Full Text Journal Articles by
Author Gustaf Ljungman

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Delivering transformative action in paediatric pain: a Lancet Child & Adolescent Health Commission.

Christopher Eccleston, Emma Fisher, Richard F Howard, Rebeccah Slater, Paula Forgeron, Tonya M Palermo, Kathryn A Birnie, Brian J Anderson, Christine T Chambers, Geert Crombez, Gustaf Ljungman, Isabel Jordan, Zachary Jordan, Caitriona Roberts, Neil Schechter, Christine B Sieberg, Dick Tibboel, Suellen M Walker, Dominic Wilkinson, Chantal Wood,

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, :]

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Malignant peripheral nerve sheath tumors in children, adolescents, and young adults: Treatment results of five Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry.

Michael T Meister, Monika Scheer, Erika Hallmen, Sabine Stegmaier, Christian Vokuhl, Thekla von Kalle, Jörg Fuchs, Marc Münter, Felix Niggli, Ruth Ladenstein, Bernarda Kazanowska, Gustaf Ljungman, Stefan Bielack, Ewa Koscielniak, Thomas Klingebiel, ,

BACKGROUND AND OBJECTIVES:Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft tissue sarcomas that present as large, invasive tumors. Our aim was to assess outcomes, identify prognostic factors, and analyze treatment strategies in a prospectively collected pediatric cohort. METHODS:Patients less than 21 years with MPNST treated in the consecutive prospective ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2020, :]

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Increased risk of mental health problems after cancer during adolescence: A register-based cohort study.

Emma Hovén, Rickard Ljung, Gustaf Ljungman, Lisa Ljungman, Charlotte Skoglund, Emma Fransson, Anna Wikman,

In this nationwide, register-based study, we estimated the risk of mental health problems in 2822 individuals diagnosed with cancer in adolescence (13-19 years). Mental health problems were assessed by psychiatric diagnoses and/or prescribed psychotropic drugs. Cox proportional hazards models estimated hazard ratio (HR) for a psychiatric diagnosis and prescription of psychotropic ... Read more >>

Int J Cancer (International journal of cancer)
[2020, :]

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Ibuprofen in needle procedures in children with cancer-A feasibility and pilot study.

Tove Kamsvåg, Lena Hedén, Louise von Essen, Gustaf Ljungman,

AIM:To investigate the feasibility, and perform a pilot study, of a randomised clinical trial, investigating whether children experience less pain, fear and/or distress when they receive oral ibuprofen vs placebo before a needle is inserted in a subcutaneously implanted intravenous port. METHODS:Twenty-three children were included consecutively and randomised to either ... Read more >>

Acta Paediatr (Acta paediatrica (Oslo, Norway : 1992))
[2020, :]

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Reducing pain and distress related to needle procedures in children with cancer: A clinical practice guideline.

Erik A H Loeffen, Renée L Mulder, Anna Font-Gonzalez, Piet L J M Leroy, Bruce D Dick, Anna Taddio, Gustaf Ljungman, Lindsay A Jibb, Perri R Tutelman, Christina Liossi, Alison Twycross, Karyn Positano, Rutger R Knops, Marc Wijnen, Marianne D van de Wetering, Leontien C M Kremer, L Lee Dupuis, Fiona Campbell, Wim J E Tissing,

BACKGROUND:Children with cancer often undergo long treatment trajectories involving repeated needle procedures that potentially cause pain and distress. As part of a comprehensive effort to develop clinical practice guidelines (CPGs) to address pain prevention and management in children with cancer, we aimed to provide recommendations on the pharmacological and psychological ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2020, 131:53-67]

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Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS).

Monika Scheer, Bernd Blank, Sebastian Bauer, Christian Vokuhl, Sabine Stegmaier, Simone Feuchtgruber, Anton Henssen, Monika Sparber-Sauer, Angelika Eggert, Ruppert Handgretinger, Arnulf Pekrun, Claudia Rossig, Stefan Rutkowski, Paul-Gerhardt Schlegel, Martin Schrappe, Thorsten Simon, Bernarda Kazanowska, Felix Niggli, Ruth Ladenstein, Gustaf Ljungman, Kirsi Jahnukainen, Jörg Fuchs, Stefan S Bielack, Ewa Koscielniak, Thomas Klingebiel, ,

BACKGROUND:Older age is associated with worse outcome in synovial sarcoma (SS) patients. Differences in disease presentation among distinct age groups, however, are currently unknown. METHODS:SS patients < 21 years registered in consecutive CWS trials over the period of 1981-2018 were evaluated. Characteristics were analyzed according to age groups using the Fisher's exact test. ... Read more >>

J Cancer Res Clin Oncol (Journal of cancer research and clinical oncology)
[2020, 146(4):953-960]

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Prevention of oral mucositis with cryotherapy in children undergoing hematopoietic stem cell transplantations-a feasibility study and randomized controlled trial.

Tove Kamsvåg, Anncarin Svanberg, Karin Garming Legert, Johan Arvidson, Louise von Essen, Karin Mellgren, Jacek Toporski, Jacek Winiarski, Gustaf Ljungman,

PURPOSE:To evaluate the feasibility of oral cryotherapy (OC) in children and to investigate if OC reduces the incidence of severe oral mucositis (OM), oral pain, and opioid use in children undergoing hematopoietic stem cell transplantation (HSCT). METHODS:Fifty-three children, 4-17 years old, scheduled for HSCT in Sweden were included and randomized to ... Read more >>

Support Care Cancer (Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer)
[2020, 28(10):4869-4879]

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Endothelial cell malignancies in infants, children and adolescents: Treatment results of three Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry.

Monika Sparber-Sauer, Ewa Koscielniak, Christian Vokuhl, Irene Schmid, Ewa Bien, Guido Seitz, Erika Hallmen, Thekla von Kalle, Monika Scheer, Marc Münter, Stefan S Bielack, Felix Niggli, Gustaf Ljungman, Joerg Fuchs, Simone Hettmer, Jochen Rössler, Thomas Klingebiel, ,

BACKGROUND:Endothelial cell malignancies are extremely rare in childhood. New identification of genetic abnormalities (WWTR1:CAMTA1 translocation) helps to recognize potential therapeutic targets. Little is known about treatment and outcome of these patients. METHODS:Clinical course, treatment, and outcome in patients with endothelial cell malignancies treated within the Cooperative Weichteilsarkom Studiengruppe (CWS) trials ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, 67(3):e28095]

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The impact of local control in the treatment of children with advanced infantile and adult-type fibrosarcoma: Experience of the cooperative weichteilsarkom studiengruppe (CWS).

Monika Sparber-Sauer, Christian Vokuhl, Guido Seitz, Sabine Stegmaier, Erika Hallmen, Thekla von Kalle, Monika Scheer, Marc Münter, Stefan S Bielack, Ruth Ladenstein, Felix Niggli, Gustaf Ljungman, Joerg Fuchs, Thomas Klingebiel, Ewa Koscielniak, ,

BACKGROUND AND OBJECTIVES:This study aims at examining the potential survival benefits of primary versus secondary surgery of children diagnosed with advanced infantile (iFS) and adult-type fibrosarcoma (aFS). METHODS:Treatment and outcome of 89 children with FS treated within prospective Cooperative Studiengruppe (CWS) trials (1981-2016) were analyzed retrospectively. RESULTS:Localized disease (LD) was ... Read more >>

J Pediatr Surg (Journal of pediatric surgery)
[2020, 55(9):1740-1747]

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Children's self-reports of fear and pain levels during needle procedures.

Lena Hedén, Louise von Essen, Gustaf Ljungman,

Aim:The objective was to determine the levels of and potential relationships between, procedure-related fear and pain in children. Design:Clinical based cross-sectional. Methods:Ninety children aged between 7-18 years were included consecutively and self-reported levels of pain and fear on a 0-100 mm visual analogue scales (VAS) when undergoing routine needle insertion into a ... Read more >>

Nurs Open (Nursing open)
[2020, 7(1):376-382]

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Low-grade fibromyxoid sarcoma: A report of the Cooperative Weichteilsarkom Studiengruppe (CWS).

Monika Scheer, Christian Vokuhl, Iris Veit-Friedrich, Marc Münter, Thekla von Kalle, Michael Greulich, Steffan Loff, Sabine Stegmaier, Monika Sparber-Sauer, Felix Niggli, Ruth Ladenstein, Bernarda Kazanowska, Gustaf Ljungman, Kirsi Jahnukainen, Jörg Fuchs, Stefan S Bielack, Ewa Koscielniak, Thomas Klingebiel, ,

BACKGROUND:Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft-tissue tumor with benign histologic appearance, though fully malignant behavior is possible. METHODS:Patients with LGFMS <21 years registered in Cooperative Weichteilsarkom Studiengruppe trials until 2017 were analyzed. Firstline treatment consisted of complete surgical resection whenever possible. RESULTS:Median age of 31 patients was 10.9 ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, 67(2):e28009]

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Pretend Play as an Intervention for Children With Cancer: A Feasibility Study.

Sara Frygner-Holm, Sandra Russ, Julia Quitmann, Lena Ring, Olena Zyga, Mats Hansson, Gustaf Ljungman, Anna T Höglund,

Children with cancer suffer from symptoms and burdensome treatments that often cause distress to children and their families. Mortality is one aspect of cancer diagnosis, while another is the quality of life and well-being during and after the treatment. By supporting children's communication, self-efficacy and coping ability in the care ... Read more >>

J Pediatr Oncol Nurs (Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses)
[2020, 37(1):65-75]

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Pharmacological interventions for chronic pain in children: an overview of systematic reviews.

Christopher Eccleston, Emma Fisher, Tess E Cooper, Marie-Claude Grégoire, Lauren C Heathcote, Elliot Krane, Susan M Lord, Navil F Sethna, Anna-Karenia Anderson, Brian Anderson, Jacqueline Clinch, Andrew L Gray, Jeffrey I Gold, Richard F Howard, Gustaf Ljungman, R Andrew Moore, Neil Schechter, Philip J Wiffen, Nick M R Wilkinson, David G Williams, Chantal Wood, Miranda A L van Tilburg, Boris Zernikow,

We know little about the safety or efficacy of pharmacological medicines for children and adolescents with chronic pain, despite their common use. Our aim was to conduct an overview review of systematic reviews of pharmacological interventions that purport to reduce pain in children with chronic noncancer pain (CNCP) or chronic ... Read more >>

Pain (Pain)
[2019, 160(8):1698-1707]

Cited: 2 times

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A preliminary validation of the Swedish version of the Pain Catastrophizing Scale for Children (PCS-C) for children and adolescents with cancer.

Jenny Thorsell Cederberg, Sandra Weineland, JoAnne Dahl, Gustaf Ljungman,

Objectives: Pain is reported as one of the most common and difficult symptoms for children and adolescents with cancer to cope with. Pain catastrophizing has been identified as a process clearly related to pain intensity and disability. The Pain Catastrophizing Scale for Children (PCS-C) has been validated in several languages ... Read more >>

J Pain Res (Journal of pain research)
[2019, 12:1803-1811]

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Distribution of hospital care among pediatric and young adult Hodgkin lymphoma survivors-A population-based cohort study from Sweden and Denmark.

Ingrid Glimelius, Annika Englund, Klaus Rostgaard, Karin E Smedby, Sandra Eloranta, Peter de Nully Brown, Christoffer Johansen, Peter Kamper, Gustaf Ljungman, Lisa Lyngsie Hjalgrim, Henrik Hjalgrim,

The burden of late effects among Hodgkin lymphoma (HL) survivors treated according to contemporary protocols remains poorly characterized. We used nation-wide registers to assess number of inpatient bed-days and specialist outpatient visits among 1048 HL-patients (<25 years, diagnosed 1990-2010) and 5175 country-, sex-, and age-matched comparators. We followed them for up ... Read more >>

Cancer Med (Cancer medicine)
[2019, 8(10):4918-4927]

Cited: 1 time

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Physical therapists' experiences of learning and delivering a complex behavioral medicine intervention to adolescents with pain.

Sara Frygner-Holm, Pernilla Åsenlöf, Gustaf Ljungman, Anne Söderlund,

The objective was to study physical therapists' (PTs') experiences of learning and delivering a complex intervention, a tailored behavioral medicine treatment (BMT) targeting adolescents with pain in primary care. Method: An explorative study with qualitative approach, using content analysis. Three primary care PTs delivering the treatments in a randomized controlled ... Read more >>

Physiother Theory Pract (Physiotherapy theory and practice)
[2019, :1-11]

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Validation of the Swedish version of the Pain Catastrophizing Scale for Parents (PCS-P) for parents of children with cancer.

Jenny Thorsell Cederberg, Sandra Weineland, JoAnne Dahl, Gustaf Ljungman,

Objectives:Pain is reported as one of the most common and burdensome symptoms for children with cancer. Pain catastrophizing is clearly related to pain intensity and disability. Catastrophizing in parents is associated with both child functioning and parent distress. The Pain Catastrophizing Scale for Parents (PCS-P) remains to be validated for ... Read more >>

J Pain Res (Journal of pain research)
[2019, 12:1017-1023]

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Reducing pain in children with cancer: Methodology for the development of a clinical practice guideline.

Erik A H Loeffen, Leontien C M Kremer, Marianne D van de Wetering, Renée L Mulder, Anna Font-Gonzalez, Lee L Dupuis, Fiona Campbell, Wim J E Tissing, ,

Although pain is one of the most prevalent and bothersome symptoms children with cancer experience, evidence-based guidance regarding assessment and management is lacking. With 44 international, multidisciplinary healthcare professionals and nine patient representatives, we aimed to develop a clinical practice guideline (following GRADE methodology), addressing assessment and pharmacological, psychological, and ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2019, 66(6):e27698]

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Rhabdomyosarcoma diagnosed in the first year of life: Localized, metastatic, and relapsed disease. Outcome data from five trials and one registry of the Cooperative Weichteilsarkom Studiengruppe (CWS).

Monika Sparber-Sauer, Sabine Stegmaier, Christian Vokuhl, Guido Seitz, Thekla von Kalle, Monika Scheer, Marc Münter, Stefan S Bielack, Jadwiga Weclawek-Tompol, Ruth Ladenstein, Felix Niggli, Gustaf Ljungman, Joerg Fuchs, Simone Hettmer, Ewa Koscielniak, Thomas Klingebiel, ,

BACKGROUND:Rhabdomyosarcoma (RMS) diagnosed during the first year of life is reported to have poor outcome. Little is known about treatment and outcome data of relapsed disease (RD). METHODS:Characteristics, treatment, and outcome of 155 patients ≤ 12 months registered within the Cooperative Weichteilsarkom Studiengruppe (CWS) between 1981 and 2016 were evaluated. RESULTS:Localized disease ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2019, 66(6):e27652]

Cited: 1 time

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Desmoplastic small round cell tumors: Multimodality treatment and new risk factors.

Monika Scheer, Christian Vokuhl, Bernd Blank, Erika Hallmen, Thekla von Kalle, Marc Münter, Rüdiger Wessalowski, Maite Hartwig, Monika Sparber-Sauer, Paul-Gerhardt Schlegel, Christof M Kramm, Udo Kontny, Bernd Spriewald, Thomas Kegel, Sebastian Bauer, Bernarda Kazanowska, Felix Niggli, Ruth Ladenstein, Gustaf Ljungman, Kirsi Jahnukainen, Jörg Fuchs, Stefan S Bielack, Thomas Klingebiel, Ewa Koscielniak, ,

BACKGROUND:To evaluate optimal therapy and potential risk factors. METHODS:Data of DSRCT patients <40 years treated in prospective CWS trials 1997-2015 were analyzed. RESULTS:Median age of 60 patients was 14.5 years. Male:female ratio was 4:1. Tumors were abdominal/retroperitoneal in 56/60 (93%). 6/60 (10%) presented with a localized mass, 16/60 (27%) regionally disseminated nodes, ... Read more >>

Cancer Med (Cancer medicine)
[2019, 8(2):527-542]

Cited: 3 times

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Study protocol for a feasibility study of an internet-administered, guided, CBT-based, self-help intervention (ENGAGE) for parents of children previously treated for cancer.

Joanne Woodford, Anna Wikman, Martin Cernvall, Gustaf Ljungman, Amanda Romppala, Helena Grönqvist, Louise von Essen,

INTRODUCTION:A subgroup of parents of children previously treated for cancer report long-term psychological distress after end of treatment. However, needs for psychological support are commonly unmet and there is a lack of evidence-based treatments tailored to the specific needs of this population. An internet-administered, guided, cognitive-behavioural therapy-based, self-help intervention (ENGAGE) ... Read more >>

BMJ Open (BMJ open)
[2018, 8(6):e023708]

Cited: 3 times

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An open trial of individualized face-to-face cognitive behavior therapy for psychological distress in parents of children after end of treatment for childhood cancer including a cognitive behavioral conceptualization.

Lisa Ljungman, Martin Cernvall, Ata Ghaderi, Gustaf Ljungman, Louise von Essen, Brjánn Ljótsson,

Objective:A subgroup of parents of children who have been treated for childhood cancer report high levels of psychological distress. To date there is no empirically supported psychological treatment targeting cancer-related psychological distress in this population. The aim of the current study was to test the feasibility and preliminarily evaluate the ... Read more >>

PeerJ (PeerJ)
[2018, 6:e4570]

Cited: 2 times

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Systemic therapy of aggressive fibromatosis in children and adolescents: Report of the Cooperative Weichteilsarkom Studiengruppe (CWS).

Monika Sparber-Sauer, Guido Seitz, Thekla von Kalle, Christian Vokuhl, Ivo Leuschner, Monika Scheer, Marc Münter, Gustaf Ljungman, Stefan S Bielack, Felix Niggli, Ruth Ladenstein, Thomas Klingebiel, Joerg Fuchs, Ewa Koscielniak, ,

BACKGROUND:Treatment algorithms for patients with aggressive fibromatosis (AF) are challenging. There are limited data available about the use of systemic therapy (ST) in pediatric patients with AF. METHODS:Patient-, tumor-, and treatment-related factors of 90 children and adolescents with AF treated on multiple prospective trials of the Cooperative Weichteilsarkom Studiengruppe (1981-2015) ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2018, 65(5):e26943]

Cited: 0 times

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An acceptance-based intervention for children and adolescents with cancer experiencing acute pain - a single-subject study.

Jenny Thorsell Cederberg, JoAnne Dahl, Louise von Essen, Gustaf Ljungman,

BACKGROUND:Children and adolescents with cancer report pain as one of their most recurrent and troublesome symptoms throughout the cancer trajectory. Pain evokes psychological distress, which in turn has an amplifying effect on the pain experience. Acceptance-based interventions for experimentally induced acute pain predict increased pain tolerance, decreased pain intensity and ... Read more >>

J Pain Res (Journal of pain research)
[2017, 10:2195-2203]

Cited: 1 time

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Twelve-Month Follow-Up of a Randomized Controlled Trial of Internet-Based Guided Self-Help for Parents of Children on Cancer Treatment.

Martin Cernvall, Per Carlbring, Anna Wikman, Lisa Ljungman, Gustaf Ljungman, Louise von Essen,

BACKGROUND:A substantial proportion of parents of children on cancer treatment report psychological distress such as symptoms of post-traumatic stress (PTSS), depression, and anxiety. During their child's treatment many parents also experience an economic burden. OBJECTIVE:The aim of this study was to evaluate the long-term efficacy of Internet-based guided self-help for ... Read more >>

J Med Internet Res (Journal of medical Internet research)
[2017, 19(7):e273]

Cited: 9 times

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