Full Text Journal Articles by
Author Hadas Lewy

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Personalized Health Systems-Past, Present, and Future of Research Development and Implementation in Real-Life Environment.

Hadas Lewy, Refael Barkan, Tomer Sela,

Personal health systems (PHS) are designed to provide the individual with tailored care while enabling the healthcare system to deliver high-quality care to large populations and maintain a sustainable system. Solutions using electronic health records (EHRs) that include predictive models for the risk of disease onset and deterioration enable the ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2019, 6:149]

Cited: 0 times

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Estimating dyskinesia severity in Parkinson's disease by using a waist-worn sensor: concurrent validity study.

Alejandro Rodríguez-Molinero, Carlos Pérez-López, Albert Samà, Daniel Rodríguez-Martín, Sheila Alcaine, Berta Mestre, Paola Quispe, Benedetta Giuliani, Gabriel Vainstein, Patrick Browne, Dean Sweeney, Leo R Quinlan, J Manuel Moreno Arostegui, Àngels Bayes, Hadas Lewy, Alberto Costa, Roberta Annicchiarico, Timothy Counihan, Gearòid Ò Laighin, Joan Cabestany,

Our research team previously developed an accelerometry-based device, which can be worn on the waist during daily life activities and detects the occurrence of dyskinesia in patients with Parkinson's disease. The goal of this study was to analyze the magnitude of correlation between the numeric output of the device algorithm ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):13434]

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Corrigendum: Analysis of Correlation between an Accelerometer-Based Algorithm for Detecting Parkinsonian Gait and UPDRS Subscales.

Alejandro Rodríguez-Molinero, Albert Samà, Carlos Pérez-López, Daniel Rodríguez-Martín, Sheila Alcaine, Berta Mestre, Paola Quispe, Benedetta Giuliani, Gabriel Vainstein, Patrick Browne, Dean Sweeney, Leo R Quinlan, J Manuel Moreno Arostegui, Àngels Bayes, Hadas Lewy, Alberto Costa, Roberta Annicchiarico, Timothy Counihan, Gearòid Ò Laighin, Joan Cabestany,

[This corrects the article on p. 431 in vol. 8, PMID: 28919877.]. ... Read more >>

Front Neurol (Frontiers in neurology)
[2017, 8:604]

Cited: 1 time

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A "HOLTER" for Parkinson's disease: Validation of the ability to detect on-off states using the REMPARK system.

Àngels Bayés, Albert Samá, Anna Prats, Carlos Pérez-López, Maricruz Crespo-Maraver, Juan Manuel Moreno, Sheila Alcaine, Alejandro Rodriguez-Molinero, Berta Mestre, Paola Quispe, Ana Correia de Barros, Rui Castro, Alberto Costa, Roberta Annicchiarico, Patrick Browne, Tim Counihan, Hadas Lewy, Gabriel Vainstein, Leo R Quinlan, Dean Sweeney, Gearóid ÓLaighin, Jordi Rovira, Daniel Rodrigue Z-Martin, Joan Cabestany,

The treatment of Parkinson's disease (PD) with levodopa is very effective. However, over time, motor complications (MCs) appear, restricting the patient from leading a normal life. One of the most disabling MCs is ON-OFF fluctuations. Gathering accurate information about the clinical status of the patient is essential for planning treatment ... Read more >>

Gait Posture (Gait & posture)
[2018, 59:1-6]

Cited: 2 times

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Analysis of Correlation between an Accelerometer-Based Algorithm for Detecting Parkinsonian Gait and UPDRS Subscales.

Alejandro Rodríguez-Molinero, Albert Samà, Carlos Pérez-López, Daniel Rodríguez-Martín, Leo R Quinlan, Sheila Alcaine, Berta Mestre, Paola Quispe, Benedetta Giuliani, Gabriel Vainstein, Patrick Browne, Dean Sweeney, J Manuel Moreno Arostegui, Àngels Bayes, Hadas Lewy, Alberto Costa, Roberta Annicchiarico, Timothy Counihan, Gearòid Ò Laighin, Joan Cabestany,

BACKGROUND:Our group earlier developed a small monitoring device, which uses accelerometer measurements to accurately detect motor fluctuations in patients with Parkinson's (On and Off state) based on an algorithm that characterizes gait through the frequency content of strides. To further validate the algorithm, we studied the correlation of its outputs ... Read more >>

Front Neurol (Frontiers in neurology)
[2017, 8:431]

Cited: 5 times

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Editorial: 'The healthcare systems have a growing need for systems that enable holistic approaches for treatment of age-related conditions, supporting active and healthy ageing and interactions with the patients, their caregivers and healthcare professionals.'

Refael Barkan, Hadas Lewy,

Healthc Technol Lett (Healthcare technology letters)
[2017, 4(3):82]

Cited: 0 times

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Data-as-a-Service Platform for Delivering Healthy Lifestyle and Preventive Medicine: Concept and Structure of the DAPHNE Project.

Catherine Gibbons, Gonzalo Bailador Del Pozo, Javier Andrés, Tim Lobstein, Melania Manco, Hadas Lewy, Einat Bergman, David O'Callaghan, Gavin Doherty, Olga Kudrautseva, Angel Palomares, Roni Ram, Alberto Olmo,

Overweight and obesity is related to many health problems and diseases. The current obesity epidemic, which is a major health problem, is closely related to a lack of physical activity, high levels of sedentary behavior, and increased energy intake; with evidence to show increasing incidence of these issues in the ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2016, 5(4):e222]

Cited: 2 times

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Home detection of freezing of gait using support vector machines through a single waist-worn triaxial accelerometer.

Daniel Rodríguez-Martín, Albert Samà, Carlos Pérez-López, Andreu Català, Joan M Moreno Arostegui, Joan Cabestany, Àngels Bayés, Sheila Alcaine, Berta Mestre, Anna Prats, M Cruz Crespo, Timothy J Counihan, Patrick Browne, Leo R Quinlan, Gearóid ÓLaighin, Dean Sweeney, Hadas Lewy, Joseph Azuri, Gabriel Vainstein, Roberta Annicchiarico, Alberto Costa, Alejandro Rodríguez-Molinero,

Among Parkinson's disease (PD) symptoms, freezing of gait (FoG) is one of the most debilitating. To assess FoG, current clinical practice mostly employs repeated evaluations over weeks and months based on questionnaires, which may not accurately map the severity of this symptom. The use of a non-invasive system to monitor ... Read more >>

PLoS ONE (PloS one)
[2017, 12(2):e0171764]

Cited: 18 times

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Dopaminergic-induced dyskinesia assessment based on a single belt-worn accelerometer.

Carlos Pérez-López, Albert Samà, Daniel Rodríguez-Martín, Juan Manuel Moreno-Aróstegui, Joan Cabestany, Angels Bayes, Berta Mestre, Sheila Alcaine, Paola Quispe, Gearóid Ó Laighin, Dean Sweeney, Leo R Quinlan, Timothy J Counihan, Patrick Browne, Roberta Annicchiarico, Alberto Costa, Hadas Lewy, Alejandro Rodríguez-Molinero,

After several years of treatment, patients with Parkinson's disease (PD) tend to have, as a side effect of the medication, dyskinesias. Close monitoring may benefit patients by enabling doctors to tailor a personalised medication regimen. Moreover, dyskinesia monitoring can help neurologists make more informed decisions in patient's care.To design and ... Read more >>

Artif Intell Med (Artificial intelligence in medicine)
[2016, 67:47-56]

Cited: 9 times

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Detecting freezing of gait with a tri-axial accelerometer in Parkinson's disease patients.

Claas Ahlrichs, Albert Samà, Michael Lawo, Joan Cabestany, Daniel Rodríguez-Martín, Carlos Pérez-López, Dean Sweeney, Leo R Quinlan, Gearòid Ò Laighin, Timothy Counihan, Patrick Browne, Lewy Hadas, Gabriel Vainstein, Alberto Costa, Roberta Annicchiarico, Sheila Alcaine, Berta Mestre, Paola Quispe, Àngels Bayes, Alejandro Rodríguez-Molinero,

Freezing of gait (FOG) is a common motor symptom of Parkinson's disease (PD), which presents itself as an inability to initiate or continue gait. This paper presents a method to monitor FOG episodes based only on acceleration measurements obtained from a waist-worn device. Three approximations of this method are tested. ... Read more >>

Med Biol Eng Comput (Medical & biological engineering & computing)
[2016, 54(1):223-233]

Cited: 20 times

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Seasonality of birth of patients with juvenile idiopathic arthritis.

Yackov Berkun, Hadas Lewy, Shai Padeh, Zvi Laron,

The aim of this study was to determine the seasonality of month of birth (MOB) in children with juvenile idiopathic arthritis (JIA) as compared to the general population.Cosinor analysis was used to analyse MOB rhythmicity in 558 children with JIA from a simple rheumatology clinic compared with the MOB pattern ... Read more >>

Clin. Exp. Rheumatol. (Clinical and experimental rheumatology)
[2015, 33(1):122-126]

Cited: 4 times

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Wearable technologies - future challenges for implementation in healthcare services.

Hadas Lewy,

The growing use of wearable technologies increases the ability to have more information from the patient including clinical, behavioural and self-monitored data. The availability and large amounts of data that did not exist before brings an opportunity to develop new tools with intelligent analyses and decision support tools for use ... Read more >>

Healthc Technol Lett (Healthcare technology letters)
[2015, 2(1):2-5]

Cited: 7 times

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A double closed loop to enhance the quality of life of Parkinson's Disease patients: REMPARK system.

Albert Samà, Carlos Pérez-López, Daniel Rodríguez-Martín, J Manuel Moreno-Aróstegui, Jordi Rovira, Claas Ahlrichs, Rui Castro, João Cevada, Ricardo Graça, Vânia Guimarães, Bernardo Pina, Timothy Counihan, Hadas Lewy, Roberta Annicchiarico, Angels Bayés, Alejandro Rodríguez-Molinero, Joan Cabestany,

This paper presents REMPARK system, a novel approach to deal with Parkinson's Disease (PD). REMPARK system comprises two closed loops of actuation onto PD. The first loop consists in a wearable system that, based on a belt-worn movement sensor, detects movement alterations that activate an auditory cueing system controlled by ... Read more >>

Stud Health Technol Inform (Studies in health technology and informatics)
[2014, 207:115-124]

Cited: 2 times

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Habitual moderate alcohol consumption desynchronizes circadian physiologic rhythms and affects reaction-time performance.

Alain Reinberg, Yvan Touitou, Hadas Lewy, Mohamed Mechkouri,

The authors studied longitudinally four healthy young adults to explore if habitual evening intake of a "moderate" amount of wine alters parameters, including period (τ) of circadian rhythms. Subjects, synchronized by diurnal activity from 07.30 h ± 60 min to 23.00 h ± 90 min and nocturnal rest, were studied during a continuous 22-day span: 11 days without ... Read more >>

Chronobiol. Int. (Chronobiology international)
[2010, 27(9-10):1930-1942]

Cited: 14 times

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Seasonality of birth month of children with celiac disease differs from that in the general population and between sexes and is linked to family history and environmental factors.

Hadas Lewy, Hadas Meirson, Zvi Laron,

BACKGROUND: Patients with autoimmune diseases, such as type 1 diabetes mellitus, atopic dermatitis, autoimmune thyroid diseases, and multiple sclerosis have a different seasonality of month of birth (MOB) from the general population. This study was undertaken to determine the seasonality of MOB in children with celiac disease (CD), an autoimmune-mediated ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2009, 48(2):181-185]

Cited: 19 times

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Juvenile multiple sclerosis similar to type I diabetes mellitus has a seasonality of month of birth which differs from that in the general population.

Hadas Lewy, Amihai Rotstein, Esther Kahana, Maria G Marrosu, Eleonora Cocco, Zvi Laron,

J. Pediatr. Endocrinol. Metab. (Journal of pediatric endocrinology & metabolism : JPEM)
[2008, 21(5):473-477]

Cited: 4 times

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Seasonality of month of birth differs between type 1 diabetes patients with pronounced beta-cell autoimmunity and individuals with lesser or no beta-cell autoimmunity.

Hadas Lewy, Christiane S Hampe, Olga Kordonouri, Holger Haberland, Mona Landin-Olsson, Carina Torn, Zvi Laron,

OBJECTIVE:To establish whether children with type 1 diabetes mellitus (T1D) with signs of pronounced beta-cell-specific autoimmunity as reflected by high autoantibody titers or positivity for several beta-cell-specific autoantibodies show a different pattern of month of birth (MOB) compared with children with T1D and low beta-cell autoimmunity and that of the ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2008, 9(1):46-52]

Cited: 9 times

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Method and system for automated sampling and analysis using a personal sampler device

HADAS LEWY, NOAM ASNA, DORON LEVI,

The present invention is a system and a method for blood or urine sampling and sample-analysis, through a sampler that is a self blood-testing device or a urine-testing device. The system comprises a sampler, a transmission unit and an analysis unit. A patient may place a sampled blood drops on ... Read more >>

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Possible linkage between the ability to change the period (tau) of the prolactin and cortisol rhythms in women and breast cancer risk.

Hadas Lewy, Erhard Haus, Israel E Ashkenazi,

The 24 h profiles of plasma hormone concentrations are rhythmic. The circadian period (tau) changes in development, with seasons, and in women with different stages of the menstrual cycle. It is known that the rhythms of prolactin and cortisol are sensitive to environmental time cues, such as changes in day ... Read more >>

Chronobiol. Int. (Chronobiology international)
[2007, 24(2):365-381]

Cited: 6 times

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Seasonality of month of birth of patients with Graves' and Hashimoto's diseases differ from that in the general population.

Gerasimos E Krassas, Konstantinos Tziomalos, Nikolaos Pontikides, Hadas Lewy, Zvi Laron,

We aimed to test the viral hypothesis in the pathogenesis of autoimmune thyroid disease (AITD).We determined the pattern of month of birth (MOB) distribution in patients with AITD and in the general population and searched for differences between them.A total of 1023 patients were included in this study; 359 patients ... Read more >>

Eur. J. Endocrinol. (European journal of endocrinology)
[2007, 156(6):631-636]

Cited: 23 times

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Seasonality of month of birth of children and adolescents with type 1 diabetes mellitus in homogenous and heterogeneous populations.

Zvi Laron, Hadas Lewy, Igor Wilderman, Anna Casu, Jinny Willis, Maria Jose Redondo, Ingrid Libman, Neil White, Maria Craig,

BACKGROUND: Type 1 childhood-onset diabetes mellitus has a multifactorial origin involving an interplay between genetic and environmental factors. We have previously shown that many children who subsequently develop T1DM have a different seasonality of birth than the total live births of the same population, supporting the hypothesis that perinatal viral ... Read more >>

Isr. Med. Assoc. J. (The Israel Medical Association journal : IMAJ)
[2005, 7(6):381-384]

Cited: 17 times

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Gonadotropin releasing hormone (GnRH) and estradiol (E(2)) regulation of cell cycle in gonadotrophs.

Hadas Lewy, I E Ashkenazi, Z Naor,

The number of pituitary cells, their size, hormonal content and release and response to external cues varies between day and night and during the estrus cycle. Previous studies have demonstrated that pituitary cells proliferate rhythmically and that estradiol (E(2)) is a mitogen of alpha T3 cells. We, therefore, studied the ... Read more >>

Mol. Cell. Endocrinol. (Molecular and cellular endocrinology)
[2003, 203(1-2):25-32]

Cited: 6 times

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Differences between males and females in the seasonality of birth and month of clinical onset of disease in children with type 1 diabetes mellitus in Ireland.

Edna F Roche, Hadas Lewy, Hilary M C V Hoey, Zvi Laron,

The aim was to study the monthly rhythm of birth and clinical onset in 303 children with type 1 diabetes mellitus (DM1) aged 0-15 years (156 males, 147 females) born between 1980 and 1996 in Ireland and compare to 951,717 infants born in the general population during the same period. ... Read more >>

J. Pediatr. Endocrinol. Metab. (Journal of pediatric endocrinology & metabolism : JPEM)
[2003, 16(5):779-782]

Cited: 9 times

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Seasonality of month of birth of children and adolescents with type 1 diabetes mellitus in Berlin differs from the general population.

Olga Kordonouri, Nicole Shuga, Hadas Lewy, Israel Ashkenazi, Zvi Laron,

Eur. J. Pediatr. (European journal of pediatrics)
[2002, 161(5):291-292]

Cited: 6 times

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Seasonality of birth and onset of clinical disease in children and adolescents (0-19 years) with type 1 diabetes mellitus in Canterbury, New Zealand.

Jinny A Willis, Russell S Scott, Brian A Darlow, Hadas Lewy, Israel Ashkenazi, Zvi Laron,

AIMS:To determine the seasonality of clinical disease onset and month of birth in type 1 diabetes mellitus (DM) in the southern hemisphere. PATIENTS:Two hundred and seventy-five children with type 1 DM in the South Island of New Zealand were studied. The total live births (91,394) of the same period were ... Read more >>

J. Pediatr. Endocrinol. Metab. (Journal of pediatric endocrinology & metabolism : JPEM)
[2002, 15(5):645-647]

Cited: 26 times

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