Full Text Journal Articles by
Author H Bart van der Worp

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Multicentre Randomised trial of Acute Stroke treatment in the Ambulance with a nitroglycerin Patch (MR ASAP): study protocol for a randomised controlled trial.

Sophie A van den Berg, Diederik W J Dippel, Jeannette Hofmeijer, Puck S S Fransen, Klaartje Caminada, Arjen Siegers, Nyika D Kruyt, Henk Kerkhoff, Frank-Erik de Leeuw, Paul J Nederkoorn, H Bart van der Worp, ,

BACKGROUND:Some studies have suggested that transdermal administration of glyceryl trinitrate (GTN; nitroglycerin) in the first few hours after symptom onset increases the chance of a favourable outcome after ischaemic stroke or intracerebral haemorrhage, possibly through an increase in intracranial collateral blood flow and a reduction in blood pressure. The Multicentre ... Read more >>

Trials (Trials)
[2019, 20(1):383]

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Stenting for symptomatic vertebral artery stenosis: a preplanned pooled individual patient data analysis.

Hugh S Markus, Eric L Harshfield, Annette Compter, Wilhelm Kuker, L Jaap Kappelle, Andrew Clifton, H Bart van der Worp, Peter Rothwell, Ale Algra, ,

BACKGROUND:Symptomatic vertebral artery stenosis is associated with a high risk of recurrent stroke, with higher risks for intracranial than for extracranial stenosis. Vertebral artery stenosis can be treated with stenting with good technical results, but whether it results in improved clinical outcome is uncertain. We aimed to compare vertebral stenting ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2019, 18(7):666-673]

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Endovascular Treatment With or Without Prior Intravenous Alteplase for Acute Ischemic Stroke.

Vicky Chalos, Natalie E LeCouffe, Maarten Uyttenboogaart, Hester F Lingsma, Maxim J H L Mulder, Esmee Venema, Kilian M Treurniet, Omid Eshghi, H Bart van der Worp, Aad van der Lugt, Yvo B W E M Roos, Charles B L M Majoie, Diederik W J Dippel, Bob Roozenbeek, Jonathan M Coutinho, ,

Background It is unclear whether intravenous thrombolysis ( IVT ) with alteplase before endovascular treatment ( EVT ) is beneficial for patients with acute ischemic stroke caused by a large vessel occlusion. We compared clinical and procedural outcomes, safety, and workflow between patients treated with both IVT and EVT and ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2019, 8(11):e011592]

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[Broader indications for treatment of ischaemic stroke].

Jeroen C de Jonge, H Bart van der Worp, L Jaap Kappelle,

Broader indications for treatment of ischaemic stroke Current guidelines suggest that selected patients with ischaemic stroke can be treated with intravenous thrombolysis or mechanical thrombectomy within 4.5 or 6 hours, respectively, after onset of the stroke. Recent developments in imaging have made it possible to distinguish permanently damaged brain tissue ... Read more >>

Ned Tijdschr Geneeskd (Nederlands tijdschrift voor geneeskunde)
[2019, 163:]

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Impact of single phase CT angiography collateral status on functional outcome over time: results from the MR CLEAN Registry.

Ivo Gh Jansen, Maxim Jhl Mulder, Robert-Jan B Goldhoorn, Anna Mm Boers, Adriaan Cgm van Es, Lonneke Sf Yo, Jeannette Hofmeijer, Jasper M Martens, Marianne Aa van Walderveen, Bas Fw van der Kallen, Sjoerd Fm Jenniskens, Kilian M Treurniet, Henk A Marquering, Marieke Es Sprengers, Wouter J Schonewille, Joost Cj Bot, Geert J Lycklama A Nijeholt, Hester F Lingsma, David S Liebeskind, Jelis Boiten, Jan Albert Vos, Yvo Bwem Roos, Robert J van Oostenbrugge, Aad van der Lugt, Wim H van Zwam, Diederik Wj Dippel, Ido R van den Wijngaard, Charles Blm Majoie, ,

BACKGROUND:Collateral status modified the effect of endovascular treatment (EVT) for stroke in several randomized trials. We assessed the association between collaterals and functional outcome in EVT treated patients and investigated if this association is time dependent. METHODS:We included consecutive patients from the Multicenter Randomized Clinical Trial of Endovascular Treatment for ... Read more >>

J Neurointerv Surg (Journal of neurointerventional surgery)
[2019, 11(9):866-873]

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Endovascular Treatment.

Kars C J Compagne, Pieter M van der Sluijs, Ido R van den Wijngaard, Bob Roozenbeek, Maxim J H L Mulder, Wim H van Zwam, Bart J Emmer, Charles B L M Majoie, Albert J Yoo, Geert J Lycklama À Nijeholt, Hester F Lingsma, Diederik W J Dippel, Aad van der Lugt, Adriaan C G M van Es, , , , , , , , , , ,

Background and Purpose- It is unclear whether endovascular treatment (EVT) is beneficial for patients with acute ischemic stroke with occlusion of the M2 segment of the middle cerebral artery. We aimed to compare functional outcomes, technical aspects, and complications of EVT between patients with acute ischemic stroke because of M2 ... Read more >>

Stroke (Stroke)
[2019, 50(2):419-427]

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Which patients with acute stroke due to proximal occlusion should not be treated with endovascular thrombectomy?

Mayank Goyal, Mohammed A Almekhlafi, Christoph Cognard, Ryan McTaggart, Kristine Blackham, Alessandra Biondi, Aad van der Lugt, Charles B L M Majoie, Wim H van Zwam, H Bart van der Worp, Michael D Hill,

Neuroradiology (Neuroradiology)
[2019, 61(1):3-8]

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Fluoxetine and recovery after stroke.

H Bart van der Worp,

Lancet (Lancet (London, England))
[2019, 393(10168):206-207]

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Silent Intracerebral Hemorrhage in Patients Randomized to Stenting or Endarterectomy for Symptomatic Carotid Stenosis.

Mandy D Müller, Lisa M Jongen, Aysun Altinbas, Kristine A Blackham, Paul J Nederkoorn, Sumaira Macdonald, Rolf Jäger, Thomas Wolff, Philippe A Lyrer, L Jaap Kappelle, Stephan G Wetzel, Toby Richards, Jeroen Hendrikse, Gert J de Borst, H Bart van der Worp, Stefan T Engelter, David J Werring, Martin M Brown, Leo H Bonati,

J Stroke (Journal of stroke)
[2019, 21(1):116-119]

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Reader response: Comparative safety and efficacy of combined IVT and MT with direct MT in large vessel occlusion.

Natalie E LeCouffe, Kilian M Treurniet, Charles B L M Majoie, Yvo B W E M Roos, Jonathan M Coutinho, ,

Neurology (Neurology)
[2018, 91(24):1115]

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Restenosis and risk of stroke after stenting or endarterectomy for symptomatic carotid stenosis in the International Carotid Stenting Study (ICSS): secondary analysis of a randomised trial.

Leo H Bonati, John Gregson, Joanna Dobson, Dominick J H McCabe, Paul J Nederkoorn, H Bart van der Worp, Gert J de Borst, Toby Richards, Trevor Cleveland, Mandy D Müller, Thomas Wolff, Stefan T Engelter, Philippe A Lyrer, Martin M Brown, ,

BACKGROUND:The risk of stroke associated with carotid artery restenosis after stenting or endarterectomy is unclear. We aimed to compare the long-term risk of restenosis after these treatments and to investigate if restenosis causes stroke in a secondary analysis of the International Carotid Stenting Study (ICSS). METHODS:ICSS is a parallel-group randomised ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2018, 17(7):587-596]

Cited: 1 time

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Fever worsens outcomes in animal models of ischaemic stroke: A systematic review and meta-analysis.

Jeroen C de Jonge, Justin Wallet, H Bart van der Worp,

Background:Subfebrile temperatures and fever in the first days after stroke are associated with a greater risk of a poor outcome. If this relation is causal, prevention of hyperthermia may improve outcome. Causality can be tested in animal models. We therefore assessed the effects of hyperthermia on outcomes in animal models ... Read more >>

Eur Stroke J (European stroke journal)
[2019, 4(1):29-38]

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Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials: An Academic Research Consortium Initiative.

Alexandra J Lansky, Steven R Messé, Adam M Brickman, Michael Dwyer, H Bart van der Worp, Ronald M Lazar, Cody G Pietras, Kevin J Abrams, Eugene McFadden, Nils H Petersen, Jeffrey Browndyke, Bernard Prendergast, Vivian G Ng, Donald E Cutlip, Samir Kapadia, Mitchell W Krucoff, Axel Linke, Claudia Scala Moy, Joachim Schofer, Gerrit-Anne van Es, Renu Virmani, Jeffrey Popma, Michael K Parides, Susheel Kodali, Michel Bilello, Robert Zivadinov, Joseph Akar, Karen L Furie, Daryl Gress, Szilard Voros, Jeffrey Moses, David Greer, John K Forrest, David Holmes, Arie P Kappetein, Michael Mack, Andreas Baumbach,

Surgical and catheter-based cardiovascular procedures and adjunctive pharmacology have an inherent risk of neurological complications. The current diversity of neurological endpoint definitions and ascertainment methods in clinical trials has led to uncertainties in the neurological risk attributable to cardiovascular procedures and inconsistent evaluation of therapies intended to prevent or mitigate ... Read more >>

Eur. Heart J. (European heart journal)
[2018, 39(19):1687-1697]

Cited: 1 time

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High-Resolution Imaging of Interaction Between Thrombus and Stent-Retriever in Patients With Acute Ischemic Stroke.

Anouchska S A Autar, Hajo M Hund, Sharad A Ramlal, Daniël Hansen, Geert J Lycklama À Nijeholt, Bart J Emmer, Moniek P M de Maat, Diederik W J Dippel, Aad van der Lugt, Adriaan C G M van Es, Heleen M M van Beusekom, ,

BACKGROUND:Currently, acute ischemic stroke is still a leading cause of mortality and morbidity. Approximately 2 years ago, mechanical thrombectomy was proven beneficial as a revolutionary new therapy for stroke in the MR-CLEAN trial (A Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands). However, the mechanisms ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2018, 7(13):]

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PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke. Rationale and design of a randomised, open, phase III, clinical trial with blinded outcome assessment.

Hendrik Reinink, Jeroen C de Jonge, Philip M Bath, Diederik van de Beek, Eivind Berge, Saskia Borregaard, Alfonso Ciccone, Laszlo Csiba, Jacques Demotes, Diederik W Dippel, Janika Kõrv, Iwona Kurkowska-Jastrzebska, Kennedy R Lees, Malcolm R Macleod, George Ntaios, Gary Randall, Götz Thomalla, H Bart van der Worp,

Elderly patients are at high risk of complications after stroke, such as infections and fever. The occurrence of these complications has been associated with an increased risk of death or dependency.Hypothesis: Prevention of aspiration, infections, or fever with metoclopramide, ceftriaxone, paracetamol, or any combination of these in the first four ... Read more >>

Eur Stroke J (European stroke journal)
[2018, 3(3):291-298]

Cited: 2 times

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Conscious sedation or local anesthesia during endovascular treatment for acute ischemic stroke.

Rob A van de Graaf, Noor Samuels, Maxim J H L Mulder, Ismail Eralp, Adriaan C G M van Es, Diederik W J Dippel, Aad van der Lugt, Bart J Emmer, ,

OBJECTIVE:To investigate the effect of conscious sedation (CS) on functional outcome and complication rates after intra-arterial treatment (IAT) for acute ischemic stroke (AIS) compared to the use of local anesthesia (LA) at the puncture site only. METHODS:Patients undergoing IAT for AIS with CS or LA in the Erasmus University Medical ... Read more >>

Neurology (Neurology)
[2018, 91(1):e19-e25]

Cited: 1 time

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Development and internal validation of a prediction rule for post-stroke infection and post-stroke pneumonia in acute stroke patients.

Willeke F Westendorp, Jan-Dirk Vermeij, Nina A Hilkens, Matthijs C Brouwer, Ale Algra, H Bart van der Worp, Diederik Wj Dippel, Diederik van de Beek, Pual J Nederkoorn,

Patients with acute stroke are at high risk for infection. These infections are associated with unfavourable outcome after stroke. A prediction rule can identify the patients at the highest risk for strategies to prevent infection. We aim to develop a prediction rule for post-stroke pneumonia and other infections in patients ... Read more >>

Eur Stroke J (European stroke journal)
[2018, 3(2):136-144]

Cited: 2 times

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Etiology of language network changes during recovery of aphasia after stroke.

Casper A M M van Oers, H Bart van der Worp, L Jaap Kappelle, Mathijs A H Raemaekers, Willem M Otte, Rick M Dijkhuizen,

Knowledge of spatiotemporal patterns of language network changes may help in predicting outcome in aphasic stroke patients. Here we assessed language function and performed functional MRI four times during one year to measure language network activation and cerebrovascular reactivity (with breath-holding) in twelve left-hemispheric stroke patients, of whom two dropped ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):856]

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Endovascular treatment for acute ischaemic stroke in routine clinical practice: prospective, observational cohort study (MR CLEAN Registry).

Ivo G H Jansen, Maxim J H L Mulder, Robert-Jan B Goldhoorn, ,

To determine outcomes and safety of endovascular treatment for acute ischaemic stroke, due to proximal intracranial vessel occlusion in the anterior circulation, in routine clinical practice.Ongoing, prospective, observational cohort study.16 centres that perform endovascular treatment in the Netherlands.1488 patients included in the Multicentre Randomised Controlled Trial of Endovascular Treatment for ... Read more >>

BMJ (BMJ (Clinical research ed.))
[2018, 360:k949]

Cited: 6 times

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Statistical analysis plan for the EuroHYP-1 trial: European multicentre, randomised, phase III clinical trial of the therapeutic hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke.

Per Winkel, Philip M Bath, Christian Gluud, Jane Lindschou, H Bart van der Worp, Malcolm R Macleod, Istvan Szabo, Isabelle Durand-Zaleski, Stefan Schwab, ,

Cooling may reduce infarct size and improve neurological outcomes in patients with ischaemic stroke. In phase II trials, cooling awake patients with ischaemic stroke has been shown to be feasible and safe, but the effects in functional outcomes has not yet been investigated in an adequately sized randomised clinical trial.The ... Read more >>

Trials (Trials)
[2017, 18(1):573]

Cited: 1 time

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Predictive accuracy of physicians' estimates of outcome after severe stroke.

Marjolein Geurts, Floor A S de Kort, Paul L M de Kort, Julia H van Tuijl, L Jaap Kappelle, H Bart van der Worp,

INTRODUCTION:End-of-life decisions after stroke should be guided by accurate estimates of the patient's prognosis. We assessed the accuracy of physicians' estimates regarding mortality, functional outcome, and quality of life in patients with severe stroke. METHODS:Treating physicians predicted mortality, functional outcome (modified Rankin scale (mRS)), and quality of life (visual analogue ... Read more >>

PLoS ONE (PloS one)
[2017, 12(9):e0184894]

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Brain stimulation for arm recovery after stroke (B-STARS): protocol for a randomised controlled trial in subacute stroke patients.

Eline C C van Lieshout, Johanna M A Visser-Meily, Sebastiaan F W Neggers, H Bart van der Worp, Rick M Dijkhuizen,

INTRODUCTION:Many patients with stroke have moderate to severe long-term sensorimotor impairments, often including inability to execute movements of the affected arm or hand. Limited recovery from stroke may be partly caused by imbalanced interaction between the cerebral hemispheres, with reduced excitability of the ipsilesional motor cortex while excitability of the ... Read more >>

BMJ Open (BMJ open)
[2017, 7(8):e016566]

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Advance directives, proxy opinions, and treatment restrictions in patients with severe stroke.

Floor A S de Kort, Marjolein Geurts, Paul L M de Kort, Julia H van Tuijl, Ghislaine J M W van Thiel, L Jaap Kappelle, H Bart van der Worp,

BACKGROUND:Patients with severe stroke often do not have the capacity to participate in discussions on treatment restrictions because of a reduced level of consciousness, aphasia, or another cognitive disorder. We assessed the role of advance directives and proxy opinions in the decision-making process of incapacitated patients. METHODS:Sixty patients with severe ... Read more >>

BMC Palliat Care (BMC palliative care)
[2017, 16(1):52]

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Pioglitazone and the secondary prevention of cardiovascular disease. A meta-analysis of randomized-controlled trials.

Marit de Jong, H Bart van der Worp, Yolanda van der Graaf, Frank L J Visseren, Jan Westerink,

Pioglitazone targets multiple pathogenic pathways involved in the development of cardiovascular diseases (CVD). The aim of this systematic review and meta-analysis is to assess the effects of pioglitazone treatment on the secondary prevention of CVD.Randomized-controlled trials of pioglitazone in patients with CVD were identified through PubMed, Embase, Cochrane and CINAHL, ... Read more >>

Cardiovasc Diabetol (Cardiovascular diabetology)
[2017, 16(1):134]

Cited: 12 times

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Detecting Intracranial Vessel Wall Lesions With 7T-Magnetic Resonance Imaging: Patients With Posterior Circulation Ischemia Versus Healthy Controls.

Anita A Harteveld, Anja G van der Kolk, H Bart van der Worp, Nikki Dieleman, Jaco J M Zwanenburg, Peter R Luijten, Jeroen Hendrikse,

Vessel wall magnetic resonance imaging sequences have been developed to directly visualize the intracranial vessel wall, enabling detection of vessel wall changes, including those that have not yet caused luminal narrowing. In this study, vessel wall lesion burden was assessed in patients with recent posterior circulation ischemia using 7T-magnetic resonance ... Read more >>

Stroke (Stroke)
[2017, 48(9):2601-2604]

Cited: 3 times

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