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Author Guilherme Godoy

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A High-Fat Diet Induces Lower Systemic Inflammation than a High-Carbohydrate Diet in Mice.

Camila B de Almeida-Souza, Marina M Antunes, Fabiana Carbonera, Guilherme Godoy, Maria A R C P da Silva, Laureane N Masi, Jesui V Visentainer, Rui Curi, Roberto B Bazotte,

<b><i>Background:</i></b> We previously established that male Swiss mice (<i>Mus musculus</i>) receiving a high-fat diet <b>(</b>HFD) during 8 weeks exhibit similar caloric ingestion and body weight (grams) compared with mice fed a high-carbohydrate diet (HCD). HFD mice exhibit a lower inflammatory state than an HCD in the liver, skeletal muscle, and ... Read more >>

Metab Syndr Relat Disord (Metabolic syndrome and related disorders)
[2021, 19(5):296-304]

Cited: 0 times

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The Dietary Replacement of Soybean Oil by Canola Oil Does Not Prevent Liver Fatty Acid Accumulation and Liver Inflammation in Mice.

Marina Masetto Antunes, Guilherme Godoy, Ingrid de Lima Fernandes, Luciana Pelissari Manin, Caroline Zappielo, Laureane Nunes Masi, Vivian Araújo Barbosa de Oliveira, Jesuí Vergílio Visentainer, Rui Curi, Roberto Barbosa Bazotte,

A high-carbohydrate diet (HCD) is a well-established experimental model of accelerated liver fatty acid (FA) deposition and inflammation. In this study, we evaluated whether canola oil can prevent these physiopathological changes. We evaluated hepatic FA accumulation and inflammation in mice fed with a HCD (72.1% carbohydrates) and either canola oil ... Read more >>

Nutrients (Nutrients)
[2020, 12(12):]

Cited: 0 times

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Decreased Docosahexaenoic Acid Levels in Serum of HIV Carrier Patients.

Guilherme Godoy, Marina Masetto Antunes, Maria Angélica Raffaini Covas Pereira da Silva, Ingrid de Lima Fernandes, Jesuí Vergílio Visentainer, Jeane Eliete Laguila Visentainer, Rui Curi, Roberto Barbosa Bazotte,

The study aimed to measure serum fatty acids (FAs) composition in HIV carrier patients and compare it with non-HIV carrier patients. The FAs composition was measured by gas chromatography as follows: four saturated FAs myristic acid (14:0), palmitic acid (16:0), stearic acid (18:0), and docosanoic acid (22:0); four monounsaturated FAs ... Read more >>

J Med Food (Journal of medicinal food)
[2021, 24(6):670-673]

Cited: 0 times

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Primary chemoablation of low-grade upper tract urothelial carcinoma using UGN-101, a mitomycin-containing reverse thermal gel (OLYMPUS): an open-label, single-arm, phase 3 trial.

Nir Kleinmann, Surena F Matin, Phillip M Pierorazio, John L Gore, Ahmad Shabsigh, Brian Hu, Karim Chamie, Guilherme Godoy, Scott Hubosky, Marcelino Rivera, Michael O'Donnell, Marcus Quek, Jay D Raman, John J Knoedler, Douglas Scherr, Joshua Stern, Christopher Weight, Alon Weizer, Michael Woods, Hristos Kaimakliotis, Angela B Smith, Jennifer Linehan, Jonathan Coleman, Mitchell R Humphreys, Raymond Pak, David Lifshitz, Michael Verni, Mehrad Adibi, Mahul B Amin, Elyse Seltzer, Ifat Klein, Marina Konorty, Dalit Strauss-Ayali, Gil Hakim, Mark Schoenberg, Seth P Lerner,

<h4>Background</h4>Most patients with low-grade upper tract urothelial cancer are treated by radical nephroureterectomy. We aimed to assess the safety and activity of a non-surgical treatment using instillation of UGN-101, a mitomycin-containing reverse thermal gel.<h4>Methods</h4>In this open-label, single-arm, phase 3 trial, participants were recruited from 24 academic sites in the USA ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2020, 21(6):776-785]

Cited: 6 times

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Reply by Authors.

Vitaly Margulis, Maneka Puligandla, Edouard J Trabulsi, Elizabeth R Plimack, Elizabeth R Kessler, Surena F Matin, Guilherme Godoy, Ajjai Alva, Noah M Hahn, Michael A Carducci, Jean Hoffman-Censits, ,

J Urol (The Journal of urology)
[2020, 203(4):697-698]

Cited: 0 times

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Phase II Trial of Neoadjuvant Systemic Chemotherapy Followed by Extirpative Surgery in Patients with High Grade Upper Tract Urothelial Carcinoma.

Vitaly Margulis, Maneka Puligandla, Edouard J Trabulsi, Elizabeth R Plimack, Elizabeth R Kessler, Surena F Matin, Guilherme Godoy, Ajjai Alva, Noah M Hahn, Michael A Carducci, Jean Hoffman-Censits, ,

<h4>Purpose</h4>Data supporting neoadjuvant chemotherapy of high grade upper tract urothelial carcinoma are scant. In this multi-institution, prospective, phase II trial we investigated pathological complete responses after neoadjuvant chemotherapy of high grade upper tract urothelial carcinoma.<h4>Materials and methods</h4>Patients with high grade upper tract urothelial carcinoma in whom nephroureterectomy was planned were ... Read more >>

J Urol (The Journal of urology)
[2020, 203(4):690-698]

Cited: 5 times

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ICUD-SIU International Consultation on Bladder Cancer 2017: management of non-muscle invasive bladder cancer.

Leonardo L Monteiro, J Alfred Witjes, Piyush K Agarwal, Christopher B Anderson, Trinity J Bivalacqua, Bernard H Bochner, Joost L Boormans, Sam S Chang, Jose L Domínguez-Escrig, James M McKiernan, Colin Dinney, Guilherme Godoy, Girish S Kulkarni, Paramananthan Mariappan, Michael A O'Donnell, Cyrill A Rentsch, Jay B Shah, Eduardo Solsona, Robert S Svatek, Antoine G van der Heijden, F Johannes P van Valenberg, Wassim Kassouf,

<h4>Purpose</h4>To provide a summary of the Third International Consultation on Bladder Cancer recommendations for the management of non-muscle invasive bladder cancer (NMIBC).<h4>Methods</h4>A detailed review of the literature was performed focusing on original articles for the management of NMIBC. An international committee assessed and graded the articles based on the Oxford ... Read more >>

World J Urol (World journal of urology)
[2019, 37(1):51-60]

Cited: 9 times

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Integrated Molecular Characterization of Testicular Germ Cell Tumors.

Hui Shen, Juliann Shih, Daniel P Hollern, Linghua Wang, Reanne Bowlby, Satish K Tickoo, Vésteinn Thorsson, Andrew J Mungall, Yulia Newton, Apurva M Hegde, Joshua Armenia, Francisco Sánchez-Vega, John Pluta, Louise C Pyle, Rohit Mehra, Victor E Reuter, Guilherme Godoy, Jeffrey Jones, Carl S Shelley, Darren R Feldman, Daniel O Vidal, Davor Lessel, Tomislav Kulis, Flavio M Cárcano, Kristen M Leraas, Tara M Lichtenberg, Denise Brooks, Andrew D Cherniack, Juok Cho, David I Heiman, Katayoon Kasaian, Minwei Liu, Michael S Noble, Liu Xi, Hailei Zhang, Wanding Zhou, Jean C ZenKlusen, Carolyn M Hutter, Ina Felau, Jiashan Zhang, Nikolaus Schultz, Gad Getz, Matthew Meyerson, Joshua M Stuart, , Rehan Akbani, David A Wheeler, Peter W Laird, Katherine L Nathanson, Victoria K Cortessis, Katherine A Hoadley,

We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited high aneuploidy and a paucity of somatic mutations. Somatic mutation of only three genes achieved significance-KIT, KRAS, and NRAS-exclusively in samples with seminoma components. Integrated analyses identified distinct molecular ... Read more >>

Cell Rep (Cell reports)
[2018, 23(11):3392-3406]

Cited: 102 times

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Transurethral biopsy of the prostatic urethra is associated with final apical margin status at radical cystoprostatectomy.

Friedrich-Carl von Rundstedt, Douglas A Mata, Steven Shen, Yi Li, Guilherme Godoy, Seth P Lerner,

<h4>Purpose</h4>Biopsy of the prostatic urethra is an integral part of clinical staging in patients prior to radical cystoprostatectomy (RC) and urinary diversion. We examined whether preoperative transurethral resection (TUR) biopsy was associated with final apical urethral margin status and hypothesized that a negative biopsy could replace intraoperative frozen section for ... Read more >>

J Clin Urol (Journal of clinical urology)
[2016, 9(6):404-408]

Cited: 0 times

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Effects of Androgen and Estrogen Receptor Signaling Pathways on Bladder Cancer Initiation and Progression.

Guilherme Godoy, Georgios Gakis, Carolyn L Smith, Omar Fahmy,

Epidemiologic studies have long demonstrated clear differences in incidence and progression of bladder cancer between genders suggesting that the mechanisms of development and progression in these tumors have a strong association with steroid hormonal pathways. Such observations led to preclinical studies investigating the role of androgen and estrogen receptors, as ... Read more >>

Bladder Cancer (Bladder cancer (Amsterdam, Netherlands))
[2016, 2(2):127-137]

Cited: 21 times

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External Validation of Bladder Cancer Predictive Nomograms for Recurrence, Cancer-Free Survival and Overall Survival following Radical Cystectomy.

Michael Brooks, Guilherme Godoy, Maxine Sun, Shahrokh F Shariat, Gilad E Amiel, Seth P Lerner,

<h4>Purpose</h4>We externally validated 3 previously published nomograms to predicting recurrence, and cancer specific and overall survival following radical cystectomy and pelvic lymph node dissection for urothelial carcinoma of the bladder.<h4>Materials and methods</h4>Two surgeons from a single institution performed a total of 197 consecutive radical cystectomies and pelvic lymph node dissections ... Read more >>

J Urol (The Journal of urology)
[2016, 195(2):283-289]

Cited: 6 times

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Significance of lymphovascular invasion in organ-confined, node-negative urothelial cancer of the bladder: data from the prospective p53-MVAC trial.

Friedrich-Carl von Rundstedt, Douglas A Mata, Susan Groshen, John P Stein, Donald G Skinner, Walter M Stadler, Richard J Cote, Oleksandr N Kryvenko, Guilherme Godoy, Seth P Lerner,

<h4>Objectives</h4>To investigate the association between lymphovascular invasion (LVI) and clinical outcome in organ-confined, node-negative urothelial cancer of the bladder (UCB) in a post hoc analysis of a prospective clinical trial. To explore the effect of adjuvant chemotherapy with methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) on outcome in the subset of ... Read more >>

BJU Int (BJU international)
[2015, 116(1):44-49]

Cited: 8 times

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Erectile dysfunction as a marker for cardiovascular disease diagnosis and intervention: a cost analysis.

Alexander W Pastuszak, Daniel A Hyman, Naveen Yadav, Guilherme Godoy, Larry I Lipshultz, Andre B Araujo, Mohit Khera,

<h4>Introduction</h4>Erectile dysfunction (ED) is a risk factor for cardiovascular disease (CVD). We examine the costs of screening men with ED for CVD risk factors and the cost savings of treating these at risk men.<h4>Aim</h4>This study aims to evaluate the effect of screening men presenting with ED for CVD risk factors ... Read more >>

J Sex Med (The journal of sexual medicine)
[2015, 12(4):975-984]

Cited: 9 times

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Usefulness of transurethral biopsy for staging the prostatic urethra before radical cystectomy.

Friedrich Carl von Rundstedt, Seth P Lerner, Guilherme Godoy, Gilad Amiel, Thomas M Wheeler, Luan D Truong, Steven S Shen,

<h4>Purpose</h4>We determined the likelihood that transurethral resection biopsy of the prostatic urethra adjacent to the verumontanum would detect prostatic involvement of urothelial carcinoma in patients with bladder carcinoma.<h4>Materials and methods</h4>We compared precystectomy transurethral resection biopsy specimens of the prostatic urethra with those of the matched radical cystoprostatectomy in 272 patients ... Read more >>

J Urol (The Journal of urology)
[2015, 193(1):58-63]

Cited: 7 times

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Assessing the quality of studies on the diagnostic accuracy of tumor markers.

Peter J Goebell, Ashish M Kamat, Richard J Sylvester, Peter Black, Michael Droller, Guilherme Godoy, M'Liss A Hudson, Kerstin Junker, Wassim Kassouf, Margaret A Knowles, Wolfgang A Schulz, Roland Seiler, Bernd J Schmitz-Dräger,

<h4>Objectives</h4>With rapidly increasing numbers of publications, assessments of study quality, reporting quality, and classification of studies according to their level of evidence or developmental stage have become key issues in weighing the relevance of new information reported. Diagnostic marker studies are often criticized for yielding highly discrepant and even controversial ... Read more >>

Urol Oncol (Urologic oncology)
[2014, 32(7):1051-1060]

Cited: 10 times

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Prospective evaluation of plasma kinetic bipolar resection of bladder cancer: comparison to monopolar resection and pathologic findings.

Joseph Mashni, Guilherme Godoy, Chadwick Haarer, Guido Dalbagni, Victor E Reuter, Hikmat Al-Ahmadie, Bernard H Bochner,

<h4>Objective</h4>To determine whether the Gyrus ACMI plasma kinetic bipolar device (Gyrus ACMI, Southborough, MA) improves pathologic specimen preservation and clinical outcomes compared to standard monopolar electrocautery.<h4>Patients and methods</h4>In our prospective study, 83 patients underwent monopolar or bipolar transurethral resection of bladder tumors between April 2006 and February 2007 at Memorial ... Read more >>

Int Urol Nephrol (International urology and nephrology)
[2014, 46(9):1699-1705]

Cited: 18 times

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Maternal thyroid hormones during pregnancy, childhood adiposity and cardiovascular risk factors: the Generation R Study.

Guilherme A F Godoy, Tim I M Korevaar, Robin P Peeters, Albert Hofman, Yolanda B de Rijke, Jacoba J Bongers-Schokking, Henning Tiemeier, Vincent W V Jaddoe, Romy Gaillard,

OBJECTIVE: Variation in maternal thyroid function during early pregnancy may permanently affect childhood growth and cardiovascular development. We examined the associations of early pregnancy maternal TSH and free T4 (FT4) levels with childhood growth, body composition and cardiovascular characteristics. METHODS: We performed a population-based prospective cohort study among 5646 mothers ... Read more >>

Clin Endocrinol (Oxf) (Clinical endocrinology)
[2014, 81(1):117-125]

Cited: 14 times

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Comparison of transperineal mapping biopsy results with whole-mount radical prostatectomy pathology in patients with localized prostate cancer.

Darren J Katz, Rodrigo Pinochet, Kyle A Richards, Guilherme Godoy, Kazuma Udo, Lucas Nogueira, Angel M Cronin, Samson W Fine, Peter T Scardino, Jonathon A Coleman,

Objective. We sought to evaluate the accuracy of transperineal mapping biopsy (TMB) by comparing it to the pathology specimen of patients who underwent radical prostatectomy (RP) for localized prostate cancer. Methods. From March 2007 to September 2009, 78 men at a single center underwent TMB; 17 of 78 subsequently underwent ... Read more >>

Prostate Cancer (Prostate cancer)
[2014, 2014:781438]

Cited: 2 times

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Salvage prostatectomy post-definitive radiation therapy: The Vancouver experience.

Niall M Corcoran, Guilherme Godoy, Rodney C Studd, Rowan G Casey, Antonio Hurtado-Coll, Scott Tyldesley, S Larry Goldenberg, Martin E Gleave,

<h4>Introduction</h4>Prostate cancer recurrence following primary radiation is common. If the recurrence remains localized to the prostate gland, surgical removal may result in long-term local control or cure. Despite the well-established oncological outcomes, salvage prostatectomy is infrequently performed or reported. We present our experience with salvage prostatectomy at a Canadian centre.<h4>Methods</h4>We ... Read more >>

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2013, 7(3-4):87-92]

Cited: 1 time

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Testosterone replacement therapy in patients with prostate cancer after radical prostatectomy.

Alexander W Pastuszak, Amy M Pearlman, Win Shun Lai, Guilherme Godoy, Kumaran Sathyamoorthy, Joceline S Liu, Brian J Miles, Larry I Lipshultz, Mohit Khera,

<h4>Purpose</h4>Testosterone replacement therapy in men with prostate cancer is controversial, with concern that testosterone can stimulate cancer growth. We evaluated the safety and efficacy of testosterone in hypogonadal men with prostate cancer treated with radical prostatectomy.<h4>Materials and methods</h4>We performed a review of 103 hypogonadal men with prostate cancer treated with ... Read more >>

J Urol (The Journal of urology)
[2013, 190(2):639-644]

Cited: 67 times

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Innovations in radical cystectomy and pelvic lymph node dissection.

Lambros Stamatakis, Guilherme Godoy, Seth P Lerner,

Radical cystectomy with bilateral pelvic lymphadenectomy remains the gold standard in the surgical management of muscle-invasive urothelial carcinoma of the bladder and provides optimal locoregional cancer control in conjunction with perioperative cisplatin-based chemotherapy. Improvements in preoperative staging can aid in the identification of patients who may optimally benefit from neoadjuvant ... Read more >>

Semin Oncol (Seminars in oncology)
[2012, 39(5):573-582]

Cited: 12 times

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Adenocarcinoma following urinary diversion.

Peter Yicum Jian, Guilherme Godoy, Michael Coburn, Garrett Lynch, Jae Y Ro, Qihui Jim Zhai, Michiya Nishino, Seth P Lerner,

The use of bowel segments in urinary diversions has been associated with an increased risk of neoplasia. This report describes three cases of intestinal adenocarcinoma following urinary diversion. In the first case, a 73-year-old woman developed moderately-differentiated colonic adenocarcinoma in her Indiana pouch 10.5 years after cystectomy. The second case ... Read more >>

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2012, 6(2):E77-80]

Cited: 3 times

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Higher RENAL Nephrometry Score is predictive of longer warm ischemia time and collecting system entry during laparoscopic and robotic-assisted partial nephrectomy.

Wesley A Mayer, Guilherme Godoy, Judy M Choi, Alvin C Goh, Shelly X Bian, Richard E Link,

<h4>Objective</h4>To investigate the predictive value of the RENAL Nephrometry Score (RNS) on operative outcomes during both laparoscopic partial nephrectomy (LPN) and robotic-assisted partial nephrectomy (RPN).<h4>Methods</h4>We reviewed 67 consecutive patients with suspicious renal lesions and available radiographic data who underwent LPN or RPN by a single surgeon. Data included operative type, ... Read more >>

Urology (Urology)
[2012, 79(5):1052-1056]

Cited: 29 times

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Translation and cross-cultural adaptation of the International Hip Outcome Tool (iHOT) into Portuguese.

Giancarlo Cavalli Polesello, Guilherme Finardi Godoy, Christiano Augusto de Castro Trindade, Marcelo Cavalheiro de Queiroz, Emerson Honda, Nelson Keiske Ono,

<h4>Objective</h4>iHOT12/33 is an outcome tool designed for young patients with hip problems. The objective of this study is to translate and establish a cross-cultural adaptation of this questionnaire to Portuguese.<h4>Method</h4>The Guillemin guidelines were followed for the translation and cross-cultural adaptation consisting on: translation, back-translation, prefinal version, administration of the Questionnaire, ... Read more >>

Acta Ortop Bras (Acta ortopedica brasileira)
[2012, 20(2):88-92B]

Cited: 8 times

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Urine survivin as a diagnostic biomarker for bladder cancer: a systematic review.

Ja Hyeon Ku, Guilherme Godoy, Gilad E Amiel, Seth P Lerner,

What's known on the subject? and What does the study add? Although many tests for identifying patients with new or recurrent bladder cancer have been used, a reliable method has yet to be established. Recently, increasing attention has focused on the role of survivin in bladder cancer detection. Because urine ... Read more >>

BJU Int (BJU international)
[2012, 110(5):630-636]

Cited: 25 times

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