

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In vitro antioxidant and reducing capability of weight loss tablet formulation.

Syed RashidAli Jaffary, Syed Waseemuddin Ahmed, Sadia Shakeel, Hafiz Muhammad Asif, Khan Usmanghani,

Antioxidants are used as an influential counteractive measure in opposing the generation of reactive oxygen species. The current study was carried out to investigate antioxidant potential and reducing capability of developed weight reducing tablet formulation. When tablets were evaluated at concentrations of 50, 100 and 500μ/ml, antioxidant activity improved in ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2016, 29(5 Suppl):1749-1753]

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Efficacy and safety of Entoban for the treatment of chronic diarrhea.

Sadia Shakeel, Khan Usmanghani, Hafiz Muhammad Asif,

The current randomized clinical trial was conducted to assess the safety and effectiveness of Entoban for treating patients of chronic diarrhea. The study enrolled 150 patients fulfilling the inclusion criteria, among them 95 were males and 55 were females. Written informed consent was obtained from all study participants. Metronidazole tablets ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2016, 29(6 Suppl):2349-2353]

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Evaluation of in vitro urease and lipoxygenase inhibition activity of weight reducing tablets.

Syed Rashid Ali Jaffary, Syed Waseemuddin Ahmed, Sadia Shakeel, Hafiz Muhammad Asif, Khan Usmanghani,

Enzyme inhibition is a significant part of research in pharmaceutical field in view of the fact that these studies have directed to the innovations of drugs having remarkable performance in diverse physiological conditions. The present study was aimed to assess urease and lipoxygenase inhibitory activity of weight reducing tablets. For ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2016, 29(4 Suppl):1397-1400]

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HER-2 Positive Breast Cancer - a Mini-Review.

Hafiz Muhammad Asif, Sabira Sultana, Saeed Ahmed, Naheed Akhtar, Muhammad Tariq,

Breast cancer is one of among all cancers with increased incidence, high mortality rate, and high economic and social costs. The the most common type of cancer among females worldwide, breast cancer is actually the uncontrolled proliferation of cells which attain malignancy. Recently it has shown that breast cancer contributes ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2016, 17(4):1609-1615]

Cited: 15 times

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Update knowledge on cervical cancer incidence and prevalence in Asia.

Muhammad Daniyal, Naheed Akhtar, Saeed Ahmad, Urooj Fatima, Muhammad Akram, Hafiz Muhammad Asif,

Cervical cancer is the second most common cause of cancer-related death among women worldwide, with over 500,000 new cases diagnosed annually and 50% mortality rate in Asia. In the United States, approximately 10,370 new cases of cervical cancer are diagnosed annually, and estimated 3,710 deaths occur from the disease, making ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2015, 16(9):3617-3620]

Cited: 10 times

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Phytomedicine-based and Quadruple Therapies in Helicobacter pylori Infection: A Comparative, Randomized Trial.

Hafiz Muhammad Asif, Syed Faisal Zaidi, Toshiro Sugiyama, Naveed Akhtar, Khan Usmanghani,

CONTEXT: Helicobacter pylori (H pylori) is strongly associated with the development of gastritis, duodenal and gastric ulcers, gastric mucosa-associated lymphoid tissue (MALT) lymphomas and gastric carcinoma. Emerging antibiotic resistance and patients' poor compliance with modern therapies have resulted in increasing eradication failure. OBJECTIVES: The current trial was conducted to evaluate ... Read more >>

Altern Ther Health Med (Alternative therapies in health and medicine)
[2015, 21 Suppl 2:33-39]

Cited: 1 time

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Risk Factors and Epidemiology of Gastric Cancer in Pakistan.

Muhammad Daniyal, Saeed Ahmad, Mukhtiar Ahmad, Hafiz Muhammad Asif, Muhammad Akram, Saif Ur Rehman, Sabira Sultana,

Gastric cancer is the 2nd most common cause of death among all cancers and is the 4th most common cancer in the world. The number of deaths due to gastric cancer is about 800,000 annually. Gastric cancer is more common in men as compared to women and is 3rd most ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2015, 16(12):4821-4824]

Cited: 9 times

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Medicinal plants combating against cancer--a green anticancer approach.

Sabira Sultana, Hafiz Muhammad Asif, Hafiz Muhammad Irfan Nazar, Naveed Akhtar, Jalil Ur Rehman, Riaz Ur Rehman,

Cancer is the most deadly disease that causes the serious health problems, physical disabilities, mortalities, and morbidities around the world. It is the second leading cause of death all over the world. Although great advancement have been made in the treatment of cancer progression, still significant deficiencies and room for ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2014, 15(11):4385-4394]

Cited: 10 times

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Clinical efficacy of herbal coded formulation ocucure for the improvement of presbyopia: a randomized comparative clinical trial.

Muhammad Muslim Khan, Khan Usmanghani, Halima Nazar, Hafiz Muhammad Asif,

A progressively diminishing capacity of eye to visualize for close proximity increasing by age is known as presbyopia which is usually resulted due to loss of elasticity of crystalline lens. A clinical trial was conducted to evaluate the efficacy of coded herbal formulation "ocucure" (Test drug) for the treatment of ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2014, 27(2):317-320]

Cited: 0 times

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Prevalence, risk factors and disease knowledge of breast cancer in Pakistan.

Hafiz Muhammad Asif, Sabira Sultana, Naveed Akhtar, Jalil Ur Rehman, Riaz Ur Rehman,

Breast cancer is the most common cancer in females all over the world with approximately one million new cases each year as well as one of second leading causes of death among females. In Pakistan, the most frequently diagnosed cancer among females is also breast cancer, accounting for nearly one ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2014, 15(11):4411-4416]

Cited: 12 times

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Efficacy of herbal coded Hepcon on drug induced hepatitis in experimental animals through histopathological and biochemical analysis.

Muhammad Saim Jamil, Zahid Mahmood, Aftab Saeed, Amir Jamil, Khan Usmanghani, Hafiz Muhammad Asif, Sajjad-al-Hassan, Mahira Roohi,

Drug-induced liver injury is the leading cause for more than 50 percent of cases of acute liver failure. This study was conducted on herbo-mineral formulation "Hepcon" to evaluate its hepatoprotective effects in drug induced hepatitis in experimental animals. The liver injury was introduced with over dosage of non steroidal anti-inflammatory ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2013, 26(5):991-997]

Cited: 1 time

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