Full Text Journal Articles by
Author Gretchen M Brophy

Advertisement

Find full text journal articles






Anticoagulation reversal for intracranial hemorrhage in the era of the direct oral anticoagulants.

Micheal Strein, Scott May, Gretchen M Brophy,

PURPOSE OF REVIEW:This review focuses on recent relevant literature that examines the reversal of direct oral anticoagulants (DOACs) in patients with intracranial hemorrhage (ICH). The aim of this review is to provide an insightful description of available reversal agents and their clinical utility. RECENT FINDINGS:Increases in prescribing of DOACs has ... Read more >>

Curr Opin Crit Care (Current opinion in critical care)
[2020, 26(2):122-128]

Cited: 0 times

View full text PDF listing >>



High-Dose Intravenous Ascorbic Acid: Ready for Prime Time in Traumatic Brain Injury?

Stefan W Leichtle, Anand K Sarma, Micheal Strein, Vishal Yajnik, Dennis Rivet, Adam Sima, Gretchen M Brophy,

Traumatic brain injury (TBI) is one of the leading public health problems in the USA and worldwide. It is the number one cause of death and disability in children and adults between ages 1-44. Despite efforts to prevent TBIs, the incidence continues to rise. Secondary brain injury occurs in the ... Read more >>

Neurocrit Care (Neurocritical care)
[2020, 32(1):333-339]

Cited: 0 times

View full text PDF listing >>



Advertisement

Unique Uses of Cooling Strategies.

Michael Kurz, Kees Polderman, Gretchen M Brophy, Byron Drumheller,

Ther Hypothermia Temp Manag (Therapeutic hypothermia and temperature management)
[2019, 9(3):168-172]

Cited: 0 times

View full text PDF listing >>



Targeted Temperature Management in Nursing Care.

Gretchen M Brophy, David A Hildebrandt, Elizabeth A Moore, Todd J Van de Bussche,

Ther Hypothermia Temp Manag (Therapeutic hypothermia and temperature management)
[2019, 9(3):173-176]

Cited: 0 times

View full text PDF listing >>



Prevention, Treatment, and Monitoring of Seizures in the Intensive Care Unit.

Micheal Strein, John P Holton-Burke, LaTangela R Smith, Gretchen M Brophy,

The diagnosis and management of seizures in the critically ill patient can sometimes present a unique challenge for practitioners due to lack of exposure and complex patient comorbidities. The reported incidence varies between 8% and 34% of critically ill patients, with many patients often showing no overt clinical signs of ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(8):]

Cited: 0 times

View full text PDF listing >>



Current Practices of Intraventricular Antibiotic Therapy in the Treatment of Meningitis and Ventriculitis: Results from a Multicenter Retrospective Cohort Study.

John J Lewin, Aaron M Cook, Cynthia Gonzales, David Merola, Ron Neyens, William J Peppard, Gretchen M Brophy, Lisa Kurczewski, Melissa Giarratano, Jason Makii, A Shaun Rowe, Eljim P Tesoro, Amber Zaniewski, Sarah Clark, Wendy C Ziai,

BACKGROUND:Central nervous system (CNS) infections are particularly prevalent in the adult neurocritical care patient population and are associated with significant morbidity and mortality. Factors relevant to the nature of CNS infections pose significant challenges to clinicians treating afflicted patients. Intraventricular (IVT) administration of antibiotics may offer several benefits over systemic ... Read more >>

Neurocrit Care (Neurocritical care)
[2019, 30(3):609-616]

Cited: 0 times

View full text PDF listing >>



Common Data Elements for Unruptured Intracranial Aneurysms and Aneurysmal Subarachnoid Hemorrhage: Recommendations from the Working Group on Hospital Course and Acute Therapies-Proposal of a Multidisciplinary Research Group.

Airton Leonardo de Oliveira Manoel, Mathieu van der Jagt, Sepideh Amin-Hanjani, Nicholas C Bambakidis, Gretchen M Brophy, Ketan Bulsara, Jan Claassen, E Sander Connolly, S Alan Hoffer, Brian L Hoh, Robert G Holloway, Adam G Kelly, Stephan A Mayer, Peter Nakaji, Alejandro A Rabinstein, Peter Vajkoczy, Mervyn D I Vergouwen, Henry Woo, Gregory J Zipfel, Jose I Suarez, ,

INTRODUCTION:The Common Data Elements (CDEs) initiative is a National Institute of Health/National Institute of Neurological Disorders and Stroke (NINDS) effort to standardize naming, definitions, data coding, and data collection for observational studies and clinical trials in major neurological disorders. A working group of experts was established to provide recommendations for ... Read more >>

Neurocrit Care (Neurocritical care)
[2019, 30(Suppl 1):36-45]

Cited: 0 times

View full text PDF listing >>



Platelets retain inducible alpha granule secretion by P-selectin expression but exhibit mechanical dysfunction during trauma-induced coagulopathy.

Alexander E St John, Jason C Newton, Erika J Martin, Bassem M Mohammed, Daniel Contaifer, Jessica L Saunders, Gretchen M Brophy, Bruce D Spiess, Kevin R Ward, Donald F Brophy, José A López, Nathan J White,

Essentials Platelets in trauma-induced coagulopathy (TIC) are impaired, but the mechanism is not known. We performed comprehensive longitudinal platelet function testing in trauma patient samples. Platelets in TIC are widely impaired early after injury, but platelet activatability is intact. This suggests a mechanism of transient platelet cytoskeletal/integrin dysfunction during TIC. ... Read more >>

J. Thromb. Haemost. (Journal of thrombosis and haemostasis : JTH)
[2019, 17(5):771-781]

Cited: 0 times

View full text PDF listing >>



Prevention Strategies to Improve Outcomes in Critically Ill Adults.

Robert MacLaren, Gretchen M Brophy,

Pharmacotherapy (Pharmacotherapy)
[2019, 39(3):212-214]

Cited: 0 times

View full text PDF listing >>



Periprocedural Neuroendovascular Antiplatelet Strategies for Thrombosis Prevention in Clopidogrel-Hyporesponsive Patients.

Megan E Barra, Karen Berger, Eljim P Tesoro, Gretchen M Brophy,

Patients undergoing neuroendovascular procedures such as cerebral aneurysm coiling and intracranial stent deployment are frequently treated with antiplatelet agents to prevent thrombotic complications. The combination of aspirin and a P2Y12 inhibitor such as clopidogrel is often initiated days before elective procedures or as loading doses for emergent procedures; however, some ... Read more >>

Pharmacotherapy (Pharmacotherapy)
[2019, 39(3):317-334]

Cited: 0 times

View full text PDF listing >>



Early Acute Ischemic Stroke Management for Pharmacists.

Michael Armahizer, Alison Blackman, Michael Plazak, Gretchen M Brophy,

Hosp Pharm (Hospital pharmacy)
[2020, 55(1):12-25]

Cited: 0 times

View full text PDF listing >>



Temporal Profile of Microtubule-Associated Protein 2: A Novel Indicator of Diffuse Brain Injury Severity and Early Mortality after Brain Trauma.

Linda Papa, Steven A Robicsek, Gretchen M Brophy, Kevin K W Wang, H Julia Hannay, Shelley Heaton, Ilona Schmalfuss, Andrea Gabrielli, Ronald L Hayes, Claudia S Robertson,

This study compared cerebrospinal fluid (CSF) levels of microtubule-associated protein 2 (MAP-2) from adult patients with severe traumatic brain injury (TBI) with uninjured controls over 10 days, and examined the relationship between MAP-2 concentrations and acute clinical and radiologic measures of injury severity along with mortality at 2 weeks and ... Read more >>

J. Neurotrauma (Journal of neurotrauma)
[2018, 35(1):32-40]

Cited: 2 times

View full text PDF listing >>



Pharmacotherapy Pearls for Emergency Neurological Life Support.

Gretchen M Brophy, Theresa Human,

The appropriate use of medications during Emergency Neurological Life Support (ENLS) is essential to optimize patient care. Important considerations when choosing the appropriate agent include the patient's organ function and medication allergies, potential adverse drug effects, drug interactions and critical illness and aging pathophysiologic changes. Critical medications used during ENLS ... Read more >>

Neurocrit Care (Neurocritical care)
[2017, 27(Suppl 1):51-73]

Cited: 1 time

View full text PDF listing >>



Guidelines for Family-Centered Care in Neuro-ICU Populations: Caveats for Routine Palliative Care.

Michel T Torbey, Gretchen M Brophy, Panayiotis N Varelas, Julian Bösel, Edward Manno, Mary Kay Bader, Jose I Suarez, David Seder, W David Freeman,

Crit. Care Med. (Critical care medicine)
[2017, 45(6):e620-e621]

Cited: 1 time

View full text PDF listing >>



Clevidipine Versus Nicardipine for Acute Blood Pressure Reduction in a Neuroscience Intensive Care Population.

Jacqueline R Finger, Lisa M Kurczewski, Gretchen M Brophy,

Currently, a lack of published literature exists regarding the use of clevidipine in the neuroscience population. This agent may be preferred in some patients because of its short half-life, potentially leading to more narrow blood pressure (BP) control in comparison with other agents. The purpose of this study was to ... Read more >>

Neurocrit Care (Neurocritical care)
[2017, 26(2):167-173]

Cited: 3 times

View full text PDF listing >>



Development of the Critical Care Pharmacotherapy Trials Network.

Seth R Bauer, Prasad E Abraham, Jeffrey F Barletta, Gretchen M Brophy, Brian L Erstad, Jeffrey P Gonzales, Curtis E Haas, Robert MacLaren, Eric W Mueller, Keith M Olsen, Ishaq Lat,

PURPOSE:The development of the Critical Care Pharmacotherapy Trials Network (CCPTN) as a model for practice-based pharmacotherapy research is described. SUMMARY:The CCPTN was formed in 2010 as a collaborative research network dedicated to scientific investigation in the field of critical care pharmacotherapy. The CCPTN organizational structure is consistent with many professional ... Read more >>

Am J Health Syst Pharm (American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists)
[2017, 74(5):287-293]

Cited: 0 times

View full text PDF listing >>



Temperature Management in Neurological and Neurosurgical Intensive Care Unit.

Patrick Lyden, Gretchen M Brophy, Nicolas Deye, Christopher M Horn,

Ther Hypothermia Temp Manag (Therapeutic hypothermia and temperature management)
[2016, 6(4):164-168]

Cited: 1 time

View full text PDF listing >>



Intravenous Versus Oral Acetaminophen for Pain Control in Neurocritical Care Patients.

Dan C Nichols, Pramit A Nadpara, Perry D Taylor, Gretchen M Brophy,

Acetaminophen (APAP) is used in neurocritical care (NCC) patients for analgesia without sedation or antiplatelet activity. Research suggests that intravenous (IV) APAP produces earlier and higher serum levels compared to oral (PO) APAP. This retrospective study evaluates the associated analgesic effects of IV and PO APAP and use of adjunctive ... Read more >>

Neurocrit Care (Neurocritical care)
[2016, 25(3):400-406]

Cited: 0 times

View full text PDF listing >>



Clinical Q & A: Translating Therapeutic Temperature Management from Theory to Practice.

Mary Kay Bader, Gretchen M Brophy, Teresa Wavra, Claranne Mathiesen, Mary Kay Bader,

Ther Hypothermia Temp Manag (Therapeutic hypothermia and temperature management)
[2016, 6(4):218-222]

Cited: 0 times

View full text PDF listing >>



What's new in refractory status epilepticus?

Stephane Legriel, Mauro Oddo, Gretchen M Brophy,

Intensive Care Med (Intensive care medicine)
[2017, 43(4):543-546]

Cited: 5 times

View full text PDF listing >>



Clinical Q & A: Translating Therapeutic Temperature Management from Theory to Practice.

Mary Kay Bader, Mary McKenna Guanci, Stephen A Figueroa, Gretchen M Brophy, Chris Laux,

Ther Hypothermia Temp Manag (Therapeutic hypothermia and temperature management)
[2016, 6(3):146-149]

Cited: 0 times

View full text PDF listing >>



Managing Status Epilepticus in the Older Adult.

Stephane Legriel, Gretchen M Brophy,

The aim of this systematic review was to describe particularities in epidemiology, outcome, and management modalities in the older adult population with status epilepticus. There is a higher incidence of status epilepticus in the older adult population, and it commonly has a nonconvulsive presentation. Diagnosis in this population may be ... Read more >>

J Clin Med (Journal of clinical medicine)
[2016, 5(5):]

Cited: 4 times

View full text PDF listing >>



Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury.

Linda Papa, Gretchen M Brophy, Robert D Welch, Lawrence M Lewis, Carolina F Braga, Ciara N Tan, Neema J Ameli, Marco A Lopez, Crystal A Haeussler, Diego I Mendez Giordano, Salvatore Silvestri, Philip Giordano, Kurt D Weber, Crystal Hill-Pryor, Dallas C Hack,

IMPORTANCE:Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) have been widely studied and show promise for clinical usefulness in suspected traumatic brain injury (TBI) and concussion. Understanding their diagnostic accuracy over time will help translate them into clinical practice. OBJECTIVES:To evaluate the temporal profiles of GFAP and ... Read more >>

JAMA Neurol (JAMA neurology)
[2016, 73(5):551-560]

Cited: 85 times

View full text PDF listing >>



Medical management of epileptic seizures: challenges and solutions.

Anand K Sarma, Nabil Khandker, Lisa Kurczewski, Gretchen M Brophy,

Epilepsy is one of the most common neurologic illnesses. This condition afflicts 2.9 million adults and children in the US, leading to an economic impact amounting to $15.5 billion. Despite the significant burden epilepsy places on the population, it is not very well understood. As this understanding continues to evolve, ... Read more >>

Neuropsychiatr Dis Treat (Neuropsychiatric disease and treatment)
[2016, 12:467-485]

Cited: 9 times

View full text PDF listing >>



Emergency Neurological Life Support: Pharmacotherapy.

Gretchen M Brophy, Theresa Human, Lori Shutter,

The appropriate use of medications during Emergency Neurological Life Support (ENLS) is essential to optimize patient care. Important considerations when choosing the appropriate agent include the patient's organ function and medication allergies, potential adverse drug effects, drug interactions, and critical illness and aging pathophysiologic changes. Critical medications used during ENLS ... Read more >>

Neurocrit Care (Neurocritical care)
[2015, 23 Suppl 2:S48-68]

Cited: 9 times

View full text PDF listing >>



Advertisement

Disclaimer
0.9987 s