Full Text Journal Articles by
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THE MANAGEMENT OF DISTAL URETER DURING RADICAL NEPHROURETERECTOMY DOES NOT INFLUENCE BLADDER RECURRENCE.

Marina Pizzighella, Franck Bruyere, Benoit Peyronnet, Vivien Grafeille, Nicolas Brichart, Keiichiro Mori, Gregory Verhoest, Karim Bensalah, Marco Moschini, Evenguelos Xylinas, Benjamin Pradere,

<h4>Purpose</h4>The bladder cuff management and its surgical approach represent an essential and debated step in radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). The objective of our study was to determine which bladder-cuff management has the best oncological outcomes in terms of bladder recurrence-free survival ( BRFS).<h4>Methods</h4>We retrospectively analyzed ... Read more >>

J Endourol (Journal of endourology)
[2021, :]

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Predicting Complications After Robotic Partial Nephrectomy: Back to Simplicity.

Zine-Eddine Khene, Clément Mazouin, Alessandro Larcher, Benoit Peyronnet, Anis Gasmi, Mathieu Roumiguié, Grégory Verhoest, Umberto Capitanio, Romain Mathieu, Nicolas Doumerc, Francesco Montorsi, Karim Bensalah,

<h4>Background</h4>Robotic partial nephrectomy (RPN) has a significant morbidity. Nephrometry scores have been described to predict the occurrence of complications. Their usefulness is debated.<h4>Objective</h4>To evaluate the clinical utility of three nephrometry scores (radius, exophytic/endophytic, nearness, anterior/posterior, location [RENAL], preoperative aspects and dimensions used for an anatomical [PADUA], and simplified PADUA Renal ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Multiple metastatic clones assessed by an integrative multiomics strategy in clear cell renal carcinoma: a case study.

Julien Dagher, Angelique Brunot, Bertrand Evrard, Solene-Florence Kammerer-Jacquet, Marion Beaumont, Laurence Cornevin, Fanny Derquin, Gregory Verhoest, Karim Bensalah, Alexandra Lespagnol, Frederic Dugay, Marc-Antoine Belaud-Rotureau, Frédéric Chalmel, Nathalie Rioux-Leclercq,

The dynamics of metastatic evolution in clear cell renal cell carcinoma (ccRCC) are complex. We report a case study where tumour heterogeneity resulting from clonal evolution is a frequent feature and could play a role in metastatic dissemination.We used an integrative multiomics strategy combining genomic and transcriptomic data to classify ... Read more >>

J Clin Pathol (Journal of clinical pathology)
[2021, :]

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Complete Transurethral Resection before Radical Cystectomy May Improve Oncological Outcomes.

Vivien Graffeille, Grégory Verhoest, Alexandre Gryn, Solène-Florence Kammerer-Jacquet, Quentin Alimi, Jean-Baptiste Beauval, Luc Beuzit, Benjamin Pradère, Matthieu Thoulouzan, Zine Eddine Khene, François Guille, Nathalie Rioux-Leclercq, Romain Mathieu, Xavier Gamé, Karim Bensalah, Michel Soulié, Mathieu Roumiguié, Benoit Peyronnet,

<h4>Objectives</h4>The objective of this study was to assess the impact of complete transurethral resection of bladder tumors (TURBTs) before radical cystectomy on pathological and oncological outcomes of patients with muscle-invasive bladder cancer (MIBC) and high-risk non-MIBC.<h4>Materials and methods</h4>The charts of all patients who underwent radical cystectomy for bladder cancer in ... Read more >>

Urol Int (Urologia internationalis)
[2021, :1-8]

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Robot-Assisted Cystectomy and Ileal Conduit for Neurogenic Bladder: Comparison of Extracorporeal vs Intracorporeal Urinary Diversion.

Clément Mazouin, Jacques Hubert, Thibault Tricard, Pierre Lecoanet, Camille Haudebert, Imad Bentellis, Pierre Baron, Juliette Hascoet, Camille Castes, Grégory Verhoest, Branwell Tibi, Benjamin Pradere, Franck Bruyere, Grégoire Capon, Andréa Manunta, Christian Saussine, Benoit Peyronnet,

<b><i>Objectives:</i></b> The aim of the present study was to compare the perioperative outcomes of extracorporeal (EXTRA) <i>vs</i> intracorporeal (INTRA) urinary diversion in patients undergoing robotic cystectomy and ileal conduit for neurogenic bladder. <b><i>Methods:</i></b> All consecutive patients who underwent robot-assisted cystectomy and ileal conduit for neurogenic bladder in six centers between ... Read more >>

J Endourol (Journal of endourology)
[2021, :]

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Comparison of the prognosis of primary vs. progressive muscle invasive bladder cancer after radical cystectomy: Results from a large multicenter study.

François-Xavier Nouhaud, Marouene Chakroun, Claire Lenormand, Idir Ouzaid, Benoit Peyronnet, Alexandre Gryn, Thomas Prudhomme, Vivien Grafeille, Michel Soulié, Mathieu Roumiguié, Grégory Verhoest, Evanguelos Xylinas, Abderrazak Bouzouita, Mohamed Chebil, Christian Pfister,

<h4>Purpose</h4>To assess whether progressive and primary muscle invasive bladder cancer (MIBC) have different prognosis after radical cystectomy or not. To date only a few data are available on this topic with conflicting results. Further studies on large cohort are needed to clarify these outcomes that may influence bladder cancer management ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(3):195.e1-195.e6]

Cited: 1 time

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Renal cell carcinoma with leiomyomatous stroma in tuberous sclerosis complex: a distinct entity.

Marjorie Gournay, Frédéric Dugay, Marc-Antoine Belaud-Rotureau, Benoit Peyronnet, Romain Mathieu, Gregory Verhoest, Karim Bensalah, Sylvie Odent, Philippe Denizeau, Cécile Vigneau, Aurélien Morini, Nathalie Rioux-Leclercq, Solène-Florence Kammerer-Jacquet,

Renal cell carcinoma with leiomyomatous stroma (RCCLS) is an emerging entity frequently associated with tuberous sclerosis complex (TSC). We described herein a series of RCCLS in TSC patients at pathological and cytogenetic levels. Three male patients with TSC and RCCLS were identified between 2000 and 2019 at the University Hospital ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2021, 478(4):793-799]

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PD-L1 expression and pattern of immune cells in pre-treatment specimens are associated with disease-free survival for HR-NMIBC undergoing BCG treatment.

Mathieu Roumiguié, Eva Compérat, Léonor Chaltiel, François Xavier Nouhaud, Gregory Verhoest, Alexandra Masson-Lecomte, Pierre Colin, François Audenet, Nadine Houédé, Stéphane Larré, Evanguelos Xylinas, Serge Brunelle, Jeanne Piana-Thomassin, Juliette Cotte, Géraldine Pignot, Yann Neuzillet, Morgan Rouprêt,

<h4>Purpose</h4>To assess the association between PD-L1 expression and disease-free survival (DFS) in High-Risk Non-Muscle Invasive Bladder Cancer (HR-NMIBC) patients treated with intravesical Bacillus Calmette-Guerin (BCG) instillations (IBI).<h4>Methods</h4>Retrospective study in five French centres between 2001 and 2015. Participants were 140 patients with histologically confirmed HR-NMIBC. All patients received induction and maintenance ... Read more >>

World J Urol (World journal of urology)
[2020, :]

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Endophytic Renal Cell Carcinoma Treated with Robot-Assisted Surgery: Functional Outcomes - A Comprehensive Review of the Current Literature.

Zine-Eddine Khene, Benoit Peyronnet, Anis Gasmi, Grégory Verhoest, Romain Mathieu, Karim Bensalah,

<h4>Introduction</h4>Robotic surgery for the management of localized renal cell carcinoma (RCC) has gained increasing popularity during the last decade. An endophytic renal tumour represents a surgical technical challenge in terms of identification and resection related to the lack of external visual cues on the kidney surface.<h4>Materials and methods</h4>There is little ... Read more >>

Urol Int (Urologia internationalis)
[2020, 104(5-6):343-350]

Cited: 1 time

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Immunotherapy in Renal Cell Carcinoma: The Future Is Now.

Antoine Deleuze, Judikaël Saout, Frédéric Dugay, Benoit Peyronnet, Romain Mathieu, Gregory Verhoest, Karim Bensalah, Laurence Crouzet, Brigitte Laguerre, Marc-Antoine Belaud-Rotureau, Nathalie Rioux-Leclercq, Solène-Florence Kammerer-Jacquet,

Renal cell carcinoma is the third type of urologic cancer and has a poor prognosis with 30% of metastatic patients at diagnosis. The antiangiogenics and targeted immunotherapies led to treatment remodeling emphasizing the role of the tumour microenvironment. However, long-term responses are rare with a high rate of resistance. New ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(7):]

Cited: 6 times

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De novo renal carcinoma arising in non-functional kidney graft: a national retrospective study.

Lionel Vaudreuil, Thomas Bessede, Romain Boissier, Sébastien Bouye, Julien Branchereau, Kevin Caillet, François Kleinclauss, Gregory Verhoest, Xavier Tillou,

<h4>Aim</h4>Characteristics of renal carcinoma arising in non-functional graft in renal transplant recipients (RTR) are unknown. We studied a large national retrospective cohort to analyze circumstances of diagnosis, treatment and outcome compared to the literature.<h4>Methods</h4>Study included all RTR presenting with kidney graft tumors irrespective of the histology, except those with lymphoma ... Read more >>

Int Urol Nephrol (International urology and nephrology)
[2020, 52(7):1235-1241]

Cited: 1 time

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Robotic versus open radical cystectomy throughout the learning phase: insights from a real-life multicenter study.

Louis Lenfant, Riccardo Campi, Jérôme Parra, Vivien Graffeille, Alexandra Masson-Lecomte, Dimitri Vordos, Alexandre de La Taille, Mathieu Roumiguie, Marine Lesourd, Lionel Taksin, Vincent Misraï, Benjamin Granger, Guillaume Ploussard, Christophe Vaessen, Gregory Verhoest, Morgan Rouprêt,

<h4>Background and objectives</h4>Robot-assisted radical cystectomy (RARC) has been shown to be non-inferior to open radical cystectomy (ORC) for the treatment of bladder cancer (BC). However, most data on RARC come from high-volume surgeons at high-volume centers. The objective of the study was to compare perioperative and mid-term oncologic outcomes of ... Read more >>

World J Urol (World journal of urology)
[2020, 38(8):1951-1958]

Cited: 3 times

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Prospective Assessment of the Sexual Function After Greenlight Endoscopic Enucleation and Greenlight 180W XPS Photoselective Vaporization of the Prostate.

Romain Huet, Benoit Peyronnet, Zine-Eddine Khene, Lucas Freton, Grégory Verhoest, Andréa Manunta, Karim Bensalah, Sébastien Vincendeau, Romain Mathieu,

OBJECTIVE:To evaluate the impact of Greenlight 180W photoselective vaporization of the prostate (PVP) and endoscopic enucleation of the prostate (GreenLEP) on ejaculatory and erectile functions. MATERIALS AND METHODS:Between January 2014 and September 2016, 440 men with low urinary tract symptoms or complications related to benign prostate obstruction with prostate >80 ... Read more >>

Urology (Urology)
[2019, 131:184-189]

Cited: 2 times

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Kidney Graft Urothelial Carcinoma: Results From a Multicentric Retrospective National Study.

Grégoire Leon, Nicolas Szabla, Romain Boissier, Marc Gigante, Kevin Caillet, Gregory Verhoest, Xavier Tillou, ,

OBJECTIVE:To calculate the incidence of renal graft urothelial carcinoma in renal transplant recipients in a national large retrospective cohort and to analyze circumstances of diagnosis, treatment and outcome. MATERIAL AND METHODS:We conducted a national retrospective, multicenter study. Thirty two transplant centers were asked to report its cases of kidney graft ... Read more >>

Urology (Urology)
[2020, 135:101-105]

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Diagnosis of uncommon renal epithelial neoplasms: performances of fluorescence in situ hybridization.

Marion Beaumont, Frédéric Dugay, Solène-Florence Kammerer-Jacquet, Sylvie Jaillard, Florian Cabillic, Romain Mathieu, Gregory Verhoest, Karim Bensalah, Nathalie Rioux-Leclercq, Marc-Antoine Belaud-Rotureau, ,

Renal cell carcinomas (RCC) are divided in several subtypes, characterized by morphological and histological features, protein expression patterns and genetics criteria. The main subtypes include Clear cell renal cell carcinoma (CCRCC), Papillary RCC (PRCC), Chromophobe RCC (ChRCC), oncocytoma, TFE3 and TFEB Translocation renal cell carcinoma (TRCC). In most cases, RCC ... Read more >>

Hum Pathol (Human pathology)
[2019, 92:81-90]

Cited: 1 time

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Renal outcome after simultaneous heart and kidney transplantation.

Théodore Toinet, Inès Dominique, Irène Cholley, Victor Vanalderwerelt, Anna Goujon, Fanny Paret, Thomas Bessede, Véronique Delaporte, Laurent Salomon, Lionel Badet, Jean-Michel Boutin, Gregory Verhoest, Julien Branchereau, Marc-Olivier Timsit, ,

Simultaneous heart-kidney transplant (HKTx) is a valid treatment for patients with coexisting heart and renal failure. The aim of this study was to assess renal outcome in HKTx and to identify predictive factors for renal loss. A retrospective study was conducted among 73 HKTx recipients: Donors' and recipients' records were ... Read more >>

Clin Transplant (Clinical transplantation)
[2019, 33(7):e13615]

Cited: 1 time

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A preoperative nomogram to predict major complications after robot assisted partial nephrectomy (UroCCR-57 study).

Zine-Eddine Khene, Benoit Peyronnet, Jean-Christophe Bernhard, Neil J Kocher, Christophe Vaessen, Nicolas Doumerc, Benjamin Pradere, Thomas Seisen, Jean-Baptiste Beauval, Grégory Verhoest, Mathieu Roumiguié, Alexandre De la Taille, Franck Bruyere, Morgan Roupret, Arnaud Mejean, Romain Mathieu, Shahrokh Shariat, Jay D Raman, Karim Bensalah, ,

<h4>Objective</h4>To generate a nomogram based on preoperative parameters to predict the occurrence of a major complication within 30-days of robotic partial nephrectomy.<h4>Materials and methods</h4>The study included 1,342 patients with a clinically localized renal tumor who underwent robotic partial nephrectomy (RPN) between 2010 and 2017 at 7 academic centers. The primary ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(9):577.e1-577.e7]

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Impact of routine imaging in the diagnosis of recurrence for patients with localized and locally advanced renal tumor treated with nephrectomy.

Baptiste Gires, Zine-Eddine Khene, Pierre Bigot, Quentin Alimi, Benoit Peyronnet, Grégory Verhoest, Andrea Manunta, Karim Bensalah, Romain Mathieu,

OBJECTIVE:Modalities of surveillance to detect recurrence after nephrectomy for localized or locally advanced renal tumor are not standardized. The aim was to assess the impact of surveillance scheme on oncological outcomes. METHODS:Patients treated for localized or locally advanced renal tumor with total or partial nephrectomy between 2006 and 2010 in ... Read more >>

World J Urol (World journal of urology)
[2019, 37(12):2727-2736]

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Targeting the PD-1/PD-L1 Pathway in Renal Cell Carcinoma.

Solène-Florence Kammerer-Jacquet, Antoine Deleuze, Judikaël Saout, Romain Mathieu, Brigitte Laguerre, Gregory Verhoest, Frédéric Dugay, Marc-Antoine Belaud-Rotureau, Karim Bensalah, Nathalie Rioux-Leclercq,

Renal cell carcinoma encompass distinct diseases with different pathologic features and distinct molecular pathways. Immune checkpoint inhibitors targeting the programmed death receptor ligand 1 (PD-L1)/programmed death receptor 1 (PD-1) pathway alone or in combination have greatly changed clinical management of metastatic renal cell carcinoma, now competing with antiangiogenic drugs in ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(7):]

Cited: 16 times

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Metastatic Clear-cell Renal Cell Carcinoma With a Long-term Response to Sunitinib: A Distinct Phenotype Independently Associated With Low PD-L1 Expression.

Solène-Florence Kammerer-Jacquet, Angelique Brunot, Mathilde Lefort, Sahar Bayat, Benoit Peyronnet, Gregory Verhoest, Romain Mathieu, Alexandra Lespagnol, Jean Mosser, Brigitte Laguerre, Alain Ravaud, Jean-Christophe Bernhard, Frantz Dupuis, Mokrane Yacoub, Marc-Antoine Belaud-Rotureau, Karim Bensalah, Nathalie Rioux-Leclercq,

BACKGROUND:Long-term responders (LTRs) are defined by at least 18 months of response to sunitinib in metastatic clear-cell renal cell carcinoma (ccRCC). Well-described by clinical studies, the phenotype of these tumors has never been explored. PATIENTS AND METHODS:In a retrospective and multicenter study, 90 ccRCCs of patients with metastatic disease were ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2019, 17(3):169-176.e1]

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Simplified robot-assisted partial nephrectomy: step-by-step technique and perioperative outcomes.

Benjamin Pradere, Benoit Peyronnet, Zine-Eddine Khene, Romain Mathieu, Gregory Verhoest, Karim Bensalah,

Controversies have been raised and still exist regarding several technical aspects of robot-assisted partial nephrectomy (RAPN). While the "perfect RAPN" has still to be determined, we aimed to report a simplified technique of RAPN in a step-by-step fashion and the perioperative outcomes of a single-center series. A simplified technique of ... Read more >>

J Robot Surg (Journal of robotic surgery)
[2019, 13(2):245-251]

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What Is Better for Predicting Morbidity of Robotic Partial Nephrectomy-A Score or Your Clinical Judgement?

Zine-Eddine Khene, Benoit Peyronnet, Lucas Freton, Vivien Graffeille, Benjamin Pradere, Corentin Robert, Solène-Florence Kammerer-Jacquet, Grégory Verhoest, Nathalie Rioux-Leclercq, Shahrokh Shariat, Romain Mathieu, Karim Bensalah,

<h4>Background</h4>Little is known about the predictive value of surgeon's judgement to estimate perioperative outcomes following robotic partial nephrectomy (RPN).<h4>Objective</h4>To evaluate the accuracy of surgeon's intuition to estimate perioperative outcomes of patients undergoing RPN and compare its predictive value with that of objective scoring systems.<h4>Design, setting, and participants</h4>We prospectively analysed 100 ... Read more >>

Eur Urol Focus (European urology focus)
[2020, 6(2):313-319]

Cited: 0 times

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Perioperative outcomes and complications of intracorporeal vs extracorporeal urinary diversion after robot-assisted radical cystectomy for bladder cancer: a real-life, multi-institutional french study.

Louis Lenfant, Gregory Verhoest, Riccardo Campi, Jérôme Parra, Vivien Graffeille, Alexandra Masson-Lecomte, Dimitri Vordos, Alexandre de La Taille, Mathieu Roumiguie, Marine Lesourd, Lionel Taksin, Vincent Misraï, Pietro Grande, Christophe Vaessen, Guillaume Ploussard, Benjamin Granger, Morgan Rouprêt,

PURPOSE:To compare perioperative outcomes and complications of extracorporeal (ECUD) vs intracorporeal urinary diversion (ICUD) in patients after undergoing robot-assisted radical cystectomy (RARC) at five referral centers in France. METHODS:We retrospectively reviewed our multi-institutional, prospectively-collected database to select patients undergoing RARC between 2010 and 2016 with at least 3 months of follow-up. ... Read more >>

World J Urol (World journal of urology)
[2018, 36(11):1711-1718]

Cited: 11 times

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Does tumour effraction during robotic partial nephrectomy have any impact on recurrence?

Zine-Eddine Khene, Benoit Peyronnet, Benjamin Pradère, Corentin Robert, Anna Goujon, Solène-Florence Kammerer-Jacquet, Grégory Verhoest, Nathalie Rioux-Leclercq, Romain Mathieu, Karim Bensalah,

<h4>Objective</h4>To evaluate the impact of accidental surgical incision into the tumour (ASIT) on oncological outcomes in patients undergoing RPN for a malignant tumour.<h4>Materials and methods</h4>A retrospective review of our prospectively maintained database was performed to identify all patients who underwent RPN for a localized RCC between June 2010 and July ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2019, 24(1):87-93]

Cited: 0 times

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Predicting morbidity after robotic partial nephrectomy: The effect of tumor, environment, and patient-related factors.

Zine-Eddine Khene, Benoit Peyronnet, Neil J Kocher, Haley Robyak, Corentin Robert, Benjamin Pradere, Emmanuel Oger, Solène-Florence Kammerer-Jacquet, Grégory Verhoest, Nathalie Rioux-Leclercq, Romain Mathieu, Jay D Raman, Karim Bensalah,

PURPOSE:To investigate the effect of tumor and nontumor related parameters on perioperative outcomes of robotic partial nephrectomy (RPN). PATIENTS AND METHODS:Patients who underwent RPN for a localized renal tumor at 2 institutions between June 2010 and November 2016 were reviewed. RENAL and Mayo adhesive probability (MAP) scores were calculated and ... Read more >>

Urol Oncol (Urologic oncology)
[2018, 36(7):338.e19-338.e26]

Cited: 3 times

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