Full Text Journal Articles by
Author H Bart van der Worp

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Stroke Etiology and Thrombus Computed Tomography Characteristics in Patients With Acute Ischemic Stroke: A MR CLEAN Registry Substudy.

Nikki Boodt, Kars C J Compagne, Bruna G Dutra, Noor Samuels, Manon L Tolhuisen, Heitor C B R Alves, Manon Kappelhof, Geert J Lycklama À Nijeholt, Henk A Marquering, Charles B L M Majoie, Hester F Lingsma, Diederik W J Dippel, Aad van der Lugt, ,

Background and Purpose- If a relationship between stroke etiology and thrombus computed tomography characteristics exists, assessing these characteristics in clinical practice could serve as a useful additional diagnostic tool for the identification of stroke subtype. Our purpose was to study the association of stroke etiology and thrombus computed tomography characteristics ... Read more >>

Stroke (Stroke)
[2020, 51(6):1727-1735]

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Endovascular Treatment for Acute Ischemic Stroke in Patients on Oral Anticoagulants: Results From the MR CLEAN Registry.

Robert-Jan B Goldhoorn, Rob A van de Graaf, Jan M van Rees, Hester F Lingsma, Diederik W J Dippel, Wouter H Hinsenveld, Alida Postma, Ido van den Wijngaard, Wim H van Zwam, Robert J van Oostenbrugge, Bob Roozenbeek, ,

Background and Purpose- The use of oral anticoagulants (OAC) is considered a contra-indication for intravenous thrombolytics as acute treatment of ischemic stroke. However, little is known about the risks and benefits of endovascular treatment in patients on prior OAC. We aim to compare outcomes after endovascular treatment between patients with ... Read more >>

Stroke (Stroke)
[2020, 51(6):1781-1789]

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Clinical and Imaging Determinants of Collateral Status in Patients With Acute Ischemic Stroke in MR CLEAN Trial and Registry.

Eveline J A Wiegers, Maxim J H L Mulder, Ivo G H Jansen, Esmee Venema, Kars C J Compagne, Olvert A Berkhemer, Bart J Emmer, Henk A Marquering, Adriaan C G M van Es, Marieke E Sprengers, Wim H van Zwam, Robert J van Oostenbrugge, Yvo B W E M Roos, Charles B L M Majoie, Bob Roozenbeek, Hester F Lingsma, Diederik W J Dippel, Aad van der Lugt, ,

Background and Purpose- Collateral circulation status at baseline is associated with functional outcome after ischemic stroke and effect of endovascular treatment. We aimed to identify clinical and imaging determinants that are associated with collateral grade on baseline computed tomography angiography in patients with acute ischemic stroke due to an anterior ... Read more >>

Stroke (Stroke)
[2020, 51(5):1493-1502]

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Signs of Pulmonary Infection on Admission Chest Computed Tomography Are Associated With Pneumonia or Death in Patients With Acute Stroke.

Jeroen C de Jonge, Richard A P Takx, Frans Kauw, Pim A de Jong, Jan W Dankbaar, H Bart van der Worp,

Background and Purpose- In patients with acute stroke, the occurrence of pneumonia has been associated with poor functional outcomes and an increased risk of death. We assessed the presence and consequences of signs of pulmonary infection on chest computed tomography (CT) before the development of clinically overt pneumonia. Methods- In ... Read more >>

Stroke (Stroke)
[2020, 51(6):1690-1695]

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Intracranial Atherosclerosis Assessed with 7-T MRI: Evaluation of Patients with Ischemic Stroke or Transient Ischemic Attack.

Arjen Lindenholz, Anja G van der Kolk, Irene C van der Schaaf, H Bart van der Worp, Anita A Harteveld, Nikki Dieleman, Michiel L Bots, Jeroen Hendrikse,

Background Intracranial atherosclerosis is an important cause of ischemic stroke and is associated with several vascular risk factors. Current imaging is mainly based on the assessment of luminal narrowing rather than abnormalities in the vessel wall. Purpose To investigate the relationship between vascular risk factors and atherosclerotic lesion burden of ... Read more >>

Radiology (Radiology)
[2020, 295(1):162-170]

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Timing of Repetitive Transcranial Magnetic Stimulation Onset for Upper Limb Function After Stroke: A Systematic Review and Meta-Analysis.

Eline C C van Lieshout, H Bart van der Worp, Johanna M A Visser-Meily, Rick M Dijkhuizen,

Background: Repetitive transcranial magnetic stimulation (rTMS) is a promising intervention to promote upper limb recovery after stroke. We aimed to identify differences in the efficacy of rTMS treatment on upper limb function depending on the onset time post-stroke. Methods: We searched PubMed, Embase, and the Cochrane Library to identify relevant ... Read more >>

Front Neurol (Frontiers in neurology)
[2019, 10:1269]

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Collateral Circulation and Outcome in Atherosclerotic Versus Cardioembolic Cerebral Large Vessel Occlusion.

Valeria Guglielmi, Natalie E LeCouffe, Sanne M Zinkstok, Kars C J Compagne, Reyhan Eker, Kilian M Treurniet, Manon L Tolhuisen, H Bart van der Worp, Ivo G H Jansen, Robert J van Oostenbrugge, Henk A Marquering, Diederik W J Dippel, Bart J Emmer, Charles B L M Majoie, Yvo B W E M Roos, Jonathan M Coutinho, ,

Background and Purpose- Due to chronic hypoperfusion, cervical atherosclerosis may promote cerebral collateral circulation. We hypothesized that patients with ischemic stroke due to cervical carotid atherosclerosis have a more extensive collateral circulation and better outcomes than patients with cardioembolism. We tested this hypothesis in a population of patients who underwent ... Read more >>

Stroke (Stroke)
[2019, 50(12):3360-3368]

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Stent Design, Restenosis and Recurrent Stroke After Carotid Artery Stenting in the International Carotid Stenting Study.

Mandy D Müller, John Gregson, Dominick J H McCabe, Paul J Nederkoorn, H Bart van der Worp, Gert J de Borst, Trevor Cleveland, Thomas Wolff, Stefan T Engelter, Philippe A Lyrer, Martin M Brown, Leo H Bonati,

Background and Purpose- Open-cell carotid artery stents are associated with a higher peri-procedural stroke risk than closed-cell stents. However, the effect of stent design on long-term durability of carotid artery stenting (CAS) is unknown. We compared the medium- to long-term risk of restenosis and ipsilateral stroke between patients treated with ... Read more >>

Stroke (Stroke)
[2019, 50(11):3013-3020]

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Consensus statements and recommendations from the ESO-Karolinska Stroke Update Conference, Stockholm 11-13 November 2018.

Niaz Ahmed, Heinrich Audebert, Guillaume Turc, Charlotte Cordonnier, Hanne Christensen, Simona Sacco, Else Charlotte Sandset, George Ntaios, Andreas Charidimou, Danilo Toni, Christian Pristipino, Martin Köhrmann, Joji B Kuramatsu, Götz Thomalla, Robert Mikulik, Gary A Ford, Joan Martí-Fàbregas, Urs Fischer, Magnus Thoren, Erik Lundström, Gabriel Je Rinkel, H Bart van der Worp, Marius Matusevicius, Georgios Tsivgoulis, Haralampos Milionis, Marta Rubiera, Robert Hart, Tiago Moreira, Maria Lantz, Christina Sjöstrand, Grethe Andersen, Peter Schellinger, Konstantinos Kostulas, Katharina Stibrant Sunnerhagen, Boris Keselman, Eleni Korompoki, Jan Purrucker, Pooja Khatri, William Whiteley, Eivind Berge, Michael Mazya, Diederik Wj Dippel, Satu Mustanoja, Mads Rasmussen, Åsa Kuntze Söderqvist, Irene Escudero-Martínez, Thorsten Steiner,

The purpose of the European Stroke Organisation-Karolinska Stroke Update Conference is to provide updates on recent stroke therapy research and to give an opportunity for the participants to discuss how these results may be implemented into clinical routine. The meeting started 22 years ago as Karolinska Stroke Update, but since ... Read more >>

Eur Stroke J (European stroke journal)
[2019, 4(4):307-317]

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Workflow Intervals of Endovascular Acute Stroke Therapy During On- Versus Off-Hours: The MR CLEAN Registry.

Wouter H Hinsenveld, Inger R de Ridder, Robert J van Oostenbrugge, Jan A Vos, Adrien E Groot, Jonathan M Coutinho, Geert J Lycklama À Nijeholt, Jelis Boiten, Wouter J Schonewille, ,

Background and Purpose- Endovascular treatment (EVT) of patients with acute ischemic stroke because of large vessel occlusion involves complicated logistics, which may cause a delay in treatment initiation during off-hours. This might lead to a worse functional outcome. We compared workflow intervals between endovascular treatment-treated patients presenting during off- and ... Read more >>

Stroke (Stroke)
[2019, 50(10):2842-2850]

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Periprocedural Intravenous Heparin During Endovascular Treatment for Ischemic Stroke: Results From the MR CLEAN Registry.

Rob A van de Graaf, Vicky Chalos, Adriaan C G M van Es, Bart J Emmer, Geert J Lycklama À Nijeholt, H Bart van der Worp, Wouter J Schonewille, Aad van der Lugt, Diederik W J Dippel, Hester F Lingsma, Bob Roozenbeek, ,

Background and Purpose- Intravenous administration of heparin during endovascular treatment for ischemic stroke may improve outcomes. However, risks and benefits of this adjunctive therapy remain uncertain. We aimed to evaluate periprocedural intravenous heparin use in Dutch stroke intervention centers and to assess its efficacy and safety. Methods- Patients registered between ... Read more >>

Stroke (Stroke)
[2019, 50(8):2147-2155]

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Multicentre Randomised trial of Acute Stroke treatment in the Ambulance with a nitroglycerin Patch (MR ASAP): study protocol for a randomised controlled trial.

Sophie A van den Berg, Diederik W J Dippel, Jeannette Hofmeijer, Puck S S Fransen, Klaartje Caminada, Arjen Siegers, Nyika D Kruyt, Henk Kerkhoff, Frank-Erik de Leeuw, Paul J Nederkoorn, H Bart van der Worp, ,

BACKGROUND:Some studies have suggested that transdermal administration of glyceryl trinitrate (GTN; nitroglycerin) in the first few hours after symptom onset increases the chance of a favourable outcome after ischaemic stroke or intracerebral haemorrhage, possibly through an increase in intracranial collateral blood flow and a reduction in blood pressure. The Multicentre ... Read more >>

Trials (Trials)
[2019, 20(1):383]

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Stenting for symptomatic vertebral artery stenosis: a preplanned pooled individual patient data analysis.

Hugh S Markus, Eric L Harshfield, Annette Compter, Wilhelm Kuker, L Jaap Kappelle, Andrew Clifton, H Bart van der Worp, Peter Rothwell, Ale Algra, ,

BACKGROUND:Symptomatic vertebral artery stenosis is associated with a high risk of recurrent stroke, with higher risks for intracranial than for extracranial stenosis. Vertebral artery stenosis can be treated with stenting with good technical results, but whether it results in improved clinical outcome is uncertain. We aimed to compare vertebral stenting ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2019, 18(7):666-673]

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Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial.

H Bart van der Worp, Malcolm R Macleod, Philip Mw Bath, Raj Bathula, Hanne Christensen, Bridget Colam, Charlotte Cordonnier, Jacques Demotes-Mainard, Isabelle Durand-Zaleski, Christian Gluud, Janus Christian Jakobsen, Bernd Kallmünzer, Rainer Kollmar, Derk W Krieger, Kennedy R Lees, Dominik Michalski, Carlos Molina, Joan Montaner, Risto O Roine, Jesper Petersson, Richard Perry, Nikola Sprigg, Dimitre Staykov, Istvan Szabo, Geert Vanhooren, Joanna M Wardlaw, Per Winkel, Stefan Schwab, ,

Introduction:We assessed whether modest systemic cooling started within 6 hours of symptom onset improves functional outcome at three months in awake patients with acute ischaemic stroke. Patients and methods:In this European randomised open-label clinical trial with blinded outcome assessment, adult patients with acute ischaemic stroke were randomised to cooling to ... Read more >>

Eur Stroke J (European stroke journal)
[2019, 4(3):254-262]

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Endovascular Treatment With or Without Prior Intravenous Alteplase for Acute Ischemic Stroke.

Vicky Chalos, Natalie E LeCouffe, Maarten Uyttenboogaart, Hester F Lingsma, Maxim J H L Mulder, Esmee Venema, Kilian M Treurniet, Omid Eshghi, H Bart van der Worp, Aad van der Lugt, Yvo B W E M Roos, Charles B L M Majoie, Diederik W J Dippel, Bob Roozenbeek, Jonathan M Coutinho, ,

Background It is unclear whether intravenous thrombolysis ( IVT ) with alteplase before endovascular treatment ( EVT ) is beneficial for patients with acute ischemic stroke caused by a large vessel occlusion. We compared clinical and procedural outcomes, safety, and workflow between patients treated with both IVT and EVT and ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2019, 8(11):e011592]

Cited: 1 time

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[Broader indications for treatment of ischaemic stroke].

Jeroen C de Jonge, H Bart van der Worp, L Jaap Kappelle,

Broader indications for treatment of ischaemic stroke Current guidelines suggest that selected patients with ischaemic stroke can be treated with intravenous thrombolysis or mechanical thrombectomy within 4.5 or 6 hours, respectively, after onset of the stroke. Recent developments in imaging have made it possible to distinguish permanently damaged brain tissue ... Read more >>

Ned Tijdschr Geneeskd (Nederlands tijdschrift voor geneeskunde)
[2019, 163:]

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Women in the European Stroke Organisation: One, two, many… - A Top Down and Bottom Up approach.

Else Charlotte Sandset, Diana Aguiar de Sousa, Hanne Christensen, Charlotte Cordonnier, Urs Fischer, Mira Katan, Christine Kremer, Aleksandra Pavlovic, Nikola Sprigg, H Bart van der Worp, Marialuisa Zedde, Valeria Caso,

Background:An increasing proportion of physicians are women, yet they still face challenges with career advancement. In 2014, the European Stroke Organisation established the goal of increasing the number and participation of women within the society using a Top Down and Bottom Up approach. The 'Women's Initiative for Stroke in Europe' ... Read more >>

Eur Stroke J (European stroke journal)
[2019, 4(3):247-253]

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Impact of single phase CT angiography collateral status on functional outcome over time: results from the MR CLEAN Registry.

Ivo Gh Jansen, Maxim Jhl Mulder, Robert-Jan B Goldhoorn, Anna Mm Boers, Adriaan Cgm van Es, Lonneke Sf Yo, Jeannette Hofmeijer, Jasper M Martens, Marianne Aa van Walderveen, Bas Fw van der Kallen, Sjoerd Fm Jenniskens, Kilian M Treurniet, Henk A Marquering, Marieke Es Sprengers, Wouter J Schonewille, Joost Cj Bot, Geert J Lycklama A Nijeholt, Hester F Lingsma, David S Liebeskind, Jelis Boiten, Jan Albert Vos, Yvo Bwem Roos, Robert J van Oostenbrugge, Aad van der Lugt, Wim H van Zwam, Diederik Wj Dippel, Ido R van den Wijngaard, Charles Blm Majoie, ,

BACKGROUND:Collateral status modified the effect of endovascular treatment (EVT) for stroke in several randomized trials. We assessed the association between collaterals and functional outcome in EVT treated patients and investigated if this association is time dependent. METHODS:We included consecutive patients from the Multicenter Randomized Clinical Trial of Endovascular Treatment for ... Read more >>

J Neurointerv Surg (Journal of neurointerventional surgery)
[2019, 11(9):866-873]

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Endovascular Treatment: The Role of Dominant Caliber M2 Segment Occlusion in Ischemic Stroke.

Kars C J Compagne, Pieter M van der Sluijs, Ido R van den Wijngaard, Bob Roozenbeek, Maxim J H L Mulder, Wim H van Zwam, Bart J Emmer, Charles B L M Majoie, Albert J Yoo, Geert J Lycklama À Nijeholt, Hester F Lingsma, Diederik W J Dippel, Aad van der Lugt, Adriaan C G M van Es, ,

Background and Purpose- It is unclear whether endovascular treatment (EVT) is beneficial for patients with acute ischemic stroke with occlusion of the M2 segment of the middle cerebral artery. We aimed to compare functional outcomes, technical aspects, and complications of EVT between patients with acute ischemic stroke because of M2 ... Read more >>

Stroke (Stroke)
[2019, 50(2):419-427]

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Which patients with acute stroke due to proximal occlusion should not be treated with endovascular thrombectomy?

Mayank Goyal, Mohammed A Almekhlafi, Christoph Cognard, Ryan McTaggart, Kristine Blackham, Alessandra Biondi, Aad van der Lugt, Charles B L M Majoie, Wim H van Zwam, H Bart van der Worp, Michael D Hill,

Neuroradiology (Neuroradiology)
[2019, 61(1):3-8]

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Fluoxetine and recovery after stroke.

H Bart van der Worp,

Lancet (Lancet (London, England))
[2019, 393(10168):206-207]

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Silent Intracerebral Hemorrhage in Patients Randomized to Stenting or Endarterectomy for Symptomatic Carotid Stenosis.

Mandy D Müller, Lisa M Jongen, Aysun Altinbas, Kristine A Blackham, Paul J Nederkoorn, Sumaira Macdonald, Rolf Jäger, Thomas Wolff, Philippe A Lyrer, L Jaap Kappelle, Stephan G Wetzel, Toby Richards, Jeroen Hendrikse, Gert J de Borst, H Bart van der Worp, Stefan T Engelter, David J Werring, Martin M Brown, Leo H Bonati, ,

J Stroke (Journal of stroke)
[2019, 21(1):116-119]

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Reader response: Comparative safety and efficacy of combined IVT and MT with direct MT in large vessel occlusion.

Natalie E LeCouffe, Kilian M Treurniet, Charles B L M Majoie, Yvo B W E M Roos, Jonathan M Coutinho, ,

Neurology (Neurology)
[2018, 91(24):1115]

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Restenosis and risk of stroke after stenting or endarterectomy for symptomatic carotid stenosis in the International Carotid Stenting Study (ICSS): secondary analysis of a randomised trial.

Leo H Bonati, John Gregson, Joanna Dobson, Dominick J H McCabe, Paul J Nederkoorn, H Bart van der Worp, Gert J de Borst, Toby Richards, Trevor Cleveland, Mandy D Müller, Thomas Wolff, Stefan T Engelter, Philippe A Lyrer, Martin M Brown, ,

BACKGROUND:The risk of stroke associated with carotid artery restenosis after stenting or endarterectomy is unclear. We aimed to compare the long-term risk of restenosis after these treatments and to investigate if restenosis causes stroke in a secondary analysis of the International Carotid Stenting Study (ICSS). METHODS:ICSS is a parallel-group randomised ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2018, 17(7):587-596]

Cited: 2 times

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High-Resolution Imaging of Interaction Between Thrombus and Stent-Retriever in Patients With Acute Ischemic Stroke.

Anouchska S A Autar, Hajo M Hund, Sharad A Ramlal, Daniël Hansen, Geert J Lycklama À Nijeholt, Bart J Emmer, Moniek P M de Maat, Diederik W J Dippel, Aad van der Lugt, Adriaan C G M van Es, Heleen M M van Beusekom, ,

BACKGROUND:Currently, acute ischemic stroke is still a leading cause of mortality and morbidity. Approximately 2 years ago, mechanical thrombectomy was proven beneficial as a revolutionary new therapy for stroke in the MR-CLEAN trial (A Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands). However, the mechanisms ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2018, 7(13):]

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