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Author Guanghan Kan

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Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.

Dingsheng Zhao, Guohui Zhong, Jianwei Li, Junjie Pan, Yinlong Zhao, Hailin Song, Weijia Sun, Xiaoyan Jin, Yuheng Li, Ruikai Du, Jielin Nie, Tong Liu, Junmeng Zheng, Yixin Jia, Zifan Liu, Wei Liu, Xinxin Yuan, Zizhong Liu, Jinping Song, Guanghan Kan, Youyou Li, Caizhi Liu, Xingcheng Gao, Wenjuan Xing, Yan-Zhong Chang, Yingxian Li, Shukuan Ling,

<h4>Background</h4>Without adequate treatment, pathological cardiac hypertrophy induced by sustained pressure overload eventually leads to heart failure. WWP1 (WW domain-containing E3 ubiquitin protein ligase 1) is an important regulator of aging-related pathologies, including cancer and cardiovascular diseases. However, the role of WWP1 in pressure overload-induced cardiac remodeling and heart failure is ... Read more >>

Circulation (Circulation)
[2021, 144(9):694-711]

Cited: 2 times

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Casein Kinase-2 Interacting Protein-1 Regulates Physiological Cardiac Hypertrophy via Inhibition of Histone Deacetylase 4 Phosphorylation.

Yinlong Zhao, Shukuan Ling, Guohui Zhong, Yuheng Li, Jianwei Li, Ruikai Du, Xiaoyan Jin, Dingsheng Zhao, Zizhong Liu, Guanghan Kan, Yan-Zhong Chang, Yingxian Li,

Different kinds of mechanical stimuli acting on the heart lead to different myocardial phenotypes. Physiological stress, such as exercise, leads to adaptive cardiac hypertrophy, which is characterized by a normal cardiac structure and improved cardiac function. Pathological stress, such as sustained cardiac pressure overload, causes maladaptive cardiac remodeling and, eventually, ... Read more >>

Front Physiol (Frontiers in physiology)
[2021, 12:678863]

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Simulated Space Environmental Factors of Weightlessness, Noise and Low Air Pressure Differentially Affect the Circadian Rhythm and Gut Microbiome

Huan Ma, Xihui Gan, Jianwei Zhao, Yin Zhang, Silin Li, Guanghan Kan, Bo Wang, Peng Zhang, Xiaohong Ma, Hongni Tian, Meimei Liao, Dapeng Ju, Shuihong Xu, Lulin Chang, Xiaoping Chen, Jinhu Guo,

<h4>Background: </h4> he circadian clock extensively regulates physiology and behavior. In space, the astronauts encounter many environmental factors that are dramatically different from those on earth, however, the effects of these factors on circadian rhythms and the mechanisms remain largely unknown. The present study aimed to investigate the changes in ... Read more >>

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Microbiota–Muscle/–Immune Interactions in Rhesus Macaque under Simulated Weightlessness Revealed by Integrated Multi-Omics Analysis

Peng Zhang, Libin Shao, Jie Zhang, Lu Wang, Huimei Yuan, Xiangsheng Pang, Guangyi Fan, Ling Peng, Guanghan Kan, Wenjiong Li, Xinming Liang, Xin Liu, Xiaoping Chen,

<h4>Background: </h4> Long-term exposure to microgravity during spaceflight has adverse effects on human health including muscle atrophy, impaired immune function, and alterations in gut microbiome profile. Gut microorganisms influence a wide range of host biological processes, but their interactions with skeletal muscle and the immune system under microgravity are not ... Read more >>

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Simulated weightlessness procedure, head-down bed rest impairs adult neurogenesis in the hippocampus of rhesus macaque.

Xu Zhang, Xixia Chu, Lei Chen, Juan Fu, Shuai Wang, Jinjing Song, Guanghan Kan, Weizhong Jiang, Guang He, Xiaoping Chen, Weidong Li,

The microgravity environment in space can impact astronauts' cognitive and behavioral activities. However, due to the limitations of research conditions, studies of biological changes in the primate brain, such as neurogenesis, have been comparatively few. We take advantage of - 6° head-down bed rest (HDBR), one of the most implemented space ... Read more >>

Mol Brain (Molecular brain)
[2019, 12(1):46]

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Hematopoietic stem cells and lineage cells undergo dynamic alterations under microgravity and recovery conditions.

Dengchao Cao, Jinping Song, Shukuan Ling, Shuaishuai Niu, Liang Lu, Zhengzhi Cui, Yuheng Li, Shanshan Hao, Guohui Zhong, Zhihong Qi, Weijia Sun, Xinxin Yuan, Hongxing Li, Dingsheng Zhao, Xiaoyan Jin, Caizhi Liu, Xiaorui Wu, Guanghan Kan, Hongqing Cao, Youmin Kang, Shuyang Yu, Yingxian Li,

Spaceflight leads to health risks including bone demineralization, skeletal muscle atrophy, cardiovascular dysfunction, and disorders of almost all physiologic systems. However, the impacts of microgravity on blood lineage cells and hematopoietic stem cells (HSCs) in vivo are largely unknown. In this study, we analyzed peripheral blood samples from 6 astronauts ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2019, 33(6):6904-6918]

Cited: 7 times

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Integrated multi-omics analysis to study the effects of simulated weightlessness on rhesus macaques (Macaca mulatta)

Peng Zhang, Libin Shao, Jie Zhang, Wenjiong Li, Guangyi Fan, Ying Zhou, Guanghan Kan, Hongju Liu, Weidong Li, Fei Wang, Xixia Chu, Peng Han, Ling Peng, Xingmin Liu, Jianwei Chen, Xinming Liang, Jingkai Ji, Shiyi Du, Zhanlong Mei, Ronghui Li, Xun Xu, Shanguang Chen, Xin Liu, Xiaoping Chen,

Safety and health of astronauts in space is one of the most important aspects of space exploration, however, the genomic research about how a weightless space can affect astronaut’s health was limited. In this study, we sequenced 25 transcriptomic, 42 metabolomic and 35 metagenomic data of 15 rhesus macaques (Macaca ... Read more >>

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Functional annotation of extensively and divergently expressed miRNAs in suprachiasmatic nucleus of Clock Δ19 mutant mice.

Yanli Wang, Ke Lv, Hailong Chen, Mei Zhao, Guohua Ji, Yongliang Zhang, Hongqing Cao, Guanghan Kan, Yinghui Li, Lina Qu,

Circadian locomotor output cycles kaput protein (CLOCK) is a core transcription factor of complex integrated feedback loops in mammalian circadian clock. More genes have been reported to be regulated by CLOCK, however little is known about the role of CLOCK-mediated miRNAs. To dissect this, we used microarray analysis to measure ... Read more >>

Biosci Rep (Bioscience reports)
[2018, 38(6):]

Cited: 1 time

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Involvement of Cholinergic Dysfunction and Oxidative Damage in the Effects of Simulated Weightlessness on Learning and Memory in Rats.

Yongliang Zhang, Qiong Wang, Hailong Chen, Xinmin Liu, Ke Lv, Tingmei Wang, Yanli Wang, Guohua Ji, Hongqing Cao, Guanghan Kan, Yinghui Li, Lina Qu,

The present study aimed to determine how the learning and memory gradually change with the prolonged hindlimb unloading (HU) treatment in rats. Different HU durations (7 d, 14 d, 21 d, and 28 d) in Sprague-Dawley (SD) rats were implemented. Cognitive function was assessed using the Morris water maze (MWM) and the shuttle box ... Read more >>

Biomed Res Int (BioMed research international)
[2018, 2018:2547532]

Cited: 8 times

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Levels of Leydig cell autophagy regulate the fertility of male naked mole-rats.

Wenjing Yang, Li Li, Xiaofeng Huang, Guanghan Kan, Lifang Lin, Jishuai Cheng, Chen Xu, Wei Sun, Wei Cong, Shanmin Zhao, Shufang Cui,

Fertility is abolished in nonbreeding males in colonies of natal naked mole-rats (NMRs). Although spermatogenesis occurs in both breeding and nonbreeding male NMRs, the mechanisms underlying the differences in fertility between breeders and nonbreeders remain unexplored. In this study, a significant decrease in autophagy was observed in Leydig cells of ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(58):98677-98690]

Cited: 4 times

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Transcriptome sequencing of the naked mole rat (Heterocephalus glaber) and identification of hypoxia tolerance genes.

Bang Xiao, Li Li, Chang Xu, Shanmin Zhao, Lifang Lin, Jishuai Cheng, Wenjing Yang, Wei Cong, Guanghan Kan, Shufang Cui,

The naked mole rat (NMR; <i>Heterocephalus glaber</i>) is a small rodent species found in regions of Kenya, Ethiopia and Somalia. It has a high tolerance for hypoxia and is thus considered one of the most important natural models for studying hypoxia tolerance mechanisms. The various mechanisms underlying the NMR's hypoxia ... Read more >>

Biol Open (Biology open)
[2017, 6(12):1904-1912]

Cited: 2 times

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HIF-1α contributes to hypoxia adaptation of the naked mole rat.

Bang Xiao, Shiyong Wang, Guoshi Yang, Xiaoxi Sun, Shanmin Zhao, Lifang Lin, Jishuai Cheng, Wenjing Yang, Wei Cong, Wei Sun, Guanghan Kan, Shufang Cui,

<h4>Background/aims</h4>Naked mole rats (NMRs) spend their lives in burrow systems containing very low levels of oxygen, indicating long-term hypoxic exposure, and suggesting that pathological changes caused by hypoxia are attenuated or absent in this hypoxia-tolerant species. The mechanisms underlying NMRs hypoxia tolerance remain poorly understood. In this study, we explored ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(66):109941-109951]

Cited: 9 times

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Intramuscular injection of mechano growth factor E domain peptide regulated expression of memory-related sod, miR-134 and miR-125b-3p in rat hippocampus under simulated weightlessness

Hailong Chen, Guanghan Kan, Guohua Ji, Ke Lv, Lina Qu, Tingmei Wang, Yanli Wang, Yinghui Li, Yongliang Zhang, Zhongquan Dai,

OBJECTIVE: To investigate the expression of memory-related antioxidant genes and miRNAs under simulated weightlessness and the regulation of mechano growth factor (MGF) E domain, the peptide preventing nerve damage. RESULTS: Igf-iea and mgf mRNA levels, expression of antioxidant genes sod1 and sod2 and levels of miR-134 and miR-125b-3p increased in ... Read more >>

Biotechnol Lett (Biotechnology letters)
[2016, 38(12):2071-2080]

Cited: 0 times

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Activation of HIF-1α and its downstream targets in rat hippocampus after long-term simulated microgravity exposure.

Tingmei Wang, Hailong Chen, Ke Lv, Guohua Ji, Fengji Liang, Yongliang Zhang, Yanli Wang, Xinmin Liu, Hongqing Cao, Guanghan Kan, Jianghui Xiong, Yinghui Li, Lina Qu,

Microgravity has many detrimental impact on brain functions, however the underlying mechanism remain unclear. In present study, 28 days of tail-suspension (30°) was used to simulate microgravity in rats. We showed that oxidative stress in hippocampus was increased after 28 days of simulated microgravity in consideration of the decreased expression ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2017, 485(3):591-597]

Cited: 3 times

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Simulated Microgravity and Recovery-Induced Remodeling of the Left and Right Ventricle.

Guohui Zhong, Yuheng Li, Hongxing Li, Weijia Sun, Dengchao Cao, Jianwei Li, Dingsheng Zhao, Jinping Song, Xiaoyan Jin, Hailin Song, Xinxin Yuan, Xiaorui Wu, Qi Li, Qing Xu, Guanghan Kan, Hongqing Cao, Shukuan Ling, Yingxian Li,

Physiological adaptations to microgravity involve alterations in cardiovascular systems. These adaptations result in cardiac remodeling and orthostatic hypotension. However, the response of the left ventricle (LV) and right ventricle (RV) following hindlimb unloading (HU) and hindlimb reloading (HR) is not clear and the underlying mechanism remains to be understood. In ... Read more >>

Front Physiol (Frontiers in physiology)
[2016, 7:274]

Cited: 4 times

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Intramuscular injection of mechano growth factor E domain peptide regulated expression of memory-related sod, miR-134 and miR-125b-3p in rat hippocampus under simulated weightlessness.

Hailong Chen, Ke Lv, Zhongquan Dai, Guohua Ji, Tingmei Wang, Yanli Wang, Yongliang Zhang, Guanghan Kan, Yinghui Li, Lina Qu,

<h4>Objective</h4>To investigate the expression of memory-related antioxidant genes and miRNAs under simulated weightlessness and the regulation of mechano growth factor (MGF) E domain, the peptide preventing nerve damage.<h4>Results</h4>Igf-iea and mgf mRNA levels, expression of antioxidant genes sod1 and sod2 and levels of miR-134 and miR-125b-3p increased in rat hippocampus after ... Read more >>

Biotechnol Lett (Biotechnology letters)
[2016, 38(12):2071-2080]

Cited: 0 times

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The protective role of autophagy in Heterocephalus glaber hepatic stellate cells exposed to H2O2 or nutritional stress.

Shanmin Zhao, Hong Luo, Guanghan Kan, Yong Zhao, Lifang Lin, Qiu Tang, Chenlin Yu, Wei Sun, Liping Cai, Shufang Cui,

<h4>Background/aims</h4>Naked mole rats (NMRs) survive and thrive in dark, dank environments with low levels of oxygen and poor quality nutrition. Their long lifespan is attributed to sustained good health and pronounced resistance to cancer. Physiological and biochemical processes, such as autophagy, may contribute to the successful aging of this exceptionally ... Read more >>

Cell Physiol Biochem (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology)
[2014, 34(2):463-473]

Cited: 8 times

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Dynamic changes of macaque cancellous bone following head-down bed rest.

Honglei Ma, Yu Zhu, Yanhua Xiao, Guanghan Kan, Xin Jin, King H Yang, Albert I King,

<h4>Introduction</h4>Skeletal unloading during a spaceflight could result in bone loss and osteopenia, ultimately leading to poor bone strength. The purpose of the present study was to investigate the influence of bone loss on the dynamic behavior of cancellous bone.<h4>Methods</h4>Microgravity-induced bone loss and osteopenia were simulated in a macaque head-down bed ... Read more >>

Aviat Space Environ Med (Aviation, space, and environmental medicine)
[2014, 85(2):130-134]

Cited: 0 times

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High autophagy in the naked mole rat may play a significant role in maintaining good health.

Shanmin Zhao, Lifang Lin, Guanghan Kan, Chang Xu, Qiu Tang, Chenlin Yu, Wei Sun, Liping Cai, Chen Xu, Shufang Cui,

<h4>Background/aims</h4>The maximum lifespan of the naked mole rat is over 28.3 years, which exceeds that of any other rodent species, suggesting that age-related changes in its body composition and functionality are either attenuated or delayed in this extraordinarily long-lived species. However, the mechanisms underlying the aging process in this species ... Read more >>

Cell Physiol Biochem (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology)
[2014, 33(2):321-332]

Cited: 28 times

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miR-214 targets ATF4 to inhibit bone formation.

Xiaogang Wang, Baosheng Guo, Qi Li, Jiang Peng, Zhijun Yang, Aiyuan Wang, Dong Li, Zhibo Hou, Ke Lv, Guanghan Kan, Hongqing Cao, Heng Wu, Jinping Song, Xiaohua Pan, Qiao Sun, Shukuan Ling, Yuheng Li, Mu Zhu, Pengfei Zhang, Songlin Peng, Xiaoqing Xie, Tao Tang, An Hong, Zhaoxiang Bian, Yanqiang Bai, Aiping Lu, Yinghui Li, Fuchu He, Ge Zhang, Yingxian Li,

Emerging evidence indicates that microRNAs (miRNAs) have important roles in regulating osteogenic differentiation and bone formation. Thus far, no study has established the pathophysiological role for miRNAs identified in human osteoporotic bone specimens. Here we found that elevated miR-214 levels correlated with a lower degree of bone formation in bone ... Read more >>

Nat Med (Nature medicine)
[2013, 19(1):93-100]

Cited: 262 times

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CKIP-1 inhibits cardiac hypertrophy by regulating class II histone deacetylase phosphorylation through recruiting PP2A.

Shukuan Ling, Qiao Sun, Yuheng Li, Luo Zhang, Pengfei Zhang, Xiaogang Wang, Chunyan Tian, Qi Li, Jinping Song, Hongju Liu, Guanghan Kan, Hongqing Cao, Zengming Huang, Jielin Nie, Yanqiang Bai, Shanguang Chen, Yinghui Li, Fuchu He, Lingqiang Zhang, Yingxian Li,

<h4>Background</h4>Sustained cardiac pressure overload-induced hypertrophy and pathological remodeling frequently leads to heart failure. Casein kinase-2 interacting protein-1 (CKIP-1) has been identified to be an important regulator of cell proliferation, differentiation, and apoptosis. However, the physiological role of CKIP-1 in the heart is unknown.<h4>Methods and results</h4>The results of echocardiography and histology ... Read more >>

Circulation (Circulation)
[2012, 126(25):3028-3040]

Cited: 35 times

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[Experimental study of novel injectable nucleus pulposus prostheses implant].

Xiaofei Cheng, Dewei Zou, Jigong Wu, Huasong Ma, Xinlin Tuo, Xiaogong Wang, Guanghan Kan,

<h4>Objective</h4>To explore the histological and the hematological change of rabbits after implanting novel injectable artificial nucleus prostheses, and to evaluate the biological safety.<h4>Methods</h4>In accordance with Biological Evaluation of Medical Devices, materials of polyurethane, silicone rubber and macromolecular polyethylene for medical use were made into short column 1 cm in length ... Read more >>

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi (Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery)
[2009, 23(6):670-676]

Cited: 1 time

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Fluid-change cell culture box

YINGJUN TAN, JIELIN NIE, CHUNYAN WANG, BAI DING, JIANRU YU, YINGHUI LI, YUE LIU, ZENGMING HUANG, SHUKUAN LING, GUANGHAN KAN,

The utility model relates to a disposable fluid-change cell culture box which has the capacities of storing and updating cell culture fluid and reagent. The disposable fluid-change cell culture box is characterized by comprising a culture box main body, a bottom plug, a movable sealing plug, a top plug, a ... Read more >>

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