Full Text Journal Articles by
Author Guy De Backer

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National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries.

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BACKGROUND:Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries. METHODS:We pooled 458 population-based ... Read more >>

Int J Epidemiol (International journal of epidemiology)
[2019, :]

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Rising rural body-mass index is the main driver of the global obesity epidemic in adults.

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Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities1,2. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity3-6. Here we use ... Read more >>

Nature (Nature)
[2019, 569(7755):260-264]

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Risk scoring in primary prevention of atherosclerotic cardiovascular disease: Strengths and limitations.

Guy G De Backer,

Eur J Prev Cardiol (European journal of preventive cardiology)
[2019, :2047487319847007]

Cited: 0 times

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Management of dyslipidaemia in patients with coronary heart disease: Results from the ESC-EORP EUROASPIRE V survey in 27 countries.

Guy De Backer, Piotr Jankowski, Kornelia Kotseva, Erkin Mirrakhimov, Željko Reiner, Lars Rydén, Lale Tokgözoğlu, David Wood, Dirk De Bacquer, , , , , , , , , ,

BACKGROUND AND AIMS:One of the objectives of the ESC-EORP EUROASPIRE V survey is to determine how well European guidelines on the management of dyslipidaemias are implemented in coronary patients. METHODS:Standardized methods were used by trained technicians to collect information on 7824 patients from 130 centers in 27 countries, from the ... Read more >>

Atherosclerosis (Atherosclerosis)
[2019, 285:135-146]

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Lifestyle and impact on cardiovascular risk factor control in coronary patients across 27 countries: Results from the European Society of Cardiology ESC-EORP EUROASPIRE V registry.

Kornelia Kotseva, Guy De Backer, Dirk De Bacquer, Lars Rydén, Arno Hoes, Diederick Grobbee, Aldo Maggioni, Pedro Marques-Vidal, Catriona Jennings, Ana Abreu, Carlos Aguiar, Jolita Badariene, Jan Bruthans, Almudena Castro Conde, Renata Cifkova, Jim Crowley, Kairat Davletov, Jaap Deckers, Delphine De Smedt, Johan De Sutter, Mirza Dilic, Marina Dolzhenko, Vilnis Dzerve, Andrejs Erglis, Zlatko Fras, Dan Gaita, Nina Gotcheva, Peter Heuschmann, Hosam Hasan-Ali, Piotr Jankowski, Nebojsa Lalic, Seppo Lehto, Dragan Lovic, Silvia Mancas, Linda Mellbin, Davor Milicic, Erkin Mirrakhimov, Rafael Oganov, Nana Pogosova, Zeljko Reiner, Stefan Stöerk, Lâle Tokgözoğlu, Costas Tsioufis, Dusko Vulic, David Wood, ,

AIMS:The aim of this study was to determine whether the Joint European Societies guidelines on secondary cardiovascular prevention are followed in everyday practice. DESIGN:A cross-sectional ESC-EORP survey (EUROASPIRE V) at 131 centres in 81 regions in 27 countries. METHODS:Patients (<80 years old) with verified coronary artery events or interventions were ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2019, 26(8):824-835]

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Incidence of cardiovascular events in patients with stabilized coronary heart disease: the EUROASPIRE IV follow-up study.

Dirk De Bacquer, Delphine De Smedt, Kornelia Kotseva, Catriona Jennings, David Wood, Lars Rydén, Viveca Gyberg, Bahira Shahim, Philippe Amouyel, Jan Bruthans, Almudena Castro Conde, Renata Cífková, Jaap W Deckers, Johan De Sutter, Mirza Dilic, Maryna Dolzhenko, Andrejs Erglis, Zlatko Fras, Dan Gaita, Nina Gotcheva, John Goudevenos, Peter Heuschmann, Aleksandras Laucevicius, Seppo Lehto, Dragan Lovic, Davor Miličić, David Moore, Evagoras Nicolaides, Raphael Oganov, Andrzej Pajak, Nana Pogosova, Zeljko Reiner, Martin Stagmo, Stefan Störk, Lale Tokgözoğlu, Dusko Vulic, Martin Wagner, Guy De Backer, ,

The EUROASPIRE surveys (EUROpean Action on Secondary Prevention through Intervention to Reduce Events) demonstrated that most European coronary patients fail to achieve lifestyle, risk factor and therapeutic targets. Here we report on the 2-year incidence of hard cardiovascular (CV) endpoints in the EUROASPIRE IV cohort. EUROASPIRE IV (2012-2013) was a ... Read more >>

Eur. J. Epidemiol. (European journal of epidemiology)
[2019, 34(3):247-258]

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2018 ESC/ESH Guidelines for the management of arterial hypertension.

Bryan Williams, Giuseppe Mancia, Wilko Spiering, Enrico Agabiti Rosei, Michel Azizi, Michel Burnier, Denis L Clement, Antonio Coca, Giovanni de Simone, Anna Dominiczak, Thomas Kahan, Felix Mahfoud, Josep Redon, Luis Ruilope, Alberto Zanchetti, Mary Kerins, Sverre E Kjeldsen, Reinhold Kreutz, Stephane Laurent, Gregory Y H Lip, Richard McManus, Krzysztof Narkiewicz, Frank Ruschitzka, Roland E Schmieder, Evgeny Shlyakhto, Costas Tsioufis, Victor Aboyans, Ileana Desormais, ,

Eur. Heart J. (European heart journal)
[2018, 39(33):3021-3104]

Cited: 52 times

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Reversal of Aging-Induced Increases in Aortic Stiffness by Targeting Cytoskeletal Protein-Protein Interfaces.

Christopher J Nicholson, Kuldeep Singh, Robert J Saphirstein, Yuan Z Gao, Qian Li, Joanna G Chiu, Paul Leavis, Germaine C Verwoert, G F Mitchell, , Tyrone Porter, Kathleen G Morgan,

BACKGROUND:The proximal aorta normally functions as a critical shock absorber that protects small downstream vessels from damage by pressure and flow pulsatility generated by the heart during systole. This shock absorber function is impaired with age because of aortic stiffening. METHODS AND RESULTS:We examined the contribution of common genetic variation ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2018, 7(15):]

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Adverse effects of statin therapy: perception vs. the evidence - focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract.

François Mach, Kausik K Ray, Olov Wiklund, Alberto Corsini, Alberico L Catapano, Eric Bruckert, Guy De Backer, Robert A Hegele, G Kees Hovingh, Terry A Jacobson, Ronald M Krauss, Ulrich Laufs, Lawrence A Leiter, Winfried März, Børge G Nordestgaard, Frederick J Raal, Michael Roden, Raul D Santos, Evan A Stein, Erik S Stroes, Paul D Thompson, Lale Tokgözoglu, Georgirene D Vladutiu, Baris Gencer, Jane K Stock, Henry N Ginsberg, M John Chapman, ,

To objectively appraise evidence for possible adverse effects of long-term statin therapy on glucose homeostasis, cognitive, renal and hepatic function, and risk for haemorrhagic stroke or cataract.A literature search covering 2000-2017 was performed. The Panel critically appraised the data and agreed by consensus on the categorization of reported adverse effects. ... Read more >>

Eur. Heart J. (European heart journal)
[2018, 39(27):2526-2539]

Cited: 8 times

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Cost-effectiveness of optimized adherence to prevention guidelines in European patients with coronary heart disease: Results from the EUROASPIRE IV survey.

Delphine De Smedt, Lieven Annemans, Guy De Backer, Kornelia Kotseva, Lars Rydèn, David Wood, Philippe Amouyel, Jan Bruthans, Renata Cifkova, Johan De Sutter, Marina Dolzhenko, Andrejs Erglis, Nina Gotcheva, Viveca Gyberg, Aleksandras Laucevicius, Dragan Lovic, Rafael Oganov, Andrzej Pajak, Nana Pogosova, Željko Reiner, Martin Stagmo, Dirk De Bacquer,

BACKGROUND:This study aims to assess the cost-effectiveness of optimized guideline adherence in patients with a history of coronary heart disease. METHODS:An individual-based decision tree model was developed using the SMART risk score tool which estimates the 10-year risk for recurrent vascular events in patients with manifest cardiovascular disease (CVD). Analyses ... Read more >>

Int. J. Cardiol. (International journal of cardiology)
[2018, 272:20-25]

Cited: 0 times

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Prevention of cardiovascular disease: Much more is needed.

Guy G De Backer,

Eur J Prev Cardiol (European journal of preventive cardiology)
[2018, 25(10):1083-1086]

Cited: 1 time

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Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants.

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Background:Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). ... Read more >>

Int J Epidemiol (International journal of epidemiology)
[2018, :]

Cited: 2 times

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New strategies for the development of lipid-lowering therapies to reduce cardiovascular risk.

Ian Graham, Chuck Shear, Pieter De Graeff, Caroline Boulton, Alberico L Catapano, Wendy Gattis Stough, Stefan C Carlsson, Guy De Backer, Joseph Emmerich, Scott Greenfeder, Albert M Kim, Dominik Lautsch, Tu Nguyen, Steven E Nissen, Krishna Prasad, Kausik K Ray, Jennifer G Robinson, William J Sasiela, Karsten Bruins Slot, Erik Stroes, Tom Thuren, Bart Van der Schueren, Maja Velkovski-Rouyer, Scott M Wasserman, Olov Wiklund, Emmanouil Zouridakis, ,

The very high occurrence of cardiovascular events presents a major public health issue, because treatment remains suboptimal. Lowering LDL cholesterol (LDL-C) with statins or ezetimibe in combination with a statin reduces major adverse cardiovascular events. The cardiovascular risk reduction in relation to the absolute LDL-C reduction is linear for most ... Read more >>

Eur Heart J Cardiovasc Pharmacother (European heart journal. Cardiovascular pharmacotherapy)
[2018, 4(2):119-127]

Cited: 1 time

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Lifestyle behaviour and risk factor control in coronary patients: Belgian results from the cross-sectional EUROASPIRE surveys.

Delphine De Smedt, Johan De Sutter, Michel De Pauw, Hans Vandekerckhove, Jan Trouerbach, Guy De Backer, Anne-Marie Willems, Sofie Pardaens, Pieter Vervaet, Nancy Deweerdt, Dirk De Bacquer,

OBJECTIVE:The aim of this study was to assess lifestyle behaviour as well as risk factor management across Belgian coronary patients who participated in the cross-sectional European Action on Secondary Prevention through Intervention to Reduce Events (EUROASPIRE) surveys. METHODS:Analyses are based on a series of coronary patients by combining data from ... Read more >>

Acta Cardiol (Acta cardiologica)
[2019, 74(1):21-27]

Cited: 1 time

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Undetected dysglycaemia common in primary care patients treated for hypertension and/or dyslipidaemia: on the need for a screening strategy in clinical practice. A report from EUROASPIRE IV a registry from the EuroObservational Research Programme of the European Society of Cardiology.

Bahira Shahim, Viveca Gyberg, Dirk De Bacquer, Kornelia Kotseva, Guy De Backer, Oliver Schnell, Jaakko Tuomilehto, David Wood, Lars Rydén,

BACKGROUND:Dysglycaemia defined as type 2 diabetes (T2DM) and impaired glucose tolerance (IGT), increases the risk of cardiovascular disease (CVD). The negative impact is more apparent in the presence of hypertension and/or dyslipidaemia. Thus, it seems reasonable to screen for dysglycaemia in patients treated for hypertension and/or dyslipidaemia. A simple screening ... Read more >>

Cardiovasc Diabetol (Cardiovascular diabetology)
[2018, 17(1):21]

Cited: 2 times

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Serum uric acid levels are associated with cardiovascular risk score: A post hoc analysis of the EURIKA study.

Claudio Borghi, Fernando Rodriguez-Artalejo, Guy De Backer, Jean Dallongeville, Jesús Medina, Javier Nuevo, Eliseo Guallar, Joep Perk, José R Banegas, Florence Tubach, Carine Roy, Julian P Halcox,

BACKGROUND:Reports are conflicting on whether serum uric acid (sUA) levels are independently associated with increased cardiovascular (CV) death risk. METHODS:This post hoc analysis assessed the relationship between sUA levels and CV death risk score in 7531 patients from the cross-sectional, multinational EURIKA study (NCT00882336). Patients had at least one CV ... Read more >>

Int. J. Cardiol. (International journal of cardiology)
[2018, 253:167-173]

Cited: 4 times

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Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults.

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BACKGROUND:Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare trends with ... Read more >>

Lancet (Lancet (London, England))
[2017, 390(10113):2627-2642]

Cited: 225 times

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Prevention of cardiovascular disease in the working population at high cardiovascular risk.

Guy G De Backer,

Eur J Prev Cardiol (European journal of preventive cardiology)
[2017, 24(14):1541-1543]

Cited: 0 times

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The Prognostic Value of Fasting Plasma Glucose, Two-Hour Postload Glucose, and HbA1c in Patients With Coronary Artery Disease: A Report From EUROASPIRE IV: A Survey From the European Society of Cardiology.

Bahira Shahim, Dirk De Bacquer, Guy De Backer, Viveca Gyberg, Kornelia Kotseva, Linda Mellbin, Oliver Schnell, Jaakko Tuomilehto, David Wood, Lars Rydén,

Three tests are recommended for identifying dysglycemia: fasting glucose (FPG), 2-h postload glucose (2h-PG) from an oral glucose tolerance test (OGTT), and glycated hemoglobin A1c (HbA1c). This study explored the prognostic value of these screening tests in patients with coronary artery disease (CAD).FPG, 2h-PG, and HbA1c were used to screen ... Read more >>

Diabetes Care (Diabetes care)
[2017, 40(9):1233-1240]

Cited: 5 times

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Food supplements with red yeast rice: More regulations are needed.

Guy G De Backer,

Eur J Prev Cardiol (European journal of preventive cardiology)
[2017, 24(13):1429-1430]

Cited: 1 time

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One-year and longer dual antiplatelet therapy after an acute coronary syndrome: a Belgian position paper.

Peter R Sinnaeve, Walter Desmet, Olivier Descamps, Sofie Gevaert, Guy De Backer, Philippe Kolh, Mathias Vrolix, Philippe Van De Borne, Antoine De Meester, Marc J Claeys, Christophe Beauloye,

Acute coronary syndrome patients receive DAPT up to one year after their initial event. Exceptions to the guideline-recommended one-year rule, however, are not uncommon. The reasoning behind shorter treatments, such as unacceptable bleeding risk or urgent surgery, should be well documented in the patient's charts and discharge letter. Based on ... Read more >>

Acta Cardiol (Acta cardiologica)
[2017, 72(1):19-27]

Cited: 1 time

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2016 ESC/EAS Guidelines for the Management of Dyslipidaemias.

Alberico L Catapano, Ian Graham, Guy De Backer, Olov Wiklund, M John Chapman, Heinz Drexel, Arno W Hoes, Catriona S Jennings, Ulf Landmesser, Terje R Pedersen, Željko Reiner, Gabriele Riccardi, Marja-Riita Taskinen, Lale Tokgozoglu, W M Monique Verschuren, Charalambos Vlachopoulos, David A Wood, Jose Luis Zamorano, , Marie-Therese Cooney,

Rev Esp Cardiol (Engl Ed) (Revista espanola de cardiologia (English ed.))
[2017, 70(2):115]

Cited: 4 times

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Epidemiology and prevention of cardiovascular disease: Quo vadis?

Guy De Backer,

With observational epidemiological studies it has been possible in the 1950-60 s to identify what has been called cardiovascular risk factors. The multifactorial origin of atherothrombotic cardiovascular disease has been elucidated and in multifactorial intervention trials it was demonstrated that lifestyle changes related to smoking, diet and exercise can prevent the ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2017, 24(7):768-772]

Cited: 3 times

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Time-saving screening for diabetes in patients with coronary artery disease: a report from EUROASPIRE IV.

Viveca Gyberg, Dirk De Bacquer, Kornelia Kotseva, Guy De Backer, Oliver Schnell, Jaakko Tuomilehto, David Wood, Lars Rydén,

BACKGROUND:WHO advocates 2-hour oral glucose tolerance test (OGTT) for detecting diabetes mellitus (DM). OGTT is the most sensitive method to detect DM in patients with coronary artery disease (CAD). Considered time consuming, the use of OGTT is unsatisfactory. A 1-hour plasma glucose (1hPG) test has not been evaluated as an ... Read more >>

BMJ Open (BMJ open)
[2016, 6(12):e013835]

Cited: 2 times

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Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants.

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BACKGROUND:Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher ... Read more >>

Lancet (Lancet (London, England))
[2017, 389(10064):37-55]

Cited: 171 times

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