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Cystathionine gamma-lyase/H2 S signaling facilitates myogenesis under aging and injury condition.

Yanjie Zhang, Laura Masters, Yuehong Wang, Lingyun Wu, Yanxi Pei, Baoqing Guo, Amadeo Parissenti, Simon J Lees, Rui Wang, Guangdong Yang,

Hydrogen sulfide (H<sub>2</sub> S) can be endogenously produced and belongs to the class of signaling molecules known as gasotransmitters. Cystathionine gamma-lyase (CSE)-derived H<sub>2</sub> S is implicated in the regulation of cell differentiation and the aging process, but the involvements of the CSE/H<sub>2</sub> S system in myogenesis upon aging and injury ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(5):e21511]

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H2S Persulfidated and Increased Kinase Activity of MPK4 to Response Cold Stress in Arabidopsis.

Xinzhe Du, Zhuping Jin, Zhiqiang Liu, Danmei Liu, Liping Zhang, Xiaoli Ma, Guangdong Yang, Sha Liu, Yarong Guo, Yanxi Pei,

Hydrogen sulfide (H<sub>2</sub>S) is a gasotransmitter along with nitric oxide and carbon oxide, which is involved in plant growth and development as well as biotic and abiotic stress resistance. In a previous study, we reported that mitogen-activated protein kinases, especially MPK4, are important downstream components of H<sub>2</sub>S involved in alleviating ... Read more >>

Front Mol Biosci (Frontiers in molecular biosciences)
[2021, 8:635470]

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Disrupted H2S Signaling by Cigarette Smoking and Alcohol Drinking: Evidence from Cellular, Animal, and Clinical Studies.

Ethan Read, Jiechun Zhu, Guangdong Yang,

The role of endogenous hydrogen sulfide (H<sub>2</sub>S) as an antioxidant regulator has sparked interest in its function within inflammatory diseases. Cigarette and alcohol use are major causes of premature death, resulting from chronic oxidative stress and subsequent tissue damage. The activation of the Nrf2 antioxidant response by H<sub>2</sub>S suggests that ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2021, 10(1):]

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Interaction among estrogen, IGF-1, and H2S on smooth muscle cell proliferation.

Tian Shuang, Ming Fu, Guangdong Yang, Ying Huang, Zhongming Qian, Lingyun Wu, Rui Wang,

Both estrogen and hydrogen sulfide (H2S) inhibit the proliferation of vascular smooth muscle cells (SMCs) and development of atherosclerosis. In the absence of endogenous H2S as occurred in CSE-knockout (KO) mouse, however, estrogen stimulates the proliferation of vascular SMCs. The underlying mechanisms for this seemingly controversial vascular effect of estrogen ... Read more >>

J Endocrinol (The Journal of endocrinology)
[2021, 248(1):17-30]

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Gasotransmitter signaling in energy homeostasis and metabolic disorders.

Amr Ali, Yuehong Wang, Lingyun Wu, Guangdong Yang,

Gasotransmitters are small molecules of gases, including nitric oxide (NO), hydrogen sulfide (H<sub>2</sub>S), and carbon monoxide (CO). These three gasotransmitters can be endogenously produced and regulate a wide range of pathophysiological processes by interacting with specific targets upon diffusion in the biological media. By redox and epigenetic regulation of various ... Read more >>

Free Radic Res (Free radical research)
[2020, :1-23]

Cited: 1 time

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Hydrogen sulfide guards myoblasts from ferroptosis by inhibiting ALOX12 acetylation.

Yuehong Wang, Ruihuan Yu, Lingyun Wu, Guangdong Yang,

Recognized as a novel and important gasotransmitter, hydrogen sulfide (H<sub>2</sub>S) is widely present in various tissues and organs. Cystathionine gamma-lyase (CSE)-derived H<sub>2</sub>S has been shown to regulate oxidative stress and lipid metabolism. The aim of the present study is to examine the role of H<sub>2</sub>S in ferroptosis and lipid peroxidation ... Read more >>

Cell Signal (Cellular signalling)
[2021, 78:109870]

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Spermine Protects Cardiomyocytes from High Glucose-Induced Energy Disturbance by Targeting the CaSR-gp78-Ubiquitin Proteasome System.

Yuehong Wang, Yuwen Wang, Fadong Li, Xinying Zhang, Hongzhu Li, Guangdong Yang, Changqing Xu, Can Wei,

<h4>Purpose</h4>To determine the mediation of spermine on energy metabolism disorder and diabetic cardiomyopathy (DCM) development as well as the underlying mechanisms.<h4>Methods</h4>An in vitro model of DCM was established by incubating primary cultured neonatal rat cardiomyocytes with high glucose (HG). Spermine content was assessed by RP-HPLC. The protein levels were detected ... Read more >>

Cardiovasc Drugs Ther (Cardiovascular drugs and therapy)
[2021, 35(1):73-85]

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Hydrogen sulfide signaling in regulation of cell behaviors.

Yuehong Wang, Ruihuan Yu, Lingyun Wu, Guangdong Yang,

Recent advances in the biomedical importance of H<sub>2</sub>S have help us understand various cellular functions and pathophysiological processes from a new aspect. Specially, H<sub>2</sub>S has been demonstrated to play multiple roles in regulating cell behaviors, including cell survival, cell differentiation, cell senescence, cell hypertrophy, cell atrophy, cell metaplasia, and cell ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 103:9-19]

Cited: 3 times

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H2S as a potential defense against COVID-19?

Guangdong Yang,

The outbreak of COVID-19 pneumonia caused by a new coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) is posing a global health emergency and has led to more than 380,000 deaths worldwide. The cell entry of SARS-CoV-2 depends on two host proteins angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine ... Read more >>

Am J Physiol Cell Physiol (American journal of physiology. Cell physiology)
[2020, 319(2):C244-C249]

Cited: 4 times

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Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.

Yuehong Wang, Junting Chen, Siwei Li, Xinying Zhang, Zuoming Guo, Jing Hu, Xiaoting Shao, Ningyang Song, Yajun Zhao, Hongzhu Li, Guangdong Yang, Changqing Xu, Can Wei,

Diabetic cardiomyopathy (DCM) is a severe complication of type 1 diabetic (T1D) patients, manifested as combined diastolic and systolic dysfunction. DCM is associated with impaired calcium homeostasis secondary to decreased calcium-sensitive receptor (CaSR) expression. Spermine, a direct agonist of CaSR, was found deficient in cardiomyocytes of T1D rats. However, the ... Read more >>

Redox Biol (Redox biology)
[2020, 32:101514]

Cited: 3 times

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Cystathionine gamma-lyase/H2S system suppresses hepatic acetyl-CoA accumulation and nonalcoholic fatty liver disease in mice.

Amr Ali, Yanjie Zhang, Ming Fu, Yanxi Pei, Lingyun Wu, Rui Wang, Guangdong Yang,

AIMS:Hydrogen sulfide (H2S) as a novel gasotransmitter can be endogenously produced in liver by cystathionine gamma-lyase (CSE). The dysfunctions of CSE/H2S system have been linked to various liver diseases. Acetyl-CoA is the key intermediate from the metabolism of lipid. This study examined the roles of H2S in hepatic acetyl-CoA and ... Read more >>

Life Sci (Life sciences)
[2020, 252:117661]

Cited: 1 time

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Golgi Stress Response, Hydrogen Sulfide Metabolism, and Intracellular Calcium Homeostasis.

Yanjie Zhang, Yuehong Wang, Ethan Read, Ming Fu, Yanxi Pei, Lingyun Wu, Rui Wang, Guangdong Yang,

<b><i>Aims:</i></b> The physiological and pathological importance of hydrogen sulfide (H<sub>2</sub>S) as a novel gasotransmitter has been widely recognized. Cystathionine gamma-lyase (CSE) is one of the major H<sub>2</sub>S-producing enzymes and it regulates diverse functions in connection with intracellular calcium (Ca<sup>2+</sup>). The aim of this study is to examine the role of ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2020, 32(9):583-601]

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H2S Protects against Cardiac Cell Hypertrophy through Regulation of Selenoproteins.

Adam Greasley, Yanjie Zhang, Bo Wu, Yanxi Pei, Nelson Belzile, Guangdong Yang,

Cardiac hypertrophy is defined as the enlargement of the cardiac myocytes, leading to improper nourishment and oxygen supply due to the increased functional demand. This increased stress on the cardiac system commonly leads to myocardial infarction, contributing to 85% of all cardiac-related deaths. Cystathionine gamma-lyase- (CSE-) derived H2S is a ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2019, 2019:6494306]

Cited: 1 time

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Light regulates hydrogen sulfide signalling during skoto- and photo-morphogenesis in foxtail millet.

Zhiqiang Liu, Chunyu Cao, Yawen Li, Guangdong Yang, Yanxi Pei,

Signal transduction mediated by photoreceptors regulates many physiological processes during plant growth and development including seed germination, flowering and photosynthesis, which are also regulated by hydrogen sulfide (H2S). However, studies of the connection between the vital environmental factors - light and the significant endogenous gasotransmitter - H2S, is lacking. Here, ... Read more >>

Funct Plant Biol (Functional plant biology : FPB)
[2019, 46(10):916-924]

Cited: 1 time

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Induction of cystathionine gamma-lyase expression and metallothionein-1 S-sulfhydration alleviate cadmium-induced cell death in myoblast cells.

Yanjie Zhang, Amr Ali, Zhuping Jin, Yanxi Pei, Guangdong Yang,

Hydrogen sulfide (H<sub>2</sub>S), a multifunctional gasotransmitter, participates in a wide range of cellular signal transduction and pathophysiological processes. Cystathionine gamma-lyase (CSE) acts as a major H<sub>2</sub>S-generating enzyme in peripheral organs and tissues. As a cysteine-rich and heavy metal-binding protein, metallothionein-1 (MT-1) is known to protect cells from various environmental stresses. ... Read more >>

Ecotoxicol Environ Saf (Ecotoxicology and environmental safety)
[2019, 179:222-231]

Cited: 1 time

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Cloning and functional analysis of four O-Acetylserine (thiol) lyase family genes from foxtail millet.

Danmei Liu, Juan Li, Juanjuan Lu, Baohua Tian, Xin Liu, Guangdong Yang, Yanxi Pei,

Cysteine is the first organic molecule generated during the assimilation of sulfate. As such, cysteine and its derivatives are always essential signal molecules and thus have important roles in the regulation of many plant processes. O-acetylserine (thiol) lyase (OASTL) catalyzes the last step of the biosynthesis of cysteine. At present, ... Read more >>

Plant Physiol Biochem (Plant physiology and biochemistry : PPB)
[2019, 139:325-332]

Cited: 0 times

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Efflux inhibition by H2S confers sensitivity to doxorubicin-induced cell death in liver cancer cells.

Eric Stokes, Tian Shuang, Yanjie Zhang, Yanxi Pei, Ming Fu, Baoqing Guo, Amadeo Parissenti, Lingyun Wu, Rui Wang, Guangdong Yang,

<h4>Aims</h4>Hydrogen sulfide (H<sub>2</sub>S), an important gasotransmitter, is involved in a variety of cellular functions and pathophysiologic processes. Drug resistance due to alterations in drug trafficking and metabolism severely limits the effectiveness of cancer therapy. This study examined the role of H<sub>2</sub>S in drug resistance in liver cancer cells.<h4>Materials and methods</h4>Human ... Read more >>

Life Sci (Life sciences)
[2018, 213:116-125]

Cited: 2 times

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Hydrogen Sulfide Regulates Energy Production to Delay Leaf Senescence Induced by Drought Stress in Arabidopsis.

Zhuping Jin, Limin Sun, Guangdong Yang, Yanxi Pei,

Hydrogen sulfide (H<sub>2</sub>S) is a novel gasotransmitter in both mammals and plants. H<sub>2</sub>S plays important roles in various plant developmental processes and stress responses. Leaf senescence is the last developmental stage and is a sequential degradation process that eventually leads to leaf death. A mutation of the H<sub>2</sub>S-producing enzyme-encoding gene ... Read more >>

Front Plant Sci (Frontiers in plant science)
[2018, 9:1722]

Cited: 5 times

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Hydrogen sulfide and hepatic lipid metabolism - a critical pairing for liver health.

Julie J Loiselle, Guangdong Yang, Lingyun Wu,

Hydrogen sulfide (H<sub>2</sub> S) is the most recently recognized gasotransmitter, influencing a wide range of physiological processes. As a critical regulator of metabolism, H<sub>2</sub> S has been suggested to be involved in the pathology of many diseases, particularly obesity, diabetes and cardiovascular disorders. Its involvement in liver health has been ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2020, 177(4):757-768]

Cited: 2 times

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Reversal of Sp1 transactivation and TGFβ1/SMAD1 signaling by H2S prevent nickel-induced fibroblast activation.

Mélanie Racine, Ming Fu, Tian Shuang, Yanjie Zhang, Yanxi Pei, Lingyun Wu, Rui Wang, Guangdong Yang,

Nickel as a heavy metal is known to bring threat to human health, and nickel exposure is associated with changes in fibroblast activation which may contribute to its fibrotic properties. H<sub>2</sub>S has recently emerged as an important gasotransmitter involved in numerous cellular signal transduction and pathophysiological responses. Interaction of nickel ... Read more >>

Toxicol Appl Pharmacol (Toxicology and applied pharmacology)
[2018, 356:25-35]

Cited: 5 times

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The interaction of IGF-1/IGF-1R and hydrogen sulfide on the proliferation of mouse primary vascular smooth muscle cells.

Tian Shuang, Ming Fu, Guangdong Yang, Lingyun Wu, Rui Wang,

Hydrogen sulfide (H<sub>2</sub>S) is mostly produced by cystathionine-gamma-lyase (CSE) in vascular system and it inhibits the proliferation of vascular smooth muscle cells (SMCs). Insulin-like growth factor-1 (IGF-1), via its receptor (IGF-1R), exerts multiple physiological and pathophysiological effects on the vasculature, including stimulating SMC proliferation and migration, and inhibiting SMC apoptosis. ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2018, 149:143-152]

Cited: 8 times

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H₂S-Mediated Protein S-Sulfhydration: A Prediction for Its Formation and Regulation.

Youngjun Ju, Ming Fu, Eric Stokes, Lingyun Wu, Guangdong Yang,

Protein <i>S</i>-sulfhydration is a newly discovered post-translational modification of specific cysteine residue(s) in target proteins, which is involved in a broad range of cellular functions and metabolic pathways. By changing local conformation and the final activity of target proteins, <i>S</i>-sulfhydration is believed to mediate most cellular responses initiated by H₂S, ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2017, 22(8):]

Cited: 5 times

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Trend in H₂S Biology and Medicine Research-A Bibliometric Analysis.

Guangdong Yang, Lingyun Wu,

The biological and medical importance of hydrogen sulfide (H₂S) has been recognized for decades. The aim of this bibliometric study is to analyze the quantity and quality of publications in H₂S biology and medicine (H₂SBM) based on the databases of Web of Science and Google Scholar. A total of 5881 ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2017, 22(12):]

Cited: 6 times

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Hydrogen sulfide alleviates the cold stress through MPK4 in Arabidopsis thaliana.

Xinzhe Du, Zhuping Jin, Danmei Liu, Guangdong Yang, Yanxi Pei,

Hydrogen sulfide (H<sub>2</sub>S) is a gaseous signaling molecule that mediates physiological processes in animals and plants. In this study, we investigated the relationship of H<sub>2</sub>S and mitogen activated protein kinase (MAPK) under cold stress in Arabidopsis. H<sub>2</sub>S up-regulated MAPK expression levels and was involved in the cold stress-related upregulation of ... Read more >>

Plant Physiol Biochem (Plant physiology and biochemistry : PPB)
[2017, 120:112-119]

Cited: 4 times

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Cystathionine gamma-lyase/hydrogen sulfide system is essential for adipogenesis and fat mass accumulation in mice.

Guangdong Yang, Youngjun Ju, Ming Fu, Yanjie Zhang, Yanxi Pei, Mélanie Racine, Simran Baath, Thomas J S Merritt, Rui Wang, Lingyun Wu,

Hydrogen sulfide (H2S) has been recognized as an important gasotransmitter analogous to nitric oxide and carbon monoxide. Cystathionine gamma-lyase (CSE)-derived H2S is implicated in the regulation of insulin resistance and glucose metabolism, but the involvement of CSE/H2S system in energy homeostasis and fat mass has not been extensively explored. In ... Read more >>

Biochim Biophys Acta Mol Cell Biol Lipids (Biochimica et biophysica acta. Molecular and cell biology of lipids)
[2018, 1863(2):165-176]

Cited: 4 times

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