Full Text Journal Articles by
Author Guanglei Zhuang

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Urinary Molecular Pathology for Patients with Newly Diagnosed Urothelial Bladder Cancer.

Ruiyun Zhang, Jingyu Zang, Feng Xie, Yue Zhang, Yiqiu Wang, Ying Jing, Yi Zhang, Zhaoxiong Chen, Akezhouli Shahatiaili, Mei-Chun Cai, Zhixin Zhao, Pan Du, Shidong Jia, Guanglei Zhuang, Haige Chen,

<h4>Purpose</h4>Next-generation sequencing (NGS)-based profiling of both urinary tumor DNA (utDNA) and circulating tumor DNA (ctDNA) shows promise for noninvasive detection and surveillance of urothelial bladder cancer (UBC). However, the analytic performance of these assays remains undefined in the real-world setting. Here, we sought to evaluate the concordance between tumor DNA ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001878]

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Radiographic features and prognosis of early- and late-onset non-small cell lung cancer immune checkpoint inhibitor-related pneumonitis.

Aiben Huang, Yang Xu, Xuelei Zang, Chongchong Wu, Jie Gao, Xiaoli Sun, Mei Xie, Xidong Ma, Hui Deng, Jialin Song, Fangping Ren, Li Pang, Jin Qian, Zhaofeng Yu, Shiyu Wan, Yuanyuan Chen, Lei Pan, Guanglei Zhuang, Sanhong Liu, Xinying Xue,

<h4>Background</h4>Immunotherapy is becoming a standard of care for non-small cell lung cancer (NSCLC). Checkpoint inhibitor-associated pneumonia (CIP) is a rare and potentially life-threatening event that can occur at any time during tumor immunotherapy. However, there may be differences in the radiological patterns and prognosis of CIP during different periods. This ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):634]

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Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2.

Hengyue Shan, Jianping Liu, Jiali Shen, Jialin Dai, Gang Xu, Kuankuan Lu, Chao Han, Yaru Wang, Xiaolong Xu, Yilun Tong, Huaijiang Xiang, Zhiyuan Ai, Guanglei Zhuang, Junhao Hu, Zheng Zhang, Ying Li, Lifeng Pan, Li Tan,

The COVID-19 pandemic has been disastrous to society and effective drugs are urgently needed. The papain-like protease domain (PLpro) of SARS-CoV-2 (SCoV2) is indispensable for viral replication and represents a putative target for pharmacological intervention. In this work, we describe the development of a potent and selective SCoV2 PLpro inhibitor, ... Read more >>

Cell Chem Biol (Cell chemical biology)
[2021, :]

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Radiographic Features and Prognosis of Early- and Late-onset Non-small Cell Lung Cancer Immune Checkpoint Inhibitor-related Pneumonitis

Aiben Huang, Yang Xu, Xuelei Zang, Chongchong Wu, Jie Gao, Xiaoli Sun, Mei Xie, Xidong Ma, Hui Deng, Jialin Song, Fangping Ren, Li Pang, Jin Qian, Zhaofeng Yu, Shiyu Wan, Yuanyuan Chen, Lei Pan, Guanglei Zhuang, Sanhong Liu, Xinying Xue,

<h4>Background: </h4> Immunotherapy is becoming a standard of care for non-small cell lung cancer (NSCLC). Checkpoint inhibitor-associated pneumonia (CIP) is a rare and potentially life-threatening event that can occur at any time during tumor immunotherapy. However, there may be differences in the radiological patterns and prognosis of CIP during different ... Read more >>

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Erratum: Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through repression of phosphoglycerate dehydrogenase: Erratum.

Jiang-Kai Dong, Hui-Min Lei, Qian Liang, Ya-Bin Tang, Ye Zhou, Yang Wang, Shengzhe Zhang, Wen-Bin Li, Yunguang Tong, Guanglei Zhuang, Liang Zhang, Hong-Zhuan Chen, Liang Zhu, Ying Shen,

[This corrects the article DOI: 10.7150/thno.23177.]. ... Read more >>

Theranostics (Theranostics)
[2021, 11(8):3963]

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Immunotherapy in the Treatment of Urothelial Bladder Cancer: Insights From Single-Cell Analysis

Jingyu Zang, Kaiyan Ye, Yang Fei, Ruiyun Zhang, Haige Chen, Guanglei Zhuang,

Urothelial bladder cancer (UBC) is a global challenge of public health with limited therapeutic options. Although the emergence of cancer immunotherapy, most notably immune checkpoint inhibitors, represents a major breakthrough in the past decade, many patients still suffer from unsatisfactory clinical outcome. A thorough understanding of the fundamental cellular and ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:]

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Multi-omics prediction of immune-related adverse events during checkpoint immunotherapy.

Ying Jing, Jin Liu, Youqiong Ye, Lei Pan, Hui Deng, Yushu Wang, Yang Yang, Lixia Diao, Steven H Lin, Gordon B Mills, Guanglei Zhuang, Xinying Xue, Leng Han,

Immune-related adverse events (irAEs), caused by anti-PD-1/PD-L1 antibodies, can lead to fulminant and even fatal consequences and thus require early detection and aggressive management. However, a comprehensive approach to identify biomarkers of irAE is lacking. Here, we utilize a strategy that combines pharmacovigilance data and omics data, and evaluate associations ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):4946]

Cited: 1 time

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Baseline immunity and impact of chemotherapy on immune microenvironment in cervical cancer.

Yi Zhang, Minhua Yu, Ying Jing, Jiejun Cheng, Caiyan Zhang, Lin Cheng, Haijiao Lu, Mei-Chun Cai, Jie Wu, Wenjing Wang, Weihua Lou, Lihua Qiu, Li Tan, Huaiwu Lu, Xia Yin, Guanglei Zhuang, Wen Di,

<h4>Background</h4>We aimed to comprehensively evaluate the immunologic landscape at baseline and upon chemotherapy in cervical cancer. The information should aid ongoing clinical investigations of checkpoint blockade immunotherapies in this disease setting.<h4>Methods</h4>A series of 109 cervical carcinoma patients was retrospectively assayed before and after neoadjuvant chemotherapy. Tumour-infiltrating immune markers (CD3, CD4, ... Read more >>

Br J Cancer (British journal of cancer)
[2021, 124(2):414-424]

Cited: 1 time

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T-cell exhaustion interrelates with immune cytolytic activity to shape the inflamed tumor microenvironment.

Mei-Chun Cai, Xiaojing Zhao, Min Cao, Pengfei Ma, Minjiang Chen, Jie Wu, Chenqiang Jia, Chunming He, Yujie Fu, Li Tan, Xinying Xue, Zhuang Yu, Guanglei Zhuang,

Direct quantification of exhausted T cells in human cancer is lacking, and its predictive value for checkpoint-based treatment remains poorly investigated. We sought to systematically characterize the pan-cancer landscape and molecular hallmarks of T-cell dysfunction for the purpose of precision immunotherapy. Here, we defined a transcriptional signature for T-cell exhaustion ... Read more >>

J Pathol (The Journal of pathology)
[2020, 251(2):147-159]

Cited: 1 time

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Multiregion whole-genome sequencing depicts intratumour heterogeneity and punctuated evolution in ovarian clear cell carcinoma.

Xia Yin, Rui Bi, Pengfei Ma, Shengzhe Zhang, Yang Zhang, Yunheng Sun, Yi Zhang, Ying Jing, Minhua Yu, Wenjing Wang, Li Tan, Wen Di, Guanglei Zhuang, Mei-Chun Cai,

<h4>Background</h4>Ovarian clear cell carcinoma (OCCC) arises from endometriosis and represents a difficult-to-treat gynaecological malignancy, in part, because its spatial intratumour heterogeneity and temporal evolutionary trajectories have not been explicitly defined.<h4>Methods</h4>We performed whole-genome sequencing on six pathologically confirmed patients with OCCC. An R package named KataegisPortal was developed to identify and ... Read more >>

J Med Genet (Journal of medical genetics)
[2020, 57(9):605-609]

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PAX8 regulon in human ovarian cancer links lineage dependency with epigenetic vulnerability to HDAC inhibitors.

Kaixuan Shi, Xia Yin, Mei-Chun Cai, Ying Yan, Chenqiang Jia, Pengfei Ma, Shengzhe Zhang, Zhenfeng Zhang, Zhenyu Gu, Meiying Zhang, Wen Di, Guanglei Zhuang,

PAX8 is a prototype lineage-survival oncogene in epithelial ovarian cancer. However, neither its underlying pro-tumorigenic mechanisms nor potential therapeutic implications have been adequately elucidated. Here, we identified an ovarian lineage-specific PAX8 regulon using modified cancer outlier profile analysis, in which PAX8-FGF18 axis was responsible for promoting cell migration in an ... Read more >>

Elife (eLife)
[2019, 8:]

Cited: 8 times

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Clinicopathological, microenvironmental and genetic determinants of molecular subtypes in KEAP1/NRF2-mutant lung cancer.

Mei-Chun Cai, Minjiang Chen, Pengfei Ma, Jie Wu, Haijiao Lu, Shengzhe Zhang, Jin Liu, Xiaojing Zhao, Guanglei Zhuang, Zhuang Yu, Yujie Fu,

Somatic KEAP1-NRF2 pathway alterations are frequently detected in both lung adenocarcinomas and squamous cell carcinomas. However, the biological characteristics and molecular subtypes of KEAP1/NRF2-mutant lung cancer remain largely undefined. Here, we performed a stepwise, integrative analytic and experimental interrogation of primary tumors and cancer cell lines harboring KEAP1 or NFE2L2 ... Read more >>

Int J Cancer (International journal of cancer)
[2019, 144(4):788-801]

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Hybrid sequencing-based personal full-length transcriptomic analysis implicates proteostatic stress in metastatic ovarian cancer.

Ying Jing, Yi Zhang, Hui Zhu, Ke Zhang, Mei-Chun Cai, Pengfei Ma, Peiye Shen, Zhenfeng Zhang, Minghui Shao, Jing Wang, Minhua Yu, Xia Yin, Meiying Zhang, Yuan Hu, Danni Chen, Wen Di, Xiaojie Wang, Guanglei Zhuang,

Comprehensive molecular characterization of myriad somatic alterations and aberrant gene expressions at personal level is key to precision cancer therapy, yet limited by current short-read sequencing technology, individualized catalog of complete genomic and transcriptomic features is thus far elusive. Here, we integrated second- and third-generation sequencing platforms to generate a ... Read more >>

Oncogene (Oncogene)
[2019, 38(16):3047-3060]

Cited: 1 time

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Molecular Targeted Therapies Elicit Concurrent Apoptotic and GSDME-Dependent Pyroptotic Tumor Cell Death.

Haijiao Lu, Shengzhe Zhang, Jie Wu, Minjiang Chen, Mei-Chun Cai, Yujie Fu, Wenfeng Li, Jing Wang, Xiaojing Zhao, Zhuang Yu, Pengfei Ma, Guanglei Zhuang,

<h4>Purpose</h4>The induced death signals following oncogene inhibition underlie clinical efficacy of molecular targeted therapies against human cancer, and defects of intact cell apoptosis machinery often lead to therapeutic failure. Despite potential importance, other forms of regulated cell death triggered by pharmacologic intervention have not been systematically characterized.<h4>Experimental design</h4>Pyroptotic cell death ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2018, 24(23):6066-6077]

Cited: 32 times

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Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors.

Shengzhe Zhang, Meiying Zhang, Ying Jing, Xia Yin, Pengfei Ma, Zhenfeng Zhang, Xiaojie Wang, Wen Di, Guanglei Zhuang,

MCL1 is a pivot member of the anti-apoptotic BCL-2 family proteins. While a distinctive feature of MCL1 resides in its efficient ubiquitination and destruction, the deubiquitinase USP9X has been implicated in the preservation of MCL1 expression by removing the polyubiquitin chains. Here we perform an unbiased siRNA screen and identify ... Read more >>

Nat Commun (Nature communications)
[2018, 9(1):215]

Cited: 29 times

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Comprehensive genomic profiling of neuroendocrine bladder cancer pinpoints molecular origin and potential therapeutics.

Peiye Shen, Ying Jing, Ruiyun Zhang, Mei-Chun Cai, Pengfei Ma, Haige Chen, Guanglei Zhuang,

Neuroendocrine bladder cancer is a relatively rare but often lethal malignancy, with cell of origin, oncogenomic architecture and standard treatment poorly defined. Here we performed comprehensive whole-genome and transcriptome sequencing on a unique cohort of genitourinary neuroendocrine neoplasms, mainly small cell carcinomas of the urinary bladder. The mutational landscape and ... Read more >>

Oncogene (Oncogene)
[2018, 37(22):3039-3044]

Cited: 6 times

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Prevalence and clonality of synchronous primary carcinomas in the bladder and prostate.

Ying Jing, Ruiyun Zhang, Pengfei Ma, Mei-Chun Cai, Guanglei Zhuang, Haige Chen,

Incidental prostate adenocarcinoma (IPCa) has been frequently discovered during postoperative histopathological evaluation of radical cystoprostatectomy specimens in patients with bladder cancer (BCa). However, there is currently no conclusive study addressing the clinical significance of IPCa and the clonal relatedness of IPCa and BCa. Here, we performed a retrospective single-center review ... Read more >>

J Pathol (The Journal of pathology)
[2018, 244(1):5-10]

Cited: 0 times

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Clonality, Heterogeneity, and Evolution of Synchronous Bilateral Ovarian Cancer.

Xia Yin, Ying Jing, Mei-Chun Cai, Pengfei Ma, Yi Zhang, Cong Xu, Meiying Zhang, Wen Di, Guanglei Zhuang,

Synchronous bilateral ovarian cancer (SBOC) represents a relatively frequent occurrence and clinically relevant diagnostic dilemma. Delineation of its clonal architecture, genetic heterogeneity, and evolutionary trajectories may have important implications for prognosis and management of patients with SBOC. Here, we describe the results of next-generation whole-exome or whole-genome sequencing of specimens ... Read more >>

Cancer Res (Cancer research)
[2017, 77(23):6551-6561]

Cited: 10 times

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Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer.

Pengfei Ma, Yujie Fu, Mei-Chun Cai, Ying Yan, Ying Jing, Shengzhe Zhang, Minjiang Chen, Jie Wu, Ying Shen, Liang Zhu, Hong-Zhuan Chen, Wei-Qiang Gao, Mengzhao Wang, Zhenyu Gu, Trever G Bivona, Xiaojing Zhao, Guanglei Zhuang,

Recent genomic analyses have revealed substantial tumor heterogeneity across various cancers. However, it remains unclear whether and how genomic heterogeneity is constrained during tumor evolution. Here, we sequence a unique cohort of multiple synchronous lung cancers (MSLCs) to determine the relative diversity and uniformity of genetic drivers upon identical germline ... Read more >>

Nat Commun (Nature communications)
[2017, 8(1):823]

Cited: 18 times

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Preclinical Efficacy and Molecular Mechanism of Targeting CDK7-Dependent Transcriptional Addiction in Ovarian Cancer.

Zhenfeng Zhang, Huixin Peng, Xiaojie Wang, Xia Yin, Pengfei Ma, Ying Jing, Mei-Chun Cai, Jin Liu, Meiying Zhang, Shengzhe Zhang, Kaixuan Shi, Wei-Qiang Gao, Wen Di, Guanglei Zhuang,

Ovarian cancer remains a significant cause of gynecologic cancer mortality, and novel therapeutic strategies are urgently needed in clinic as new treatment options. We previously showed that BET bromodomain inhibitors displayed promising efficacy for the treatment of epithelial ovarian cancer by downregulating pivot transcription factors. However, the potential antitumor activities ... Read more >>

Mol Cancer Ther (Molecular cancer therapeutics)
[2017, 16(9):1739-1750]

Cited: 15 times

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TP53 mutation-mediated genomic instability induces the evolution of chemoresistance and recurrence in epithelial ovarian cancer.

Meiying Zhang, Guanglei Zhuang, Xiangjun Sun, Yanying Shen, Wenjing Wang, Qing Li, Wen Di,

<h4>Background</h4>Genomic instability caused by mutation of the checkpoint molecule TP53 may endow cancer cells with the ability to undergo genomic evolution to survive stress and treatment. We attempted to gain insight into the potential contribution of ovarian cancer genomic instability resulted from TP53 mutation to the aberrant expression of multidrug ... Read more >>

Diagn Pathol (Diagnostic pathology)
[2017, 12(1):16]

Cited: 15 times

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A VEGF-dependent gene signature enriched in mesenchymal ovarian cancer predicts patient prognosis.

Xia Yin, Xiaojie Wang, Boqiang Shen, Ying Jing, Qing Li, Mei-Chun Cai, Zhuowei Gu, Qi Yang, Zhenfeng Zhang, Jin Liu, Hongxia Li, Wen Di, Guanglei Zhuang,

We have previously reported surrogate biomarkers of VEGF pathway activities with the potential to provide predictive information for anti-VEGF therapies. The aim of this study was to systematically evaluate a new VEGF-dependent gene signature (VDGs) in relation to molecular subtypes of ovarian cancer and patient prognosis. Using microarray profiling and ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:31079]

Cited: 8 times

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Adaptive and Acquired Resistance to EGFR Inhibitors Converge on the MAPK Pathway.

Pengfei Ma, Yujie Fu, Minjiang Chen, Ying Jing, Jie Wu, Ke Li, Ying Shen, Jian-Xin Gao, Mengzhao Wang, Xiaojing Zhao, Guanglei Zhuang,

Both adaptive and acquired resistance significantly limits the efficacy of the epidermal growth factor receptor (EGFR) kinase inhibitors. However, the distinct or common mechanisms of adaptive and acquired resistance have not been fully characterized. Here, through systematic modeling of erlotinib resistance in lung cancer, we found that feedback reactivation of ... Read more >>

Theranostics (Theranostics)
[2016, 6(8):1232-1243]

Cited: 19 times

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Concomitant BET and MAPK blockade for effective treatment of ovarian cancer.

Ying Jing, Zhenfeng Zhang, Pengfei Ma, Shimin An, Ying Shen, Liang Zhu, Guanglei Zhuang,

Ovarian cancer is the most lethal gynecologic malignancy, and it is imperative to develop new treatments to ameliorate patient survival. Using an anti-cancer drug library containing 180 small molecule inhibitors, we performed a high-content image-based screen and found that BET and MEK inhibitors are among the candidates which were able ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(3):2545-2554]

Cited: 19 times

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Risk prediction model for epithelial ovarian cancer using molecular markers and clinical characteristics.

Meiying Zhang, Guanglei Zhuang, Xiangjun Sun, Yanying Shen, Aimin Zhao, Wen Di,

BACKGROUND:A high-quality risk prediction model is urgently needed for the clinical management of ovarian cancer. However most existing models are solely based on clinical parameters, and molecular classifications in recent reports are still being debated. This study aimed to establish a risk prediction model by using both clinicopathological and molecular ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2015, 8:67]

Cited: 7 times

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