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Author Guangming Ye

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Evaluation of sex-related hormones and semen characteristics in reproductive-aged male COVID-19 patients.

Ling Ma, Wen Xie, Danyang Li, Lei Shi, Guangming Ye, Yanhong Mao, Yao Xiong, Hui Sun, Fang Zheng, Zhimin Chen, Jyuling Qin, Jing Lyu, Yuanzhen Zhang, Ming Zhang,

In the past several months, the outbreak of SARS-CoV-2-associated infection (coronavirus disease 2019, COVID-19) developed rapidly and has turned into a global pandemic. Although SARS-CoV-2 mainly attacks respiratory systems, manifestations of multiple organs have been observed. Great concern was raised about whether COVID-19 may affect male reproductive functions. In this ... Read more >>

J. Med. Virol. (Journal of medical virology)
[2020, :]

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Letter to the Editor: Low-density lipoprotein is a potential predictor of poor prognosis in patients with coronavirus disease 2019.

Junli Fan, Hui Wang, Guangming Ye, Xiaoling Cao, Xianqun Xu, Wenbin Tan, Yongxi Zhang,

BACKGROUND:The pandemic of coronavirus disease 2019 (COVID-19) has become a global threat to public health. The lipid pathophysiology in COVID-19 is unknown. METHODS:In this retrospective longitudinal study, we monitored the serum lipids in 17 surviving and 4 non-surviving COVID-19 cases prior to their viral infections and duration the entire disease ... Read more >>

Metab. Clin. Exp. (Metabolism: clinical and experimental)
[2020, 107:154243]

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Environmental contamination of SARS-CoV-2 in healthcare premises.

Guangming Ye, Hualiang Lin, Song Chen, Shichan Wang, Zhikun Zeng, Wei Wang, Shiyu Zhang, Terri Rebmann, Yirong Li, Zhenyu Pan, Zhonghua Yang, Ying Wang, Fubing Wang, Zhengmin Qian, Xinghuan Wang,

OBJECTIVES:A large number of healthcare workers (HCWs) were infected by SARS-CoV-2 during the ongoing outbreak of COVID-19 in Wuhan, China. Hospitals are significant epicenters for the human-to-human transmission of the SARS-CoV-2 for HCWs, patients, and visitors. No data has been reported on the details of hospital environmental contamination status in ... Read more >>

J. Infect. (The Journal of infection)
[2020, :]

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The presence of SARS-CoV-2 RNA in the feces of COVID-19 patients.

Yifei Chen, Liangjun Chen, Qiaoling Deng, Guqin Zhang, Kaisong Wu, Lan Ni, Yibin Yang, Bing Liu, Wei Wang, Chaojie Wei, Jiong Yang, Guangming Ye, Zhenshun Cheng,

In December 2019, coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in Wuhan, China, and has spread globally. However, the transmission route of SARS-CoV-2 has not been fully understood. In this study, we aimed to investigate SARS-CoV-2 shedding in the excreta of COVID-19 patients. Electronical ... Read more >>

J. Med. Virol. (Journal of medical virology)
[2020, 92(7):833-840]

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Family cluster of three recovered cases of pneumonia due to severe acute respiratory syndrome coronavirus 2 infection.

Yong Xiong, Shihui Song, Guangming Ye, Xinghuan Wang,

The coronavirus disease (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China, in late 2019 and has affected more than 1 270 000 people worldwide. The numbers of reported cases continue to rise and threaten global health. Transmissions among family members are frequently observed, ... Read more >>

BMJ Case Rep (BMJ case reports)
[2020, 13(5):]

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Re: Profile of specific antibodies to SARS-CoV-2: The first report.

Zhikun Zeng, Liangjun Chen, Yunbao Pan, Qiaoling Deng, Guangming Ye, Yirong Li, Xinghuan Wang,

J. Infect. (The Journal of infection)
[2020, 81(1):e80-e81]

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Asymptomatic SARS-CoV-2 Infection in Household Contacts of a Healthcare Provider, Wuhan, China.

Yi Luo, Edwin Trevathan, Zhengmin Qian, Yirong Li, Jin Li, Wei Xiao, Ning Tu, Zhikun Zeng, Pingzheng Mo, Yong Xiong, Guangming Ye,

We found that all 5 asymptomatic household contacts of a Wuhan, China, physician with coronavirus disease had severe acute respiratory syndrome coronavirus 2 detected by PCR. The index patient and 2 contacts also had abnormal chest computed tomography scans. Asymptomatic infected household contacts of healthcare workers with coronavirus disease might ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2020, 26(8):]

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Environmental contamination of the SARS-CoV-2 in healthcare premises: An urgent call for protection for healthcare workers

Guangming Ye, Hualiang Lin, Liangjun Chen, Shichan Wang, Zhikun Zeng, Wei Wang, Shiyu Zhang, Terri Rebmann, Yirong Li, Zhenyu Pan, Zhonghua Yang, Ying Wang, Fubing Wang, Zhengmin Qian, Xinghuan Wang,

Importance A large number of healthcare workers (HCWs) were infected by SARS-CoV-2 during the ongoing outbreak of COVID-19 in Wuhan, China. Hospitals are significant epicenters for the human-to-human transmission of the SARS-CoV-2 for HCWs, patients, and visitors. No data has been reported on the details of hospital environmental contamination status ... Read more >>

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Can routine laboratory tests discriminate 2019 novel coronavirus infected pneumonia from other community-acquired pneumonia?

Yunbao Pan, Guangming Ye, Xiantao Zeng, Guohong Liu, Xiaojiao Zeng, Xianghu Jiang, Jin Zhao, Liangjun Chen, Shuang Guo, Qiaoling Deng, Xiaoyue Hong, Ying Yang, Yirong Li, Xinghuan Wang,

Background. The clinical presentation of 2019 Novel Coronavirus (2019-nCov) infected pneumonia (NCIP) resembles that of other etiologies of community-acquired pneumonia (CAP). We aimed to identify clinical laboratory features to distinguish NCIP from CAP. Methods. We compared the ability of the hematological and biochemical features of 84 patients with NCIP at ... Read more >>

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Clinical characteristics of severe acute respiratory syndrome coronavirus 2 reactivation.

Guangming Ye, Zhenyu Pan, Yunbao Pan, Qiaoling Deng, Liangjun Chen, Jin Li, Yirong Li, Xinghuan Wang,

OBJECTIVES:Previous studies on the pneumonia outbreak caused by the 2019 novel coronavirus disease (COVID-19) were based on information from the general population. However, limited data was available for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reactivation. This study aimed to evaluate the clinical characteristics of the SARS-CoV-2 reactivation. METHODS:Clinical records, ... Read more >>

J. Infect. (The Journal of infection)
[2020, 80(5):e14-e17]

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Positive RT-PCR Test Results in Patients Recovered From COVID-19.

Lan Lan, Dan Xu, Guangming Ye, Chen Xia, Shaokang Wang, Yirong Li, Haibo Xu,

JAMA (JAMA)
[2020, :]

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Can routine laboratory tests discriminate SARS-CoV-2-infected pneumonia from other causes of community-acquired pneumonia?

Yunbao Pan, Guangming Ye, Xiantao Zeng, Guohong Liu, Xiaojiao Zeng, Xianghu Jiang, Jin Zhao, Liangjun Chen, Shuang Guo, Qiaoling Deng, Xiaoyue Hong, Ying Yang, Yirong Li, Xinghuan Wang,

BACKGROUND:The clinical presentation of SARS-CoV-2-infected pneumonia (COVID-19) resembles that of other etiologies of community-acquired pneumonia (CAP). We aimed to identify clinical laboratory features to distinguish COVID-19 from CAP. METHODS:We compared the hematological and biochemical features of 84 patients with COVID-19 at hospital admission and 221 patients with CAP. Parameters independently ... Read more >>

Clin Transl Med (Clinical and translational medicine)
[2020, 10(1):161-168]

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RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak.

Liangjun Chen, Weiyong Liu, Qi Zhang, Ke Xu, Guangming Ye, Weichen Wu, Ziyong Sun, Fang Liu, Kailang Wu, Bo Zhong, Yi Mei, Wenxia Zhang, Yu Chen, Yirong Li, Mang Shi, Ke Lan, Yingle Liu,

From December 2019, an outbreak of unusual pneumonia was reported in Wuhan with many cases linked to Huanan Seafood Market that sells seafood as well as live exotic animals. We investigated two patients who developed acute respiratory syndromes after independent contact history with this market. The two patients shared common ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):313-319]

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APOE gene polymorphism in long-lived individuals from a central China population.

Guodong Liu, Xiang Liu, Pulin Yu, Qi Wang, Hua Wang, Chenfang Li, Guangming Ye, Xiaoling Wu, Chunling Tan,

Previous studies from European and East Asian cohorts reported conflicting results over whether and how the frequencies of the three common alleles, ε2, ε3 and ε4, of the apolioprotein E gene (APOE), in long-lived individuals differ from those in younger age groups. This study was the first to analyse these ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):3292]

Cited: 1 time

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Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice.

Feng Wu, Yihua Qiu, Guangming Ye, Hede Luo, Junsong Jiang, Feng Yu, Wei Zhou, Shuai Zhang, Jinzhong Feng,

Diabetic cardiomyopathy, a disorder of the heart muscle in diabetic patients, is one of the major causes of heart failure. The aim of present study was to investigate the therapeutic effect of hydrogen molecule on streptozotocin-induced diabetic cardiomyopathy in mice.Diabetes was induced in adult male mice by consecutive peritoneal injection ... Read more >>

Cardiovasc. Pathol. (Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology)
[2015, 24(5):294-303]

Cited: 4 times

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Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells.

Jia Nie, Chao Sun, Omar Faruque, Guangming Ye, Jia Li, Qiangrong Liang, Zhijie Chang, Wannian Yang, Xiao Han, Yuguang Shi,

The p21-activated kinase-1 (PAK1) is implicated in regulation of insulin exocytosis as an effector of Rho GTPases. PAK1 is activated by the onset of glucose-stimulated insulin secretion (GSIS) through phosphorylation of Thr-423, a major activation site by Cdc42 and Rac1. However, the kinase(s) that phosphorylates PAK1 at Thr-423 in islet ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2012, 287(31):26435-26444]

Cited: 21 times

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Functional identification of a novel 14-3-3 epsilon splicing variant suggests dimerization is not necessary for 14-3-3 epsilon to inhibit UV-induced apoptosis.

Dingding Han, Guangming Ye, Tingting Liu, Cong Chen, Xianmei Yang, Bo Wan, Yuanwang Pan, Long Yu,

14-3-3 proteins function as a dimer and have been identified to involve in diverse signaling pathways. Here we reported the identification of a novel splicing variant of human 14-3-3 epsilon (14-3-3 epsilon sv), which is derived from a novel exon 1' insertion. The insertion contains a stop codon and leads ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2010, 396(2):401-406]

Cited: 13 times

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Characterization of a novel human CDK5 splicing variant that inhibits Wnt/beta-catenin signaling.

Qiang Li, Xianghua Liu, Mingjun Zhang, Guangming Ye, Qian Qiao, Yichen Ling, Yanhua Wu, Yuanyuan Zhang, Long Yu,

The cyclin-dependent kinases (CDKs) are a family of serine/threonine kinases, playing an essential role in regulating cell-cycle progression. In our present work, human CDK5 and a novel CDK5 splicing variant, named as CDK5-SV, were cloned from the cDNA library of human testis. CDK5-SV lacking the exon 7 of CDK5 encodes ... Read more >>

Mol. Biol. Rep. (Molecular biology reports)
[2010, 37(5):2415-2421]

Cited: 9 times

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Simultaneous determination of vancomycin and ceftazidime in cerebrospinal fluid in craniotomy patients by high-performance liquid chromatography.

Guangming Ye, Xuejian Cai, Biao Wang, Zhongxian Zhou, Xiaohua Yu, Weibin Wang, Jiandong Zhang, Yuhai Wang, Jierong Dong, Yunyun Jiang,

A simple, accurate and rapid method for simultaneous analysis of vancomycin and ceftazidime in cerebrospinal fluid (CSF), utilizing high-performance liquid chromatography (HPLC), has been developed and thoroughly validated to satisfy strict FDA guidelines for bioanalytical methods. Protein precipitation was used as the sample pretreatment method. In order to increase the ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2008, 48(3):860-865]

Cited: 13 times

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Molecular Cloning and Characterization of a Novel Human Glycine-N-acyltransferase Gene 1, Which Activates Transcriptional Activity of HSE Pathway.

Haoxing Zhang, Qingyu Lang, Jie Li, Zhaomin Zhong, Fang Xie, Guangming Ye, Bo Wan, Long Yu,

The glycine-N-acyltransferase (GLYAT) is well known to be involved in the detoxification of endogenous and exogenous xenobiotic acyl-CoA’s in mammals. Unfortunately, the knowledge about the gene encoding GLYAT is very limited. Here we report a novel gene encoding a GLYAT member, designated as GLYATL1, which was 1546 base pairs in ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2007, 8(5):433-444]

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Cloning of a novel human NHEDC1 (Na+/H+ exchanger like domain containing 1) gene expressed specifically in testis.

Guangming Ye, Cong Chen, Dingding Han, Xiabin Xiong, Yahui Kong, Bo Wan, Long Yu,

The Na+/H+ exchangers (NHEs) catalyze the transport of Na+ in exchange for H+ across membranes in organisms and are required for numerous physiological processes. Here we report the cloning and characterization of a novel human NHEDC1 (Na+/H+ exchanger like domain containing 1) gene, which was mapped to human chromosome 4p24. ... Read more >>

Mol. Biol. Rep. (Molecular biology reports)
[2006, 33(3):175-180]

Cited: 11 times

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