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Author Guimin Wang

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Smoking cessation mutually facilitates alcohol drinking cessation among tobacco and alcohol co-users: A cross-sectional study in a rural area of Shanghai, China.

Ruiping Wang, Bin Li, Yonggen Jiang, Ying Guan, Guimin Wang, Genming Zhao,

INTRODUCTION:Tobacco smoking and alcohol drinking are strongly paired behaviours, affecting millions of people worldwide. Studies in western countries demonstrate that alcohol use among smokers makes it harder to quit smoking, and addressing alcohol use is particularly important for smoking cessation, but the evidence is limited in China. We conducted a ... Read more >>

Tob Induc Dis (Tobacco induced diseases)
[2019, 17:85]

Cited: 2 times

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Substrate Transport is Mediated not only by P-glycoprotein but also by Lipid Penetration

Yuqi Yu, Jinan Wang, Zhaoqiang Chen, Guimin Wang, Zhijian Xu, Qiang Shao, Jiye Shi, Weiliang Zhu,

<h4>ABSTRACT</h4> In association with large-scale conformational changes, the members of the ATP-binding cassette (ABC) transporter superfamily such as P-glycoprotein (P-gp) pump endogenous cytotoxic substances and exogenous drugs out of cells. Here, a series of nonequilibrium-driven molecular dynamics (MD) simulations are sophisticatedly combined to provide a generally effective access to quantitatively ... Read more >>

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Prevalence of tobacco related chronic diseases and its role in smoking cessation among smokers in a rural area of Shanghai, China: a cross sectional study.

Ruiping Wang, Yonggen Jiang, Chunxia Yao, Meiying Zhu, Qi Zhao, Limei Huang, Guimin Wang, Ying Guan, Engelgau Michael, Genming Zhao,

<h4>Background</h4>Tobacco smoking is a recognized risk factor for many chronic diseases and previous study evidences have indicated that smokers receive smoking cessation service after the diagnosis of chronic diseases increases successful rate in quitting. But the prevalence of tobacco related chronic diseases (TCD) among smokers, as well as the role ... Read more >>

BMC Public Health (BMC public health)
[2019, 19(1):753]

Cited: 10 times

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Halogen bonding in differently charged complexes: basic profile, essential interaction terms and intrinsic σ-hole.

Zhengdan Zhu, Guimin Wang, Zhijian Xu, Zhaoqiang Chen, Jinan Wang, Jiye Shi, Weiliang Zhu,

Studies on halogen bonds (XB) between organohalogens and their acceptors in crystal structures revealed that the XB donor and acceptor could be differently charged, making it difficult to understand the nature of the interaction, especially the negatively charged donor's electrophilicity and positively charged acceptor's nucleophilicity. In this paper, 9 XB ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2019, 21(27):15106-15119]

Cited: 3 times

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Design, Synthesis and Pharmacological Evaluation of Novel Hsp90N-terminal Inhibitors Without Induction of Heat Shock Response.

Peng Liu, Xiangling Chen, Jianming Zhu, Bo Li, Zhaoqiang Chen, Guimin Wang, Haiguo Sun, Zhijian Xu, Zhixin Zhao, Chen Zhou, Chengying Xie, Liguang Lou, Weiliang Zhu,

Heat shock protein 90 (Hsp90) is a potential oncogenic target. However, Hsp90 inhibitors in clinical trial induce heat shock response, resulting in drug resistance and inefficiency. In this study, we designed and synthesized a series of novel triazine derivatives (<b>A1</b>-<b>26</b>, <b>B1</b>-<b>13</b>, <b>C1</b>-<b>23</b>) as Hsp90 inhibitors. Compound <b>A14</b> directly bound to ... Read more >>

ChemistryOpen (ChemistryOpen)
[2019, 8(3):344-353]

Cited: 2 times

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Exploring binding mechanisms of VEGFR2 with three drugs lenvatinib, sorafenib, and sunitinib by molecular dynamics simulation and free energy calculation.

Yu Wang, Cheng Peng, Guimin Wang, Zhijian Xu, Yongfeng Luo, Jinan Wang, Weiliang Zhu,

Lenvatinib (LEN), sorafenib (SOR), and sunitinib (SUN) are drugs targeting vascular endothelial growth factor receptor 2 (VEGFR2). Despite sharing similar chemical structures and bioactivities, LEN and SOR bind to different functional states of VEGFR2, viz. DFG-in and DFG-out state, respectively. SUN binds to the DFG-out state of VEGFR2 just like ... Read more >>

Chem Biol Drug Des (Chemical biology & drug design)
[2019, 93(5):934-948]

Cited: 1 time

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Improving the accuracy of predicting protein-ligand binding-free energy with semiempirical quantum chemistry charge.

Cheng Peng, Jinan Wang, Yuqi Yu, Guimin Wang, Zhaoqiang Chen, Zhijian Xu, Tingting Cai, Qiang Shao, Jiye Shi, Weiliang Zhu,

<b>Aim:</b> It is a challenge to predict binding-free energy (Δ<i>G</i>) accurately. <b>Methodology/results:</b> For accurate Δ<i>G</i> prediction, a new strategy combining solvated interaction energy (SIE) or molecular mechanics/generalized Born surface area (MM/GBSA) approach with the Coulson charge of both protein and ligand calculated by semiempirical quantum mechanics (SQM), named SIE-SQMPC or ... Read more >>

Future Med Chem (Future medicinal chemistry)
[2019, 11(4):303-321]

Cited: 1 time

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Gossypol inhibits 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase: Its possible use for the treatment of prostate cancer.

Shuyan Cao, Guimin Wang, Fei Ge, Xiaoheng Li, Qiqi Zhu, Ren-Shan Ge, Yunshan Wang,

Gossypol is a yellow polyphenol isolated from cotton seeds. It has the antitumor activity and it is being tested to treat prostate cancer. However, its underlying mechanisms are still not well understood. The present study investigated the inhibitory effects of gossypol acetate on rat 5α-reductase 1, 3α-hydroxysteroid dehydrogenase, and retinol ... Read more >>

Fitoterapia (Fitoterapia)
[2019, 133:102-108]

Cited: 2 times

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4-Bromodiphenyl ether delays pubertal Leydig cell development in rats.

Xianwu Chen, Yaoyao Dong, Erpo Tian, Lubin Xie, Guimin Wang, Xiaoheng Li, Xiuxiu Chen, Yong Chen, Yao Lv, Chaobo Ni, Yinghui Fang, Ying Zhong, Ren-Shan Ge,

Polybrominated diphenyl ethers are a class of brominated flame retardants that are potential endocrine disruptors. 4-Bromodiphenyl ether (BDE-3) is the most abundant photodegradation product of higher polybrominated diphenyl ethers. However, whether BDE-3 affects Leydig cell development during puberty is still unknown. The objective of this study was to explore effects ... Read more >>

Chemosphere (Chemosphere)
[2018, 211:986-997]

Cited: 1 time

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Platelet-derived growth factor BB stimulates differentiation of rat immature Leydig cells.

Yiyan Wang, Xiaoheng Li, Fei Ge, Kaiming Yuan, Zhijian Su, Guimin Wang, Qingquan Lian, Ren-Shan Ge,

Platelet-derived growth factor (PDGF) is one family of growth factors that regulate cell growth and differentiation. Rat Leydig cells express PDGF-β receptor (PDGFRB) during pubertal development. However, the mechanism of PDGF in the regulation of Leydig cell development is unclear. In the present study, rat immature Leydig cells were isolated ... Read more >>

J Mol Endocrinol (Journal of molecular endocrinology)
[2018, 60(1):29-43]

Cited: 0 times

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Primary peripheral nerve sheath tumors of the thyroid gland: A case report and literature review.

Guang Chen, Zengguang Liu, Chang Su, Qiang Guan, Fang Wan, Bingfei Dong, Liang Bao, Wenxin Zhang, Yinping Wang, Guimin Wang,

Primary peripheral nerve sheath tumors (PNSTs) of the thyroid gland are rare, with fewer than 30 cases reported in the medical literature to date. Primary PNSTs of the thyroid gland are classified into malignant and benign PNSTs. The benign PNSTs may be further subclassified into neurofibromas and Schwannomas. This is ... Read more >>

Mol Clin Oncol (Molecular and clinical oncology)
[2016, 4(2):209-210]

Cited: 2 times

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Clinical characteristics and treatment outcomes of parathyroid carcinoma: A retrospective review of 234 cases.

Peisong Wang, Shuai Xue, Shuo Wang, Zhi Lv, Xianying Meng, Guimin Wang, Wei Meng, Jia Liu, Guang Chen,

Parathyroid carcinoma (PC) is one of the rarest known types of cancer and has a moderate prognosis, with estimated 5- and 10-year overall survival rates between 78-85% and between 49-70%, respectively. To raise awareness of this disease, and to optimize its diagnosis, clinical management and prognosis, the present study retrospectively ... Read more >>

Oncol Lett (Oncology letters)
[2017, 14(6):7276-7282]

Cited: 6 times

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Combined Virtual Screening and Substructure Search for Discovery of Novel FABP4 Inhibitors.

Haiyan Cai, Ting Wang, Zhuo Yang, Zhijian Xu, Guimin Wang, He-Yao Wang, Weiliang Zhu, Kaixian Chen,

Fatty acid-binding protein 4 (FABP4, AFABP) is a potential drug target for diabetes and atherosclerosis. In this study, a series of novel FABP4 inhibitors were discovered through combining virtual screening and substructure search. Seventeen compounds exhibited FABP4 inhibitory activities with IC<sub>50</sub> < 10 μM, among which 11 compounds showed high ... Read more >>

J Chem Inf Model (Journal of chemical information and modeling)
[2017, 57(9):2329-2335]

Cited: 1 time

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A brief exposure to cadmium impairs Leydig cell regeneration in the adult rat testis.

Xiaolong Wu, Xiaoling Guo, Huang Wang, Songyi Zhou, Lili Li, Xiaomin Chen, Guimin Wang, Jianpeng Liu, Hong-Shan Ge, Ren-Shan Ge,

Cadmium is an endocrine disruptor, impairing male reproduction. The objective of this study is to investigate whether cadmium affects rat Leydig cell regeneration and to dissect the underlying mechanism. Adult male Sprague-Dawley rats received a single intraperitoneal injection (i.p.) of 0, 0.5 or 1.0 mg/kg of cadmium chloride, followed by ethane ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):6337]

Cited: 10 times

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A role of KIT receptor signaling for proliferation and differentiation of rat stem Leydig cells in vitro.

Shiwen Liu, Xiaomin Chen, Yiyan Wang, Linxi Li, Guimin Wang, Xiaoheng Li, Haolin Chen, Jingjing Guo, Han Lin, Qing-Quan Lian, Ren-Shan Ge,

In the testis, KIT ligand (KITL, also called stem cell factor) is expressed by Sertoli cells and its receptor (c-kit, KIT) is expressed by spermatogonia and Leydig cells. Although KITL-KIT signaling is critical for the spermatogenesis, its roles in Leydig cell development during puberty are not clear. In the present ... Read more >>

Mol Cell Endocrinol (Molecular and cellular endocrinology)
[2017, 444:1-8]

Cited: 8 times

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The Interactions between Imidazolium-Based Ionic Liquids and Stable Nitroxide Radical Species: A Theoretical Study.

Shaoze Zhang, Guimin Wang, Yunxiang Lu, Weiliang Zhu, Changjun Peng, Honglai Liu,

In this work, the interactions between imidazolium-based ionic liquids and some stable radicals based on 2,2,6,6-tetramethylpiperidine-1-yloxyl (TEMPO) have been systematically investigated using density functional theory calculations at the level of M06-2x. Several different substitutions, such as hydrogen bonding formation substituent (OH) and ionic substituents (N(CH3)3(+) and OSO3(-)), are presented at ... Read more >>

J Phys Chem A (The journal of physical chemistry. A)
[2016, 120(30):6089-6102]

Cited: 1 time

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MicroRNA-497 inhibits thyroid cancer tumor growth and invasion by suppressing BDNF.

Peisong Wang, Xianying Meng, Yan Huang, Zhi Lv, Jia Liu, Guimin Wang, Wei Meng, Shuai Xue, Qiang Zhang, Pengju Zhang, Guang Chen,

miR-497 reportedly plays critical roles in tumor development and progression in many types of cancers. We therefore investigated the function and underlying mechanism of miR-497 in thyroid cancer. We found that miR-497 is downregulated in thyroid cancer tissues, and that miR-497 levels are negatively correlated with advanced clinical stage and ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(2):2825-2834]

Cited: 23 times

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Molecular docking for drug discovery and development: a widely used approach but far from perfect.

Guimin Wang, Weiliang Zhu,

Future Med Chem (Future medicinal chemistry)
[2016, 8(14):1707-1710]

Cited: 10 times

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How Do Distance and Solvent Affect Halogen Bonding Involving Negatively Charged Donors?

Zhaoqiang Chen, Guimin Wang, Zhijian Xu, Jinan Wang, Yuqi Yu, Tingting Cai, Qiang Shao, Jiye Shi, Weiliang Zhu,

It was reported that negatively charged donors can form halogen bonding, which is stable, especially, in a polar environment. On the basis of a survey of the Protein Data Bank, we noticed that the distance between the negative charge center and the halogen atom of an organohalogen may vary greatly. ... Read more >>

J Phys Chem B (The journal of physical chemistry. B)
[2016, 120(34):8784-8793]

Cited: 8 times

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Suppression of rat and human androgen biosynthetic enzymes by apigenin: Possible use for the treatment of prostate cancer.

Xiudi Wang, Guimin Wang, Xiaoheng Li, Jianpeng Liu, Tingting Hong, Qiqi Zhu, Ping Huang, Ren-Shan Ge,

Apigenin is a natural flavone. It has recently been used as a chemopreventive agent. It may also have some beneficial effects to treat prostate cancer by inhibiting androgen production. The objective of the present study was to investigate the effects of apigenin on the steroidogenesis of rat immature Leydig cells ... Read more >>

Fitoterapia (Fitoterapia)
[2016, 111:66-72]

Cited: 2 times

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X66, a novel N-terminal heat shock protein 90 inhibitor, exerts antitumor effects without induction of heat shock response.

Zhixin Zhao, Jianming Zhu, Haitian Quan, Guimin Wang, Bo Li, Weiliang Zhu, Chengying Xie, Liguang Lou,

Heat shock protein 90 (HSP90) is essential for cancer cells to assist the function of various oncoproteins, and it has been recognized as a promising target in cancer therapy. Although the HSP90 inhibitors in clinical trials have shown encouraging clinical efficacy, these agents induce heat shock response (HSR), which undermines ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(20):29648-29663]

Cited: 6 times

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Stability and Characteristics of the Halogen Bonding Interaction in an Anion-Anion Complex: A Computational Chemistry Study.

Guimin Wang, Zhaoqiang Chen, Zhijian Xu, Jinan Wang, Yang Yang, Tingting Cai, Jiye Shi, Weiliang Zhu,

Halogen bonding is the noncovalent interaction between the positively charged σ-hole of organohalogens and nucleophiles. In reality, both the organohalogen and nucleophile could be deprotonated to form anions, which may lead to the vanishing of the σ-hole and possible repulsion between the two anions. However, our database survey in this ... Read more >>

J Phys Chem B (The journal of physical chemistry. B)
[2016, 120(4):610-620]

Cited: 12 times

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Macular Abnormalities in Chinese Patients with Uveitis.

Tingting Liu, Hongsheng Bi, Xingrong Wang, Yane Gao, Guimin Wang, Wenzun Ma,

<h4>Purpose</h4>To investigate the prevalence of macular abnormalities in Chinese patients affected by uveitis.<h4>Methods</h4>A retrospective study was performed by reviewing the medical records and high-definition spectral domain optical coherence tomography (SD-OCT) scans in a cohort of 413 uveitis eyes to assess the presence of macular abnormalities.<h4>Results</h4>Macular abnormalities were observed in 242 ... Read more >>

Optom Vis Sci (Optometry and vision science : official publication of the American Academy of Optometry)
[2015, 92(8):858-862]

Cited: 3 times

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Deficiency of CDKN1A or both CDKN1A and CDKN1B affects the pubertal development of mouse Leydig cells.

Han Lin, Yadong Huang, Zhijian Su, Qiqi Zhu, Yufei Ge, Guimin Wang, Claire Q F Wang, Motoko Mukai, Denise R Holsberger, Paul S Cooke, Qing-Quan Lian, Ren-Shan Ge,

Cyclin-dependent kinase inhibitors p21(Cip1) (CDKN1A) and p27(Kip1) (CDKN1B) are expressed in Leydig cells. Previously, we reported that Cdkn1b knockout in the mouse led to increased Leydig cell proliferative capacity and lower steroidogenesis. However, the relative importance of CDKN1A and CDKN1B in these regulations was unclear. In the present study, we ... Read more >>

Biol Reprod (Biology of reproduction)
[2015, 92(3):77]

Cited: 3 times

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Optical coherence tomography and histopathology of macular uveitis.

Yan Cui, Guimin Wang, Yang Li, Ying Wang, Xingrong Wang, Hongsheng Bi,

<h4>Purpose</h4>Spectral-domain optical coherence tomography (SD-OCT) is a noninvasive technique that can provide high-resolution images of macular morphology. The purpose of this study was to examine the pathological mechanism of uveitis and compare the changes in the macula of uveitis patients and the histopathological features of experimentally induced uveitis in mice.<h4>Methods</h4>Macular ... Read more >>

Optom Vis Sci (Optometry and vision science : official publication of the American Academy of Optometry)
[2014, 91(11):1335-1342]

Cited: 5 times

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