Full Text Journal Articles by
Author Guy Laurent

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Randomized Phase III Trial of Dose-dense Methotrexate, Vinblastine, Doxorubicin, and Cisplatin, or Gemcitabine and Cisplatin as Perioperative Chemotherapy for Patients with Muscle-invasive Bladder Cancer. Analysis of the GETUG/AFU V05 VESPER Trial Secondary Endpoints: Chemotherapy Toxicity and Pathological Responses.

Christian Pfister, Gwenaelle Gravis, Aude Fléchon, Michel Soulié, Laurent Guy, Brigitte Laguerre, Nicolas Mottet, Florence Joly, Yves Allory, Valentin Harter, Stéphane Culine, ,

BACKGROUND:Perioperative chemotherapy (neoadjuvant or adjuvant) has been developed to increase overall survival for nonmetastatic muscle-invasive bladder cancer (MIBC). Retrospective studies or prospective phase II trials have been reported to use dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin (dd-MVAC) or gemcitabine and cisplatin (GC). As dd-MVAC has shown higher response rates in ... Read more >>

Eur. Urol. (European urology)
[2020, :]

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Role of JMJD3 Demethylase and Its Inhibitor GSK-J4 in Regulation of MGMT, TRA2A, RPS6KA2, and U2AF1 Genes in Prostate Cancer Cell Lines.

Anna Sanchez, Driss El Ouardi, Fatma Zohra Houfaf Khoufaf, Mouhamed Idrissou, Tiphanie Boisnier, Frédérique Penault-Llorca, Yves-Jean Bignon, Laurent Guy, Dominique Bernard-Gallon,

OMICS (Omics : a journal of integrative biology)
[2020, 24(8):505-507]

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Posttraumatic Stress Disorder Symptoms in Lymphoma Patients: A Prospective Study.

Claire Camille, Chloé Dimeglio, Antoine Yrondi, Gisèle Compaci, Emmanuelle Delmas, Mélanie Gauché, Guy Laurent, Philippe Birmes,

The cancer experience may be marked by repeat stressors and/or traumas. The aim of our study was to assess traumatic events in a group of patients diagnosed with lymphoma and to determine which of these contribute to the development of Post-Traumatic Stress Disorder/PTSD. Two weeks after receiving a diagnosis of ... Read more >>

(Frontiers in psychiatry)
[2020, 11:201]

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Psychotropic drug initiation in patients diagnosed with chronic myeloid leukemia: a population-based study in France.

Martin Gauthier, Cécile Conte, Aurore Palmaro, Emilie Patras De Campaigno, Sandra De Barros, Françoise Huguet, Guy Laurent, Maryse Lapeyre-Mestre, Fabien Despas,

Psychotropic drugs (PD) are often used close to a cancer diagnosis and may be considered as a way of coping. We aimed to determine the incidence of anxiolytics, hypnotics, antidepressants, and antipsychotics initiation around a diagnosis of chronic myelogenous leukemia (CML). Population-based cohort: Data were extracted from Systeme National des ... Read more >>

Fundam Clin Pharmacol (Fundamental & clinical pharmacology)
[2020, 34(5):612-622]

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The Inhibition of the Histone Methyltransferase EZH2 by DZNEP or SiRNA Demonstrates Its Involvement in MGMT, TRA2A, RPS6KA2, and U2AF1 Gene Regulation in Prostate Cancer.

Driss El Ouardi, Mouhamed Idrissou, Anna Sanchez, Frédérique Penault-Llorca, Yves-Jean Bignon, Laurent Guy, Dominique Bernard-Gallon,

OMICS (Omics : a journal of integrative biology)
[2020, 24(2):116-118]

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Real-world costs of illness of Hodgkin and the main B-Cell Non-Hodgkin lymphomas in France.

Michael Mounié, Nadège Costa, Cécile Conte, Dominique Petiot, Didier Fabre, Fabien Despas, Maryse Lapeyre-Mestre, Guy Laurent, Nicolas Savy, Laurent Molinier,

Background: Lymphomas are costly diseases that suffer from a lack of detailed economic information, notably in a real-world setting. Decision-makers are increasing the search for Real-World Evidence (RWE) to assess the impact, in real-life, of healthcare management and to support their public decisions. Thus, we aimed to assess the real-world ... Read more >>

J Med Econ (Journal of medical economics)
[2020, 23(3):235-242]

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Sustained degradation of quality of life in a subgroup of lymphoma survivors: a two-year prospective survey.

Gisèle Compaci, Cécile Conte, Lucie Oberic, Loïc Ysebaert, Guy Laurent, Fabien Despas,

BACKGROUND:Previous studies have suggested that lymphoma survivors commonly display altered Health-Related Quality of Life (HRQoL). Because these were predominantly cross-sectional studies, the dynamic of events as well as the factors which influence HRQoL remain to be determined. METHODS:We conducted a prospective study on a cohort of 204 Hodgkin and non-Hodgkin ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):1178]

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Are social inequalities in acute myeloid leukemia survival explained by differences in treatment utilization? Results from a French longitudinal observational study among older patients.

Eloïse Berger, Cyrille Delpierre, Fabien Despas, Sarah Bertoli, Emilie Bérard, Oriane Bombarde, Pierre Bories, Audrey Sarry, Guy Laurent, Christian Récher, Sébastien Lamy,

BACKGROUND:Evidences support social inequalities in cancer survival. Studies on hematological malignancies, and more specifically Acute Myeloid Leukemia (AML), are sparser. Our study assessed: 1/ the influence of patients' socioeconomic position on survival, 2/ the role of treatment in this relationship, and 3/ the influence of patients' socioeconomic position on treatment ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):883]

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Combining Ellipsometry and AFM To Probe Subnanometric Precursor Film Dynamics of Polystyrene Melts.

Claire Schune, Marc Yonger, Bruno Bresson, Christian Fretigny, Laurent Guy, Thomas Chaussée, François Lequeux, Hélène Montes, Emilie Verneuil,

We investigate the evolution over time of the space profiles of precursor films spreading away from a droplet of polymer in the poorly explored pseudo-partial wetting case. We use polystyrene melt droplets on oxidized silicon wafers. Interestingly, the film thicknesses measured by ellispometric microscopy are found in the 0.01 to ... Read more >>

Langmuir (Langmuir : the ACS journal of surfaces and colloids)
[2019, 35(24):7727-7734]

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Apalutamide for Metastatic, Castration-Sensitive Prostate Cancer.

Kim N Chi, Neeraj Agarwal, Anders Bjartell, Byung Ha Chung, Andrea J Pereira de Santana Gomes, Robert Given, Álvaro Juárez Soto, Axel S Merseburger, Mustafa Özgüroğlu, Hirotsugu Uemura, Dingwei Ye, Kris Deprince, Vahid Naini, Jinhui Li, Shinta Cheng, Margaret K Yu, Ke Zhang, Julie S Larsen, Sharon McCarthy, Simon Chowdhury, ,

BACKGROUND:Apalutamide is an inhibitor of the ligand-binding domain of the androgen receptor. Whether the addition of apalutamide to androgen-deprivation therapy (ADT) would prolong radiographic progression-free survival and overall survival as compared with placebo plus ADT among patients with metastatic, castration-sensitive prostate cancer has not been determined. METHODS:In this double-blind, phase ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2019, 381(1):13-24]

Cited: 26 times

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Work adjustments and employment among breast cancer survivors: a French prospective study.

Flora Vayr, Marion Montastruc, Frédéric Savall, Fabien Despas, Elodie Judic, Maud Basso, Charlotte Dunet, Florence Dalenc, Guy Laurent, Jean Marc Soulat, Fabrice Herin,

PURPOSE:The objective of our study was to assess the rate of work adjustments 1 year after the diagnosis in a population of female breast cancer (BC) survivors, in the context of the French system of social protection. We also characterised these adjustments and their influence on the reduction of professional exclusion ... Read more >>

Support Care Cancer (Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer)
[2020, 28(1):185-192]

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Oncology nurse phone calls halve the risk of reduced dose intensity of immunochemotherapy: results of the randomized FORTIS study in chronic lymphocytic leukemia.

Loic Ysebaert, Marie Larcher, Gisele Compaci, Lucie Oberic, Laurence Sahnes, Anne Banos, Carla Araujo, Agnes Sommet, Guy Laurent, Fabien Despas,

Delivering of > 80% planned relative dose intensity (RDI) of fludarabine-cyclophosphamide-rituximab (FCR) is key to benefit from longer progression free survival (PFS) and survivals in CLL. In this randomized trial, we sought to investigate whether a telephone intervention strategy (called AMA) delivered by an oncology nurse could reduce the risk of ... Read more >>

Ann Hematol (Annals of hematology)
[2019, 98(4):931-939]

Cited: 2 times

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The impact of chronic myeloid leukemia on employment: the French prospective study.

Sandra De Barros, Flora Vayr, Fabien Despas, Mathilde Strumia, Clémentine Podevin, Martin Gauthier, Eric Delabesse, Jean-Marc Soulat, Guy Laurent, Françoise Huguet, Fabrice Herin,

Patients with chronic myeloid leukemia treated with breakpoint cluster region-Abelson tyrosine kinase inhibitors are likely to survive in excess of 20 years after diagnosis. New challenges appear as we consider life after the disease, including professional challenges and the social reintegration of patients. The purpose of this study was to determine ... Read more >>

Ann. Hematol. (Annals of hematology)
[2019, 98(3):615-623]

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Profiling Immune Escape in Hodgkin's and Diffuse large B-Cell Lymphomas Using the Transcriptome and Immunostaining.

Sarah Péricart, Marie Tosolini, Pauline Gravelle, Cédric Rossi, Alexandra Traverse-Glehen, Nadia Amara, Camille Franchet, Elodie Martin, Christine Bezombes, Guy Laurent, Pierre Brousset, Jean-Jacques Fournié, Camille Laurent,

Therapeutic blockade of PD-1/PD-L1 shows promising results in Hodgkin's lymphoma (HL) and in some diffuse large B-cell lymphoma (DLBCL) patients, but biomarkers predicting such responses are still lacking. To this end, we recently developed a transcriptional scoring of immune escape (IE) in cancer biopsies. Using this method in DLBCL, we ... Read more >>

(Cancers)
[2018, 10(11):]

Cited: 4 times

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Individual Comparison of Cholesterol Metabolism in Normal and Tumour Areas in Radical Prostatectomy Specimens from Patients with Prostate Cancer: Results of the CHOMECAP Study.

Olivier Celhay, Laura Bousset, Laurent Guy, Jean-Louis Kemeny, Valerio Leoni, Claudio Caccia, Amalia Trousson, Christelle Damon-Soubeyrant, Angélique De Haze, Laura Sabourin, Catherine Godfraind, Cyrille de Joussineau, Bruno Pereira, Laurent Morel, Jean Marc Lobaccaro, Silvère Baron,

BACKGROUND:Deregulation of cholesterol metabolism represents a hallmark of prostate cancer (PCa) and promotes its development. OBJECTIVE:To compare cholesterol metabolism on individual paired normal and tumour prostate tissues obtained from patients with PCa. DESIGN, SETTING, AND PARTICIPANTS:Between 2008 and 2012, normal and tumour paired tissue samples were collected from radical prostatectomy ... Read more >>

Eur Urol Oncol (European urology oncology)
[2019, 2(2):198-206]

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Sunitinib Alone or after Nephrectomy in Metastatic Renal-Cell Carcinoma.

Arnaud Méjean, Alain Ravaud, Simon Thezenas, Sandra Colas, Jean-Baptiste Beauval, Karim Bensalah, Lionnel Geoffrois, Antoine Thiery-Vuillemin, Luc Cormier, Hervé Lang, Laurent Guy, Gwenaelle Gravis, Frederic Rolland, Claude Linassier, Eric Lechevallier, Christian Beisland, Michael Aitchison, Stephane Oudard, Jean-Jacques Patard, Christine Theodore, Christine Chevreau, Brigitte Laguerre, Jacques Hubert, Marine Gross-Goupil, Jean-Christophe Bernhard, Laurence Albiges, Marc-Olivier Timsit, Thierry Lebret, Bernard Escudier,

BACKGROUND:Cytoreductive nephrectomy has been the standard of care in metastatic renal-cell carcinoma for 20 years, supported by randomized trials and large, retrospective studies. However, the efficacy of targeted therapies has challenged this standard. We assessed the role of nephrectomy in patients with metastatic renal-cell carcinoma who were receiving targeted therapies. ... Read more >>

N Engl J Med (The New England journal of medicine)
[2018, 379(5):417-427]

Cited: 79 times

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A new metabolic gene signature in prostate cancer regulated by JMJD3 and EZH2.

Marine Daures, Mouhamed Idrissou, Gaëlle Judes, Khaldoun Rifaï, Frédérique Penault-Llorca, Yves-Jean Bignon, Laurent Guy, Dominique Bernard-Gallon,

Histone methylation is essential for gene expression control. Trimethylated lysine 27 of histone 3 (H3K27me3) is controlled by the balance between the activities of JMJD3 demethylase and EZH2 methyltransferase. This epigenetic mark has been shown to be deregulated in prostate cancer, and evidence shows H3K27me3 enrichment on gene promoters in ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(34):23413-23425]

Cited: 3 times

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[Impact of obesity in kidney transplantation: Monocentric cohort study and review of the literature].

Clarisse Grèze, Bruno Pereira, Yves Boirie, Laurent Guy, Cyril Garrouste, Anne-Élisabeth Heng,

Post-kidney transplantation outcomes in obese patients remain uncertain. The aim of this study is to compare patient and graft survival and post-transplant complications in obese patients and non-obese patients. We performed a retrospective analysis of a sample of 245kidney transplantations performed between 2008 and 2014 in Clermont-Ferrand. Obese patients and ... Read more >>

Nephrol. Ther. (Nephrologie & therapeutique)
[2018, 14(6):454-461]

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DNA polymerase ν gene expression influences fludarabine resistance in chronic lymphocytic leukemia independently of p53 status.

Srdana Grgurevic, Patricia Montilla-Perez, Alice Bradbury, Julia Gilhodes, Sophie Queille, Sandrine Pelofy, Aurélien Bancaud, Thomas Filleron, Loïc Ysebaert, Christian Récher, Guy Laurent, Jean-Jacques Fournié, Christophe Cazaux, Anne Quillet-Mary, Jean-Sébastien Hoffmann,

Alteration in the DNA replication, repair or recombination processes is a highly relevant mechanism of genomic instability. Despite genomic aberrations manifested in hematologic malignancies, such a defect as a source of biomarkers has been underexplored. Here, we investigated the prognostic value of expression of 82 genes involved in DNA replication-repair-recombination ... Read more >>

Haematologica (Haematologica)
[2018, 103(6):1038-1046]

Cited: 1 time

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Management of relapsed or refractory follicular lymphoma patients in daily practice - a French non-interventional study.

Pierre Feugier, Pauline Brice, Marc Maynadié, Patricia Franchi-Rezgui, Maya Hacini, Guy Laurent, Etienne Suc, Olivier Fitoussi, Philippe Solal-Celigny, Ghandi Damaj, Corinne Haioun, Pierre Leconte, Fatima Lazreg, Frédéric Boissard, David Pau, Gilles Salles,

Leuk. Lymphoma (Leukemia & lymphoma)
[2018, 59(10):2485-2488]

Cited: 1 time

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Improved outcome for AML patients over the years 2000-2014.

Sarah Bertoli, Suzanne Tavitian, Anne Huynh, Cécile Borel, Sarah Guenounou, Isabelle Luquet, Eric Delabesse, Audrey Sarry, Guy Laurent, Michel Attal, Françoise Huguet, Emilie Bérard, Christian Récher,

Few recent studies from registries have reported an improvement in overall survival of younger patients with acute myeloid leukemia (AML). However, reasons for this improvement are not defined. We analyzed the therapeutic course and outcome of 976 patients treated by intensive chemotherapy between 2000 and 2014. The number of patients ... Read more >>

Blood Cancer J (Blood cancer journal)
[2017, 7(12):635]

Cited: 12 times

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Non-cancer drug consumption during the early trajectory of lymphoma survivorship.

Catherine Rioufol, Sébastien Lamy, Cécile Conte, Pauline Jeanneau, Giselle Compaci, Cyrille Delpierre, Maryse Lapeyre-Mestre, Guy Laurent, Fabien Despas,

PURPOSE:This study explored the use of non-cancer drugs in lymphoma survivors during the early trajectory (0 to 2 years) of cancer survivorship and determined the factors that influenced this consumption. METHODS:Between January and March 2014, a cross-sectional survey was conducted to assess drug consumption in adult lymphoma survivors at the ... Read more >>

Therapie (Therapie)
[2018, 73(4):307-317]

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EZH2 Histone Methyltransferase and JMJD3 Histone Demethylase Implications in Prostate Cancer.

Mouhamed Idrissou, Marine Daures, Amani Ben Jemia, Gaëlle Judes, Khaldoun Rifaï, Frédérique Penault-Llorca, Yves-Jean Bignon, Laurent Guy, Dominique Bernard-Gallon,

OMICS (Omics : a journal of integrative biology)
[2017, 21(12):751-753]

Cited: 1 time

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Antiproliferative effect of dexamethasone in the MCF-7 breast cancer cell line.

Frederic Buxant, Nadège Kindt, Guy Laurent, Jean-Christophe Noël, Sven Saussez,

Glucocorticoids (GCs) are used in the treatment of cancer to induce programmed cell death in the transformed cells of the hematopoietic system and to reduce side effects. Additionally, GCs are described as an inhibitor of certain chemotherapy or radiation‑induced apoptosis and also an inhibitor of cancer progression by downregulating or ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2015, 12(3):4051-4054]

Cited: 15 times

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A diagnostic protocol designed for determining allergic causes in patients with blood eosinophilia.

Jean-François Magnaval, Guy Laurent, Noémie Gaudré, Judith Fillaux, Antoine Berry,

Blood eosinophilia is a common laboratory abnormality, and its characterization frequently represents a quandary for primary care physicians. Consequently, in France, specialists and particularly hematologists, often must investigate patients who present with blood eosinophilia that often, but not always, occurs because of allergic causes. Both the Departments of Hematology and ... Read more >>

Mil Med Res (Military Medical Research)
[2017, 4:15]

Cited: 3 times

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