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Author Guanghua Liu

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The effects of different parity and delivery mode on wheezing disorders in the children-a retrospective cohort study in Fujian, China.

Haiyan Gao, Chong Miao, Haibo Li, Meng Bai, Huijie Zhang, Zhengqin Wu, Wei Li, Wenjuan Liu, Libo Xu, Guanghua Liu, Yibing Zhu,

<h4>Background</h4>The relationship between childbirth delivery methods and the risk of wheezing in children remains controversial. Few studies have explored it under different maternal conditions.<h4>Objective</h4>To explore the influence of childbirth delivery method on the onset of wheezing in children of different parity.<h4>Methods</h4>A total of 21716 patients were included in this retrospective ... Read more >>

J Asthma (The Journal of asthma : official journal of the Association for the Care of Asthma)
[2021, :1-8]

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Seeded Synthesis of Unconventional 2H-Phase Pd Alloy Nanomaterials for Highly Efficient Oxygen Reduction.

Yiyao Ge, Xixi Wang, Biao Huang, Zhiqi Huang, Bo Chen, Chongyi Ling, Jiawei Liu, Guanghua Liu, Jie Zhang, Gang Wang, Ye Chen, Lujiang Li, Lingwen Liao, Lei Wang, Qinbai Yun, Zhuangchai Lai, Shiyao Lu, Qinxin Luo, Jinlan Wang, Zijian Zheng, Hua Zhang,

Crystal phase engineering of noble-metal-based alloy nanomaterials paves a new way to the rational synthesis of high-performance catalysts for various applications. However, the controlled preparation of noble-metal-based alloy nanomaterials with unconventional crystal phases still remains a great challenge due to their thermodynamically unstable nature. Herein, we develop a robust and ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2021, :]

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Correction: A machine learning approach to predict intravenous immunoglobulin resistance in Kawasaki disease patients: A study based on a Southeast China population.

Tengyang Wang, Guanghua Liu, Hongye Lin,

[This corrects the article DOI: 10.1371/journal.pone.0237321.]. ... Read more >>

PLoS One (PloS one)
[2021, 16(6):e0253675]

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Design and Implementation of 16 Quality Indices for Neonatal Screening

Yao Chen, Yinglin Zeng, Xiaolong Qiu, Feng Lin, Hong Zhao, Honghua Zhang, Weifen Chen, Qingying Lin, Guanghua Liu, Wenbin Zhu,

<h4>Background: </h4> We aim to explore the realization of 16 quality control indices of neonatal disease screening in neonatal disease management information system, and to establish the multi-center management evaluation model under the framework of the whole province. <h4>Methods: </h4>: Based on the network management system for neonatal screening originally ... Read more >>

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Age-specific risk factors of severe pneumonia among pediatric patients hospitalized with community-acquired pneumonia.

Lumin Chen, Chong Miao, Yanling Chen, Xian Han, Ziying Lin, Hong Ye, Chengyi Wang, Huijie Zhang, Jingjing Li, Qiuyu Tang, Yuan Dong, Meng Bai, Yibing Zhu, Guanghua Liu,

<h4>Background</h4>Risk factors that predispose the development of severe community-acquired pneumonia (CAP) among pediatric CAP patients of different age ranges are yet to be identified.<h4>Methods</h4>We retrospectively analyzed pediatric in-patients (< 6 years old) diagnosed with CAP in our hospital. We subdivided patients into four age groups (< 6 months, 6 months-1 year, 1-2 years, and 2-6 years). Their medical ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2021, 47(1):100]

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Retroperitoneoscopic partial nephrectomy using a 980/1470-nm dual-diode laser for small exophytic renal tumors.

Jie Dong, Weifeng Xu, Guanghua Liu, Yi Xie, Yi Qiao, Zhigang Ji,

Laser-supported laparoscopic partial nephrectomy is a promising new technique, but remains under experiment. We presented our single institutional experience of laparoscopic partial nephrectomy using the 980/1470-nm dual-diode laser system to investigate its feasibility, and oncological and functional outcomes. The study retrospectively evaluated 25 patients with small exophytic renal tumors, who ... Read more >>

Lasers Med Sci (Lasers in medical science)
[2021, :]

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Gene diagnosis and pedigree analysis of two Han ethnicity families with propionic acidemia in Fujian.

Yao Chen, Xuehua Lin, Qingying Lin, Yinglin Zeng, Xiaolong Qiu, Guanghua Liu, Wenbin Zhu,

<h4>Abstract</h4>Propionic acidemia is associated with pathogenic variants in PCCA or PCCB gene. We investigated the potential pathogenic variants in PCCA or PCCB genes in Fujian Han population.Two probands and their families of Han ethnicity containing two generations were subject to newborn screening using tandem mass spectrometry, followed by diagnosis using ... Read more >>

Medicine (Baltimore) (Medicine)
[2021, 100(10):e24161]

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Gene spectrum and clinical traits of 10 patients with primary carnitine deficiency.

Yao Chen, Qingying Lin, Yinglin Zeng, Xiaolong Qiu, Guanghua Liu, Wenbin Zhu,

<h4>Background</h4>Rare studies focused on the tandem mass spectrometry (MS/MS) findings for the primary carnitine deficiency (PCD) in the neonates in China mainland. In this study, we aim to analyze the gene mutation spectrum of PCD in Fujian Province in China mainland.<h4>Methods</h4>Primary carnitine deficiency (PCD) samples used in this study were ... Read more >>

Mol Genet Genomic Med (Molecular genetics & genomic medicine)
[2021, 9(2):e1583]

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Knowledge Graphs of Kawasaki Disease.

Zhisheng Huang, Qing Hu, Mingqun Liao, Cong Miao, Chengyi Wang, Guanghua Liu,

Kawasaki Disease is a vasculitis syndrome that is extremely harmful to children. Kawasaki Disease can cause severe symptoms of ischemic heart disease or develop into ischemic heart disease, leading to death in children. Researchers and clinicians need to analyze various knowledge and data resources to explore aspects of Kawasaki Disease. ... Read more >>

Health Inf Sci Syst (Health information science and systems)
[2021, 9(1):11]

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A Risk Score Model Based on Nine Differentially Methylated mRNAs for Predicting Prognosis of Patients with Clear Cell Renal Cell Carcinoma.

Jingmin Zhou, Guanghua Liu, Xingcheng Wu, Zhien Zhou, Jialin Li, Zhigang Ji,

<h4>Purpose</h4>DNA methylation alterations play important roles in initiation and progression of clear cell renal cell carcinoma (ccRCC). In this study, we attempted to identify differentially methylated mRNA signatures with prognostic value for ccRCC.<h4>Methods</h4>The mRNA methylation and expression profiling data of 306 ccRCC tumors were downloaded from The Cancer Genome Atlas ... Read more >>

Dis Markers (Disease markers)
[2021, 2021:8863799]

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Risk factors associated with wheezing in severe pediatric community-acquired pneumonia: a retrospective study.

Lumin Chen, Chong Miao, Yanling Chen, Xian Han, Ziying Lin, Hong Ye, Chengyi Wang, Huijie Zhang, Jingjing Li, Xi Liu, Libo Xu, Guanghua Liu,

<h4>Background</h4>Wheezing is a common clinical manifestation in children with pneumonia. However, the risk factors associated with the development of wheezing pneumonia and its clinical features are not fully characterized, especially in children with severe pneumonia.<h4>Methods</h4>We retrospectively recruited 1434 pediatric patients diagnosed with severe pneumonia between April 2012 and September 2019 ... Read more >>

Minerva Pediatr (Minerva pediatrica)
[2021, :]

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Production of lentiviral vectors in suspension cells using low proportion of supercoiled circular plasmid DNA.

Xin-An Lu, Ting He, Zhihai Han, Yanping Ding, Liang Zhao, Guanghua Liu, Floris De Smet, Xiaojun Huang, Danqing Chen, Feifei Qi, Xiangyu Zhao,

The supercoiled circular (SC) topology form of plasmid DNA has been regarded to be advantageous over open circular or linearized analogue in transfection and expression efficiency, and therefore are largely demanded in the biopharmaceutical manufacturing. However, production of high-purity SC plasmid DNA would result in high manufacturing cost. The effect ... Read more >>

Cytotechnology (Cytotechnology)
[2020, :]

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Phase-Selective Epitaxial Growth of Heterophase Nanostructures on Unconventional 2H-Pd Nanoparticles.

Yiyao Ge, Zhiqi Huang, Chongyi Ling, Bo Chen, Guigao Liu, Ming Zhou, Jiawei Liu, Xiao Zhang, Hongfei Cheng, Guanghua Liu, Yonghua Du, Cheng-Jun Sun, Chaoliang Tan, Jingtao Huang, Pengfei Yin, Zhanxi Fan, Ye Chen, Nailiang Yang, Hua Zhang,

Heterostructured, including heterophase, noble-metal nanomaterials have attracted much interest due to their promising applications in diverse fields. However, great challenges still remain in the rational synthesis of well-defined noble-metal heterophase nanostructures. Herein, we report the preparation of Pd nanoparticles with an unconventional hexagonal close-packed (2H type) phase, referred to as ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2020, 142(44):18971-18980]

Cited: 1 time

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[Clinical and genetic analysis of two patients with congenital neutropenia caused by ELANE gene mutation].

Hui Liu, Guanghua Liu, Peiran Zhao, Liang Huang, Youfeng Zhou, Xiaojian Qiu, Liangpu Xu,

<h4>Objective</h4>To explore the clinical characteristics of congenital neutropenia caused by ELANE gene mutations.<h4>Methods</h4>Clinical manifestations, absolute blood neutrophil count, high-throughput exome sequencing for mutation screening, suspected locus Sanger sequencing verification, processes of diagnosis and treatment of two patients with congenital neutropenia caused by ELANE gene mutation were retrospectively analyzed.<h4>Results</h4>High-throughput sequencing has ... Read more >>

Zhonghua Yi Xue Yi Chuan Xue Za Zhi (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics)
[2020, 37(10):1097-1101]

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A machine learning approach to predict intravenous immunoglobulin resistance in Kawasaki disease patients: A study based on a Southeast China population.

Tengyang Wang, Guanghua Liu, Hongye Lin,

Kawasaki disease is the leading cause of pediatric acquired heart disease. Coronary artery abnormalities are the main complication of Kawasaki disease. Kawasaki disease patients with intravenous immunoglobulin resistance are at a greater risk of developing coronary artery abnormalities. Several scoring models have been established to predict resistance to intravenous immunoglobulin, ... Read more >>

PLoS One (PloS one)
[2020, 15(8):e0237321]

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Novel compound variants of the TMTC3 gene cause cobblestone lissencephaly-like syndrome: A case report.

Guanghua Liu, Qing Zhou, Han Lin, Niu Li, Hong Ye, Jian Wang,

Biallelic variants in the transmembrane O-mannosyltransferase targeting cadherins 3 (<i>TMTC3</i>) gene have been reported to cause two distinct types of neuron migration defect diseases, known as cobblestone lissencephaly (COB) and periventricular nodular heterotopia (PVNH), combined with intellectual disability and nocturnal seizures. The aim of the current study was to identify ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2020, 20(5):97]

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The prevalence of mental distress and association with social changes among postgraduate students in China: a cross-temporal meta-analysis.

Liping P Guo, Zhihong H Li, Taolin L Chen, Guanghua H Liu, Huiyong Y Fan, Kehu H Yang,

<h4>Objective</h4>This study aims to estimate the mental distress prevalence of Chinese postgraduate students and the association with the social changes based on the data between 2000 and 2019.<h4>Study design</h4>This is a cross-temporal meta-analysis study.<h4>Methods</h4>The literature was retrieved with both English and Chinese electronic databases, including articles published from 2002 to ... Read more >>

Public Health (Public health)
[2020, 186:178-184]

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The clinical outcomes of fresh versus cryopreserved CD19-directed chimeric antigen receptor T cells in non-Hodgkin lymphoma patients.

Tong Su, Zhitao Ying, Xin-An Lu, Ting He, Yuqin Song, Xiaopei Wang, Lingyan Ping, Yan Xie, Meifeng Tu, Guanghua Liu, Feifei Qi, Yanping Ding, Hongmei Jing, Jun Zhu,

CD19-directed chimeric antigen receptor T (CAR-T) cells have been widely reported in the therapy of relapsed/refractory non-Hodgkin lymphoma (NHL). Both cryopreserved and fresh formulations of CAR-T have been used in previous studies. However, quite a few studies investigated the effects of cryopreservation on the clinical outcomes of CAR-T cells. Here ... Read more >>

Cryobiology (Cryobiology)
[2020, 96:106-113]

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Type 2 diabetes mellitus worsens the prognosis of intermediate-stage hepatocellular carcinoma after transarterial chemoembolization.

Guanghua Liu, Fang Xia, Guoping Fan, Juming Yu, Lei Bao, Caiyuan Zhang, Runmin Chi, Tingting Zhang, Lijun Wang, Feng Shen, Dengbin Wang,

<h4>Aims</h4>The aim of this study was to investigate the impact of type 2 diabetes mellitus (T2DM) on the prognosis of hepatocellular carcinoma (HCC) patients following transarterial chemoembolization (TACE).<h4>Methods</h4>Time to progression (TTP) and cancer-specific mortality (CSM) in competing risk model were compared in patients with (n = 289) or without (n = 763) T2DM. Propensity ... Read more >>

Diabetes Res Clin Pract (Diabetes research and clinical practice)
[2020, 169:108375]

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Sodium butyrate protects against oxidative stress in human nucleus pulposus cells via elevating PPARγ-regulated Klotho expression.

Xinxin Liu, Chang Jiang, Guanghua Liu, Ping Wang, Mingfang Shi, Mingzhen Yang, Zongye Zhong, Shenglong Ding, Yun Li, Bangzhong Liu, Yuanwu Cao,

We investigated the involvement of klotho in the inhibition of oxidative stress by sodium butyrate (NaB) in human nucleus pulposus cells (NPCs). NPCs were pretreated with different concentrations of NaB for 2 h before stimulation with tert-butyl hydroperoxide (TBHP). NaB alleviated TBHP-induced oxidative injury in the NPCs, as evident by the ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2020, 85:106657]

Cited: 4 times

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Response to Letter Regarding "A Randomized Controlled Trial on the Effects of Low-Dose Extracorporeal Shockwave Therapy in Patients With Knee Osteoarthritis".

Zongye Zhong, Bangzhong Liu, Guanghua Liu, Jun Chen, Yun Li, Jianxin Chen, Xinxin Liu, Yiwen Hu,

Arch Phys Med Rehabil (Archives of physical medicine and rehabilitation)
[2020, 101(7):1266]

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Perinatal risk factors for congenital hypothyroidism: A retrospective cohort study performed at a tertiary hospital in China.

Jinfu Zhou, Jinying Luo, Junyu Lin, Yinglin Zeng, Xiaolong Qiu, Wenbin Zhu, Guanghua Liu,

Congenital hypothyroidism (CH) is one of the most common neonatal endocrine diseases. This retrospective cohort study aimed to identify the potential perinatal risk factors for CH and to differentiate between transient and permanent CH (TCH and PCH, respectively) as well as determine their prevalence in a southeastern Chinese population.This study ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(26):e20838]

Cited: 2 times

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[Genetic analysis of a male infant with Menkes disease].

Yan Huang, Guanghua Liu, Shibiao Wang, Hui Liu, Youfeng Zhou,

<h4>Objective</h4>To carry out genetic testing for a male infant suspected for Menkes disease.<h4>Methods</h4>Genomic DNA of the proband and his parents were extracted and subjected to family trio whole exome sequencing (WES). Microduplication and microdeletion of the ATP7A gene were detected by multiplex ligation-dependent probe amplification (MLPA). Suspected variants were subjected ... Read more >>

Zhonghua Yi Xue Yi Chuan Xue Za Zhi (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics)
[2020, 37(4):479-482]

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GreenLight Laser photoselective vapo-enucleation of the prostate with front-firing emission versus plasmakinetic resection of the prostate for benign prostate hyperplasia.

Xiangming Cheng, Zikai Qiu, Jie Dong, Guanghua Liu, Yi Xie, Weifeng Xu, Zhigang Ji,

Background:Although the conventional, monopolar transurethral resection of the prostate (TURP) has proven to be an effective and relatively safe treatment for patients with benign prostatic hyperplasia (BPH), many new endoscopic technologies have been introduced to treat BPH. With the development of laser, there are several alternative transurethral procedures embracing laser ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(2):544-552]

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Effectiveness of dignity therapy for patients with advanced cancer: A systematic review and meta-analysis of 10 randomized controlled trials.

Yanfei Li, Xiuxia Li, Liangying Hou, Liujiao Cao, Guanghua Liu, Kehu Yang,

BACKGROUND:Dignity is a vitally important aspect of the lives of advanced cancer patients. We conducted a systematic review and meta-analysis of the effectiveness of dignity therapy in this patient population. METHODS:We searched for randomized controlled trials comparing dignity therapy versus standard care for patients with advanced cancer in five comprehensive ... Read more >>

Depress Anxiety (Depression and anxiety)
[2020, 37(3):234-246]

Cited: 3 times

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