Full Text Journal Articles by
Author Guo Liang Xu

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Reversal of nucleobase methylation by dioxygenases.

Guo-Liang Xu, Matthias Bochtler,

The repertoire of nucleobase methylation in DNA and RNA, introduced by chemical agents or enzymes, is large. Most methylation can be reversed either directly by restoration of the original nucleobase or indirectly by replacement of the methylated nucleobase with an unmodified nucleobase. In many direct and indirect demethylation reactions, ALKBH ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, 16(11):1160-1169]

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β-Catenin safeguards the ground state of mousepluripotency by strengthening the robustness of the transcriptional apparatus.

Meng Zhang, Yiwei Lai, Vladislav Krupalnik, Pengcheng Guo, Xiangpeng Guo, Jianguo Zhou, Yan Xu, Zhijun Yu, Longqi Liu, Ao Jiang, Wenjuan Li, Mazid Md Abdul, Gang Ma, Na Li, Xiuling Fu, Yuan Lv, Mengling Jiang, Muqddas Tariq, Shahzina Kanwal, Hao Liu, Xueting Xu, Hui Zhang, Yinghua Huang, Lulu Wang, Shuhan Chen, Isaac A Babarinde, Zhiwei Luo, Dongye Wang, Tiantian Zhou, Carl Ward, Minghui He, David P Ibañez, Yunpan Li, Jiajian Zhou, Jie Yuan, Yayan Feng, Karthik Arumugam, Umberto Di Vicino, Xichen Bao, Guangming Wu, Axel Schambach, Huating Wang, Hao Sun, Fei Gao, Baoming Qin, Andrew P Hutchins, Bradley W Doble, Christine Hartmann, Maria Pia Cosma, Yan Qin, Guo-Liang Xu, Runsheng Chen, Giacomo Volpe, Liang Chen, Jacob H Hanna, Miguel A Esteban,

Mouse embryonic stem cells cultured with MEK (mitogen-activated protein kinase kinase) and GSK3 (glycogen synthase kinase 3) inhibitors (2i) more closely resemble the inner cell mass of preimplantation blastocysts than those cultured with SL [serum/leukemia inhibitory factor (LIF)]. The transcriptional mechanisms governing this pluripotent ground state are unresolved. Release of ... Read more >>

Sci Adv (Science advances)
[2020, 6(29):eaba1593]

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Author Correction: N6-methyladenine is incorporated into mammalian genome by DNA polymerase.

Xiaoling Liu, Weiyi Lai, Yao Li, Shaokun Chen, Baodong Liu, Ning Zhang, Jiezhen Mo, Cong Lyu, Jing Zheng, Ya-Rui Du, Guibin Jiang, Guo-Liang Xu, Hailin Wang,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Cell Res. (Cell research)
[2020, :]

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N6-methyladenine is incorporated into mammalian genome by DNA polymerase.

Xiaoling Liu, Weiyi Lai, Yao Li, Shaokun Chen, Baodong Liu, Ning Zhang, Jiezhen Mo, Cong Lyu, Jing Zheng, Ya-Rui Du, Guibin Jiang, Guo-Liang Xu, Hailin Wang,

Cell Res. (Cell research)
[2020, :]

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The utility of EBUS-TBNA in the diagnosis of suspected intrathoracic recurrence after esophageal cancer surgery.

Jun Chi, Shan-Shan Lian, Qing Yang, Guang-Yu Luo, Guo-Liang Xu,

OBJECTIVES:Postoperative recurrences, especially anastomotic recurrence and regional lymph node recurrence were common in patients even with curative esophageal cancer surgery. Endobronchial ultrasound-guided transbronchial needle aspiration is an alternative to mediastinoscopy in patients with lung cancer and mediastinal lymphadenopathy. The aim of our study is to evaluate the utility of endobronchial ... Read more >>

Jpn. J. Clin. Oncol. (Japanese journal of clinical oncology)
[2020, 50(5):602-608]

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Both combinatorial K4me0-K36me3 marks on sister histone H3s of a nucleosome are required for Dnmt3a-Dnmt3L mediated de novo DNA methylation.

Ting Gong, Xin Gu, Yu-Ting Liu, Zhen Zhou, Ling-Li Zhang, Yang Wen, Wei-Li Zhong, Guo-Liang Xu, Jin-Qiu Zhou,

A nucleosome contains two copies of each histone H2A, H2B, H3 and H4. Histone H3 K4me0 and K36me3 are two key chromatin marks for de novo DNA methylation catalyzed by DNA methyltransferases in mammals. However, it remains unclear whether K4me0 and K36me3 marks on both sister histone H3s regulate de ... Read more >>

J Genet Genomics (Journal of genetics and genomics = Yi chuan xue bao)
[2020, 47(2):105-114]

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The prognostic value of a seven-lncRNA signature in patients with esophageal squamous cell carcinoma: a lncRNA expression analysis.

Nuo-Qing Weng, Jun Chi, Jing Wen, Shi-Juan Mai, Mei-Yin Zhang, Long Huang, Ji Liu, Xian-Zi Yang, Guo-Liang Xu, Jian-Hua Fu, Hui-Yun Wang,

BACKGROUND:Long non-coding RNAs (lncRNAs) have been reported to be prognostic biomarkers in many types of cancer. We aimed to identify a lncRNA signature that can predict the prognosis in patients with esophageal squamous cell carcinoma (ESCC). METHODS:Using a custom microarray, we retrospectively analyzed lncRNA expression profiles in 141 samples of ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):47]

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Tet1 Deficiency Leads to Premature Reproductive Aging by Reducing Spermatogonia Stem Cells and Germ Cell Differentiation.

Guian Huang, Linlin Liu, Huasong Wang, Mo Gou, Peng Gong, Chenglei Tian, Wei Deng, Jiao Yang, Tian-Tian Zhou, Guo-Liang Xu, Lin Liu,

Ten-eleven translocation (Tet) enzymes are involved in DNA demethylation, important in regulating embryo development, stem cell pluripotency and tumorigenesis. Alterations of DNA methylation with age have been shown in various somatic cell types. We investigated whether Tet1 and Tet2 regulate aging. We showed that Tet1-deficient mice undergo a progressive reduction ... Read more >>

iScience (iScience)
[2020, 23(3):100908]

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Phosphorylation of Tet3 by cdk5 is critical for robust activation of BRN2 during neuronal differentiation.

Vinay Kumar Rao, Adusumalli Swarnaseetha, Guo-Hong Tham, Wei-Qi Lin, Bin-Bin Han, Touati Benoukraf, Guo-Liang Xu, Chin-Tong Ong,

Tet3 regulates the dynamic balance between 5-methylcyotsine (5mC) and 5-hydroxymethylcytosine (5hmC) in DNA during brain development and homeostasis. However, it remains unclear how its functions are modulated in a context-dependent manner during neuronal differentiation. Here, we show that cyclin-dependent kinase 5 (cdk5) phosphorylates Tet3 at the highly conserved serine 1310 ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2020, 48(3):1225-1238]

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Submucosal Saline Injection Followed by Endoscopic Ultrasound versus Endoscopic Ultrasound Only for Distinguishing between T1a and T1b Esophageal Cancer.

Long-Jun He, Chuanbo Xie, Zi-Xian Wang, Yin Li, Yi-Tai Xiao, Xiao-Yan Gao, Hong-Bo Shan, Lin-Na Luo, Li-Ming Chen, Guang-Yu Luo, Ping Yang, Shuo-Chun Zeng, Guo-Liang Xu, Jian-Jun Li,

PURPOSE:To examine whether submucosal saline injection (SSI) can improve traditional endoscopic ultrasound (EUS) accuracy in distinguishing between T1a and T1b stage esophageal squamous cell carcinoma (ESCC). EXPERIMENTAL DESIGN:Patients with T1N0M0 stage ESCC (n = 180) ages 18 to 85 years were enrolled between February 14, 2012 to June 4, 2018 ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2020, 26(2):384-390]

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The anti-diabetic activities, gut microbiota composition, the anti-inflammatory effects of Scutellaria-coptis herb couple against insulin resistance-model of diabetes involving the toll-like receptor 4 signaling pathway.

Chang-Hua Zhang, Jun-Qing Sheng, Surendra Sarsaiya, Fu-Xing Shu, Tong-Tong Liu, Xiu-Ying Tu, Guang-Qiang Ma, Guo-Liang Xu, Hong-Xiang Zheng, Li-Fen Zhou,

ETHNOPHARMACOLOGICAL RELEVANCE:Scutellaria-coptis herb couple (SC) is one of the well-known herb couples in many traditional Chinese compound formulas used for the treatment of diabetes mellitus (DM), which has been used to treat DM for thousands of years in China. AIM OF THE STUDY:Few studies have confirmed in detail the anti-diabetic ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2019, 237:202-214]

Cited: 1 time

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[DNA methylation in adipose tissue and the development of diabetes and obesity].

Xin Huang, Yong Qiang Chen, Guo Liang Xu, Shu Hong Peng,

Diabetes and obesity are complicated metabolic diseases which frequently occur together and are affected by environmental, hereditary and metabolic factors. Adipose tissue is involved in various physiological and pathological processes and plays an essential role as an endocrine organ which regulates the metabolic balance of the body. DNA methylation of ... Read more >>

Yi Chuan (Yi chuan = Hereditas)
[2019, 41(2):98-110]

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Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1.

Yingfeng Li, Zhuqiang Zhang, Jiayu Chen, Wenqiang Liu, Weiyi Lai, Baodong Liu, Xiang Li, Liping Liu, Shaohua Xu, Qiang Dong, Mingzhu Wang, Xiaoya Duan, Jiajun Tan, Yong Zheng, Pumin Zhang, Guoping Fan, Jiemin Wong, Guo-Liang Xu, Zhigao Wang, Hailin Wang, Shaorong Gao, Bing Zhu,

Postnatal growth of mammalian oocytes is accompanied by a progressive gain of DNA methylation, which is predominantly mediated by DNMT3A, a de novo DNA methyltransferase1,2. Unlike the genome of sperm and most somatic cells, the oocyte genome is hypomethylated in transcriptionally inert regions2-4. However, how such a unique feature of ... Read more >>

Nature (Nature)
[2018, 564(7734):136-140]

Cited: 20 times

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Efficacy of Endoscopic Ultrasonography for Determining Clinical T Category for Esophageal Squamous Cell Carcinoma: Data From 1434 Surgical Cases.

Jie Yang, Guang-Yu Luo, Run-Bin Liang, Tai-Shan Zeng, Hao Long, Jian-Hua Fu, Guo-Liang Xu, Mu-Zi Yang, Shuo Li, Lan-Jun Zhang, Peng Lin, Xin Wang, Xue Hou, Hao-Xian Yang,

BACKGROUND:The efficacy of endoscopic ultrasonography (EUS) for determining T category is variable for esophageal squamous cell carcinoma (ESCC). We aimed to assess the efficacy of EUS in accurately identifying T category for ESCC based on the 8th AJCC Cancer Staging Manual. METHODS:A retrospective analysis was conducted using a prospectively collected ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2018, 25(7):2075-2082]

Cited: 1 time

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Ultrasound-guided fine needle aspiration of retropharyngeal lymph nodes after radiotherapy for nasopharyngeal carcinoma: a novel technique for accurate diagnosis.

Long-Jun He, Chuanbo Xie, Yin Li, Lin-Na Luo, Ke Pan, Xiao-Yan Gao, Li-Zhi Liu, Jian-Ming Gao, Guang-Yu Luo, Hong-Bo Shan, Ming-Yuan Chen, Chong Zhao, Wei-Jun Fan, Ping Yang, Guo-Liang Xu, Jian-Jun Li,

BACKGROUND:Enlarged retropharyngeal lymph nodes (RLNs) are very common in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy. The most suitable treatment option for enlarged RLNs depends on the pathological results. However, RLN sampling is difficult and imminent in the clinic setting. We recently developed a novel minimally invasive technique termed endoscopic ... Read more >>

Cancer Commun (Lond) (Cancer communications (London, England))
[2018, 38(1):20]

Cited: 1 time

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Endoscopic Ultrasound for Preoperative Esophageal Squamous Cell Carcinoma: a Meta-Analysis.

Lin-Na Luo, Long-Jun He, Xiao-Yan Gao, Xin-Xin Huang, Hong-Bo Shan, Guang-Yu Luo, Yin Li, Shi-Yong Lin, Guo-Bao Wang, Rong Zhang, Guo-Liang Xu, Jian-Jun Li,

BACKGROUND:Treatment options and prognosis of esophageal squamous cell carcinoma (ESCC) depend on the primary tumor depth (T-staging) and regional lymph node status (N-staging). Endoscopic ultrasound (EUS) has emerged as a useful staging tool, but studies regarding its benefits have been variable. The objective of this study was to evaluate the ... Read more >>

PLoS ONE (PloS one)
[2016, 11(7):e0158373]

Cited: 10 times

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A CRISPR-based approach for targeted DNA demethylation.

Xingxing Xu, Yonghui Tao, Xiaobo Gao, Lei Zhang, Xufang Li, Weiguo Zou, Kangcheng Ruan, Feng Wang, Guo-Liang Xu, Ronggui Hu,

In mammalian cells, DNA methylation critically regulates gene expression and thus has pivotal roles in myriad of physiological and pathological processes. Here we report a novel method for targeted DNA demethylation using the widely used clustered regularly interspaced short palindromic repeat (CRISPR)-Cas system. Initially, modified single guide RNAs (sgRNAs) (sgRNA2.0) ... Read more >>

(Cell discovery)
[2016, 2:16009]

Cited: 94 times

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Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration.

Seung-Gi Jin, Zhi-Min Zhang, Thomas L Dunwell, Matthew R Harter, Xiwei Wu, Jennifer Johnson, Zheng Li, Jiancheng Liu, Piroska E Szabó, Qiang Lu, Guo-Liang Xu, Jikui Song, Gerd P Pfeifer,

We report that the mammalian 5-methylcytosine (5mC) oxidase Tet3 exists as three major isoforms and characterized the full-length isoform containing an N-terminal CXXC domain (Tet3FL). This CXXC domain binds to unmethylated CpGs, but, unexpectedly, its highest affinity is toward 5-carboxylcytosine (5caC). We determined the crystal structure of the CXXC domain-5caC-DNA ... Read more >>

Cell Rep (Cell reports)
[2016, 14(3):493-505]

Cited: 38 times

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The Role of N-α-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting.

Chen-Cheng Lee, Shih-Huan Peng, Li Shen, Chung-Fan Lee, Ting-Huei Du, Ming-Lun Kang, Guo-Liang Xu, Anup K Upadhyay, Xiaodong Cheng, Yu-Ting Yan, Yi Zhang, Li-Jung Juan,

Genomic imprinting is an allelic gene expression phenomenon primarily controlled by allele-specific DNA methylation at the imprinting control region (ICR), but the underlying mechanism remains largely unclear. N-α-acetyltransferase 10 protein (Naa10p) catalyzes N-α-acetylation of nascent proteins, and mutation of human Naa10p is linked to severe developmental delays. Here we report ... Read more >>

Mol Cell (Molecular cell)
[2017, 68(1):89-103.e7]

Cited: 17 times

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Dampness-Heat Accelerates DMBA-Induced Mammary Tumors in Rats.

Wei Dong, Xi-Lan Tang, Guang-Bin Shang, Guo-Liang Xu, Wei-Feng Zhu, Hong-Ning Liu,

OBJECTIVE:To investigate the impact of dampness-heat (DH) on the development of mammary tumors in 7,12-dimethylbenz(a)anthracene (DMBA)-induced rats. METHODS:Forty rats were randomly divided into 3 groups in a randomized block design, including the control group (n=13), DMBA group (n=14), and DMBA plus DH group (n=13). Rats in the DMBA group and ... Read more >>

Chin J Integr Med (Chinese journal of integrative medicine)
[2018, 24(10):758-762]

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One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs.

Erwei Zuo, Yi-Jun Cai, Kui Li, Yu Wei, Bang-An Wang, Yidi Sun, Zhen Liu, Jiwei Liu, Xinde Hu, Wei Wei, Xiaona Huo, Linyu Shi, Cheng Tang, Dan Liang, Yan Wang, Yan-Hong Nie, Chen-Chen Zhang, Xuan Yao, Xing Wang, Changyang Zhou, Wenqin Ying, Qifang Wang, Ren-Chao Chen, Qi Shen, Guo-Liang Xu, Jinsong Li, Qiang Sun, Zhi-Qi Xiong, Hui Yang,

The CRISPR/Cas9 system is an efficient gene-editing method, but the majority of gene-edited animals showed mosaicism, with editing occurring only in a portion of cells. Here we show that single gene or multiple genes can be completely knocked out in mouse and monkey embryos by zygotic injection of Cas9 mRNA ... Read more >>

Cell Res. (Cell research)
[2017, 27(7):933-945]

Cited: 35 times

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Effects of omeprazole in improving concurrent chemoradiotherapy efficacy in rectal cancer.

Jin-Liang Zhang, Min Liu, Qing Yang, Shi-Yong Lin, Hong-Bo Shan, Hui-Yun Wang, Guo-Liang Xu,

To explore the effects of omeprazole on chemoradiotherapy efficacy and tumor recurrence in rectal cancer.The medical data of 125 rectal cancer patients who received the same neoadjuvant chemoradiotherapy (CRT) followed by surgery were retrospectively collected. Patients who received omeprazole (OME) orally at a dose of 20 mg at least once ... Read more >>

World J. Gastroenterol. (World journal of gastroenterology)
[2017, 23(14):2575-2584]

Cited: 4 times

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Prognostic values of apoptosis-stimulating P53-binding protein 1 and 2 and their relationships with clinical characteristics of esophageal squamous cell carcinoma patients: a retrospective study.

Xiao-Feng Xie, Qing Yang, Jun Chi, Xian-Zi Yang, Hui-Yun Wang, Guo-Liang Xu,

BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer-related death, and new prognostic biomarkers are urgently needed. Apoptosis-stimulating P53-binding protein 1 (ASPP1) and 2 (ASPP2) have been reported to play important roles in the development, progression, metastasis, and prognosis of cancers, but their roles in ESCC have not ... Read more >>

Chin J Cancer (Chinese journal of cancer)
[2017, 36(1):15]

Cited: 2 times

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Effect of Dendrobium officinale Extraction on Gastric Carcinogenesis in Rats.

Yi Zhao, Yan Liu, Xi-Ming Lan, Guo-Liang Xu, You-Zhi Sun, Fei Li, Hong-Ning Liu,

Dendrobium officinale (Tie Pi Shi Hu in Chinese) has been widely used to treat different diseases in China. Anticancer effect is one of the important effects of Dendrobium officinale. However, the molecular mechanism of its anticancer effect remains unclear. In the present study, gastric carcinogenesis in rats was used to ... Read more >>

(Evidence-based complementary and alternative medicine : eCAM)
[2016, 2016:1213090]

Cited: 7 times

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[Proteomics research of intervention effect of "Qi enriching" herbs on "Qi deficiency" rats based on technology of NanoLC-LTQ-Orbitrap].

Yin-Fang Chen, Ying-Jun Fu, Chao Liu, Min Hou, Guo-Liang Xu, Ri-Yue Yu, Hong-Ning Liu, Li-Ping Huang,

Proteomics method, based on NanoLC-LTQ-Orbitrap technology, was applied to explore the biological basis of intervention effect of "Qi enriching" herbs on "Qi deficiency" rats. The "Qi deficiency" rat model was established with caloric restriction combined with excessive swimming. Muscle proteins of vastus lateralis from the blank group, the model group ... Read more >>

Zhongguo Zhong Yao Za Zhi (Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica)
[2016, 41(19):3649-3654]

Cited: 0 times

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