Full Text Journal Articles by
Author Gregory M Miller


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Sulfated glycans engage the Ang-Tie pathway to regulate vascular development.

Matthew E Griffin, Alexander W Sorum, Gregory M Miller, William A Goddard, Linda C Hsieh-Wilson,

The angiopoietin (Ang)-Tie pathway is essential for the proper maturation and remodeling of the vasculature. Despite its importance in disease, the mechanisms that control signal transduction through this pathway are poorly understood. Here, we demonstrate that heparan sulfate glycosaminoglycans (HS GAGs) regulate Ang-Tie signaling through direct interactions with both Ang ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

Cited: 0 times

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Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling.

Jeffrey K Holden, James J Crawford, Cameron L Noland, Stephen Schmidt, Jason R Zbieg, Jennifer A Lacap, Richard Zang, Gregory M Miller, Yue Zhang, Paul Beroza, Rohit Reja, Wendy Lee, Jeffrey Y K Tom, Rina Fong, Micah Steffek, Saundra Clausen, Thjis J Hagenbeek, Taishan Hu, Zheng Zhou, Hong C Shen, Christian N Cunningham,

The transcriptional enhanced associate domain (TEAD) family of transcription factors serves as the receptors for the downstream effectors of the Hippo pathway, YAP and TAZ, to upregulate the expression of multiple genes involved in cellular proliferation and survival. Recent work identified TEAD S-palmitoylation as critical for protein stability and activity ... Read more >>

Cell Rep (Cell reports)
[2020, 31(12):107809]

Cited: 0 times

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Actions of Trace Amines in the Brain-Gut-Microbiome Axis via Trace Amine-Associated Receptor-1 (TAAR1).

Katlynn Bugda Gwilt, Dulce Pamela González, Neva Olliffe, Haley Oller, Rachel Hoffing, Marissa Puzan, Sahar El Aidy, Gregory M Miller,

Trace amines and their primary receptor, Trace Amine-Associated Receptor-1 (TAAR1) are widely studied for their involvement in the pathogenesis of neuropsychiatric disorders despite being found in the gastrointestinal tract at physiological levels. With the emergence of the "brain-gut-microbiome axis," we take the opportunity to review what is known about trace ... Read more >>

Cell. Mol. Neurobiol. (Cellular and molecular neurobiology)
[2020, 40(2):191-201]

Cited: 0 times

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Trace amine associated receptor 1 (TAAR1) expression and modulation of inflammatory cytokine production in mouse bone marrow-derived macrophages: a novel mechanism for inflammation in ulcerative colitis.

Katlynn Bugda Gwilt, Neva Olliffe, Rachel A Hoffing, Gregory M Miller,

Context: Tissue resident macrophages and peripherally infiltrating macrophages play a prominent role in maintaining homeostasis in the gastrointestinal tract (GIT), though aberrant activation is implicated in inflammatory conditions, including ulcerative colitis (UC). Recent metabolomic studies indicate that tyramine (TYR) is elevated in the stool of patients with UC. TYR activates ... Read more >>

Immunopharmacol Immunotoxicol (Immunopharmacology and immunotoxicology)
[2019, 41(6):577-585]

Cited: 0 times

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Alcohol-induced changes in the gut microbiome and metabolome of rhesus macaques.

Xiao Zhang, Koji Yasuda, Robert A Gilmore, Susan V Westmoreland, Donna M Platt, Gregory M Miller, Eric J Vallender,

RATIONALE:Increasing evidence has demonstrated that changes in the gut microbiome, including those associated with dietary influences, are associated with alterations in many physiological processes. Alcohol consumption is common across human cultures and is likely to have a major effect on the gut microbiome, but there remains a paucity of information ... Read more >>

Psychopharmacology (Berl) (Psychopharmacology)
[2019, 236(5):1531-1544]

Cited: 2 times

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Perturbations of Neuron-Restrictive Silencing Factor Modulate Corticotropin-Releasing Hormone Gene Expression in the Human Cell Line BeWo.

Vasileios Kreouzis, Guo-Lin Chen, Gregory M Miller,

Stress exacerbates disease, and understanding its molecular mechanisms is crucial to the development of novel therapeutic interventions to combat stress-related disorders. The driver of the stress response in the hypothalamic-pituitary-adrenal axis (HPA) is corticotropin-releasing hormone (CRH), a neuropeptide synthesized in the paraventricular nucleus of the hypothalamus. Evidence supports that CRH ... Read more >>

(Molecular neuropsychiatry)
[2018, 4(2):100-110]

Cited: 0 times

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Alternative REST Splicing Underappreciated.

Guo-Lin Chen, Gregory M Miller,

eNeuro (eNeuro)
[2018, 5(5):]

Cited: 6 times

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Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus α-synuclein and β-amyloid aggregates.

Barbara E Stopschinski, Brandon B Holmes, Gregory M Miller, Victor A Manon, Jaime Vaquer-Alicea, William L Prueitt, Linda C Hsieh-Wilson, Marc I Diamond,

Transcellular propagation of protein aggregate "seeds" has been proposed to mediate the progression of neurodegenerative diseases in tauopathies and α-synucleinopathies. We previously reported that tau and α-synuclein aggregates bind heparan sulfate proteoglycans (HSPGs) on the cell surface, promoting cellular uptake and intracellular seeding. However, the specificity and binding mode of ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2018, 293(27):10826-10840]

Cited: 21 times

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Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs).

Jennifer N Rauch, John J Chen, Alexander W Sorum, Gregory M Miller, Tal Sharf, Stephanie K See, Linda C Hsieh-Wilson, Martin Kampmann, Kenneth S Kosik,

The misfolding and accumulation of tau protein into intracellular aggregates known as neurofibrillary tangles is a pathological hallmark of neurodegenerative diseases such as Alzheimer's disease. However, while tau propagation is a known marker for disease progression, exactly how tau propagates from one cell to another and what mechanisms govern this ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):6382]

Cited: 25 times

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Predicting glycosaminoglycan surface protein interactions and implications for studying axonal growth.

Adam R Griffith, Claude J Rogers, Gregory M Miller, Ravinder Abrol, Linda C Hsieh-Wilson, William A Goddard,

Cell-surface carbohydrates play important roles in numerous biological processes through their interactions with various protein-binding partners. These interactions are made possible by the vast structural diversity of carbohydrates and the diverse array of carbohydrate presentations on the cell surface. Among the most complex and important carbohydrates are glycosaminoglycans (GAGs), which ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2017, 114(52):13697-13702]

Cited: 4 times

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Convergent Balancing Selection on the Mu-Opioid Receptor in Primates.

Carolyn G Sweeney, Juliette M Rando, Helen N Panas, Gregory M Miller, Donna M Platt, Eric J Vallender,

The mu opioid receptor is involved in many natural processes including stress response, pleasure, and pain. Mutations in the gene also have been associated with opiate and alcohol addictions as well as with responsivity to medication targeting these disorders. Two common and mutually exclusive polymorphisms have been identified in humans, ... Read more >>

Mol. Biol. Evol. (Molecular biology and evolution)
[2017, 34(7):1629-1643]

Cited: 4 times

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Persistent negative effects of alcohol drinking on aspects of novelty-directed behavior in male rhesus macaques.

Cassie M Chandler, Meagan E Follett, Nicholas J Porter, Kevin Y Liang, Eric J Vallender, Gregory M Miller, James K Rowlett, Donna M Platt,

Humans with histories of prolonged heavy alcohol use exhibit poorer performance on cognitive tasks associated with problem solving, short-term memory, and visuospatial reasoning, even following the cessation of drinking, when compared with healthy controls. It is unclear, however, whether the cognitive problems are a consequence of alcohol exposure or a ... Read more >>

Alcohol (Alcohol (Fayetteville, N.Y.))
[2017, 63:19-26]

Cited: 1 time

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Modulation of nuclear REST by alternative splicing: a potential therapeutic target for Huntington's disease.

Guo-Lin Chen, Qi Ma, Dharmendra Goswami, Jianyu Shang, Gregory M Miller,

Huntington's disease (HD) is caused by a genetically mutated huntingtin (mHtt) protein with expanded polyQ stretch, which impairs cytosolic sequestration of the repressor element-1 silencing transcription factor (REST), resulting in excessive nuclear REST and subsequent repression of neuronal genes. We recently demonstrated that REST undergoes extensive, context-dependent alternative splicing, of ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2017, 21(11):2974-2984]

Cited: 9 times

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"TAARgeting Addiction"--The Alamo Bears Witness to Another Revolution: An Overview of the Plenary Symposium of the 2015 Behavior, Biology and Chemistry Conference.

David K Grandy, Gregory M Miller, Jun-Xu Li,

BACKGROUND:In keeping with the free-thinking tradition San Antonians are known for, the Scientific Program Committee of the Behavior, Biology and Chemistry: Translational Research in Addiction Conference chose trace amine-associated receptor 1 (TAAR1) as the focus of the plenary symposium for its 7th annual meeting held at the University of Texas ... Read more >>

Drug Alcohol Depend (Drug and alcohol dependence)
[2016, 159:9-16]

Cited: 10 times

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Sugar-dependent modulation of neuronal development, regeneration, and plasticity by chondroitin sulfate proteoglycans.

Gregory M Miller, Linda C Hsieh-Wilson,

Chondroitin sulfate proteoglycans (CSPGs) play important roles in the developing and mature nervous system, where they guide axons, maintain stable connections, restrict synaptic plasticity, and prevent axon regeneration following CNS injury. The chondroitin sulfate glycosaminoglycan (CS GAG) chains that decorate CSPGs are essential for their functions. Through these sugar chains, ... Read more >>

Exp Neurol (Experimental neurology)
[2015, 274(Pt B):115-125]

Cited: 19 times

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Biogeography of the intestinal mucosal and lumenal microbiome in the rhesus macaque.

Koji Yasuda, Keunyoung Oh, Boyu Ren, Timothy L Tickle, Eric A Franzosa, Lynn M Wachtman, Andrew D Miller, Susan V Westmoreland, Keith G Mansfield, Eric J Vallender, Gregory M Miller, James K Rowlett, Dirk Gevers, Curtis Huttenhower, Xochitl C Morgan,

The gut microbiome is widely studied by fecal sampling, but the extent to which stool reflects the commensal composition at intestinal sites is poorly understood. We investigated this relationship in rhesus macaques by 16S sequencing feces and paired lumenal and mucosal samples from ten sites distal to the jejunum. Stool ... Read more >>

Cell Host Microbe (Cell host & microbe)
[2015, 17(3):385-391]

Cited: 86 times

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4-Phenylbutyrate attenuates the ER stress response and cyclic AMP accumulation in DYT1 dystonia cell models.

Jin A Cho, Xuan Zhang, Gregory M Miller, Wayne I Lencer, Flavia C Nery,

Dystonia is a neurological disorder in which sustained muscle contractions induce twisting and repetitive movements or abnormal posturing. DYT1 early-onset primary dystonia is the most common form of hereditary dystonia and is caused by deletion of a glutamic acid residue (302/303) near the carboxyl-terminus of encoded torsinA. TorsinA is localized ... Read more >>

PLoS One (PloS one)
[2014, 9(11):e110086]

Cited: 7 times

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Targeting the DNA repair pathway in Ewing sarcoma.

Elizabeth Stewart, Ross Goshorn, Cori Bradley, Lyra M Griffiths, Claudia Benavente, Nathaniel R Twarog, Gregory M Miller, William Caufield, Burgess B Freeman, Armita Bahrami, Alberto Pappo, Jianrong Wu, Amos Loh, Åsa Karlström, Chris Calabrese, Brittney Gordon, Lyudmila Tsurkan, M Jason Hatfield, Philip M Potter, Scott E Snyder, Suresh Thiagarajan, Abbas Shirinifard, Andras Sablauer, Anang A Shelat, Michael A Dyer,

Ewing sarcoma (EWS) is a tumor of the bone and soft tissue that primarily affects adolescents and young adults. With current therapies, 70% of patients with localized disease survive, but patients with metastatic or recurrent disease have a poor outcome. We found that EWS cell lines are defective in DNA ... Read more >>

Cell Rep (Cell reports)
[2014, 9(3):829-841]

Cited: 64 times

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Large-scale polymorphism discovery in macaque G-protein coupled receptors.

Dharmendra B Goswami, Lisa M Ogawa, Joshua M Ward, Gregory M Miller, Eric J Vallender,

G-protein coupled receptors (GPCRs) play an inordinately large role in human health. Variation in the genes that encode these receptors is associated with numerous disorders across the entire spectrum of disease. GPCRs also represent the single largest class of drug targets and associated pharmacogenetic effects are modulated, in part, by ... Read more >>

BMC Genomics (BMC genomics)
[2013, 14:703]

Cited: 2 times

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Trace amine associated receptor 1 modulates behavioral effects of ethanol.

Laurie J Lynch, Katherine A Sullivan, Eric J Vallender, James K Rowlett, Donna M Platt, Gregory M Miller,

BACKGROUND:Few treatment options for alcohol use disorders (AUDs) exist and more are critically needed. Here, we assessed whether trace amine associated receptor 1 (TAAR1), a modulator of brain monoamine systems, is involved in the behavioral and reinforcement-related effects of ethanol and whether it could potentially serve as a therapeutic target. ... Read more >>

(Substance abuse : research and treatment)
[2013, 7:117-126]

Cited: 18 times

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Semaphorin 3A binds to the perineuronal nets via chondroitin sulfate type E motifs in rodent brains.

Gunnar Dick, Chin Lik Tan, Joao Nuno Alves, Erich M E Ehlert, Gregory M Miller, Linda C Hsieh-Wilson, Kazuyuki Sugahara, Arie Oosterhof, Toin H van Kuppevelt, Joost Verhaagen, James W Fawcett, Jessica C F Kwok,

Chondroitin sulfate (CS) and the CS-rich extracellular matrix structures called perineuronal nets (PNNs) restrict plasticity and regeneration in the CNS. Plasticity is enhanced by chondroitinase ABC treatment that removes CS from its core protein in the chondroitin sulfate proteoglycans or by preventing the formation of PNNs, suggesting that chondroitin sulfate ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2013, 288(38):27384-27395]

Cited: 43 times

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Extensive alternative splicing of the repressor element silencing transcription factor linked to cancer.

Guo-Lin Chen, Gregory M Miller,

The repressor element silencing transcription factor (REST) is a coordinate transcriptional and epigenetic regulator which functions as a tumor suppressor or an oncogene depending on cellular context, and a truncated splice variant REST4 has been linked to various types of cancer. We performed a comprehensive analysis of alternative splicing (AS) ... Read more >>

PLoS One (PloS one)
[2013, 8(4):e62217]

Cited: 11 times

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Tryptophan hydroxylase-2: an emerging therapeutic target for stress disorders.

Guo-Lin Chen, Gregory M Miller,

Serotonin (5-HT) has been long recognized to modulate the stress response, and dysfunction of 5-HT has been implicated in numerous stress disorders. Accordingly, the 5-HT system has been targeted for the treatment of stress disorders. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in 5-HT synthesis, and the recent identification of ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2013, 85(9):1227-1233]

Cited: 12 times

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Nonhuman primate models in the genomic era: a paradigm shift.

Eric J Vallender, Gregory M Miller,

Because of their strong similarities to humans across physiologic, developmental, behavioral, immunologic, and genetic levels, nonhuman primates are essential models for a wide spectrum of biomedical research. But unlike other animal models, nonhuman primates possess substantial outbred genetic variation, reducing statistical power and potentially confounding interpretation of results in research ... Read more >>

ILAR J (ILAR journal)
[2013, 54(2):154-165]

Cited: 28 times

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Advances in tryptophan hydroxylase-2 gene expression regulation: new insights into serotonin-stress interaction and clinical implications.

Guo-Lin Chen, Gregory M Miller,

Serotonin (5-HT) modulates the stress response by interacting with the hormonal hypothalamic-pituitary-adrenal (HPA) axis and neuronal sympathetic nervous system (SNS). Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in 5-HT biosynthesis, and the recent identification of a second, neuron-specific TPH isoform (TPH2) opened up a new area of research. While TPH2 ... Read more >>

Am J Med Genet B Neuropsychiatr Genet (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics)
[2012, 159B(2):152-171]

Cited: 29 times

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