Full Text Journal Articles by
Author Gregory Knoll

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KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease.

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Kidney Int (Kidney international)
[2021, 99(3S):S1-S87]

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Impact of Donation Physicians on Deceased Organ Donation: A Systematic Review

Janet Squires, Laura Aloisio, Wilmer John Santos, Danielle Cho-Young, Monica Taljaard, Nills Gritters, Sonny Dhanani, Gregory Knoll,

<h4>Background: </h4> An emerging strategy to increase deceased organ donation is to use dedicated donation physicians to champion organ donation. We sought to conduct a systematic review of the effectiveness of donation physicians in improving organ donation outcomes. <h4>Methods: </h4> A systematic review was conducted following Cochrane principles. MEDLINE, Embase, ... Read more >>

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Outcomes of an Inpatient Dialysis Start in Patients With Kidney Graft Failure: A Population-Based Multicentre Cohort Study.

Kyla L Naylor, Gregory A Knoll, Eric McArthur, Amit X Garg, Ngan N Lam, Bonnie Field, Leah E Getchell, Emma Hahn, S Joseph Kim,

<h4>Background</h4>The frequency and outcomes of starting maintenance dialysis in the hospital as an inpatient in kidney transplant recipients with graft failure are poorly understood.<h4>Objective</h4>To determine the frequency of inpatient dialysis starts in patients with kidney graft failure and examine whether dialysis start status (hospital inpatient vs outpatient setting) is associated ... Read more >>

Can J Kidney Health Dis (Canadian journal of kidney health and disease)
[2021, 8:2054358120985376]

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Executive summary of the KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease.

Alfred K Cheung, Tara I Chang, William C Cushman, Susan L Furth, Fan Fan Hou, Joachim H Ix, Gregory A Knoll, Paul Muntner, Roberto Pecoits-Filho, Mark J Sarnak, Sheldon W Tobe, Charles R V Tomson, Lyubov Lytvyn, Jonathan C Craig, David J Tunnicliffe, Martin Howell, Marcello Tonelli, Michael Cheung, Amy Earley, Johannes F E Mann,

The Kidney Disease: Improving Global Outcomes (KDIGO) 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease for patients not receiving dialysis represents an update to the KDIGO 2012 guideline on this topic. Development of this guideline update followed a rigorous process of evidence review and ... Read more >>

Kidney Int (Kidney international)
[2021, 99(3):559-569]

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Impact of Donation Physicians on Deceased Organ Donation: A Systematic Review

Janet Squires, Laura Aloisio, Wilmer John Santos, Danielle Cho-Young, Monica Taljaard, Nills Gritters, Sonny Dhanani, Gregory Knoll,

<h4>Background: </h4> An emerging strategy to increase deceased organ donation is to use dedicated donation physicians to champion organ donation. We sought to conduct a systematic review of the effectiveness of donation physicians in improving organ donation outcomes. Data Sources: A systematic review was conducted following Cochrane principles. MEDLINE, Embase, ... Read more >>

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Survey of Canadian critical care physicians' knowledge and attitudes towards legislative aspects of the deceased organ donation system.

Matthew J Weiss, Shane W English, Frederick D'Aragon, François Lauzier, Alexis F Turgeon, Sonny Dhanani, Lauralyn McIntyre, Livia P Carvalho, Michael Yu, Sam D Shemie, Gregory Knoll, Dean A Fergusson, Samantha J Anthony, Adnan Haj-Moustafa, David Hartell, Jim Mohr, Michaël Chassé, ,

<h4>Purpose</h4>We surveyed Canadian critical care physicians who may care for patients who are potential organ donors to understand their attitudes and knowledge of legislation governing the deceased organ donation system.<h4>Methods</h4>We used a web-based, self-administered survey that included questions related to opt-out consent and mandatory referral legislation. Potential participants were identified ... Read more >>

Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2020, 67(10):1349-1358]

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Renal infarct in a COVID-19-positive kidney-pancreas transplant recipient.

Jieqing J Xu, Daniel Samaha, Suhas Mondhe, David Massicotte-Azarniouch, Gregory Knoll, Marcel Ruzicka,

The novel coronavirus disease 2019 (COVID-19) is associated with increased risk of thromboembolic events, but the extent and duration of this hypercoagulable state remain unknown. We describe the first case report of renal allograft infarction in a 46-year-old kidney-pancreas transplant recipient with no prior history of thromboembolism, who presented 26 days ... Read more >>

Am J Transplant (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2020, 20(11):3221-3224]

Cited: 6 times

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Information filtering by coincidence detection of synchronous population output: analytical approaches to the coherence function of a two-stage neural system.

Žiga Bostner, Gregory Knoll, Benjamin Lindner,

Information about time-dependent sensory stimuli is encoded in the activity of neural populations; distinct aspects of the stimulus are read out by different types of neurons: while overall information is perceived by integrator cells, so-called coincidence detector cells are driven mainly by the synchronous activity in the population that encodes ... Read more >>

Biol Cybern (Biological cybernetics)
[2020, 114(3):403-418]

Cited: 1 time

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Mortality and Morbidity in Kidney Transplant Recipients With a Failing Graft: A Matched Cohort Study.

Ngan N Lam, Devon J Boyne, Robert R Quinn, Peter C Austin, Brenda R Hemmelgarn, Patricia Campbell, Gregory A Knoll, Lee Anne Tibbles, Serdar Yilmaz, Hude Quan, Pietro Ravani,

<h4>Background</h4>Due to their history of renal disease and exposure to immunosuppression, kidney transplant recipients with a failing graft may be at higher risk of adverse outcomes compared to nontransplant controls. Understanding the burden of disease in transplant recipients may inform treatment decisions of people whose native kidneys are failing and ... Read more >>

Can J Kidney Health Dis (Canadian journal of kidney health and disease)
[2020, 7:2054358120908677]

Cited: 1 time

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KDIGO Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation.

Steven J Chadban, Curie Ahn, David A Axelrod, Bethany J Foster, Bertram L Kasiske, Vijah Kher, Deepali Kumar, Rainer Oberbauer, Julio Pascual, Helen L Pilmore, James R Rodrigue, Dorry L Segev, Neil S Sheerin, Kathryn J Tinckam, Germaine Wong, Gregory A Knoll,

The 2020 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation is intended to assist health care professionals worldwide who evaluate and manage potential candidates for deceased or living donor kidney transplantation. This guideline addresses general candidacy issues such as ... Read more >>

Transplantation (Transplantation)
[2020, 104(4S1 Suppl 1):S11-S103]

Cited: 3 times

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Survey of Canadian intensivists on physician non-referral and family override of deceased organ donation.

Matthew J Weiss, Shane W English, Frederick D'Aragon, François Lauzier, Alexis F Turgeon, Sonny Dhanani, Lauralyn McIntyre, Sam D Shemie, Gregory Knoll, Dean A Fergusson, Samantha J Anthony, Adnan Haj-Moustafa, David Hartell, Jim Mohr, Michaël Chassé, ,

<h4>Purpose</h4>Intensive care physicians play an important role in the identification and referral of potential organ donors in Canada. Nevertheless, little is known about intensivists' attitudes or behaviours in situations where families override previously expressed consent to donate; nor why physicians elect not to refer patients who are potential donors to ... Read more >>

Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2020, 67(3):313-323]

Cited: 2 times

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Canadian-Australasian Randomised trial of screening kidney transplant candidates for coronary artery disease-A trial protocol for the CARSK study.

Tracey Ying, Jagbir Gill, Angela Webster, S Joseph Kim, Rachael Morton, Scott W Klarenbach, Patrick Kelly, Timothy Ramsay, Gregory A Knoll, Helen Pilmore, Gillian Hughes, Charles A Herzog, Steven Chadban, John S Gill,

Transplantation is the preferred treatment for patients with kidney failure, but the need exceeds the supply of transplantable kidneys, and patients routinely wait >5 years on dialysis for a transplant. Coronary artery disease (CAD) is common in kidney failure and can exclude patients from transplantation or result in death before or ... Read more >>

Am Heart J (American heart journal)
[2019, 214:175-183]

Cited: 1 time

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Socioeconomic Status and Kidney Transplant Outcomes in a Universal Healthcare System: A Population-based Cohort Study.

Kyla L Naylor, Gregory A Knoll, Salimah Z Shariff, Eric McArthur, Amit X Garg, Carl Van Walraven, Peter C Austin, Megan K McCallum, Robert R Quinn, Vivian S Tan, S Joseph Kim,

<h4>Background</h4>Conflicting evidence exists regarding the relationship between socioeconomic status (SES) and outcomes after kidney transplantation.<h4>Methods</h4>We conducted a population-based cohort study in a publicly funded healthcare system using linked administrative healthcare databases from Ontario, Canada to assess the relationship between SES and total graft failure (ie, return to chronic dialysis, preemptive ... Read more >>

Transplantation (Transplantation)
[2019, 103(5):1024-1035]

Cited: 1 time

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Mortality in Incident Maintenance Dialysis Patients Versus Incident Solid Organ Cancer Patients: A Population-Based Cohort.

Kyla L Naylor, S Joseph Kim, Eric McArthur, Amit X Garg, Megan K McCallum, Gregory A Knoll,

<h4>Rationale & objective</h4>The mortality rate is high among dialysis patients, but how this compares with other diseases such as cancer is poorly understood. We compared the survival of maintenance dialysis patients with that for patients with common cancers to enhance the understanding of the burden of end-stage kidney disease.<h4>Study design</h4>Population-based ... Read more >>

Am J Kidney Dis (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2019, 73(6):765-776]

Cited: 9 times

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Trends in Early Hospital Readmission After Kidney Transplantation, 2002 to 2014: A Population-Based Multicenter Cohort Study.

Kyla L Naylor, Gregory A Knoll, Britney Allen, Alvin H Li, Amit X Garg, Ngan N Lam, Megan K McCallum, S Joseph Kim,

BACKGROUND:Early hospital readmission (EHR) is associated with morbidity, mortality, and significant healthcare costs. However, trends over time in EHR events in kidney transplant recipients have not been examined. We conducted a population-based cohort study using linked healthcare databases from Ontario, Canada, to determine whether the EHR incidence has changed from ... Read more >>

Transplantation (Transplantation)
[2018, 102(4):e171-e179]

Cited: 6 times

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Criteria to Identify a Potential Deceased Organ Donor: A Systematic Review.

Janet E Squires, Mary Coughlin, Kristin Dorrance, Stefanie Linklater, Michaël Chassé, Jeremy M Grimshaw, Sam D Shemie, Sonny Dhanani, Gregory A Knoll,

<h4>Objectives</h4>To systematically review the global published literature defining a potential deceased organ donor and identifying clinical triggers for deceased organ donation identification and referral.<h4>Data sources</h4>Medline and Embase databases from January 2006 to September 2017.<h4>Study selection</h4>All published studies containing a definition of a potential deceased organ donor and/or clinical triggers for ... Read more >>

Crit Care Med (Critical care medicine)
[2018, 46(8):1318-1327]

Cited: 2 times

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Barriers and Enablers to Organ Donation After Circulatory Determination of Death: A Qualitative Study Exploring the Beliefs of Frontline Intensive Care Unit Professionals and Organ Donor Coordinators.

Janet E Squires, Nicole Graham, Mary Coughlin, Michaël Chassé, Stefanie Linklater, Megan Greenough, Jeremy M Grimshaw, Sam D Shemie, Sonny Dhanani, Gregory A Knoll,

<h4>Background</h4>A shortage of transplantable organs is a global problem. The purpose of this study was to explore frontline intensive care unit professionals' and organ donor coordinators' perceptions and beliefs around the process of, and the barriers and enablers to, donation after circulatory determination death (DCDD).<h4>Methods</h4>This qualitative descriptive study used a ... Read more >>

Transplant Direct (Transplantation direct)
[2018, 4(7):e368]

Cited: 4 times

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End-Stage Kidney Disease in Patients With Autosomal Dominant Polycystic Kidney Disease: A 12-Year Study Based on the Canadian Organ Replacement Registry.

Brandon Budhram, Ayub Akbari, Pierre Brown, Mohan Biyani, Gregory Knoll, Deborah Zimmerman, Cedric Edwards, Brendan McCormick, Ann Bugeja, Manish M Sood,

<h4>Background</h4>Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease, with afflicted patients often progressing to end-stage kidney disease (ESKD) requiring renal replacement therapy (RRT). As the timelines to ESKD are predictable over decades, it follows that ADPKD patients should be optimized regarding kidney transplantation, home dialysis ... Read more >>

Can J Kidney Health Dis (Canadian journal of kidney health and disease)
[2018, 5:2054358118778568]

Cited: 0 times

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Validation of Living Donor Nephrectomy Codes.

Ngan N Lam, Krista L Lentine, Scott Klarenbach, Manish M Sood, Paul J Kuwornu, Kyla L Naylor, Gregory A Knoll, S Joseph Kim, Ann Young, Amit X Garg,

Background:Use of administrative data for outcomes assessment in living kidney donors is increasing given the rarity of complications and challenges with loss to follow-up. Objective:To assess the validity of living donor nephrectomy in health care administrative databases compared with the reference standard of manual chart review. Design:Retrospective cohort study. Setting:5 ... Read more >>

Can J Kidney Health Dis (Canadian journal of kidney health and disease)
[2018, 5:2054358118760833]

Cited: 0 times

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Evaluation of a Hockey Deceased Organ Donation Awareness Campaign: A Population-Based Cohort Study.

Kyla L Naylor, Susan McKenzie, Cindy Cherry, Eric McArthur, Alvin H Li, Megan K McCallum, S Joseph Kim, Versha Prakash, Gregory A Knoll, Amit X Garg,

<h4>Background</h4>The Kidney Foundation of Canada developed a pilot campaign to educate persons attending junior hockey league games in London, Ontario, Canada, on deceased organ donation.<h4>Objective</h4>To evaluate the impact of a hockey campaign on the number of new organ and tissue donor registrants.<h4>Design</h4>Population-based retrospective cohort study.<h4>Setting</h4>Residents of London, Ontario.<h4>Patients</h4>We included 255 ... Read more >>

Can J Kidney Health Dis (Canadian journal of kidney health and disease)
[2017, 4:2054358117717252]

Cited: 0 times

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Center Variation and the Effect of Center and Provider Characteristics on Clinical Outcomes in Kidney Transplantation: A Systematic Review of the Evidence.

Anne Tsampalieros, Gregory A Knoll, Nicholas Fergusson, Alexandria Bennett, Monica Taljaard, Dean Fergusson,

Background:Kidney transplantation is the best treatment option for patients with end-stage renal disease. While patient-level factors affecting survival are established, the presence of variation in the management of transplant recipients remains unknown. Objective:The objective of this study was to examine center variation in kidney transplantation and identify center and provider ... Read more >>

Can J Kidney Health Dis (Canadian journal of kidney health and disease)
[2017, 4:2054358117735523]

Cited: 2 times

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The Risk of Cardiovascular Disease Is Not Increasing Over Time Despite Aging and Higher Comorbidity Burden of Kidney Transplant Recipients.

Ngan N Lam, S Joseph Kim, Gregory A Knoll, Eric McArthur, Krista L Lentine, Kyla L Naylor, Alvin H Li, Salimah Z Shariff, Christine M Ribic, Amit X Garg,

<h4>Background</h4>Cardiovascular death remains the leading cause of mortality in kidney transplant recipients. Cardiovascular events are associated with significant morbidity. However, current trends in cardiovascular events after kidney transplantation are poorly understood.<h4>Methods</h4>We conducted a retrospective study using healthcare databases in Ontario, Canada, to determine whether the incidence of cardiovascular events after ... Read more >>

Transplantation (Transplantation)
[2017, 101(3):588-596]

Cited: 21 times

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The association of urinary sodium excretion and the need for renal replacement therapy in advanced chronic kidney disease: a cohort study.

Andrea Mazarova, Amber O Molnar, Ayub Akbari, Manish M Sood, Swapnil Hiremath, Kevin D Burns, Timothy O Ramsay, Ranjeeta Mallick, Gregory A Knoll, Marcel Ruzicka,

<h4>Background</h4>Restriction of dietary sodium is routinely recommended for patients with chronic kidney disease (CKD). Whether or not sodium intake is associated with the progression of CKD and mortality remains controversial. We evaluated the association of urinary sodium excretion (as a surrogate for sodium intake) on the need for renal replacement ... Read more >>

BMC Nephrol (BMC nephrology)
[2016, 17(1):123]

Cited: 3 times

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Risk factors for fracture in adult kidney transplant recipients.

Kyla L Naylor, Guangyong Zou, William D Leslie, Anthony B Hodsman, Ngan N Lam, Eric McArthur, Lisa-Ann Fraser, Gregory A Knoll, Jonathan D Adachi, S Joseph Kim, Amit X Garg,

<h4>Aim</h4>To determine the general and transplant-specific risk factors for fractures in kidney transplant recipients.<h4>Methods</h4>We conducted a cohort study of all adults who received a kidney-only transplant (n = 2723) in Ontario, Canada between 2002 and 2009. We used multivariable Cox proportional hazards regression to determine general and transplant-specific risk factors ... Read more >>

World J Transplant (World journal of transplantation)
[2016, 6(2):370-379]

Cited: 6 times

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Epidemiology of Fracture in Adults from Ontario, Canada, with Chronic Kidney Disease: An Examination of Fracture Burden Using Administrative Health Data.

Kyla L Naylor, Amit X Garg, S Joseph Kim, Gregory A Knoll,

Fractures are associated with morbidity and mortality. Individuals with chronic kidney disease (CKD) experience bone mineral metabolism changes, which increases fracture risk. Researchers have quantified the epidemiology of fractures in adults with CKD using administrative health databases from Ontario, Canada, held at the Institute for Clinical Evaluative Sciences. Results demonstrated ... Read more >>

Healthc Q (Healthcare quarterly (Toronto, Ont.))
[2016, 19(2):6-9]

Cited: 0 times

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