Full Text Journal Articles by
Author Gulam Hussain Syed


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Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host factors having implication in the disease pathogenesis and severity.

Voddu Suresh, Varshasnata Mohanty, Kiran Avula, Arup Ghosh, Bharati Singh, Rajendra Kumar Reddy, Deepti Parida, Amol Ratnakar Suryawanshi, Sunil Kumar Raghav, Soma Chattopadhyay, Punit Prasad, Rajeeb Kumar Swain, Rupesh Dash, Ajay Parida, Gulam Hussain Syed, Shantibhusan Senapati,

Syrian golden hamsters (Mesocricetus auratus) infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) manifests lung pathology. In this study, efforts were made to check the infectivity of a local SARS-CoV-2 isolate in a self-limiting and non-lethal hamster model and evaluate the differential expression of lung proteins during acute infection ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21713]

Cited: 0 times

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Endoplasmic reticulum & mitochondrial calcium homeostasis: The interplay with viruses.

Swagatika Panda, Suchismita Behera, Mohd Faraz Alam, Gulam Hussain Syed,

Calcium ions (Ca<sup>2+</sup>) act as secondary messengers in a plethora of cellular processes and play crucial role in cellular organelle function and homeostasis. The average resting concentration of Ca<sup>2+</sup> is nearly 100 nM and in certain cells it can reach up to 1 µM. The high range of Ca<sup>2+</sup> concentration across the ... Read more >>

Mitochondrion (Mitochondrion)
[2021, 58:227-242]

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TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy.

Kautilya Kumar Jena, Srinivasa Prasad Kolapalli, Subhash Mehto, Parej Nath, Biswajit Das, Pradyumna Kumar Sahoo, Abdul Ahad, Gulam Hussain Syed, Sunil K Raghav, Shantibhusan Senapati, Swati Chauhan, Santosh Chauhan,

Sequestration of protein aggregates in inclusion bodies and their subsequent degradation prevents proteostasis imbalance, cytotoxicity, and proteinopathies. The underlying molecular mechanisms controlling the turnover of protein aggregates are mostly uncharacterized. Herein, we show that a TRIM family protein, TRIM16, governs the process of stress-induced biogenesis and degradation of protein aggregates. ... Read more >>

EMBO J (The EMBO journal)
[2018, 37(18):]

Cited: 25 times

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Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease.

Emma Börgeson, Andrew M F Johnson, Yun Sok Lee, Andreas Till, Gulam Hussain Syed, Syed Tasadaque Ali-Shah, Patrick J Guiry, Jesmond Dalli, Romain A Colas, Charles N Serhan, Kumar Sharma, Catherine Godson,

The role of inflammation in obesity-related pathologies is well established. We investigated the therapeutic potential of LipoxinA4 (LXA4:5(S),6(R),15(S)-trihydroxy-7E,9E,11Z,13E,-eicosatetraenoic acid) and a synthetic 15(R)-Benzo-LXA4-analog as interventions in a 3-month high-fat diet (HFD; 60% fat)-induced obesity model. Obesity caused distinct pathologies, including impaired glucose tolerance, adipose inflammation, fatty liver, and chronic kidney ... Read more >>

Cell Metab (Cell metabolism)
[2015, 22(1):125-137]

Cited: 69 times

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Evolutionary trends and functional anatomy of the human expanded autophagy network.

Andreas Till, Rintaro Saito, Daria Merkurjev, Jing-Jing Liu, Gulam Hussain Syed, Martin Kolnik, Aleem Siddiqui, Martin Glas, Björn Scheffler, Trey Ideker, Suresh Subramani,

All eukaryotic cells utilize autophagy for protein and organelle turnover, thus assuring subcellular quality control, homeostasis, and survival. In order to address recent advances in identification of human autophagy associated genes, and to describe autophagy on a system-wide level, we established an autophagy-centered gene interaction network by merging various primary ... Read more >>

Autophagy (Autophagy)
[2015, 11(9):1652-1667]

Cited: 10 times

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Arrested cell proliferation through cysteine protease activity of eukaryotic ribosomal protein S4.

Madasu Yadaiah, Babu Sudhamalla, P Nageswara Rao, Karnati R Roy, Dasari Ramakrishna, Gulam Hussain Syed, Kolluru V A Ramaiah, Abani K Bhuyan,

S4 is an integral protein of the smaller subunit of cytosolic ribosome. In prokaryotes, it regulates the synthesis of ribosomal proteins by feedback inhibition of the α-operon gene expression, and it facilitates ribosomal RNA synthesis by direct binding to RNA polymerase. However, functional roles of S4 in eukaryotes are poorly ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2013, 27(2):803-810]

Cited: 3 times

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