Full Text Journal Articles by
Author H Xie

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Profile of the RNA in exosomes from astrocytes and microglia using deep sequencing: implications for neurodegeneration mechanisms.

Hui-Min Xie, Xing Su, Feng-Yuan Zhang, Chao-Lun Dai, Rong-Hua Wu, Yan Li, Xiao-Xiao Han, Xing-Mei Feng, Bin Yu, Shun-Xing Zhu, Song-Lin Zhou,

Glial cells play an important role in signal transduction, energy metabolism, extracellular ion homeostasis and neuroprotection of the central nervous system. However, few studies have explained the potential effects of exosomes from glial cells on central nervous system health and disease. In this study, the genes expressed in exosomes from ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(3):608-617]

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Knockdown of STK39 suppressed cell proliferation, migration, and invasion in hepatocellular carcinoma by repressing the phosphorylation of mitogen-activated protein kinase p38.

Jian Chen, Luke Zhou, Jie Yang, Hui Xie, Lin Liu, Youwei Li,

Hepatocellular carcinoma (HCC) is a serious malignant tumor of the liver. It has been reported that serine/threonine kinase 39 (STK39) participates in tumorigenesis. However, the role of STK39 in HCC remains unknown. In this study, the qRT-PCR and western blot assay demonstrated that STK39 expression was enhanced in HCC patients ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):6529-6537]

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Evaluation of nanoscaled dual targeting drug-loaded liposomes on inhibiting vasculogenic mimicry channels of brain glioma.

Hong-Jun Xie, NorBu Zhan-Dui, Jing Zhao, A G A Er-Bu, Pu Zhen, DongZhi ZhuoMa, Tre Sang,

Brain glioma is the most common primary tumour of the central nervous system. Complete surgical removal of the brain glioma is virtually impossible. Chemotherapy is still an important treatment for brain glioma. However, blood-brain barrier (BBB) and vasculogenic mimicry (VM) channels remain two hindrances in regular treatments. Herein, we developed ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2021, 49(1):596-605]

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Activation of NLR family, domain of pyrin containing 3 inflammasome by nitrous oxide through thioredoxin-interacting protein to induce nerve cell injury.

WenJuan Liu, GuangMing Zhang, Bo Sun, ShuYan Wang, YinZhong Lu, Hong Xie,

Nitrous Oxide (N<sub>2</sub>O) has been shown to be neurotoxic, but its specific mechanism is still unclear. The purpose of this work is to probe into the impact of N<sub>2</sub>O on nerve cell injury through regulating thioredoxin-interacting protein (TXNIP)/the NOD-like receptor domain of pyrin containing 3 (NLRP3) pathway. The results indicated ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):4768-4779]

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Analysis of regulatory effect of miR-149-5p on Sphingosine-1-phosphate receptor 2 of pericytes and its neuroprotective molecular mechanism after acute cerebral ischemia reperfusion in rats.

Zhenxing Yan, Yiting Deng, Yang Zou, Siqin Liu, Kaifeng Li, Juan Yang, Xihua Guo, Rongni He, Wenxia Zheng, Huifang Xie,

To investigate the effect of miR-149-5p on sphingosine-1-phosphate receptor 2 (S1PR2) expression level and contents of matrix metalloproteinase (MMP-9) and superoxide dismutase (SOD) in the pericytes after acute cerebral ischemia reperfusion in rats, so as to clarify the neuroprotective molecular mechanism induced by miR-149-5p and provide references for the treatment ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3348-3357]

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Environmental enrichment combined with fasudil promotes motor function recovery and axonal regeneration after stroke.

Yi-Tong Zhu, Qun Zhang, Hong-Yu Xie, Ke-Wei Yu, Gao-Jing Xu, Si-Yue Li, Yi Wu,

Fasudil, a Rho-associated protein kinase (ROCK) inhibitor, has a protective effect on the central nervous system. In addition, environmental enrichment is a promising technique for inducing the recovery of motor impairments in ischemic stroke models. The present study aimed to explore whether environmental enrichment combined with fasudil can facilitate motor ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(12):2512-2520]

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Analysis of role of rat cerebral pericytes in cerebral vasospasm after subarachnoid hemorrhage and molecular mechanism of neurovascular injury.

Zhenxing Yan, Yang Zou, Yiting Deng, Siqin Liu, Kaifeng Li, Juan Yang, Xihua Guo, Rongni He, Wenxia Zheng, Huifang Xie,

To investigate mechanism of pericytes in the early stage of subarachnoid haemorrhage (SAH) and its associated microvascular spasm and neurovascular injury, 100 healthy 8-week-old Sprague-Dawley male rats were taken as subjects and divided into four groups: group A (sham operation, control group), group B (SAH operation group), group C (SAH ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3957-3967]

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Novel natural inhibitors targeting B-RAF(V600E) by computational study.

Bo Wu, Zhiyun Zhang, Gaojing Dou, Xiaye Lv, Junliang Ge, Hongyu Wang, Haoqun Xie, Dong Zhu,

The aim of this research was to screen the ZINC15 database to select lead compounds and drug candidates which can inhibit B-RAF (V600E). In order to identify drugs potentially inhibited B-RAF (V600E), numerous modules of Discovery Studio 4.5 were employed. Structure-based screening using LibDock was carried out followed by ADME ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2970-2983]

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The miR-1906 mimic attenuates bone loss in osteoporosis by down-regulating the TLR4/MyD88/NF-κB pathway.

H Xie, L Cao, L Ye, G Shan, W Song,

In this study, the ability of microRNA-1906 (miR-1906) to attenuate bone loss in osteoporosis was evaluated by measuring the effects of a miR-1906 mimic and inhibitor on the cellular toxicity and cell viability of MC3T3-E1 cells. Bone marrow-derived macrophage (BMM) cells were isolated from female mice, and tartrate-resistant acid phosphatase ... Read more >>

Physiol Int (Physiology international)
[2021, 107(4):469-478]

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PET/CT Imaging for Langerhans Cell Histiocytosis Involving Only Posterior Elements of the Cervical Vertebra.

Wenjie Zhang, Hangyu Xie, Minggang Su,

<h4>Abstract</h4>Langerhans cell histiocytosis only involving the posterior elements of the spine is rare. We report the case of a 7-year-old boy who has pain and restricted motion of his neck. 18F-FDG PET/CT revealed an osteolytic lesion in the posterior elements of the fourth cervical vertebra. The lesion has high 18F-FDG ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(11):e531-e533]

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Explore the interaction mechanism between zein and EGCG using multi-spectroscopy and molecular dynamics simulation methods

Chengzhi Liu, Nan Lv, Gerui Ren, Ruibo Wu, Binju Wang, Zexing Cao, Hujun Xie,

Zein as a kind of carrier material has attracted extensive interest, while the interaction mechanism between zein and nutrients is still elusive. In this work, the binding mechanism of zein with epigallocatechin-3-gallate (EGCG) was investigated via multi-spectroscopy and molecular dynamics (MD) simulation. The quenching of zein by EGCG is mainly ... Read more >>

(Food hydrocolloids.)
[2021, 120:Not Available]

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NPCDR: natural product-based drug combination and its disease-specific molecular regulation.

Xueni Sun, Yintao Zhang, Ying Zhou, Xichen Lian, Lili Yan, Ting Pan, Ting Jin, Han Xie, Zimao Liang, Wenqi Qiu, Jianxin Wang, Zhaorong Li, Feng Zhu, Xinbing Sui,

Natural product (NP) has a long history in promoting modern drug discovery, which has derived or inspired a large number of currently prescribed drugs. Recently, the NPs have emerged as the ideal candidates to combine with other therapeutic strategies to deal with the persistent challenge of conventional therapy, and the ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2021, :]

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Knockdown of long noncoding RNA AC245100.4 inhibits the tumorigenesis of prostate cancer cells via the STAT3/NR4A3 axis.

Chi Liu, Ping Lin, Jiabin Zhao, Hui Xie, Rou Li, Xu Yang, Nan Wang, Huizhen Jia, Shan Jiang, Ke Zhang, Xiaoguang Yu,

Aim: To explore the role and mechanism of long noncoding RNA AC245100.4 and NR4A3 in prostate cancer (PCa). Methods: RNA-sequencing analysis was used to detect the downstream genes of AC245100.4. A series of gain- and loss-of-function approaches were used to investigate the roles of AC245100.4 and NR4A3. RNA immunoprecipitation was performed ... Read more >>

Epigenomics (Epigenomics)
[2021, :]

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Cryo-EM structures of pentameric autoinducer-2 exporter from E. coli reveal its transport mechanism

Radhika Khera, Ahmad Reza Mehdipour, Jani Bolla, Joerg Kahnt, Sonja Welsch, Ulrich Ermler, Cornelia Muenke, Carol Robinson, Gerhard Hummer, Hao Xie, Hartmut Michel,

Bacteria utilize small extracellular molecules to communicate in order to collectively coordinate their behaviors in response to the population density. Autoinducer-2 (AI-2), a universal molecule for both intra- and inter-species communication, is involved in the regulation of biofilm formation, virulence, motility, chemotaxis and antibiotic resistance. While many studies have been ... Read more >>

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Clinical performance characteristics of the Swift Normalase Amplicon Panel for sensitive recovery of SARS-CoV-2 genomes

Lasata Shrestha, Michelle Lin, Hong Xie, Margaret Mills, Shah A.M. Bakhash, Vinod Gaur, Robert Livingston, Jared Castor, Emily Bruce, Jason Botten, Meei-Li Huang, Keith Jerome, Alexander Greninger, Pavitra Roychoudhury,

Amplicon-based sequencing methods have been central in characterizing the diversity, transmission and evolution of SARS-CoV-2, but need to be rigorously assessed for clinical utility. Here, we validated the Swift Biosciences SARS-CoV-2 Swift Normalase Amplicon Panels using remnant clinical specimens. High quality genomes meeting our established library and sequence quality criteria ... Read more >>

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Retraction: Mouse models of GNAO1-associated movement disorder: Allele- and sex-specific differences in phenotypes.

Huijie Feng, Casandra L Larrivee, Elena Y Demireva, Huirong Xie, Jeff R Leipprandt, Richard R Neubig,

PLoS One (PloS one)
[2021, 16(10):e0258912]

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Enantioselective decarboxylative Mannich reaction of β-keto acids with C-alkynyl N-Boc N,O-acetals: access to chiral β-keto propargylamines.

Cong-Cong Zhang, Li-Jun Chen, Bao-Chun Shen, Hui-Ding Xie, Wei Li, Zhong-Wen Sun,

The chiral keto-substituted propargylamines are an essential class of multifunctional compounds in the field of organic and pharmaceutical synthesis and have attracted considerable attention, but the related synthetic approaches remain limited. Therefore, a concise and efficient method for the enantioselective synthesis of β-keto propargylamines <i>via</i> chiral phosphoric acid-catalyzed asymmetric Mannich ... Read more >>

Org Biomol Chem (Organic & biomolecular chemistry)
[2021, 19(39):8607-8612]

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Regioselective Difluoromethane sulfonylation and Triflylation of Resorufin Derivatives.

Qingwei Tan, Shuxuan Zhao, Yuyao Li, Jialing Jiang, Huiling Tang, Yefeng Chen, Yan Peng, Hexin Xie,

Reported herein is a regioselective difluoromethane sulfonylation or triflylation of resorufin derivatives, which allows easy access to 2-difluoromethane sulfonylated or triflylated resorufin derivatives in good yields. The installation of a difluoromethane sulfonyl group significantly increases the solubility of the chromophore and expands its Stokes shift. A difluoromethane sulfonylated resorufin-based fluorogenic ... Read more >>

Org Lett (Organic letters)
[2021, :]

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Mitoxantrone modulates a glycosaminoglycan-spike complex to inhibit SARS-CoV-2 infection

Qi Zhang, Peter Radvak, Juhyung Lee, Yue Xu, Vivian Cao-Dao, Miao Xu, Wei Zheng, Catherine Chen, Hang Xie, Yihong Ye,

Spike-mediated entry of SARS-CoV-2 into human airway epithelial cells is an attractive therapeutic target for COVID-19. In addition to protein receptors, the SARS-CoV-2 spike (S) protein also interacts with heparan sulfate, a negatively charged glycosaminoglycan (GAG) attached to certain membrane proteins on the cell surface. This interaction facilitates the engagement ... Read more >>

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Silencing Nogo-B improves the integrity of blood-retinal barrier in diabetic retinopathy via regulating Src, PI3K/Akt and ERK pathways.

Qian Yang, Chaoyang Zhang, Hai Xie, Lei Tang, Dandan Liu, Qinghua Qiu, Dawei Luo, Kun Liu, Jing-Ying Xu, Haibin Tian, Lixia Lu, Guo-Tong Xu, Jingfa Zhang,

To examine the mechanisms of Nogo-B (RTN4B) in the protection of blood-retinal barrier in experimental diabetic retinopathy. The level of Nogo-B in vitreous and plasma samples was detected with ELISA. Diabetes was induced in Sprague-Dawley rats with intraperitoneal injection of streptozotocin. The rats were injected intravitreally with adeno-associated virus (AAV) ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2021, 581:96-102]

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SDR7-6, a short-chain alcohol dehydrogenase/reductase family protein, regulates light-dependent cell death and defence responses in rice.

Yanmei Zheng, Yongsheng Zhu, Xiaohui Mao, Minrong Jiang, Yidong Wei, Ling Lian, Huibin Xu, Liping Chen, Huaan Xie, Guodong Lu, Jianfu Zhang,

Lesion mimic mutants resembling the hypersensitive response without pathogen attack are an ideal material to understand programmed cell death, the defence response, and the cross-talk between defence response and development in plants. In this study, mic, a lesion mimic mutant from cultivar Yunyin treated with ethyl methanesulphonate (EMS), was screened. ... Read more >>

Mol Plant Pathol (Molecular plant pathology)
[2021, :]

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Protective effect of sinomenine against inflammation and oxidative stress in gestational diabetes mellitus in female rats via TLR4/MyD88/NF-κB signaling pathway.

Yanbing Li, Hongqin Xie, Huiya Zhang,

Gestational diabetes mellitus (GDM) is a dangerous complication of pregnancy which is induced via dysfunction in glucose metabolism during pregnancy. Sinomenine (SM) has already proved an antidiabetic effect against streptozotocin (STZ)-induced diabetes mellitus (DM) in rats. In this protocol, we examined the protective effect of SM against STZ-induced GDM in ... Read more >>

J Food Biochem (Journal of food biochemistry)
[2021, :e13952]

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EEG-based clusters differentiate psychological distress, sleep quality and cognitive function in adolescents

Owen Forbes, Paul Schwenn, Paul Pao-Yen Wu, Edgar Santos-Fernandez, Hong-Bo Xie, Jim Lagopoulos, Larisa McLoughlin, Dashiell Sacks, Kerrie Mengersen, Daniel Hermens,

1 <h4>Introduction</h4> To better understand the relationships between brain activity, cognitive function and mental health risk in adolescence there is value in identifying data-driven subgroups based on measurements of brain activity and function, and then comparing cognition and mental health symptoms between such subgroups. <h4>Methods</h4> Here we implement a multi-stage ... Read more >>

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Author Correction: Integrated network analysis identifies hsa-miR-4756-3p as a regulator of FOXM1 in Triple Negative Breast Cancer.

Yuanliang Gu, Wenjuan Wang, Xuyao Wang, Hongyi Xie, Xiaojuan Ye, Peng Shu,

Sci Rep (Scientific reports)
[2021, 11(1):20732]

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SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

Wei Qiao, Hui En Lau, Huizhi Xie, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Hin Chu, Shuofeng Yuan, Terrence Tsz-Tai Yuen, Kenn Ka-Heng Chik, Jessica Oi-Ling Tsang, Chris Chun-Yiu Chan, Jian-Piao Cai, Cuiting Luo, Kwok-Yong Yuen, Kenneth Man-Chee Cheung, Jasper Fuk-Woo Chan, Kelvin Wai-Kwok Yeung,

Extrapulmonary complications of different organ systems have been increasingly recognized in patients with severe or chronic Coronavirus Disease 2019 (COVID-19). However, limited information on the skeletal complications of COVID-19 is known, even though inflammatory diseases of the respiratory tract have been known to perturb bone metabolism and cause pathological bone ... Read more >>

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