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Author Gulay Alper

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Magnetic resonance imaging in enterovirus-71, myelin oligodendrocyte glycoprotein antibody, aquaporin-4 antibody, and multiple sclerosis-associated myelitis in children.

Esther M Tantsis, Kristina Prelog, Gulay Alper, Leslie Benson, Mark Gorman, Ming Lim, Shekeeb S Mohammad, Sudarshini Ramanathan, Fabienne Brilot, Russell C Dale, ,

AIM:We used magnetic resonance imaging (MRI) to compare the neuroimaging of children with their first episode of clinical enterovirus 71-associated transverse myelitis (EV71-TM), myelin oligodendrocyte glycoprotein antibody positive transverse myelitis (MOG-TM), aquaporin-4 antibody positive transverse myelitis (AQP4-TM), transverse myelitis in multiple sclerosis (MS-TM), and unclassified transverse myelitis (UNC-TM). METHOD:We performed ... Read more >>

Dev Med Child Neurol (Developmental medicine and child neurology)
[2019, 61(9):1108-1116]

Cited: 0 times

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Correction to: Impact of an electronic monitoring device and behavioural feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial.

E Ann Yeh, Stephanie A Grover, Victoria E Powell, Gulay Alper, Brenda L Banwell, Kim Edwards, Mark Gorman, Jennifer Graves, Timothy E Lotze, Jean K Mah, Lauren Mednick, Jayne Ness, Maya Obadia, Ruth Slater, Amy Waldman, Emmanuelle Waubant, Carolyn E Schwartz, ,

The clinicaltrials.gov identifying number for the article titled "Impact of an electronic monitoring device and behavioral feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial" is NCT02234713 (https://clinicaltrials.gov/ct2/show/NCT02234713). ... Read more >>

Qual Life Res (Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation)
[2018, 27(4):1117]

Cited: 0 times

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Impact of an electronic monitoring device and behavioral feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial.

E Ann Yeh, Stephanie A Grover, Victoria E Powell, Gulay Alper, Brenda L Banwell, Kim Edwards, Mark Gorman, Jennifer Graves, Timothy E Lotze, Jean K Mah, Lauren Mednick, Jayne Ness, Maya Obadia, Ruth Slater, Amy Waldman, Emmanuelle Waubant, Carolyn E Schwartz, ,

To report the results of a randomized controlled trial using an electronic monitoring device (EM) plus a motivational interviewing (MI) intervention to enhance adherence to disease-modifying therapies (DMT) in pediatric MS.Fifty-two youth with MS (16.03 ± 2.2 years) were randomized to receive either MI (n = 25) (target intervention) or a MS medication video (n = 27) ... Read more >>

Qual Life Res (Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation)
[2017, 26(9):2333-2349]

Cited: 4 times

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Risk factors for non-adherence to disease-modifying therapy in pediatric multiple sclerosis.

Carolyn E Schwartz, Stephanie A Grover, Victoria E Powell, Austin Noguera, Jean K Mah, Soe Mar, Lauren Mednick, Brenda L Banwell, Gulay Alper, Mary Rensel, Mark Gorman, Amy Waldman, Teri Schreiner, Emmanuelle Waubant, E Ann Yeh,

BACKGROUND:Adherence to disease-modifying therapies (DMTs) in pediatric multiple sclerosis (MS) is not well understood. We examined the prevalence and risk factors for poor adherence in pediatric MS. METHODS:This cross-sectional study recruited youth with MS from 12 North American pediatric MS clinics. In addition to pharmacy-refill data, patients and parents completed ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2018, 24(2):175-185]

Cited: 5 times

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Acute disseminated encephalomyelitis: Updates on an inflammatory CNS syndrome.

Daniela Pohl, Gulay Alper, Keith Van Haren, Andrew J Kornberg, Claudia F Lucchinetti, Silvia Tenembaum, Anita L Belman,

Acute disseminated encephalomyelitis (ADEM) is an immune-mediated demyelinating CNS disorder with predilection to early childhood. ADEM is generally considered a monophasic disease. However, recurrent ADEM has been described and defined as multiphasic disseminated encephalomyelitis. ADEM often occurs postinfectiously, although a causal relationship has never been established. ADEM and multiple sclerosis ... Read more >>

Neurology (Neurology)
[2016, 87(9 Suppl 2):S38-45]

Cited: 29 times

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Acute Ataxia in Childhood: 11-Year Experience at a Major Pediatric Neurology Referral Center.

Kavita Thakkar, Stephen M Maricich, Gulay Alper,

We categorized the causes of acute ataxia in the pediatric population-referred to the Division of Neurology-at a large, urban pediatric medical center. Of the 120 cases identified over the past 11 years, post-infectious cerebellar ataxia was the most commonly diagnosed (59%), followed by drug intoxication, opsoclonus-myoclonus ataxia syndrome, episodic ataxia, ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2016, 31(9):1156-1160]

Cited: 3 times

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Rituximab monitoring and redosing in pediatric neuromyelitis optica spectrum disorder.

Margherita Nosadini, Gulay Alper, Catherine J Riney, Leslie A Benson, Shekeeb S Mohammad, Sudarshini Ramanathan, Melinda Nolan, Richard Appleton, Richard J Leventer, Kumaran Deiva, Fabienne Brilot, Mark P Gorman, Amy T Waldman, Brenda Banwell, Russell C Dale,

To study rituximab in pediatric neuromyelitis optica (NMO)/NMO spectrum disorders (NMOSD) and the relationship between rituximab, B cell repopulation, and relapses in order to improve rituximab monitoring and redosing.Multicenter retrospective study of 16 children with NMO/NMOSD receiving ≥2 rituximab courses. According to CD19 counts, events during rituximab were categorized as ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2016, 3(1):e188]

Cited: 16 times

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Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis.

Sudarshini Ramanathan, Kristina Prelog, Elizabeth H Barnes, Esther M Tantsis, Stephen W Reddel, Andrew P D Henderson, Steve Vucic, Mark P Gorman, Leslie A Benson, Gulay Alper, Catherine J Riney, Michael Barnett, John D E Parratt, Todd A Hardy, Richard J Leventer, Vera Merheb, Margherita Nosadini, Victor S C Fung, Fabienne Brilot, Russell C Dale,

Recognizing the cause of optic neuritis (ON) affects treatment decisions and visual outcomes.We aimed to define radiological features of first-episode demyelinating ON.We performed blinded radiological assessment of 50 patients presenting with first-episode myelin oligodendrocyte glycoprotein (MOG) antibody-associated ON (MOG-ON; n=19), aquaporin-4 (AQP4) antibody-associated ON (AQP4-ON; n=11), multiple sclerosis (MS)-associated ON ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2016, 22(4):470-482]

Cited: 50 times

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Utility and safety of rituximab in pediatric autoimmune and inflammatory CNS disease.

Russell C Dale, Fabienne Brilot, Lisa V Duffy, Marinka Twilt, Amy T Waldman, Sona Narula, Eyal Muscal, Kumaran Deiva, Erik Andersen, Michael R Eyre, Despina Eleftheriou, Paul A Brogan, Rachel Kneen, Gulay Alper, Banu Anlar, Evangeline Wassmer, Kirsten Heineman, Cheryl Hemingway, Catherine J Riney, Andrew Kornberg, Marc Tardieu, Amber Stocco, Brenda Banwell, Mark P Gorman, Susanne M Benseler, Ming Lim,

To assess the utility and safety of rituximab in pediatric autoimmune and inflammatory disorders of the CNS.Multicenter retrospective study.A total of 144 children and adolescents (median age 8 years, range 0.7-17; 103 female) with NMDA receptor (NMDAR) encephalitis (n = 39), opsoclonus myoclonus ataxia syndrome (n = 32), neuromyelitis optica ... Read more >>

Neurology (Neurology)
[2014, 83(2):142-150]

Cited: 81 times

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Vasogenic edema characterizes pediatric acute disseminated encephalomyelitis.

Giulio Zuccoli, Ashok Panigrahy, Gayathri Sreedher, Ariel Bailey, Ernest John Laney, Luca La Colla, Gulay Alper,

MR imaging criteria for diagnosing acute disseminated encephalomyelitis (ADEM) have not been clearly established. Due to the wide spectrum of differential considerations, new imaging features allowing early and accurate diagnosis for ADEM are needed. We hypothesized that ADEM lesions would be characterized by vasogenic edema due to the potential reversibility ... Read more >>

Neuroradiology (Neuroradiology)
[2014, 56(8):679-684]

Cited: 8 times

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Acquired demyelinating and other autoimmune disorders of the central nervous system in children.

Gulay Alper,

J. Child Neurol. (Journal of child neurology)
[2012, 27(11):1375-1377]

Cited: 1 time

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Defining encephalopathy in acute disseminated encephalomyelitis.

S E Fridinger, Gulay Alper,

The International Pediatric Multiple Sclerosis Study Group requires the presence of encephalopathy to diagnose acute disseminated encephalomyelitis. Clinical characteristics of encephalopathy are inadequately delineated in the pediatric demyelinating literature. The authors' purpose was to better define encephalopathy in pediatric acute disseminated encephalomyelitis by describing the details of the mental status ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2014, 29(6):751-755]

Cited: 1 time

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An unusual presentation of juvenile Alexander disease.

Maria Joana Osorio, Sarah Risen, Gulay Alper,

Alexander disease is a rare leukodystrophy that most often presents in infancy but also includes neonatal, juvenile, and adult variants. Juvenile Alexander disease presents primarily with bulbar symptoms between 2 and 12 years of age. The diagnosis is often suggested by the clinical course and brain magnetic resonance image pattern ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2012, 27(4):507-510]

Cited: 0 times

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Acute disseminated encephalomyelitis.

Gulay Alper,

Acute disseminated encephalomyelitis is an immune-mediated inflammatory and demyelinating disorder of the central nervous system, commonly preceded by an infection. It principally involves the white matter tracts of the cerebral hemispheres, brainstem, optic nerves, and spinal cord. Acute disseminated encephalomyelitis mainly affects children. Clinically, patients present with multifocal neurologic abnormalities ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2012, 27(11):1408-1425]

Cited: 28 times

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Management of pediatric central nervous system demyelinating disorders: consensus of United States neurologists.

Amy T Waldman, Mark P Gorman, Mary R Rensel, Tracy E Austin, Deborah P Hertz, Nancy L Kuntz, ,

Demyelinating diseases are a group of autoimmune inflammatory disorders affecting the central nervous system in adults and children; however, the diagnosis, evaluation, and treatment of these disorders are primarily based on adult data. The purpose of this study was to assess the practice patterns of US physicians who specialize in ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2011, 26(6):675-682]

Cited: 34 times

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Idiopathic acute transverse myelitis in children: an analysis and discussion of MRI findings.

Gulay Alper, Kalliopi A Petropoulou, Charles R Fitz, Yeonhee Kim,

There is lack of reported magnetic resonance imaging (MRI) studies of idiopathic acute transverse myelitis (ATM) in children.To describe the imaging features of idiopathic ATM in children.We retrospectively analyzed the spinal MRI findings of children diagnosed with ATM. The anatomic regions, vertebral segmental length, gray or white matter involvement, cord ... Read more >>

Mult. Scler. (Multiple sclerosis (Houndmills, Basingstoke, England))
[2011, 17(1):74-80]

Cited: 19 times

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Demyelinating optic neuritis in children.

Gulay Alper, Li Wang,

Acute demyelinating optic neuritis in children can occur in isolation or be associated with acute disseminated encephalomyelitis, multiple sclerosis, or neuromyelitis optica. Clinical features, neuroimaging, cerebrospinal fluid findings, and long-term prognosis were reviewed in 26 children diagnosed with optic neuritis at the first presentation of demyelinating disease. The risk factors ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2009, 24(1):45-48]

Cited: 10 times

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Multiple sclerosis and acute disseminated encephalomyelitis diagnosed in children after long-term follow-up: comparison of presenting features.

Gulay Alper, Rock Heyman, Li Wang,

The aim of this study was to compare the characteristics of the first demyelinating event between acute disseminated encephalomyelitis (ADEM) and multiple sclerosis (MS). Children with acute demyelinating disease of the central nervous system and an abnormal brain magnetic resonance image (MRI) were studied. Patients were assigned a final diagnosis ... Read more >>

Dev Med Child Neurol (Developmental medicine and child neurology)
[2009, 51(6):480-486]

Cited: 34 times

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Neuromyelitis optica in a young child with positive serum autoantibody.

Ingrid P Loma, Miya R Asato, Robyn A Filipink, Gulay Alper,

Relapsing neuromyelitis optica is rare in children. The identification of a highly specific serum autoantibody marker (neuromyelitis optica-immunoglobulin G) differentiates neuromyelitis optica from other demyelinating disorders, particularly in clinically challenging cases. We present a child with multiple episodes of transverse myelitis and optic neuritis with positive neuromyelitis optica-immunoglobulin G titers, ... Read more >>

Pediatr. Neurol. (Pediatric Neurology)
[2008, 39(3):209-212]

Cited: 2 times

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Genetic and clinical heterogeneity in eIF2B-related disorder.

Jelena Maletkovic, Raphael Schiffmann, J Rafael Gorospe, Erynn S Gordon, Michelle Mintz, Eric P Hoffman, Gulay Alper, David R Lynch, Bhim S Singhal, Cary Harding, Hernan Amartino, Candida M Brown, Alicia Chan, Deborah Renaud, Michael Geraghty, Lloyd Jensen, Nesrin Senbil, Nadja Kadom, Javad Nazarian, Yuanjian Feng, Zuyi Wang, Thomas Hartka, Hiroki Morizono, Adeline Vanderver,

Eukaryotic initiation factor 2B (eIF2B)-related disorders are heritable white matter disorders with a variable clinical phenotype (including vanishing white matter disease and ovarioleukodystrophy) and an equally heterogeneous genotype. We report 9 novel mutations in the EIF2B genes in our subject population, increasing the number of known mutations to more than ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2008, 23(2):205-215]

Cited: 23 times

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A child with transient neurologic deficits and headache associated with cerebrospinal fluid pleocytosis.

Robert Safier, Gulay Alper,

We report a case of a 10-year-old girl who had several episodes of severe headache, altered consciousness, and temporary neurologic signs and symptoms within a 2-month period. Cerebrospinal fluid examination showed lymphocytic pleocytosis and increased protein. Extensive microbiologic investigation and neuroimaging studies were negative. Cerebrospinal fluid findings were normalized within ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2005, 20(5):439-441]

Cited: 1 time

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Molecular and clinical description of the first US patients with congenital disorder of glycosylation Ig.

Erik A Eklund, John W Newell, Liangwu Sun, Neung-Seon Seo, Gulay Alper, Jessica Willert, Hudson H Freeze,

In this report we describe the first two US patients with congenital disorder of glycosylation type Ig (CDG-Ig). Both patients presented with symptoms indicating CDG, including developmental delay, hypotonia and failure to thrive, and tested positive for deficient glycosylation of transferrin. Labeling of the patients' lipid-linked oligosaccharides suggested mutations in ... Read more >>

Mol. Genet. Metab. (Molecular genetics and metabolism)
[2005, 84(1):25-31]

Cited: 21 times

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Toward the definition of acute disseminated encephalitis of childhood.

Gulay Alper, Nina Felice Schor,

PURPOSE OF REVIEW:Acute disseminated encephalomyelitis (ADEM) is a demyelinating disorder most common in childhood and adolescence and thought to have an immune pathogenesis. Some children with ADEM develop additional temporally remote episodes of demyelination with localizations that differ from those of the initial episode and multiple sclerosis is diagnosed. Others ... Read more >>

Curr. Opin. Pediatr. (Current opinion in pediatrics)
[2004, 16(6):637-640]

Cited: 12 times

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Friedreich's ataxia.

Gulay Alper, Vinodh Narayanan,

Friedreich's ataxia, the most common hereditary ataxia, is caused by expansion of a GAA triplet located within the first intron of the frataxin gene on chromosome 9q13. There is a clear correlation between size of the expanded repeat and severity of the phenotype. Frataxin is a mitochondrial protein that plays ... Read more >>

Pediatr. Neurol. (Pediatric Neurology)
[2003, 28(5):335-341]

Cited: 55 times

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