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Author Guodong Xu

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Fast food consumption among young adolescents aged 12-15 years in 54 low- and middle-income countries.

Lian Li, Ning Sun, Lina Zhang, Guodong Xu, Jingjing Liu, Jingcen Hu, Zhiying Zhang, Jianjun Lou, Hongxia Deng, Zhisen Shen, Liyuan Han,

<h4>Background</h4>Most countries worldwide, especially low- and middle-income countries (LMICs), are facing an increasing prevalence of fast-food consumption and multiple burdens of malnutrition among young adolescents.<h4>Objective</h4>To compare the prevalence of fast-food consumption among young adolescents in LMICs.<h4>Methods</h4>We used data from the most recent Global School-Based Student Health Survey (2009-2015), which had ... Read more >>

Glob Health Action (Global health action)
[2020, 13(1):1795438]

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Rapamycin alleviates cognitive impairment in murine vascular dementia: The enhancement of mitophagy by PI3K/AKT/mTOR axis.

Guimin Zheng, Lei Wang, Xiuqin Li, Xiaoli Niu, Guodong Xu, Peiyuan Lv,

There are no approved symptomatic treatments for vascular dementia (VaD). Rapamycin (RAPA) improves cognitive deficits in Alzheimer's disease rats. To explore whether RAPA improves cognitive impairment after VaD and its possible molecular mechanisms. Thirty Sprague Dawley rats were randomly divided into three groups: sham (received sham-operation), VaD model (received permanent ... Read more >>

Tissue Cell (Tissue & cell)
[2020, 69:101481]

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miRNA-1183-targeted regulation of Bcl-2 contributes to the pathogenesis of rheumatic heart disease.

Ni Li, Linwen Zhu, Hua Zhou, Dawei Zheng, Guodong Xu, Lebo Sun, Jianqing Gao, Guofeng Shao,

To determine whether up-regulation of miR-1183 targeting the gene for anti-apoptotic factor, B-cell lymphoma 2 (BCL-2) contributes to apoptosis in patients with rheumatic heart disease (RHD). Peripheral blood samples were isolated for miR-1183 characterization. The function of miRNA-1183 in RHD using miRNA mimic on PBMCs and THP-1 cell models. The ... Read more >>

Biosci Rep (Bioscience reports)
[2020, 40(11):]

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High MTHFR promoter methylation levels in men confer protection against ischemic stroke.

Shan Xu, Qianping Shi, Bo Li, Liyuan Han, Guodong Xu, Xiaolin Peng, Hongen Chen, Shuhong Dai, Wancheng Ma, Changyi Wang, Jianping Ma,

The MTHFR gene encodes methylenetetrahydrofolate reductase required for the metabolism of homocysteine (Hcy) - a previously reported independent risk factor for ischemic stroke (IS). In this study, we first aimed to clarify the association between DNA methylation levels in the MTHFR promoter and the risk of IS, followed by the ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):477-486]

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Increasement of Cd adsorption capacity of rice stubble from being alive until death in a modified rice-fish system.

Wei Luo, Ning Zhang, Zhengjie Li, Zhou Xu, Dongjie Wang, Guoping Liao, Guojun Pang, Guodong Xu, Yiyao Wang, Xiaoli Huang, Defang Chen, Cong Zeng, Zongjun Du,

Soil heavy metal contamination is an increasingly urgent problem throughout the world. Phytoremediation is a cost-effective and ecologically friendly in situ method for the remediation of heavy metal contaminated soils. Rice has the potential for use in soil remediation due to its high biomass production, however, risks related to food ... Read more >>

Ecotoxicol Environ Saf (Ecotoxicology and environmental safety)
[2021, 208:111441]

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Physical behaviors of 12-15 year-old adolescents in 54 low- and middle-income countries: Results from the Global School-based Student Health Survey.

Guodong Xu, Ning Sun, Lian Li, Wanfu Qi, Changwei Li, Maigeng Zhou, Zhu Chen, Liyuan Han,

Background:To describe and compare the separate and combined prevalence of physical activity, active transportation, physical education, and sedentary behavior among adolescents 12-15 year-olds in low- and middle-income countries (LMICs). Methods:We used the latest data from the Global School-based Student Health Survey (GSHS), which collect data on the physical behaviors of ... Read more >>

J Glob Health (Journal of global health)
[2020, 10(1):010423]

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The Effectiveness of bFGF in the Treatment of Tympanic Membrane Perforations: A Systematic Review and Meta-Analysis.

Juntao Huang, Bing Mei Teh, Robert Henry Eikelboom, Liyuan Han, Guodong Xu, Xu Yao, Yi Hu, Minghao Zheng, Yi Shen,

OBJECTIVE:To investigate the effectiveness of basic fibroblast growth factor (bFGF) versus placebo or no intervention in the treatment of tympanic membrane (TM) perforations from randomized controlled trials (RCTs), prospective and retrospective studies. DATA SOURCES:PubMed, EMBASE, and Cochrane databases were screened from their inceptions to June 2019. STUDY SELECTION:Inclusion criteria: 1) ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2020, 41(6):782-790]

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Optimizing dry anaerobic digestion at pilot scale for start-up strategy and long-term operation: Organic loading rate, temperature and co-digestion.

Hui Gong, Min Liu, Kun Li, Caibin Li, Guodong Xu, Kaijun Wang,

Dry anaerobic digestion (AD) with high total solid content might upgrade conventional wet AD by enhancing digestion and reducing liquid digestate generation, which was not so popular due to lack of adequate knowledge and perceived operational complexity. In this study long term (447 days) pilot scale investigation was performed for various ... Read more >>

Bioresour Technol (Bioresource technology)
[2020, 316:123828]

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Effect of GM6001 on the expression of syndecan-1 in rats with acute kidney injury and its protective effect on the kidneys.

Kunying Zhang, Rongxin Li, Guodong Xu, Huirong Han, Lili Qin,

Expression of syndecan-1 (SDC-1) in rats with acute kidney injury and the protective effect of GM6001 on the kidney were investigated. Fifty SD rats were selected and randomly divided into control group (CG) (n=15), treatment control group (TCG) (n=10), module group (MG) (n=15) and treatment group (TG) (n=10). In TG, ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2020, 20(3):2049-2054]

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Efficient detection of differentially methylated regions in the genome of patients with thoracic aortic dissection and association with MMP2 hypermethylation.

Ni Li, Hangjuan Lin, Hua Zhou, Dawei Zheng, Guodong Xu, Huoshun Shi, Xiuying Zhu, Jianqing Gao, Guofeng Shao, Lebo Sun,

DNA methylation is known to regulate the expression of numerous genes but its role in the pathogenesis of thoracic aortic dissection (TAD) has remained largely elusive. In the present study, the DNA methylome of patients with TAD was analyzed using a methylation microarray and bisulfite pyrosequencing was used to determine ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2020, 20(2):1073-1081]

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Significant association between DHFR promoter methylation and ischemic stroke in a Chinese hypertensive population.

Jingcen Hu, Hong Zhu, Guodong Xu, Zhu Chen, Lian Li, Shuyu Wang, Hongxia Deng, Xiaoming Bao, Zhisen Shen,

<h4>Objective</h4>DHFR encodes dihydrofolate reductase, a major enzyme in the metabolism of folate, and is a candidate gene for ischemic stroke (IS). Therefore, we aimed to investigate the association between DHFR promoter methylation and IS in a Chinese population with primary hypertension.<h4>Methods</h4>Quantitative methylation-specific PCR was used to measure the level of ... Read more >>

J Clin Lab Anal (Journal of clinical laboratory analysis)
[2020, 34(8):e23322]

Cited: 1 time

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Influence of Chronic Ethanol Consumption on Apoptosis and Autophagy Following Transient Focal Cerebral Ischemia in Male Mice.

Chun Li, Jiyu Li, Guodong Xu, Hong Sun,

Stroke remains one of the leading causes of permanent disability and death worldwide. Apoptosis and autophagy are two key elements involved in ischemic brain damage. Ethanol is a commonly used and abused chemical substance that affects the prognosis of ischemic stroke. We determined the influence of chronic ethanol consumption on ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):6164]

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Polyolefin Elastomer as the Anode Interfacial Layer for Improved Mechanical and Air Stabilities in Nonfullerene Solar Cells.

Yansong Ge, Lin Hu, Lifu Zhang, Qingxia Fu, Guodong Xu, Zhi Xing, Liqiang Huang, Weihua Zhou, Yiwang Chen,

Despite the breakthroughs in power conversion efficiency (PCE) values of organic solar cells (OSCs), the other important issue concerns stability, which is urgently needed to be resolved for potential commercialization. A commercial and chemically stable polyolefin elastomer (POE) was incorporated into high-performance PBDB-T:ITIC, PM6:IT-4F, and PM6:Y6 nonfullerene systems to serve ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2020, 12(9):10706-10716]

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Visinin-like protein-1 level is associated with short-term functional outcome of acute ischemic stroke: A prospective cohort study.

Dengjun Liu, Xiaoli Dong, Rui Yang, Hao Guo, Tao Wang, Guodong Xu,

Stroke is a serious disease that can lead to disability and death in adults, and the prediction of functional outcome is important in the management of acute ischemic stroke (AIS). Blood biomarker is a promising technique, for the measurement is fast, cheap and convenient. Visinin-like protein-1 (VILIP-1) is a classic ... Read more >>

Medicine (Madr) (Medicine)
[2020, 99(9):e19252]

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Circulating miR-3197 and miR-2116-5p as novel biomarkers for diabetic retinopathy.

Huihui Ji, Quanyong Yi, Lishuang Chen, Liping Wong, Yanfen Liu, Guodong Xu, Jun Zhao, Tianyi Huang, Bin Li, Yong Yang, Wenxia Li, Liyuan Han, Shiwei Duan,

Diabetic retinopathy (DR) is the leading cause of vision loss among older adults. The goal of this case-control study was to identify circulating miRNAs for the diagnosis of DR. The miRNeasy Serum/Plasma Kit was used to extract serum miRNAs. The μParaflo™ MicroRNA microarray was used to detect the expression levels ... Read more >>

Clin Chim Acta (Clinica chimica acta; international journal of clinical chemistry)
[2020, 501:147-153]

Cited: 3 times

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Circular RNA expression profile in peripheral whole blood of lung adenocarcinoma by high: Throughput sequencing.

Yinyu Mu, Fuyi Xie, YunFei Huang, Dongdong Yang, Guodong Xu, Chunnian Wang, Qiaoping Wu,

<h4>Background</h4>Lung adenocarcinoma (LA) is a most common form of non-small cell lung cancer (NSCLC). To date, there are still no effective early diagnosis methods for patients to be cured in time. Noncoding RNA plays an important role in oncogenesis and tumor development. The expression profile of circular RNA (circRNA) in ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(42):e17601]

Cited: 3 times

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Prevalence, risk factors, and management of asthma in China: a national cross-sectional study.

Kewu Huang, Ting Yang, Jianying Xu, Lan Yang, Jianping Zhao, Xiangyan Zhang, Chunxue Bai, Jian Kang, Pixin Ran, Huahao Shen, Fuqiang Wen, Yahong Chen, Tieying Sun, Guangliang Shan, Yingxiang Lin, Guodong Xu, Sinan Wu, Chaolong Wang, Ruiying Wang, Zhihong Shi, Yongjian Xu, Xianwei Ye, Yuanlin Song, Qiuyue Wang, Yumin Zhou, Wen Li, Liren Ding, Chun Wan, Wanzhen Yao, Yanfei Guo, Fei Xiao, Yong Lu, Xiaoxia Peng, Biao Zhang, Dan Xiao, Zuomin Wang, Zhengming Chen, Xiaoning Bu, Hong Zhang, Xiaolei Zhang, Li An, Shu Zhang, Jianguo Zhu, Zhixin Cao, Qingyuan Zhan, Yuanhua Yang, Lirong Liang, Xunliang Tong, Huaping Dai, Bin Cao, Tangchun Wu, Kian Fan Chung, Jiang He, Chen Wang, ,

<h4>Background</h4>Asthma is a common chronic airway disease worldwide. Despite its large population size, China has had no comprehensive study of the national prevalence, risk factors, and management of asthma. We therefore aimed to estimate the national prevalence of asthma in a representative sample of the Chinese population.<h4>Methods</h4>A representative sample of ... Read more >>

Lancet (Lancet (London, England))
[2019, 394(10196):407-418]

Cited: 22 times

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Serum prealbumin is a prognostic indicator in idiopathic pulmonary fibrosis.

Biyun Li, Xinran Zhang, Guodong Xu, Shu Zhang, Huifang Song, Kaiyuan Yang, Huaping Dai, Chen Wang,

<h4>Introduction</h4>Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by variable progression. The prealbumin (PA) is a parameter in a routine blood biochemistry examination. We sought to investigate the prognostic value in IPF patients.<h4>Objectives</h4>To evaluate the prognosis value in patients with IPF.<h4>Methods</h4>Blood biochemistry examination, demographics, pulmonary function data ... Read more >>

Clin Respir J (The clinical respiratory journal)
[2019, 13(8):493-498]

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Periodontal health: A national cross-sectional study of knowledge, attitudes and practices for the public oral health strategy in China.

Qian Zhao, Shi-Bin Wang, Guodong Xu, Yiqing Song, Xiaozhe Han, Zhiqiang Liu, Xuan Zhou, Tianyi Zhang, Kewu Huang, Ting Yang, Yingxiang Lin, Sinan Wu, Zuomin Wang, Chen Wang,

<h4>Aim</h4>To assess the status of periodontal health knowledge, attitudes and practices (KAP) among Chinese adults.<h4>Materials and methods</h4>A cross-sectional study was conducted in a nationally representative sample of adults (N = 50,991) aged 20 years or older from ten provinces, autonomous regions, and municipalities. Percentages of Chinese adults with correct periodontal knowledge, positive periodontal ... Read more >>

J Clin Periodontol (Journal of clinical periodontology)
[2019, 46(4):406-419]

Cited: 1 time

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Author Correction: Effect of Low-Dose Alcohol Consumption on Inflammation Following Transient Focal Cerebral Ischemia in Rats.

Kimberly D McCarter, Chun Li, Zheng Jiang, Wei Lu, Hillary A Smith, Guodong Xu, William G Mayhan, Hong Sun,

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):6404]

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Risk of all-cause and CHD mortality in women versus men with type 2 diabetes: a systematic review and meta-analysis.

Guodong Xu, Dingyun You, Liping Wong, Donghui Duan, Fanqian Kong, Xiaohong Zhang, Jinshun Zhao, Wenhua Xing, Liyuan Han, Li Li,

<h4>Objective</h4>Previous studies have shown sex-specific differences in all-cause and CHD mortality in type 2 diabetes. We performed a systematic review and meta-analysis to provide a global picture of the estimated influence of type 2 diabetes on the risk of all-cause and CHD mortality in women vs men.<h4>Methods</h4>We systematically searched PubMed, ... Read more >>

Eur J Endocrinol (European journal of endocrinology)
[2019, 180(4):243-255]

Cited: 1 time

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CBS promoter hypermethylation increases the risk of hypertension and stroke.

Changyi Wang, Guodong Xu, Qi Wen, Xiaolin Peng, Hongen Chen, Jingwen Zhang, Shan Xu, Chunhui Zhang, Min Zhang, Jianping Ma, Zhaohui Hui, Guifu Wu, Min Ma,

OBJECTIVES:Cystathionine β-synthase is a major enzyme in the metabolism of plasma homocysteine. Hyperhomocysteinemia is positively associated with hypertension and stroke. The present study was performed to examine the possible effects of Cystathionine β-synthase promoter methylation on the development of hypertension and stroke. METHODS:Using quantitative methylation-specific PCR, we determined the Cystathionine ... Read more >>

Clinics (Sao Paulo) (Clinics (Sao Paulo, Brazil))
[2019, 74:e630]

Cited: 4 times

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Dose-Dependent Influences of Ethanol on Ischemic Stroke: Role of Inflammation.

Guodong Xu, Chun Li, Anne L Parsiola, Jiyu Li, Kimberly D McCarter, Runhua Shi, William G Mayhan, Hong Sun,

Chronic ethanol consumption dose-dependently affects both incidence and prognosis of ischemic stroke. Our goal was to determine whether the influence of chronic ethanol consumption on ischemic stroke is related to an altered inflammatory profile in the brain. Male C57BL/6J mice were divided into six groups and gavage fed with 0.175, ... Read more >>

Front Cell Neurosci (Frontiers in cellular neuroscience)
[2019, 13:6]

Cited: 3 times

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Does Body Mass Index and Height Influence the Incident Risk of Ischemic Stroke in Newly Diagnosed Type 2 Diabetes Subjects?

Donghui Duan, Hui Li, Jiaying Xu, Liping Wong, Guodong Xu, Fanqian Kong, Sixuan Li, Qinghai Gong, Xiaohong Zhang, Jinshun Zhao, Lina Zhang, Guozhang Xu, Wenhua Xing, Liyuan Han,

<h4>Objective</h4>To estimate the incident risk of ischemic stroke (IS) in newly diagnosed type 2 diabetes (T2D) subjects according to different body mass index (BMI) and height categories.<h4>Methods</h4>A total of 25,130 newly diagnosed T2D subjects were included in this study. All T2D subjects were enrolled consecutively from the Chronic Disease Surveillance ... Read more >>

J Diabetes Res (Journal of diabetes research)
[2019, 2019:2591709]

Cited: 1 time

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Significant Association of Methylenetetrahydrofolate dehydrogenase 1 Promoter Hypomethylation with Stroke in a Chinese Population with Primary Hypertension.

Changyi Wang, Guodong Xu, Qi Wen, Xiaolin Peng, Hongen Chen, Jingwen Zhang, Shan Xu, Chunhui Zhang, Min Zhang, Jianping Ma, Zhaohui Hui, Jianhang Du, Guifu Wu, Min Ma,

OBJECTIVE:Hypertension and hyperhomocysteinemia are both stroke risk factors. Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) plays a vital role in one-carbon metabolism via encoding a protein with three distinct enzymatic activities (methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase, and formate-tetrahydrofolate ligase). We aimed to elucidate the association between MTHFD1 promoter methylation and stroke in a Chinese ... Read more >>

Ann Clin Lab Sci (Annals of clinical and laboratory science)
[2019, 49(1):112-118]

Cited: 1 time

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