Full Text Journal Articles by
Author Gregory Y H Lip

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Atrial Fibrillation in Heart Failure: Focus on Antithrombotic Management.

Mohammed Obeidat, Malcolm Burgess, Gregory Y H Lip,

Heart failure (HF) and atrial fibrillation (AF), increasingly common in the aging population, are closely related and commonly found together. This article explores the relationship between AF and HF and the thromboembolic effect of these diseases. Morbidity and mortality are increased when the 2 conditions are seen together. Stroke risks ... Read more >>

Heart Fail Clin (Heart failure clinics)
[2020, 16(1):107-120]

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Novel Oral Anticoagulant Based Versus Vitamin K Antagonist Based Double Therapy Among Stented Patients With Atrial Fibrillation: Insights From the PIONEER AF-PCI Trial.

Mathieu Kerneis, Megan K Yee, Roxana Mehran, Tarek Nafee, Christoph Bode, Jonathan L Halperin, Eric D Peterson, Freek W A Verheugt, Peter Wildgoose, Martin van Eickels, Gregory Y H Lip, Marc Cohen, Keith A A Fox, C Michael Gibson,

BACKGROUND:Among stented patients with atrial fibrillation, double therapy with a novel oral anticoagulant plus single antiplatelet therapy (SAPT) reduces bleeding or cardiovascular rehospitalizations compared with a vitamin K antagonist (VKA) based triple therapy regimen. A recent study demonstrated that apixaban based double therapy reduced bleeding compared with VKA based double ... Read more >>

Circ Cardiovasc Interv (Circulation. Cardiovascular interventions)
[2019, 12(11):e008160]

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A Time to Stop and Think Before the Shock.

John Mandrola, Gregory Y H Lip, Andrew Foy,

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2019, 74(18):2275-2277]

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Very late arrhythmia recurrences in patients with sinus rhythm within the first year after catheter ablation: The Leipzig Heart Center AF Ablation Registry.

Jelena Kornej, Katja Schumacher, Philipp Sommer, Tatjana Potpara, Arash Arya, Nikolaos Dagres, Andreas Bollmann, Daniela Husser-Bollmann, Gregory Y H Lip, Gerhard Hindricks,

AIMS :Arrhythmia recurrences after catheter ablation of atrial fibrillation (AF) still remain an important management issue. Recently, the APPLE score had been introduced to predict rhythm outcomes within 12 months after catheter ablation, while the simple MB-LATER score was developed for the prediction of very late recurrence of AF (VLRAF) occurring after ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2019, 21(11):1646-1652]

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Determinants of left atrium thrombi in scheduled cardioversion: an ENSURE-AF study analysis.

Jose L Merino, Gregory Y H Lip, Hein Heidbuchel, Aron-Ariel Cohen, Raffaele De Caterina, Joris R de Groot, Michael D Ezekowitz, Jean-Yves Le Heuzey, Sakis Themistoclakis, James Jin, Michael Melino, Shannon M Winters, Béla Merkely, Andreas Goette,

AIMS:ENSURE-AF (NCT02072434) was the largest prospective randomized clinical trial of anticoagulation for cardioversion in atrial fibrillation (AF), which also provides the largest prospective dataset for transoesophageal echocardiography (TOE) prior to cardioversion. This ancillary analysis investigated determinants of TOE-detected left atrium thrombi (LAT) in patients scheduled for electrical cardioversion (ECV). METHODS ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2019, 21(11):1633-1638]

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'Real-world' observational studies in arrhythmia research: data sources, methodology, and interpretation. A position document from European Heart Rhythm Association (EHRA), endorsed by Heart Rhythm Society (HRS), Asia-Pacific HRS (APHRS), and Latin America HRS (LAHRS).

Christian Torp-Pedersen, Andreas Goette, Peter Bronnum Nielsen, Tatjana Potpara, Laurent Fauchier, Alan John Camm, Elena Arbelo, Giuseppe Boriani, Flemming Skjoeth, John Rumsfeld, Frederick Masoudi, Yutao Guo, Boyoung Joung, Marwan M Refaat, Young-Hoon Kim, Christine M Albert, Jonathan Piccini, Alvaro Avezum, Gregory Y H Lip, ,

The field of observational studies or "real world studies" is in rapid development with many new techniques introduced and increased understanding of traditional methods. For this reason the current paper provides an overview of current methods with focus on new techniques. Some highlights can be emphasized: We provide an overview ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2019, :]

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Validation of the modified Microlife blood pressure monitor in patients with paroxysmal atrial fibrillation.

Nina Huppertz, Gregory Y H Lip, Deirdre A Lane,

AIMS:Undiagnosed atrial fibrillation (AF) accounts for 6% of all strokes, therefore early detection and treatment of the arrhythmia are paramount. Previous research has illustrated that the Microlife WatchBPO3 AFIB, an automated blood pressure (BP) monitor with an inbuilt AF algorithm, accurately detects permanent AF. Currently, limited data exist on whether ... Read more >>

Clin Res Cardiol (Clinical research in cardiology : official journal of the German Cardiac Society)
[2019, :]

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Reply: Direct Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation and Liver Disease.

Eue-Keun Choi, So-Ryoung Lee, Seil Oh, Gregory Y H Lip,

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2019, 74(18):2330-2331]

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Heart rate variability in atrial fibrillation: The balance between sympathetic and parasympathetic nervous system.

Ahsan A Khan, Gregory Y H Lip, Alena Shantsila,

BACKGROUND:Atrial fibrillation (AF) is the commonest abnormal heart rhythm with significant related morbidity and mortality. Several pathophysiologic mechanisms have been advocated to explain the onset of AF. There has been increasing evidence that abnormalities of the autonomic nervous system (ANS) that includes sympathetic, parasympathetic and intrinsic neural network are involved ... Read more >>

Eur. J. Clin. Invest. (European journal of clinical investigation)
[2019, 49(11):e13174]

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Comparison of Risk Scores for the Prediction of the Overall Cardiovascular Risk in Patients with Ischemic Stroke: The Athens Stroke Registry.

Georgios Georgiopoulos, George Ntaios, Kimon Stamatelopoulos, Efstathios Manios, Eleni Korompoki, Evangelia Vemmou, Haralampos Milionis, Stefano Masi, Gregory Y H Lip, Konstantinos Vemmos,

BACKGROUND:Stratification of overall vascular risk in patients with ischemic stroke is important as it may guide management decisions. Currently available schemes have only modest prognostic accuracy. The TRA2°P score aids in vascular risk stratification in patients with previous myocardial infarction (MI). AIM:We investigated whether the prognostic performance of TRA2°P can ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2019, :104415]

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Dabigatran Dual Therapy Versus Warfarin Triple Therapy in Atrial Fibrillation Post-PCI: Time in Therapeutic Range.

Gregory Y H Lip, Deepak L Bhatt, Stefan H Hohnloser, Takeshi Kimura, Corinna Miede, Matias Nordaby, Jonas Oldgren, Philippe Gabriel Steg, Jurriën M Ten Berg, Christopher P Cannon,

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2019, 74(19):2431-2433]

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Guideline-Adherent Treatment for Stroke and Death in Atrial Fibrillation Patients From UK and Japanese AF Registries.

Kazuo Miyazawa, Hisashi Ogawa, Michał Mazurek, Eduard Shantsila, Deirdre A Lane, Andreas Wolff, Masaharu Akao, Gregory Y H Lip,

BACKGROUND:Guideline-adherent antithrombotic treatment (ATT) reduces the risk of stroke and death in patients with atrial fibrillation (AF). However, the effect of ATT adherence among different ethnicities remains uncertain. We compared the prognosis of AF patients in Japan and the UK according to guideline adherence status.Methods and Results:We compared the clinical characteristics and ... Read more >>

Circ. J. (Circulation journal : official journal of the Japanese Circulation Society)
[2019, :]

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Identification of Markers Associated With Development of Stroke in "Clinically Low-Risk" Atrial Fibrillation Patients.

Seung Yong Shin, Sang-Jin Han, Jin-Seok Kim, Sung Il Im, Jaemin Shim, Jinhee Ahn, Eun Mi Lee, Yae Min Park, Jun Hyung Kim, Gregory Y H Lip, Hong Euy Lim,

Background Stroke and thromboembolic events may still occur in "clinically low-risk" atrial fibrillation (AF) patients as categorized by CHA2DS2-VASc score. Our aim was to assess the proportion of "clinically low-risk" patients using a nongender CHA2DS2-VASc (ie, CHA2DS2-VA) score of 0 to 1 among patients who experienced AF-associated stroke and to ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2019, 8(21):e012697]

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Invited review: hypertension and atrial fibrillation: epidemiology, pathophysiology, and implications for management.

Jakub Gumprecht, Magdalena Domek, Gregory Y H Lip, Alena Shantsila,

Hypertension affects around half of the adult population worldwide, being one of the most common cardiovascular disorders. On a population basis, high blood pressure is considered to be the major independent risk factor for atrial fibrillation (AF). The incidence of both diseases has increased significantly in the recent decades and ... Read more >>

J Hum Hypertens (Journal of human hypertension)
[2019, :]

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Management of Nonvariceal Upper Gastrointestinal Bleeding: Guideline Recommendations From the International Consensus Group.

Alan N Barkun, Majid Almadi, Ernst J Kuipers, Loren Laine, Joseph Sung, Frances Tse, Grigorios I Leontiadis, Neena S Abraham, Xavier Calvet, Francis K L Chan, James Douketis, Robert Enns, Ian M Gralnek, Vipul Jairath, Dennis Jensen, James Lau, Gregory Y H Lip, Romaric Loffroy, Fauze Maluf-Filho, Andrew C Meltzer, Nageshwar Reddy, John R Saltzman, John K Marshall, Marc Bardou,

Description:This update of the 2010 International Consensus Recommendations on the Management of Patients With Nonvariceal Upper Gastrointestinal Bleeding (UGIB) refines previous important statements and presents new clinically relevant recommendations. Methods:An international multidisciplinary group of experts developed the recommendations. Data sources included evidence summarized in previous recommendations, as well as systematic ... Read more >>

Ann. Intern. Med. (Annals of internal medicine)
[2019, :]

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Assessment of Arterial Stiffness in Patients with Resistant Hypertension: Additional Insights into the Pathophysiology of this condition?

Reem Alsharari, Gregory Y H Lip, Alena Shantsila,

Good understanding of the pathophysiological mechanism(s) of resistant hypertension (RH) and the relationship to vascular dysfunction is important for optimal blood pressure control. The aim of this review article is to summarise the available data on the methods of arterial stiffness assessment, and their usefulness in RH. Several studies that ... Read more >>

Am. J. Hypertens. (American journal of hypertension)
[2019, :]

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Malignant hypertension: does this still exist?

Magdalena Domek, Jakub Gumprecht, Gregory Y H Lip, Alena Shantsila,

J Hum Hypertens (Journal of human hypertension)
[2019, :]

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Antithrombotic treatment for newly diagnosed atrial fibrillation in relation to patient age: the GLORIA-AF registry programme.

Michał Mazurek, Jonathan L Halperin, Menno V Huisman, Hans-Christoph Diener, Sergio J Dubner, Chang Sheng Ma, Kenneth J Rothman, Jeff S Healey, Christine Teutsch, Miney Paquette, Lionel Riou França, Shihai Lu, Dorothee B Bartels, Gregory Y H Lip,

AIMS:To assess antithrombotic therapy choices in relation to patient age in a large, global registry on atrial fibrillation (AF). METHODS AND RESULTS:Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF) is an international programme involving patients with newly diagnosed AF and ≥1 risk factors for stroke. ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2019, :]

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The optimal drug adherence to maximize the efficacy and safety of non-vitamin K antagonist oral anticoagulant in real-world atrial fibrillation patients.

Daehoon Kim, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Jung-Hoon Sung, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y H Lip, Boyoung Joung,

AIMS:To investigate the association between adherence to non-vitamin K antagonist oral anticoagulant (NOAC) and clinical outcomes and to determine the optimal cut-off level of NOAC adherence among patients with atrial fibrillation (AF). METHODS AND RESULTS:Using the Korean National Health Insurance Service database, we identified 96 197 patients with non-valvular AF who ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2019, :]

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Prevalence and Associated Stroke Risk of Human Immunodeficiency Virus-Infected Patients With Atrial Fibrillation - A Nationwide Cohort Study.

Hyunjean Jung, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Jung-Hoon Sung, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y H Lip, Boyoung Joung,

BACKGROUND:Patients infected with human immunodeficiency virus (HIV) are at increased risk of cardiovascular diseases. However, little is known regarding the risk of ischemic stroke in HIV-infected individuals with atrial fibrillation (AF).Methods and Results:From the Korean National Health Insurance Service (NHIS) database from January 1, 2005 to December 31, 2016, we analyzed 962,116 ... Read more >>

Circ. J. (Circulation journal : official journal of the Japanese Circulation Society)
[2019, :]

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Long-Term Relationship Between Atrial Fibrillation, Multimorbidity and Oral Anticoagulant Drug Use.

Marco Proietti, Irene Marzona, Tommaso Vannini, Mauro Tettamanti, Ida Fortino, Luca Merlino, Stefania Basili, Pier Mannuccio Mannucci, Giuseppe Boriani, Gregory Y H Lip, Maria Carla Roncaglioni, Alessandro Nobili,

OBJECTIVES:To analyze the relationship between atrial fibrillation (AF) and Charlson comorbidity index (CCI) in a population-based cohort study over a long-term follow-up period, in relation to oral anticoagulant (OAC) prescriptions and outcomes. PATIENTS AND METHODS:We used data from the administrative health databases of Lombardy. All patients with AF and age ... Read more >>

Mayo Clin. Proc. (Mayo Clinic proceedings)
[2019, :]

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Venous Thromboembolism in Patients with Liver Cirrhosis: Findings from the RIETE (Registro Informatizado de la Enfermedad TromboEmbolica) Registry.

Behnood Bikdeli, David Jiménez, Guadalupe Garcia-Tsao, Raquel Barba, Carme Font, María Del Carmen Díaz-Pedroche, Lucia Mazzolai, Derek Henry Wallace Little, Antonella Tufano, Alfonso J Tafur, Deborah Siegal, Gregory Y H Lip, Manuel Monreal, ,

Patients with cirrhosis are not only at an increased risk of bleeding but also at risk of venous thromboembolism (VTE). We sought to determine the clinical characteristics, management, and outcomes after VTE in patients with cirrhosis. We used the data from RIETE (Registro Informatizado de la Enfermedad TromboEmbolica), an international ... Read more >>

Semin. Thromb. Hemost. (Seminars in thrombosis and hemostasis)
[2019, 45(8):793-801]

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Revisiting the effects of omitting aspirin in combined antithrombotic therapies for atrial fibrillation and acute coronary syndromes or percutaneous coronary interventions: meta-analysis of pooled data from the PIONEER AF-PCI, RE-DUAL PCI, and AUGUSTUS trials.

Tatjana S Potpara, Nebojsa Mujovic, Marco Proietti, Nikolaos Dagres, Gerhard Hindricks, Jean-Phillipe Collet, Marco Valgimigli, Hein Heidbuchel, Gregory Y H Lip,

AIMS:Recently, three randomized trials reported that dual antithrombotic treatments (DATs) including non-vitamin K antagonist oral anticoagulants (NOACs) and a P2Y12 inhibitor without aspirin were associated with significantly less bleeding than vitamin K antagonist (VKA)-based triple antithrombotic therapy (TAT) in atrial fibrillation (AF) patients with acute coronary syndrome (ACS) or undergoing ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2019, :]

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Breaking the rules for studies using real-world observational data: The case of direct-acting anticoagulants and antiepileptic drugs.

Joshua Brown, Brian Cicali, Phuong Pham, Stephan Schmidt, Gregory Y H Lip,

Eur Heart J Cardiovasc Pharmacother (European heart journal. Cardiovascular pharmacotherapy)
[2019, :]

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Bodyweight fluctuation is associated with increased risk of incident atrial fibrillation.

Hyun-Jung Lee, Eue-Keun Choi, Kyung-Do Han, Euijae Lee, Inki Moon, So-Ryoung Lee, Myung-Jin Cha, Seil Oh, Gregory Y H Lip,

BACKGROUND:Obesity and weight gain are established risk factors for atrial fibrillation (AF). OBJECTIVE:The purpose of this study was to investigate whether bodyweight variability is also a risk factor for AF development. METHODS:A nationwide population-based cohort of 8,091,401 adults from the Korean National Health Insurance Service database without a history of ... Read more >>

Heart Rhythm (Heart rhythm)
[2019, :]

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