Full Text Journal Articles by
Author Greta Dreyer

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Model strategies to address barriers to cervical cancer treatment and palliative care among women in Zimbabwe: a public health approach.

Oscar Tapera, Greta Dreyer, Anna Mary Nyakabau, Webster Kadzatsa, Babill Stray-Pedersen, Stephen James Heinrich Hendricks,

<h4>Background</h4>Cervical cancer treatment and care remains limited in Zimbabwe despite the growing burden of the disease among women. This study was aimed at investigating strategies to address barriers in accessing treatment and care by women with cervical cancer in Harare, Zimbabwe.<h4>Methods</h4>A qualitative inquiry was conducted to generate evidence for this ... Read more >>

BMC Womens Health (BMC women's health)
[2021, 21(1):180]

Cited: 0 times

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Highlights from the recent 2020 Annual Global IGCS Meeting.

Saketh R Guntupalli, Remi A Nout, Greta Dreyer,

Gynecol Oncol (Gynecologic oncology)
[2021, 161(2):333-335]

Cited: 0 times

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Characterization of cervical biopsies of women with HIV and HPV co-infection using p16ink4a, ki-67 and HPV E4 immunohistochemistry and DNA methylation.

Wieke W Kremer, Frederique J Vink, Marjolein van Zummeren, Greta Dreyer, Lawrence Rozendaal, John Doorbar, Maaike C G Bleeker, Chris J L M Meijer,

This study aims to characterize cervical intraepithelial neoplasia (CIN) in women living with HIV using biomarkers. Immunohistochemical (IHC) staining for human papillomavirus (HPV) E4 protein indicates CIN with productive HPV infection, whereas Ki-67 and p16<sup>ink4a</sup> indicate CIN with transforming characteristics, which may be further characterized using DNA hypermethylation, indicative for ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2020, 33(10):1968-1978]

Cited: 1 time

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Clinical evaluation and budget impact analysis of cervical cancer screening using cobas 4800 HPV screening technology in the public sector of South Africa.

Greta Dreyer, Christopher Maske, Marthinus Stander,

Cytology remains the mainstay of cervical cancer screening in South Africa (SA), however false negative rates are 25-50%. In contrast, human papillomavirus (HPV) screening techniques have higher sensitivity for cervical cancer precursors. The cobas® 4800 HPV test detects pooled high-risk HPV types and individual genotypes HPV 16 and 18. Using ... Read more >>

PLoS One (PloS one)
[2019, 14(9):e0221495]

Cited: 1 time

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The use of molecular markers for cervical screening of women living with HIV in South Africa.

Wieke W Kremer, Marjolein van Zummeren, Erika Breytenbach, Karin L Richter, Renske D M Steenbergen, Chris J L M Meijer, Greta Dreyer,

<h4>Objective</h4>To determine the performance of molecular screening strategies for detection of cervical intraepithelial neoplasia grade 3 or worse (CIN3+) in comparison with cytology screening in women living with HIV.<h4>Design</h4>Post-hoc analysis using data from a South African study cohort.<h4>Methods</h4>Cytology and human papillomavirus (HPV)-based strategies were evaluated, including single test and FAM19A4/miR124-2 ... Read more >>

AIDS (AIDS (London, England))
[2019, 33(13):2035-2042]

Cited: 3 times

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Oncological outcome of surgical management in patients with recurrent uterine cancer-a multicenter retrospective cohort study-CEEGOG EX01 Trial.

Anna Germanova, Francesco Raspagliesi, Luis Chiva, Ladislav Dusek, Macit Arvas, Eric Leblanc, Tibor Lengeyl, Violante Di Donato, Afra Zaal, Polat Dursun, Ignacio Zapardiel, Taner Turan, Sergio Augusto Triginelli, Sang Wun Kim, Matias Jurado, Jalid Sehouli, Borek Sehnal, Ladislav Masak, Nicolae loanid, Greta Dreyer, Robert Jach, Miloš Mlynček, Valentina Chiappa, Fabio Martinelli, Jiri Slama, Roman Kocian, Giorgio Bogani, David Cibula,

<h4>Objectives</h4>To assess the survival of patients who have received an operation for recurrent cervical and endometrial cancer and to determine prognostic variables for improved oncologic outcome.<h4>Methods</h4>A retrospective multicenter analysis of the medical records of 518 patients with cervical (N = 288) or endometrial cancer (N = 230) who underwent surgery ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2019, 29(4):711-720]

Cited: 0 times

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HPV16-Related Cervical Cancers and Precancers Have Increased Levels of Host Cell DNA Methylation in Women Living with HIV.

Wieke W Kremer, Marjolein van Zummeren, Daniëlle A M Heideman, Birgit I Lissenberg-Witte, Peter J F Snijders, Renske D M Steenbergen, Greta Dreyer, Chris J L M Meijer,

Data on human papillomavirus (HPV) type-specific cervical cancer risk in women living with human immunodeficiency virus (WLHIV) are needed to understand HPV⁻HIV interaction and to inform prevention programs for this population. We assessed high-risk HPV type-specific prevalence in cervical samples from 463 WLHIV from South Africa with different underlying, histologically ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2018, 19(11):]

Cited: 1 time

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Detection of hypermethylated genes as markers for cervical screening in women living with HIV.

Wieke W Kremer, Marjolein Van Zummeren, Putri W Novianti, Karin L Richter, Wina Verlaat, Peter Jf Snijders, Daniëlle Am Heideman, Renske Dm Steenbergen, Greta Dreyer, Chris Jlm Meijer,

<h4>Introduction</h4>To evaluate the performance of hypermethylation analysis of ASCL1, LHX8 and ST6GALNAC5 in physician-taken cervical scrapes for detection of cervical cancer and cervical intraepithelial neoplasia (CIN) grade 3 in women living with HIV (WLHIV) in South Africa.<h4>Methods</h4>Samples from a prospective observational cohort study were used for these analyses. Two cohorts ... Read more >>

J Int AIDS Soc (Journal of the International AIDS Society)
[2018, 21(8):e25165]

Cited: 6 times

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Selection of women at risk for cervical cancer in an HIV-infected South African population.

Marjolein Van Zummeren, Wieke W Kremer, Matthys C Van Aardt, Erika Breytenbach, Karin L Richter, Lawrence Rozendaal, Birgit I Witte, Lise M A De Strooper, Albertus T Hesselink, Daniëlle A M Heideman, Peter J F Snijders, Renske D M Steenbergen, Greta Dreyer, Chris J L M Meijer,

<h4>Objective</h4>Cervical cancer is the leading cause of cancer-related death in women in South Africa. This study evaluates DNA methylation levels in cervical (pre)cancer and aims to assess the value of high-risk human papillomavirus (hrHPV) testing and methylation analysis, alone or in combination, on physician-taken cervical scrapes to detect cervical cancer, ... Read more >>

AIDS (AIDS (London, England))
[2017, 31(14):1945-1953]

Cited: 7 times

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HPV types in cervical cancer tissue in South Africa: A head-to-head comparison by mRNA and DNA tests.

Amir Rad, Sveinung Wergeland Sørbye, Greta Dreyer, Siri Hovland, Bente Marie Falang, Melanie Louw, Finn Egil Skjeldestad,

Accurate identification of human papillomavirus (HPV)-types in cervical cancer tissue may be important for tailoring tests for primary screening and types to be included in a vaccine. The aim of this study was to compare test-performance of a 45-type HPV deoxyribonucleic acid (DNA)-test with a 9-type HPV messenger ribonucleic acid ... Read more >>

Medicine (Baltimore) (Medicine)
[2017, 96(47):e8752]

Cited: 2 times

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Clinical implications of the interaction between HPV and HIV infections.

Greta Dreyer,

HIV-related immunodeficiency has complex effects on female genital HPV, which include increased risks of infection, multiple types, persistence, reactivation and the risk to develop pre-invasive and invasive disease. Reconstitution of immunity with anti-viral drugs improves cellular immunity, but the risk of HPV-related malignancy remains higher than background incidences and presents ... Read more >>

Best Pract Res Clin Obstet Gynaecol (Best practice & research. Clinical obstetrics & gynaecology)
[2018, 47:95-106]

Cited: 7 times

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Oncogenic and incidental HPV types associated with histologically confirmed cervical intraepithelial neoplasia in HIV-positive and HIV-negative South African women.

Matthys Cornelis Van Aardt, Greta Dreyer, Leon Cornelius Snyman, Karin Louise Richter, Piet Becker, Sebolelo Mpho Mojaki,

<h4>Background</h4>In Africa, data on the relationship between oncogenic human papillomavirus (HPV) types, immune status and cervical preinvasive lesions are lacking.<h4>Methods</h4> We investigated low-risk (lrHPV) and high-risk (hrHPV) HPV types in a cohort of women with cervical intraepithelial neoplasia (CIN) II/III confirmed on histological examination, in an urban setting with a high ... Read more >>

S Afr Med J (South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde)
[2016, 106(6):]

Cited: 1 time

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School-based human papillomavirus vaccination: An opportunity to increase knowledge about cervical cancer and improve uptake of screening.

Greta Dreyer, Frederick H van der Merwe, Matthys H Botha, Leon C Snyman, Deborah Constant, Cathy Visser, Justin Harvey,

<h4>Background</h4>Poor knowledge about cervical cancer plays a role in limiting screening uptake. HPV vaccination provides an untested platform to distribute information that could possibly improve knowledge and screening coverage.<h4>Objective</h4>To measure changes in knowledge and screening uptake when information and screening opportunities were provided to mothers of adolescent HPV vaccine recipients.<h4>Methods</h4>During ... Read more >>

S Afr Med J (South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde)
[2015, 105(11):912-916]

Cited: 7 times

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Unique human papillomavirus-type distribution in South African women with invasive cervical cancer and the effect of human immunodeficiency virus infection.

Matthys Cornelis van Aardt, Greta Dreyer, Hannelie Francina Pienaar, Frank Karlsen, Siri Hovland, Karin Louise Richter, Piet Becker,

<h4>Objectives</h4>Cervical cancer is the most common cause of cancer-related deaths among South African women. Viral types associated with cervical cancer may differ not only between countries and regions, but possibly also between human immunodeficiency virus (HIV)-infected and noninfected women.<h4>Methods</h4>In a population with high HIV prevalence, human papillomavirus (HPV)-type infections detected ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2015, 25(5):919-925]

Cited: 7 times

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The Vaccine and Cervical Cancer Screen (VACCS) project: Linking cervical cancer screening to HPV vaccination in the South-West District of Tshwane, Gauteng, South Africa.

Leon C Snyman, Greta Dreyer, Matthys H Botha, Frederick Haynes van der Merwe, Piet J Becker,

<h4>Background</h4>Cervical cancer is preventable, but still highly prevalent in South Africa (SA). Screening strategies in the country have been ineffective, and new ways to prevent the disease are needed.<h4>Objectives</h4>To investigate the feasibility of linking cervical cancer screening in adult women to human papillomavirus (HPV) vaccination in schoolgirls.<h4>Methods</h4>Ten primary schools in ... Read more >>

S Afr Med J (South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde)
[2015, 105(2):115-120]

Cited: 4 times

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Human papillomavirus prevalence and type distribution in invasive cervical cancer in sub-Saharan Africa.

Lynette Denny, Isaac Adewole, Rose Anorlu, Greta Dreyer, Manivasan Moodley, Trudy Smith, Leon Snyman, Edwin Wiredu, Anco Molijn, Wim Quint, Gunasekaran Ramakrishnan, Johannes Schmidt,

In sub-Saharan Africa, invasive cervical cancer (ICC) incidence and mortality are among the highest in the world. This cross-sectional epidemiological study assessed human papillomavirus (HPV) prevalence and type distribution in women with ICC in Ghana, Nigeria, and South Africa. Cervical biopsy specimens were obtained from women aged ≥ 21 years ... Read more >>

Int J Cancer (International journal of cancer)
[2014, 134(6):1389-1398]

Cited: 59 times

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Screening for gynaecologic cancers in genetically predisposed women.

Greta Dreyer,

Hereditary breast and ovarian cancer syndrome and hereditary non-polyposis colon cancer syndrome are the two most important syndromes responsible for inherited cancers in gynaecology. Genetic testing is available for both these syndromes. Breast cancer gene testing is affordable and easy in women with ancestry where the mutation patterns are known, ... Read more >>

Best Pract Res Clin Obstet Gynaecol (Best practice & research. Clinical obstetrics & gynaecology)
[2012, 26(2):267-282]

Cited: 1 time

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Cost effectiveness of high-risk HPV DNA testing for cervical cancer screening in South Africa.

Arthi Vijayaraghavan, Molly Efrusy, Gerhard Lindeque, Greta Dreyer, Christopher Santas,

<h4>Objective</h4>To determine the cost effectiveness of several cervical cancer screening strategies utilizing HPV testing in South Africa.<h4>Methods</h4>We developed a lifetime Markov model of the costs, quality of life, and survival associated with screening and treating cervical cancer and its precursors. Screening strategies evaluated included: 1) conventional cytology, 2) cytology followed ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2009, 112(2):377-383]

Cited: 21 times

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BRCA1 mutations in South African breast and/or ovarian cancer families: evidence of a novel founder mutation in Afrikaner families.

Michelle D Reeves, Tali M Yawitch, Nerina C van der Merwe, Hester J van den Berg, Greta Dreyer, Elizabeth J van Rensburg,

Germ-line mutations within BRCA1 are responsible for different proportions of inherited susceptibility to breast/ovarian cancer, and the spectrum of mutations within this gene is often unique to certain populations. At this time, there have been no reports regarding the role of BRCA1 in South African breast and/or ovarian cancer families. ... Read more >>

Int J Cancer (International journal of cancer)
[2004, 110(5):677-682]

Cited: 27 times

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