Full Text Journal Articles by
Author Gregory R Tintinger

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Pulmonary Toxicities Associated With the Use of Immune Checkpoint Inhibitors: An Update From the Immuno-Oncology Subgroup of the Neutropenia, Infection & Myelosuppression Study Group of the Multinational Association for Supportive Care in Cancer.

Bernardo L Rapoport, Vickie R Shannon, Tim Cooksley, Douglas B Johnson, Lindsay Anderson, Ada G Blidner, Gregory R Tintinger, Ronald Anderson,

The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer treatment, with agents such as nivolumab, pembrolizumab, and cemiplimab targeting programmed cell death protein-1 (PD-1) and durvalumab, avelumab, and atezolizumab targeting PD-ligand 1 (PD-L1). Ipilimumab targets cytotoxic T lymphocyte-associated antigen-4 (CTLA-4). These inhibitors have shown remarkable efficacy in melanoma, lung ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:743582]

Cited: 0 times

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ADP-Mediated Upregulation of Expression of CD62P on Human Platelets Is Critically Dependent on Co-Activation of P2Y1 and P2Y12 Receptors.

Ronald Anderson, Annette J Theron, Helen C Steel, Jan G Nel, Gregory R Tintinger,

This study probed the differential utilization of P2Y1 and P2Y12 receptors in mobilizing CD62P (P-selectin) from intracellular granules following activation of human platelets with adenosine 5'-diphosphate (ADP, 100 µmol·L<sup>-1</sup>) Platelet-rich plasma (PRP) was prepared from the blood of adult humans. CD62P was measured by flow cytometry following activation of PRP ... Read more >>

Pharmaceuticals (Basel) (Pharmaceuticals (Basel, Switzerland))
[2020, 13(12):]

Cited: 1 time

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Submission for Special Issue: The Role of Platelet Activation in the Pathophysiology of HIV, Tuberculosis, and Pneumococcal Disease. Bedaquiline Suppresses ADP-Mediated Activation of Human Platelets In Vitro via Interference With Phosphatidylinositol 3-Kinase.

Gregory R Tintinger, Annette J Theron, Helen C Steel, Moloko C Cholo, Jan G Nel, Charles Feldman, Ronald Anderson,

Although bedaquiline has advanced the treatment of multidrug-resistant tuberculosis (TB), concerns remain about the cardiotoxic potential of this agent, albeit by unexplored mechanisms. Accordingly, we have investigated augmentation of the reactivity of human platelets <i>in vitro</i> as a potential mechanism of bedaquiline-mediated cardiotoxicity. Platelet-rich plasma (PRP) or isolated cells prepared ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:621148]

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Electronic cigarettes: where to from here?

Annette J Theron, Charles Feldman, Guy A Richards, Gregory R Tintinger, Ronald Anderson,

Although the usage of electronic (e)-cigarettes (EC) and similar devices has gained in popularity as an apparent smoking cessation strategy, serious concerns are emerging in relation to both the efficacy of this strategy, as well as the inappropriate use of these devices. While the comparative safety of e-cigarettes is based ... Read more >>

J Thorac Dis (Journal of thoracic disease)
[2019, 11(12):5572-5585]

Cited: 2 times

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Interleukin-10 and interleukin-1 receptor antagonist distinguish between patients with sepsis and the systemic inflammatory response syndrome (SIRS).

Moliehi Potjo, Annette J Theron, Riana Cockeran, Ndisha N Sipholi, Helen C Steel, Tsohadi V Bale, Pieter W A Meyer, Ronald Anderson, Gregory R Tintinger,

The current study evaluated the potential of clinical parameters and circulating biomarkers to distinguish sepsis from SIRS in patients admitted with systemic inflammation. Clinical parameters, leukocyte counts and platelets were measured on admission. Circulating C-reactive protein (CRP), procalcitonin (PCT) and cytokine concentrations were quantified using laser immunonephelometry, immunoluminescence and a ... Read more >>

Cytokine (Cytokine)
[2019, 120:227-233]

Cited: 6 times

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Clofazimine, but Not Isoniazid or Rifampicin, Augments Platelet Activation in vitro.

Ronald Anderson, Annette J Theron, Jan G Nel, Chrisna Durandt, Moloko C Cholo, Charles Feldman, Gregory R Tintinger,

Although the inclusion of the cationic amphiphilic, anti-mycobacterial agent, clofazimine, in the chemotherapeutic regimens of patients with multidrug-resistant tuberculosis (TB) has contributed to improved outcomes, concerns remain about the cardiotoxic potential of this agent. Accordingly, the current study was undertaken with the primary objective of investigating the effects of clofazimine, ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2018, 9:1335]

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Aortic Arch Baroreceptor Stimulation in an Experimental Goat Model: A Novel Method to Lower Blood Pressure.

Jacobus F Benson, Johan P Schoeman, Frans J Venter, James A Ker, Gareth E Zeiler, Lynette Bester, Janet van Niekerk, Gregory R Tintinger,

The effect of aortic baroreceptor stimulation on blood pressure manipulation was assessed using the goat species Capra aegagrus hircus. The aim of this study was to manipulate blood pressure with future intention to treat high blood pressure in humans. The ages of the animals ranged from 6 months to 2 ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2018, 5:193]

Cited: 0 times

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Pneumolysin mediates heterotypic aggregation of neutrophils and platelets in vitro.

Jan G Nel, Chrisna Durandt, Annette J Theron, Gregory R Tintinger, Roger Pool, Guy A Richards, Timothy J Mitchell, Charles Feldman, Ronald Anderson,

<h4>Objectives</h4>Platelets orchestrate the inflammatory activities of neutrophils, possibly contributing to pulmonary and myocardial damage during severe pneumococcal infection. This study tested the hypothesis that the pneumococcal toxin, pneumolysin (Ply), activates production of platelet-activating factor (PAF) and thromboxane A<sub>2</sub> (TxA<sub>2</sub>) by neutrophils, these bioactive lipids being potential mediators of neutrophil:platelet (NP) ... Read more >>

J Infect (The Journal of infection)
[2017, 74(6):599-608]

Cited: 9 times

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Detection of Acute and Early HIV-1 Infections in an HIV Hyper-Endemic Area with Limited Resources.

Simnikiwe H Mayaphi, Desmond J Martin, Thomas C Quinn, Oliver Laeyendecker, Steve A S Olorunju, Gregory R Tintinger, Anton C Stoltz,

<h4>Background</h4>Two thirds of the world's new HIV infections are in sub-Saharan Africa. Acute HIV infection (AHI) is the time of virus acquisition until the appearance of HIV antibodies. Early HIV infection, which includes AHI, is the interval between virus acquisition and establishment of viral load set-point. This study aimed to ... Read more >>

PLoS One (PloS one)
[2016, 11(10):e0164943]

Cited: 12 times

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Pneumolysin Mediates Platelet Activation In Vitro.

Jan Gert Nel, Chrisna Durandt, Timothy J Mitchell, Charles Feldman, Ronald Anderson, Gregory R Tintinger,

This study has explored the role of the pneumococcal toxin, pneumolysin (Ply), in activating human platelets. Following exposure to Ply (10-80 ng/ml), platelet activation and cytosolic Ca(2+) concentrations were measured flow cytometrically according to the level of expression of CD62P (P-selectin) and spectrofluorimetrically, respectively. Exposure to Ply resulted in marked upregulation ... Read more >>

Lung (Lung)
[2016, 194(4):589-593]

Cited: 16 times

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Formoterol is more effective than salmeterol in suppressing neutrophil reactivity.

Gregory R Tintinger, Annette J Theron, Helen C Steel, Charles Feldman, Ronald Anderson,

<b>Formoterol suppresses neutrophil reactivity <i>in vitro</i>; in COPD, this may contribute to anti-inflammatory efficacy</b> http://ow.ly/Qr9fE. ... Read more >>

ERJ Open Res (ERJ open research)
[2015, 1(1):]

Cited: 0 times

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Circulating anti-citrullinated peptide antibodies, cytokines and genotype as biomarkers of response to disease-modifying antirheumatic drug therapy in early rheumatoid arthritis.

Mahmood M T M Ally, Bridget Hodkinson, Pieter W A Meyer, Eustasius Musenge, Gregory R Tintinger, Mohammed Tikly, Ronald Anderson,

<h4>Background</h4>To measure circulating anti-citrullinated peptide antibodies (ACPA) and cytokines pre- and 6 months post-therapy as a strategy to predict and optimize responses to traditional disease-modifying antirheumatic drugs (DMARDs) in early RA, which is an unmet need in developing countries.<h4>Patients and methods</h4>A cohort of 140 predominantly (88.5 %) black female South ... Read more >>

BMC Musculoskelet Disord (BMC musculoskeletal disorders)
[2015, 16:130]

Cited: 20 times

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Oxidative induction of pro-inflammatory cytokine formation by human monocyte-derived macrophages following exposure to manganese in vitro.

Matlou I Mokgobu, Moloko C Cholo, Ronald Anderson, Helen C Steel, Maraki P Motheo, Thembani N Hlatshwayo, Gregory R Tintinger, Annette J Theron,

Manganese (as Mn(2+)), a superoxide dismutase mimetic, catalyzes the formation of the relatively stable membrane-permeable reactive oxygen species (ROS) hydrogen peroxide (H2O2), a mediator of intracellular redox signaling in immune and inflammatory cells. The goal of this study was to investigate the potential for Mn(2+), via its pro-oxidative properties, to ... Read more >>

J Immunotoxicol (Journal of immunotoxicology)
[2015, 12(1):98-103]

Cited: 8 times

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Can the anti-inflammatory activities of β2-agonists be harnessed in the clinical setting?

Annette J Theron, Helen C Steel, Gregory R Tintinger, Charles Feldman, Ronald Anderson,

Beta2-adrenoreceptor agonists (β2-agonists) are primarily bronchodilators, targeting airway smooth muscle and providing critical symptomatic relief in conditions such as bronchial asthma and chronic obstructive pulmonary disease. These agents also possess broad-spectrum, secondary, anti-inflammatory properties. These are mediated largely, though not exclusively, via interactions with adenylyl cyclase-coupled β2-adrenoreceptors on a range ... Read more >>

Drug Des Devel Ther (Drug design, development and therapy)
[2013, 7:1387-1398]

Cited: 20 times

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Cytomegalovirus viral load kinetics in patients with HIV/AIDS admitted to a medical intensive care unit: a case for pre-emptive therapy.

Simnikiwe H Mayaphi, Marieke Brauer, Daniel M Morobadi, Ahmad H Mazanderani, Rendani T Mafuyeka, Steve A S Olorunju, Gregory R Tintinger, Anton Stoltz,

<h4>Background</h4>Cytomegalovirus (CMV) infection is associated with severe diseases in immunosuppressed patients; however, there is a lack of data for pre-emptive therapy in patients with HIV/AIDS.<h4>Method</h4>This was a retrospective study, which enrolled patients diagnosed with HIV/AIDS (CD4<200 cells/μl), who had detectable CMV viral load (VL) during their stay in an adult ... Read more >>

PLoS One (PloS one)
[2014, 9(4):e93702]

Cited: 10 times

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The beta-2-adrenoreceptor agonists, formoterol and indacaterol, but not salbutamol, effectively suppress the reactivity of human neutrophils in vitro.

Ronald Anderson, Annette J Theron, Helen C Steel, Chrisna Durandt, Gregory R Tintinger, Charles Feldman,

The clinical relevance of the anti-inflammatory properties of beta-2 agonists remains contentious possibly due to differences in their molecular structures and agonist activities. The current study has compared the effects of 3 different categories of β 2-agonists, namely, salbutamol (short-acting), formoterol (long-acting) and indacaterol (ultra-long-acting), at concentrations of 1-1000 nM, with ... Read more >>

Mediators Inflamm (Mediators of inflammation)
[2014, 2014:105420]

Cited: 11 times

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Calcium-dependent potentiation of the pro-inflammatory functions of human neutrophils by tigecycline in vitro.

Riana Cockeran, Ndiafhi D Mutepe, Annette J Theron, Gregory R Tintinger, Helen C Steel, Paraskevi I Stivaktas, Guy A Richards, Charles Feldman, Ronald Anderson,

<h4>Objectives</h4>Tigecycline is the prototype of the recently introduced, intravenously administered glycylcycline class of antibiotics, developed in response to the increasing problem of antibiotic resistance in Gram-positive bacteria, especially Staphylococcus aureus, as well as Gram-negative bacteria and anaerobes. However, relatively little is known about the immunomodulatory potential of tigecycline, specifically its ... Read more >>

J Antimicrob Chemother (The Journal of antimicrobial chemotherapy)
[2012, 67(1):130-137]

Cited: 6 times

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Montelukast: more than a cysteinyl leukotriene receptor antagonist?

Gregory R Tintinger, Charles Feldman, Annette J Theron, Ronald Anderson,

The prototype cysteinyl leukotriene receptor antagonist, montelukast, is generally considered to have a niche application in the therapy of exercise- and aspirin-induced asthma. It is also used as add-on therapy in patients whose asthma is poorly controlled with inhaled corticosteroid monotherapy, or with the combination of a long-acting beta(2)-agonist and ... Read more >>

ScientificWorldJournal (TheScientificWorldJournal)
[2010, 10:2403-2413]

Cited: 38 times

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Protein kinase C promotes restoration of calcium homeostasis to platelet activating factor-stimulated human neutrophils by inhibition of phospholipase C.

Gregory R Tintinger, Annette J Theron, Helen C Steel, Riana Cockeran, Lynette Pretorius, Ronald Anderson,

<h4>Background</h4>The role of protein kinase C (PKC) in regulating the activity of phospholipase C (PLC) in neutrophils activated with the chemoattractant, platelet-activating factor (PAF, 20 and 200 nM), was probed in the current study using the selective PKC inhibitors, GF10903X (0.5 - 1 muM) and staurosporine (400 nM).<h4>Methods</h4>Alterations in cytosolic ... Read more >>

J Inflamm (Lond) (Journal of inflammation (London, England))
[2009, 6:29]

Cited: 2 times

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Comparison of the anti-inflammatory activities of imidazole antimycotics in relation to molecular structure.

Helen C Steel, Gregory R Tintinger, Ronald Anderson,

The objective of this study was to compare the anti-inflammatory potencies of the imidazole antimycotics, fluconazole, itraconazole, ketoconazole and voriconazole (0.5 and 5 microM) in relation to their molecular structures. Anti-inflammatory activity was determined according to the magnitude of inhibition of production of leukotriene B4 and influx of Ca2+ following ... Read more >>

Chem Biol Drug Des (Chemical biology & drug design)
[2008, 72(3):225-228]

Cited: 15 times

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Montelukast inhibits neutrophil pro-inflammatory activity by a cyclic AMP-dependent mechanism.

Ronald Anderson, Annette J Theron, Cornelia M Gravett, Helen C Steel, Gregory R Tintinger, Charles Feldman,

<h4>Background and purpose</h4>The objective of this study was to characterize the effects of the cysteinyl leukotriene receptor antagonist, montelukast (0.1-2 micromol x L(-1)), on Ca(2+)-dependent pro-inflammatory activities, cytosolic Ca(2+) fluxes and intracellular cAMP in isolated human neutrophils activated with the chemoattractants, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (1 micromol x L(-1)) and platelet-activating factor (200 ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2009, 156(1):105-115]

Cited: 32 times

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Reactive oxidants regulate membrane repolarization and store-operated uptake of calcium by formyl peptide-activated human neutrophils.

Gregory R Tintinger, Annette J Theron, Moliehi Potjo, Ronald Anderson,

Although the rapid and considerable membrane depolarization response which accompanies activation of the phagocyte NADPH oxidase is due to transmembrane electron fluxes, little is known about the involvement of reactive oxidant species (ROS) in the subsequent repolarization response. In the current study, we have investigated the effects of superoxide dismutase ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2007, 42(12):1851-1857]

Cited: 14 times

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Inositol 1,4,5-triphosphate-mediated shuttling between intracellular stores and the cytosol contributes to the sustained elevation in cytosolic calcium in FMLP-activated human neutrophils.

Ronald Anderson, Helen C Steel, Gregory R Tintinger,

The current study was designed to probe Ca2+ shuttling between intracellular stores and the cytosol as a potential mechanism contributing to the prolongation of elevated Ca2+ transients in N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP)-activated human neutrophils. Cytosolic Ca2+ concentrations and transmembrane fluxes of the cation were measured using spectrofluorimetric and radiometric procedures, respectively, while ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2005, 69(11):1567-1575]

Cited: 16 times

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Counteracting effects of NADPH oxidase and the Na+/Ca2+ exchanger on membrane repolarisation and store-operated uptake of Ca2+ by chemoattractant-activated human neutrophils.

Gregory R Tintinger, Ronald Anderson,

This study was designed to investigate the possible involvement of NADPH oxidase and the Na(+)/Ca(2+) exchanger in regulating membrane repolarisation and store-operated uptake of Ca(2+) by FMLP (1 microM)-activated human neutrophils. Diphenyleneiodonium chloride (DPI, 5-10 microM) and KB-R7943 (2.5-10 microM), inhibitors of NADPH oxidase and the reverse mode of the ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2004, 67(12):2263-2271]

Cited: 15 times

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