Full Text Journal Articles by
Author Gregory S Sayuk

Advertisement

Find full text journal articles






Editorial: understanding IBS pathophysiology through "converging channels" of research.

Jill E Elwing, Gregory S Sayuk,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(9):1213-1214]

Cited: 0 times

View full text PDF listing >>



Medical Therapies for Diarrhea-Predominant Irritable Bowel Syndrome.

Gregory S Sayuk,

Diarrhea-predominant irritable bowel syndrome is a common functional gastrointestinal disorder that manifests with abdominal pain and diarrheal bowel patterns, without structural explanation. Diarrhea-predominant irritable bowel syndrome is a heterogeneous condition resulting from diverse pathophysiologic processes. Treatment strategies with varied mechanisms of action are beneficial in its management. The clinician must ... Read more >>

Gastroenterol Clin North Am (Gastroenterology clinics of North America)
[2021, 50(3):611-637]

Cited: 0 times

View full text PDF listing >>



Advertisement

Increased Risk of Advanced Colonic Adenomas and Timing of Surveillance Colonoscopy Following Solid Organ Transplantation.

Motaz H Ashkar, Jacqueline Chen, Corey Shy, Jeffrey S Crippin, Chien-Huan Chen, Gregory S Sayuk, Nicholas O Davidson,

<h4>Background</h4>Detection and removal of colonic adenomatous polyps (CAP) decreases colorectal cancer (CRC) development, particularly with more or larger polyps or polyps with advanced villous/dysplastic histology. Immunosuppression following solid organ transplantation (SOT) may accelerate CAP development and progression compared to average-risk population but the benefit of earlier colonoscopic surveillance is unclear.<h4>Aims</h4>Study ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Editorial: felcisetrag-forward movement as a novel prokinetic for gastroparesis.

Benjamin D Rogers, Gregory S Sayuk,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 53(10):1158-1159]

Cited: 0 times

View full text PDF listing >>



Improved work productivity and health-related quality of life in patients with irritable bowel syndrome with diarrhea receiving eluxadoline following inadequate response to loperamide.

Darren M Brenner, Gregory S Sayuk, Jessica L Abel, Kate Burslem,

<b>BACKGROUND:</b> Irritable bowel syndrome with diarrhea (IBS-D) is a chronic disorder of gut-brain interaction that negatively affects work productivity and health-related quality of life (HRQOL). IBS-D therapeutic options are limited and include loperamide, an over-the-counter μ-opioid receptor agonist commonly used as an antidiarrheal agent, and eluxadoline, a mixed μ- and ... Read more >>

J Manag Care Spec Pharm (Journal of managed care & specialty pharmacy)
[2021, 27(4):469-477]

Cited: 0 times

View full text PDF listing >>



Randomized Trial of 2 Delayed-Release Formulations of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation.

William D Chey, Gregory S Sayuk, Wilmin Bartolini, David S Reasner, Susan M Fox, Wieslaw Bochenek, Ramesh Boinpally, Elizabeth Shea, Kenneth Tripp, Niels Borgstein,

<h4>Introduction</h4>Immediate-release (IR) formulation of linaclotide 290 μg improves abdominal pain and constipation (APC) in patients with irritable bowel syndrome (IBS) with constipation. Delayed-release (DR) formulations were developed on the premise that targeting the ileum (delayed-release formulation 1 [DR1]) or ileocecal junction and cecum (MD-7246, formerly DR2) would modulate linaclotide's secretory ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2021, 116(2):354-361]

Cited: 0 times

View full text PDF listing >>



The Brain-Gut-Microbiotal Axis: A framework for understanding functional GI illness and their therapeutic interventions.

Christopher Tait, Gregory S Sayuk,

Functional gastrointestinal disorders (FGIDs), characterized by chronic abdominal complaints without a structural or biochemical cause, are common diseases that are frequently encountered by specialists in internal medicine. Collectively, irritable bowel syndrome (IBS) and functional dyspepsia are estimated to affect up to 22% of the population, and are often associated with ... Read more >>

Eur J Intern Med (European journal of internal medicine)
[2021, 84:1-9]

Cited: 5 times

View full text PDF listing >>



A Potential Role for Stress-Induced Microbial Alterations in IgA-Associated Irritable Bowel Syndrome with Diarrhea.

Sunaina Rengarajan, Kathryn A Knoop, Arvind Rengarajan, Jiani N Chai, Jose G Grajales-Reyes, Vijay K Samineni, Emilie V Russler-Germain, Prabha Ranganathan, Alessio Fasano, Gregory S Sayuk, Robert W Gereau, Andrew L Kau, Dan Knights, Purna C Kashyap, Matthew A Ciorba, Rodney D Newberry, Chyi-Song Hsieh,

Stress is a known trigger for flares of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS); however, this process is not well understood. Here, we find that restraint stress in mice leads to signs of diarrhea, fecal dysbiosis, and a barrier defect via the opening of goblet-cell associated passages. ... Read more >>

Cell Rep Med (Cell reports. Medicine)
[2020, 1(7):]

Cited: 3 times

View full text PDF listing >>



Patient Engagement with Interactive Text Message System Improves Successful Colonoscopy Rates in an Outpatient Endoscopy Center.

Benjamin D Rogers, Corey Shy, Rajeev Rampgopal, Tricia Hengehold, Aymen Almuhaidb, Michael Weaver, Farhan Quader, Rebecca Roediger, Ted Walker, C Prakash Gyawali, Gregory S Sayuk,

<h4>Introduction</h4>Text message-based interventions reduce colonoscopy no-show rates and improve bowel preparation scores. In this non-randomized study, we assessed whether an interactive text messaging system could improve colonoscopy outcomes.<h4>Methods</h4>Colonoscopy pre-procedural instructions were programmed into a dedicated software platform created for this study. In the intervention arm, text messages were sent to ... Read more >>

Dig Dis (Digestive diseases (Basel, Switzerland))
[2021, 39(4):399-406]

Cited: 1 time

View full text PDF listing >>



Functional Dyspepsia: Diagnostic and Therapeutic Approaches.

Gregory S Sayuk, C Prakash Gyawali,

Functional dyspepsia is a common functional gastrointestinal (GI) disorder of gastroduodenal origin, diagnosed clinically in the presence of prototypical symptoms of epigastric pain and meal-related symptoms, and without structural explanation. The most recent diagnostic criteria provide for two functional dyspepsia subtypes, epigastric pain syndrome (EPS) and post-prandial distress syndrome (PDS) ... Read more >>

Drugs (Drugs)
[2020, 80(13):1319-1336]

Cited: 1 time

View full text PDF listing >>



Quality metrics of screening colonoscopies performed by PAs.

M Phillip Fejleh, Ching-Chieh Shen, Jacqueline Chen, Joseph A Bushong, Brian K Dieckgraefe, Gregory S Sayuk,

<h4>Background</h4>Many communities face a shortage of qualified endoscopists. Training physician assistants (PAs) to perform colonoscopies can expand the availability of colorectal cancer screening. This study examined screening colonoscopy metrics and quality indicators among gastroenterologists, supervised PAs, and gastroenterology fellows.<h4>Methods</h4>Consecutive patients undergoing average-risk screening colonoscopy were stratified into one of three ... Read more >>

JAAPA (JAAPA : official journal of the American Academy of Physician Assistants)
[2020, 33(4):43-48]

Cited: 0 times

View full text PDF listing >>



Response to Black et al.

Darren M Brenner, Gregory S Sayuk, Catherine R Gutman, Esther Jo, Steven J R Elmes, Louis W C Liu, Brooks D Cash,

Am J Gastroenterol (The American journal of gastroenterology)
[2020, 115(3):484-485]

Cited: 0 times

View full text PDF listing >>



Self-reported sleep disturbance in Crohn's disease is not confirmed by objective sleep measures.

Heba N Iskandar, Emily E Linan, Ami Patel, Renee Moore, Yi Lasanajak, C Prakash Gyawali, Gregory S Sayuk, Matthew A Ciorba,

Sleep disturbance and fatigue are commonly reported among patients with Crohn's disease (CD). In this prospective study, we aimed to define sleep quality in CD patients at various disease activity states and compare to healthy controls using objective and subjective measures. A prospective observational cohort study of CD patients seen ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):1980]

Cited: 1 time

View full text PDF listing >>



Perceived sleep quality mediates the relationship between posttraumatic stress and somatic symptoms.

Saankari A Challa, Robert Graziano, David R Strasshofer, Kamila S White, Gregory S Sayuk, Steven E Bruce,

<h4>Objective</h4>Posttraumatic stress symptoms (PTSS) have been associated with increased somatic symptom expression. Sleep concerns have been associated with PTSS and somatic symptoms. Previous research suggests that sleep affects multiple domains of functioning including comorbid psychological and physical health concerns. The current study examines whether perceived sleep quality or sleep efficiency/duration ... Read more >>

Psychol Trauma (Psychological trauma : theory, research, practice and policy)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Survival benefit associated with early detection of spontaneous bacterial peritonitis in veteran inpatients with cirrhotic ascites.

Luke Townsend, Pierre Blais, Alex Huh, Leela Nayak, Jill E Elwing, Gregory S Sayuk,

<h4>Background</h4>Spontaneous bacterial peritonitis (SBP) is common in hospitalized cirrhotic patients with ascites and carries high mortality. This study aimed to determine whether early diagnostic paracentesis (EDP) <12 h of hospitalization conveys an intermediate-term (6-month) survival benefit in cirrhotic patients diagnosed with SBP.<h4>Methods</h4>Consecutive US veterans with cirrhosis diagnosed with SBP over 13 ... Read more >>

JGH Open (JGH open : an open access journal of gastroenterology and hepatology)
[2020, 4(3):503-506]

Cited: 0 times

View full text PDF listing >>



Current US Food and Drug Administration-Approved Pharmacologic Therapies for the Treatment of Irritable Bowel Syndrome with Diarrhea.

Darren M Brenner, Gregory S Sayuk,

Irritable bowel syndrome (IBS) is a functional bowel disorder characterized by abdominal pain and alterations in stool form and/or frequency, leading to reduced quality of life. Pharmacologic agents currently approved by the US Food and Drug Administration for treatment of IBS with diarrhea (IBS-D) in adults are the nonsystemic antibiotic ... Read more >>

Adv Ther (Advances in therapy)
[2020, 37(1):83-96]

Cited: 1 time

View full text PDF listing >>



Editorial: obesity and chronic diarrhoea-A Hill of evidence for causation?

Gregory S Sayuk, Jill E Elwing,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2019, 50(10):1137-1138]

Cited: 0 times

View full text PDF listing >>



Efficacy and Safety of Eluxadoline in Patients With Irritable Bowel Syndrome With Diarrhea Who Report Inadequate Symptom Control With Loperamide: RELIEF Phase 4 Study.

Darren M Brenner, Gregory S Sayuk, Catherine R Gutman, Esther Jo, Steven J R Elmes, Louis W C Liu, Brooks D Cash,

<h4>Objectives</h4>Irritable bowel syndrome with diarrhea (IBS-D) is a functional gastrointestinal disorder with limited effective treatment options. We evaluated the efficacy and safety of eluxadoline in patients with IBS-D who reported inadequate symptom control with prior loperamide.<h4>Methods</h4>Three hundred forty-six adults with IBS-D (Rome III criteria) were randomly assigned to placebo or ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2019, 114(9):1502-1511]

Cited: 4 times

View full text PDF listing >>



Higher Esophageal Symptom Burden in Obese Subjects Results From Increased Esophageal Acid Exposure and Not From Dysmotility.

Benjamin D Rogers, Amit Patel, Dan Wang, Gregory S Sayuk, C Prakash Gyawali,

<h4>Background & aims</h4>Esophageal motor disorders (EMD) and pathologic reflux are often identified in obese individuals, but it is not clear how obesity contributes to these symptoms. We examined the relationships among symptom burden, EMD, acid exposure time (AET), symptom association probability, and body mass index (BMI).<h4>Methods</h4>We performed a retrospective study ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2020, 18(8):1719-1726]

Cited: 0 times

View full text PDF listing >>



Undifferentiated Abdominal Pain in Children Presenting to the Pediatric Emergency Department.

Brendan R Harris, Sri S Chinta, Ryan Colvin, David Schnadower, Phillip I Tarr, Gregory S Sayuk,

Although common, little is known about the characteristics and management of undifferentiated abdominal pain (UAP) in the pediatric emergency department (ED). This study was a 12-month retrospective study for "abdominal pain" ED visits. Patients without an identifiable diagnosis were categorized as "UAP," while others with identified disease processes were categorized ... Read more >>

Clin Pediatr (Phila) (Clinical pediatrics)
[2019, 58(11-12):1212-1223]

Cited: 1 time

View full text PDF listing >>



Health-related quality of life and long-term outcomes after endoscopic therapy for walled-off pancreatic necrosis.

Zachary L Smith, Martin H Gregory, Jeffrey Elsner, Bader A Alajlan, Divya Kodali, Thomas Hollander, Gregory S Sayuk, Gabriel D Lang, Koushik K Das, Daniel K Mullady, Dayna S Early, Vladimir M Kushnir,

<h4>Background and aim</h4>Walled-off pancreatic necrosis (WON) frequently develops after necrotizing pancreatitis. Endoscopic drainage has become the preferred modality for symptomatic or infected WON. The aim of the present study was to assess health-related quality of life (HR-QOL) and long-term outcomes in patients undergoing endoscopic drainage for WON.<h4>Methods</h4>Patients undergoing endoscopic drainage ... Read more >>

Dig Endosc (Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society)
[2019, 31(1):77-85]

Cited: 1 time

View full text PDF listing >>



Chronic Cough Is Associated With Long Breaks in Esophageal Peristaltic Integrity on High-resolution Manometry.

Michael C Bennett, Amit Patel, Nitin Sainani, Dan Wang, Gregory S Sayuk, C Prakash Gyawali,

<h4>Background/aims</h4>Breaks in the peristaltic contour on esophageal high-resolution manometry (HRM) may be associated with bolus retention in the esophagus. We evaluated the relationship between peristaltic breaks and esophageal symptoms, reflux exposure, and symptom outcomes in a prospective patient cohort.<h4>Methods</h4>Two hundred and eighteen patients (53.2 ± 0.9 years, 68.3% female) undergoing ... Read more >>

J Neurogastroenterol Motil (Journal of neurogastroenterology and motility)
[2018, 24(3):387-394]

Cited: 2 times

View full text PDF listing >>



Editorial: Functional Dyspepsia Treatment: Trials and Tribulations of Targeted Strategies.

Gregory S Sayuk,

While functional dyspepsia (FD) is an exceedingly common disorder, the number of treatment options remains limited, and strategies for the individualized implementation of these therapies largely are lacking. In the current issue of American Journal of Gastroenterology, Saito and colleagues report on a secondary analysis of data from the Functional ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2017, 112(6):910-912]

Cited: 0 times

View full text PDF listing >>



Erdheim-Chester Disease presenting with histiocytic colitis and cytokine storm.

George P Christophi, Yeshika Sharma, Quader Farhan, Umang Jain, Ted Walker, Gregory S Sayuk, Deborah C Rubin,

<h4>Background</h4>Non-Langerhans histiocytosis is a group of inflammatory lymphoproliferative disorders originating from non-clonal expansion of hematopoietic stem cells into cytokine-secreting dendritic cells or macrophages. Erdheim-Chester Disease (ECD) is a rare type of non-Langerhans cell histiocytosis characterized by tissue inflammation and injury caused by macrophage infiltration and histologic findings of foamy histiocytes. ... Read more >>

J Gastrointestin Liver Dis (Journal of gastrointestinal and liver diseases : JGLD)
[2017, 26(2):183-187]

Cited: 0 times

View full text PDF listing >>



Do Consultants Follow Up on Tests They Recommend? Insights from an Academic Inpatient Gastrointestinal Consult Service.

Benjamin E Cassell, Ted Walker, Saad Alghamdi, Jason Bill, Pierre Blais, Harold Boutté, Jeffrey W Brown, Gregory S Sayuk, C Prakash Gyawali,

<h4>Background</h4>Inpatient care is a fundamental part of gastroenterology training and involves the recommendation, performance, and interpretation of diagnostic tests. However, test results are not always communicated to patients or treating providers. We determined the process of communication of test results and recommendations in our inpatient gastroenterology (GI) consult service.<h4>Methods</h4>Test recommendations ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2017, 62(6):1448-1454]

Cited: 0 times

View full text PDF listing >>



Advertisement


Disclaimer

1.9267 s