Full Text Journal Articles by
Author H Alex Choi

Advertisement

Find full text journal articles






Relationship Between Nutrition Intake and Outcome After Subarachnoid Hemorrhage: Results From the International Nutritional Survey.

Neeraj Badjatia, Alice Ryan, H Alex Choi, Gunjan Y Parikh, Xuran Jiang, Andrew G Day, Daren K Heyland,

<h4>Background</h4>A previous study suggested an association between low caloric intake(CI), negative nitrogen balance, and poor outcome after subarachnoid hemorrhage(SAH). Objective of this multinational, multicenter study was to investigate whether clinical outcomes vary by protein intake(PI) or CI in SAH patients adjusting for the nutritional risk as judged by the modified ... Read more >>

J Intensive Care Med (Journal of intensive care medicine)
[2021, 36(10):1141-1148]

Cited: 0 times

View full text PDF listing >>



Agonism of the α7-acetylcholine receptor/PI3K/Akt pathway promotes neuronal survival after subarachnoid hemorrhage in mice.

Ari Dienel, Remya A Veettil, Kanako Matsumura, H Alex Choi, Peeyush Kumar T, Andrey S Tsvetkov, Jaroslaw Aronowski, Pramod Dash, Spiros L Blackburn, Devin W McBride,

Subarachnoid hemorrhage (SAH) results in severe neuronal dysfunction and degeneration. Since the nicotinic acetylcholine α<sub>7</sub> receptors (α<sub>7</sub>-AChR) are involved in neuronal function and survival, we investigated if stimulation of α<sub>7</sub>-AChR would promote neuronal survival and improve behavioral outcome following SAH in mice. Male mice subjected to SAH were treated with ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 344:113792]

Cited: 0 times

View full text PDF listing >>



Advertisement

Determinants of Visceral Infarction in Acute Cardioembolic Stroke Due to Atrial Fibrillation.

Sung-Il Sohn, Sang-Won Park, Younghyurk Lee, Hyungjong Park, Hyukwon Chang, H Alex Choi, Jeong-Ho Hong,

J Stroke (Journal of stroke)
[2021, 23(2):277-280]

Cited: 0 times

View full text PDF listing >>



Markers of brain and endothelial Injury and inflammation are acutely and sex specifically regulated in SARS-CoV-2 infection

Jude Savarraj, Eun Park, Gabriela Copo, Sarah Hinds, Diego Morales, Hilda Ahnstedt, Atzhiry Paz, Andres Assing, Shivanki Juneja, Eunhee Kim, Sung-min Cho, Aaron Gusdon, Pramod Dash, Louise McCullough, Alex Choi,

<h4>Objective</h4> To investigate brain injury markers (BIM), endothelial injury markers (EIM) and cytokine/chemokine (CC) markers of systemic inflammation in coronavirus disease 2019 (COVID-19) and across sex. <h4>Methods</h4> Plasma samples from 57 subjects at <48 hours of COVID-19 hospitalization, 14 subjects at 3 months of COVID-19 hospitalization and 20 matched controls ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



α7-Acetylcholine Receptor Signaling Reduces Neuroinflammation After Subarachnoid Hemorrhage in Mice.

Ari Dienel, Remya A Veettil, Kanako Matsumura, Jude P J Savarraj, H Alex Choi, Peeyush Kumar T, Jaroslaw Aronowski, Pramod Dash, Spiros L Blackburn, Devin W McBride,

Aneurysmal subarachnoid hemorrhage (aSAH) causes a robust inflammatory response which leads worse brain injury and poor outcomes. We investigated if stimulation of nicotinic acetylcholine α<sub>7</sub> receptors (α<sub>7</sub>-AChR) (receptors shown to have anti-inflammatory effects) would reduce inflammation and improve outcomes. To investigate the level of peripheral inflammation after aSAH, inflammatory markers ... Read more >>

Neurotherapeutics (Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics)
[2021, :]

Cited: 1 time

View full text PDF listing >>



Reducing acetylated tau is neuroprotective in brain injury.

Min-Kyoo Shin, Edwin Vázquez-Rosa, Yeojung Koh, Matasha Dhar, Kalyani Chaubey, Coral J Cintrón-Pérez, Sarah Barker, Emiko Miller, Kathryn Franke, Maria F Noterman, Divya Seth, Rachael S Allen, Cara T Motz, Sriganesh Ramachandra Rao, Lara A Skelton, Machelle T Pardue, Steven J Fliesler, Chao Wang, Tara E Tracy, Li Gan, Daniel J Liebl, Jude P J Savarraj, Glenda L Torres, Hilda Ahnstedt, Louise D McCullough, Ryan S Kitagawa, H Alex Choi, Pengyue Zhang, Yuan Hou, Chien-Wei Chiang, Lang Li, Francisco Ortiz, Jessica A Kilgore, Noelle S Williams, Victoria C Whitehair, Tamar Gefen, Margaret E Flanagan, Jonathan S Stamler, Mukesh K Jain, Allison Kraus, Feixiong Cheng, James D Reynolds, Andrew A Pieper,

Traumatic brain injury (TBI) is the largest non-genetic, non-aging related risk factor for Alzheimer's disease (AD). We report here that TBI induces tau acetylation (ac-tau) at sites acetylated also in human AD brain. This is mediated by S-nitrosylated-GAPDH, which simultaneously inactivates Sirtuin1 deacetylase and activates p300/CBP acetyltransferase, increasing neuronal ac-tau. ... Read more >>

Cell (Cell)
[2021, 184(10):2715-2732.e23]

Cited: 4 times

View full text PDF listing >>



Glioma and temozolomide induced alterations in gut microbiome.

Anthony Patrizz, Antonio Dono, Soheil Zorofchian, Gabriella Hines, Takeshi Takayasu, Nuruddin Husein, Yoshihiro Otani, Octavio Arevalo, H Alex Choi, Jude Savarraj, Nitin Tandon, Bhanu P Ganesh, Balveen Kaur, Louise D McCullough, Leomar Y Ballester, Yoshua Esquenazi,

The gut microbiome is fundamental in neurogenesis processes. Alterations in microbial constituents promote inflammation and immunosuppression. Recently, in immune-oncology, specific microbial taxa have been described to enhance the effects of therapeutic modalities. However, the effects of microbial dysbiosis on glioma are still unknown. The aim of this study was to ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):21002]

Cited: 2 times

View full text PDF listing >>



Real-time intracranial pressure monitoring during high-dose methotrexate treatment for primary central nervous system lymphoma.

Antonio Dono, Nuruddin Husein, Cristian Ybarra, Rodrigo Hasbun, H Alex Choi, Leomar Y Ballester, Yoshua Esquenazi,

<h4>Background</h4>Primary central nervous system lymphoma (PCNSL) is an aggressive non-Hodgkin lymphoma with exclusive central nervous system (CNS) and/or ocular involvement. Increased intracranial pressure (ICP) from cerebral edema can commonly presents secondary to the mass effect of PCNSL. Methotrexate-based induction chemotherapy is the gold standard for treatment, however, several neurotoxic complications ... Read more >>

Cancer Treat Res Commun (Cancer treatment and research communications)
[2020, 25:100234]

Cited: 0 times

View full text PDF listing >>



Machine Learning to Predict Delayed Cerebral Ischemia and Outcomes in Subarachnoid Hemorrhage.

Jude P J Savarraj, Georgene W Hergenroeder, Liang Zhu, Tiffany Chang, Soojin Park, Murad Megjhani, Farhaan S Vahidy, Zhongming Zhao, Ryan S Kitagawa, H Alex Choi,

<h4>Objective</h4>To determine whether machine learning (ML) algorithms can improve the prediction of delayed cerebral ischemia (DCI) and functional outcomes after subarachnoid hemorrhage (SAH).<h4>Methods</h4>ML models and standard models (SMs) were trained to predict DCI and functional outcomes with data collected within 3 days of admission. Functional outcomes at discharge and at ... Read more >>

Neurology (Neurology)
[2021, 96(4):e553-e562]

Cited: 2 times

View full text PDF listing >>



Three-month outcomes in hospitalized COVID-19 patients

Jude PJ Savarraj, Angela Burkett, Sarah Hinds, Atzhiry Paz, Andres Assing, Shivanki Juneja, Gabriela Delevati Colpo, Luis Torres, Aaron Gusdon, Louise McCullough, Alex Choi,

COVID-19 is an ongoing pandemic with a devastating impact on public health. Acute neurological symptoms have been reported after a COVID-19 diagnosis, however there is no data available on the long-term neurological symptoms. Using a prospective registry of hospitalized COVID-19 patients, we assessed the neurological assessments (including functional, cognitive and ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Cerebral hemorrhage in the LVAD patient: A case series and literature review.

Laura Ann Zima, Corinne Mayap Fotso, Viraj Parikh, Dallas Sheinberg, Michael Monterey, H Alex Choi, Ryan Kitagawa,

<h4>Introduction</h4>A left ventricular assist device (LVAD) is used in certain heart failure cases, but LVADs can have significant neurological complications including intracranial hemorrhages (ICH). Prediction and management of ICHs is challenging due to medical comorbidities and blood thinners.<h4>Methods</h4>A retrospective review of LVAD patients with ICHs from 2015 to 2019 was ... Read more >>

Clin Neurol Neurosurg (Clinical neurology and neurosurgery)
[2020, 197:106094]

Cited: 0 times

View full text PDF listing >>



Acute Inflammation in Traumatic Brain Injury and Polytrauma Patients Using Network Analysis.

Bradley Rowland, Jude P J Savarraj, Jay Karri, Xu Zhang, Jessica Cardenas, H Alex Choi, John B Holcomb, Charles E Wade,

<h4>Introduction</h4>Traumatic brain injury (TBI) is associated with secondary injury to the central nervous system (CNS) via inflammatory mechanisms. The combination of polytrauma and TBI further exacerbates the inflammatory response to injury; however, combined injury phenomena have not been thoroughly studied. In this study, we examined the inflammatory differences between patients ... Read more >>

Shock (Shock (Augusta, Ga.))
[2020, 53(1):24-34]

Cited: 2 times

View full text PDF listing >>



Elevated inflammation and decreased platelet activity is associated with poor outcomes after traumatic brain injury.

Cole T Lewis, Jude P J Savarraj, Mary F McGuire, Georgene W Hergenroeder, H Alex Choi, Ryan S Kitagawa,

The inflammatory processes following traumatic brain injury (TBI) have not been fully characterized. We hypothesize that differences in systemic cytokine/chemokine (CC) levels are associated with TBI clinical outcomes. To test this hypothesis, we examined systemic levels of CCs and their relationship with patient outcomes. Plasma from acute TBI subjects was ... Read more >>

J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2019, 70:37-41]

Cited: 0 times

View full text PDF listing >>



Inflammation in delayed ischemia and functional outcomes after subarachnoid hemorrhage.

Sung-Ho Ahn, Jude P J Savarraj, Kaushik Parsha, Georgene W Hergenroeder, Tiffany R Chang, Dong H Kim, Ryan S Kitagawa, Spiros L Blackburn, H Alex Choi,

<h4>Background</h4>Inflammatory mechanism has been implicated in delayed cerebral ischemia (DCI) and poor functional outcomes after subarachnoid hemorrhage (SAH). Identification of cytokine patterns associated with inflammation in acute SAH will provide insights into underlying biological processes of DCI and poor outcomes that may be amenable to interventions.<h4>Methods</h4>Serum samples were collected from ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2019, 16(1):213]

Cited: 10 times

View full text PDF listing >>



Representation Learning of 3D Brain Angiograms, an Application for Cerebral Vasospasm Prediction.

Seymanur Capoglu, Jude P Savarraj, Sunil A Sheth, H Alex Choi, Luca Giancardo,

Stroke is the fifth leading cause of death in the United States. Subarachnoid hemorrhage (SAH) is a type of stroke often caused by the spontaneous rupture of a cerebral aneurysm. About 30% of the SAH patients develop delayed cerebral ischemia (DCI) a serious secondary complication with devastating impact. Cerebral vasospasm ... Read more >>

Annu Int Conf IEEE Eng Med Biol Soc (Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference)
[2019, 2019:3394-3398]

Cited: 1 time

View full text PDF listing >>



Cocaine Use is Associated with More Rapid Clot Formation and Weaker Clot Strength in Acute Stroke Patients.

Tareq S Almaghrabi, Mark M McDonald, Chunyan Cai, Mohammed H Rahbar, H Alex Choi, Kiwon Lee, Neeraj S Naval, James C Grotta, Tiffany R Chang,

Introduction:1.1.Cocaine use is a known risk factor for stroke and has been associated with worse outcomes. Cocaine may cause an altered coagulable state by a number of different proposed mechanisms, including platelet activation, endothelial injury, and tissue factor expression. This study analyzes the effect of cocaine use on Thrombelastography (TEG) ... Read more >>

Int J Cerebrovasc Dis Stroke (International journal of cerebrovascular disease and stroke)
[2019, 2(1):]

Cited: 2 times

View full text PDF listing >>



Race is a Predictor of Withdrawal of Life Support in Patients with Intracerebral Hemorrhage.

Stuart M Fraser, Glenda L Torres, Chunyan Cai, H Alex Choi, Anjail Sharrief, Tiffany R Chang,

INTRODUCTION:Medical and socioeconomic factors may impact decisions to change the goals of care for patients with intracerebral hemorrhage (ICH) to comfort measures only. METHODS:We reviewed prospectively collected data on patients with ICH, including baseline patient demographics, Glasgow Coma Scale (GCS), National Institute of Health Stroke Scale (NIHSS), and ICH score. ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2018, 27(11):3108-3114]

Cited: 1 time

View full text PDF listing >>



The Subarachnoid Hemorrhage Early Brain Edema Score Predicts Delayed Cerebral Ischemia and Clinical Outcomes.

Sung-Ho Ahn, Jude P Savarraj, Mubashir Pervez, Wesley Jones, Jin Park, Sang-Beom Jeon, Sun U Kwon, Tiffany R Chang, Kiwon Lee, Dong H Kim, Arthur L Day, H Alex Choi,

<h4>Background</h4>Early brain injury (EBI) after subarachnoid hemorrhage (SAH) is an important determinant of clinical outcomes. However, a major hindrance to studies of EBI is the lack of radiographic surrogate marker.<h4>Objective</h4>To propose a scoring system based on early changes in clinically obtained computed tomography (CT), called the Subarachnoid hemorrhage Early Brain ... Read more >>

Neurosurgery (Neurosurgery)
[2018, 83(1):137-145]

Cited: 18 times

View full text PDF listing >>



Increased Levels of Circulating Glial Fibrillary Acidic Protein and Collapsin Response Mediator Protein-2 Autoantibodies in the Acute Stage of Spinal Cord Injury Predict the Subsequent Development of Neuropathic Pain.

Georgene W Hergenroeder, John B Redell, H Alex Choi, Lisa Schmitt, William Donovan, Gerard E Francisco, Karl Schmitt, Anthony N Moore, Pramod K Dash,

Neuropathic pain develops in 40-70% of spinal cord injury (SCI) patients and markedly compromises quality of life. We examined plasma from SCI patients for autoantibodies to glial fibrillary acidic protein (GFAP) and collapsin response mediator protein-2 (CRMP2) and evaluated their relationship to the development of neuropathic pain. In study 1, ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2018, 35(21):2530-2539]

Cited: 6 times

View full text PDF listing >>



Unique Contribution of Haptoglobin and Haptoglobin Genotype in Aneurysmal Subarachnoid Hemorrhage.

Spiros L Blackburn, Peeyush T Kumar, Devin McBride, Hussein A Zeineddine, Jenna Leclerc, H Alex Choi, Pramod K Dash, James Grotta, Jaroslaw Aronowski, Jessica C Cardenas, Sylvain Doré,

Survivors of cerebral aneurysm rupture are at risk for significant morbidity and neurological deficits. Much of this is related to the effects of blood in the subarachnoid space which induces an inflammatory cascade with numerous downstream consequences. Recent clinical trials have not been able to reduce the toxic effects of ... Read more >>

Front Physiol (Frontiers in physiology)
[2018, 9:592]

Cited: 6 times

View full text PDF listing >>



Early Brain Injury Associated with Systemic Inflammation After Subarachnoid Hemorrhage.

Jude Savarraj, Kaushik Parsha, Georgene Hergenroeder, Sungho Ahn, Tiffany R Chang, Dong H Kim, H Alex Choi,

<h4>Background</h4>Early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (aSAH) is defined as brain injury occurring within 72 h of aneurysmal rupture. Although EBI is the most significant predictor of outcomes after aSAH, its underlying pathophysiology is not well understood. We hypothesize that EBI after aSAH is associated with an increase in ... Read more >>

Neurocrit Care (Neurocritical care)
[2018, 28(2):203-211]

Cited: 17 times

View full text PDF listing >>



Thrombelastography Suggests Hypercoagulability in Patients with Renal Dysfunction and Intracerebral Hemorrhage.

Kevin Meier, Daniel M Saenz, Glenda L Torres, Chunyan Cai, Mohammed H Rahbar, Mark McDonald, Stuart Fraser, Elena Espino, H Alex Choi, Nancy J Edwards, Kiwon Lee, James C Grotta, Tiffany R Chang,

The objective of this study was to quantify coagulopathy using thrombelastography (TEG) in patients with renal dysfunction and intracerebral hemorrhage (ICH).We reviewed patients admitted with spontaneous ICH between November 2009 and May 2015. TEG was performed at the time of admission. Creatinine clearance (CCr) was calculated using the Cockroft-Gault equation. ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2018, 27(5):1350-1356]

Cited: 1 time

View full text PDF listing >>



Nocturnal Desaturation is Associated With Neurological Deterioration Following Ischemic Stroke: A Retrospective Observational Study.

Tae Jung Kim, Sang-Bae Ko, Han-Gil Jeong, Chi Kyung Kim, Yerim Kim, Kiwoong Nam, Heejung Mo, Sang Joon An, H Alex Choi, Byung-Woo Yoon,

<h4>Study objectives</h4>The mechanism of early neurological deterioration (END) in patients with stroke remains unclear. We assessed the relationship between nocturnal oxygen desaturation (NOD) in the stroke unit (SU) and END, especially occurring at nighttime, following acute stroke.<h4>Methods</h4>A retrospective analysis was performed on a total of 276 patients with ischemic stroke ... Read more >>

J Clin Sleep Med (Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine)
[2017, 13(11):1273-1279]

Cited: 2 times

View full text PDF listing >>



Dual Antiplatelet Therapy Is Associated With Coagulopathy Detectable by Thrombelastography in Acute Stroke.

Mark M McDonald, Tareq S Almaghrabi, Daniel M Saenz, Chunyan Cai, Mohammad H Rahbar, H Alex Choi, Kiwon Lee, James C Grotta, Tiffany R Chang,

<h4>Background</h4>Thrombelastography (TEG) provides a global, dynamic measure of coagulation. We examined the effect of antiplatelet (AP) medications on coagulation in patients with acute stroke as measured by TEG.<h4>Methods</h4>We reviewed prospectively collected data on patients presenting with acute ischemic stroke (AIS) and spontaneous intracerebral hemorrhage (ICH) between 2009 and 2014. Patient ... Read more >>

J Intensive Care Med (Journal of intensive care medicine)
[2020, 35(1):68-73]

Cited: 4 times

View full text PDF listing >>



Systematic model of peripheral inflammation after subarachnoid hemorrhage.

Jude P J Savarraj, Kaushik Parsha, Georgene W Hergenroeder, Liang Zhu, Suhas S Bajgur, Sungho Ahn, Kiwon Lee, Tiffany Chang, Dong H Kim, Yin Liu, H Alex Choi,

<h4>Objective</h4>To investigate inflammatory processes after aneurysmal subarachnoid hemorrhage (aSAH) with network models.<h4>Methods</h4>This is a retrospective observational study of serum samples from 45 participants with aSAH analyzed at multiple predetermined time points: <24 hours, 24 to 48 hours, 3 to 5 days, and 6 to 8 days after aSAH. Concentrations of ... Read more >>

Neurology (Neurology)
[2017, 88(16):1535-1545]

Cited: 13 times

View full text PDF listing >>



Advertisement


Disclaimer

1.1266 s