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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

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Surgical approach and short-term outcomes in adults and children undergoing total pancreatectomy with islet autotransplantation: A report from the Prospective Observational Study of TPIAT.

Jaimie D Nathan, Yi Yang, Anne Eaton, Piotr Witkowski, Martin Wijkstrom, Matthew Walsh, Guru Trikudanathan, Vikesh K Singh, Sarah J Schwarzenberg, Timothy L Pruett, Andrew Posselt, Bashoo Naziruddin, Sri Prakash Mokshagundam, Katherine Morgan, Luis F Lara, Varvara Kirchner, Jin He, Timothy B Gardner, Martin L Freeman, Kate Ellery, Darwin L Conwell, Srinath Chinnakotla, Gregory J Beilman, Syed Ahmad, Maisam Abu-El-Haija, James S Hodges, Melena D Bellin,

<h4>Background</h4>Total pancreatectomy with islet autotransplantation (TPIAT) is a viable option for treating debilitating recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) in adults and children. No data is currently available regarding variation in approach to operation.<h4>Methods</h4>We evaluated surgical techniques, islet isolation and infusion approaches, and outcomes and complications, comparing children ... Read more >>

Pancreatology (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.])
[2021, :]

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Reduced bone mineral density in the first year after total pancreatectomy with islet autotransplantation (TPIAT).

Jillian K Wothe, Robert Aidoo, Kendall R McEachron, Tasma Harindhanavudhi, Guru Trikudanathan, Martin L Freeman, Varvara Kirchner, Timothy L Pruett, Gregory J Beilman, James S Hodges, Melena D Bellin,

<h4>Background/objectives</h4>The effect of total pancreatectomy with islet autotransplantation (TPIAT) on bone mineral density (BMD) in patients with CP is unknown. We aimed to assess bone health in patients with CP after TPIAT.<h4>Methods</h4>We measured BMD, BMD Z-score, and bone mineral content (BMC) for total body, lumbar spine, right and left hip ... Read more >>

Pancreatology (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.])
[2021, :]

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Translocated microbiome composition determines immunological outcome in treated HIV infection.

Krystelle Nganou-Makamdop, Aarthi Talla, Ashish Arunkumar Sharma, Sam Darko, Amy Ransier, Farida Laboune, Jeffrey G Chipman, Gregory J Beilman, Torfi Hoskuldsson, Slim Fourati, Thomas E Schmidt, Sahaana Arumugam, Noemia S Lima, Damee Moon, Samuel Callisto, Jordan Schoephoerster, Jeffery Tomalka, Peter Mugyenyi, Francis Ssali, Proscovia Muloma, Patrick Ssengendo, Ana R Leda, Ryan K Cheu, Jacob K Flynn, Antigoni Morou, Elsa Brunet-Ratnasingham, Benigno Rodriguez, Michael M Lederman, Daniel E Kaufmann, Nichole R Klatt, Cissy Kityo, Jason M Brenchley, Timothy W Schacker, Rafick P Sekaly, Daniel C Douek,

The impact of the microbiome on HIV disease is widely acknowledged although the mechanisms downstream of fluctuations in microbial composition remain speculative. We detected rapid, dynamic changes in translocated microbial constituents during two years after cART initiation. An unbiased systems biology approach revealed two distinct pathways driven by changes in ... Read more >>

Cell (Cell)
[2021, 184(15):3899-3914.e16]

Cited: 1 time

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Gastrointestinal Bleed After Total Pancreatectomy With Islet Autotransplant.

Alexandria J Robbins, Elizabeth Lusczek, Melena D Bellin, Fatima S Alwan, James S Hodges, Scott A Chapman, Gregory J Beilman,

<h4>Objective</h4>Gastrointestinal bleeding (GIB) is an uncommon complication after abdominal surgery. Given the unique risks in the total pancreatectomy with islet autotransplant (TPIAT) population, we aimed to describe this population's incidence of postoperative GIB.<h4>Methods</h4>Prospectively collected data on patients who underwent a TPIAT from 2001 to 2018 at the University of Minnesota ... Read more >>

Pancreas (Pancreas)
[2021, 50(6):841-846]

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The Association of Smoking and Alcohol Abuse on Anxiety and Depression in Patients With Recurrent Acute or Chronic Pancreatitis Undergoing Total Pancreatectomy and Islet Autotransplantation: A Report From the Prospective Observational Study of TPIAT Cohort.

Luis F Lara, Solvejg Wastvedt, James S Hodges, Piotr Witkowski, Martin Wijkstrom, R Matthew Walsh, Vikesh K Singh, Sarah J Schwarzenberg, Timothy L Pruett, Andrew Posselt, Bashoo Naziruddin, Jaimie D Nathan, Katherine A Morgan, Rebecca Mitchell, Varvara A Kirchner, SriPrakash L Mokshagundam, Betul Hatipoglu, Timothy B Gardner, Martin L Freeman, Srinath Chinnakotla, Gregory J Beilman, Maisam Abu-El-Haija, Darwin L Conwell, Melena D Bellin, ,

<h4>Objectives</h4>Smoking and alcohol use are risk factors for acute and chronic pancreatitis, and their role on anxiety, depression, and opioid use in patients who undergo total pancreatectomy and islet autotransplantation (TPIAT) is unknown.<h4>Methods</h4>We included adults enrolled in the Prospective Observational Study of TPIAT (POST). Measured variables included smoking (never, former, ... Read more >>

Pancreas (Pancreas)
[2021, 50(6):852-858]

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Mortality After Elective Surgery: The Potential Role for Preoperative Palliative Care.

Alexandria J Robbins, Gregory J Beilman, Tatiana Ditta, Ashley Benner, Drew Rosielle, Jeffrey Chipman, Elizabeth Lusczek,

<h4>Background</h4>Preoperative optimization is increasingly emphasized for high-risk surgical patients. One critical component of this includes preoperative advanced care planning to promote goal-concordant care. We aimed to define a subset of patients that might benefit from preoperative palliative care consult for advanced care planning.<h4>Materials and methods</h4>We examined adult patients admitted from ... Read more >>

J Surg Res (The Journal of surgical research)
[2021, 266:44-53]

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Thromboembolic Complications in the First Year After Acute Pancreatitis Diagnosis.

Alexandria J Robbins, Elizabeth Lusczek, Melena D Bellin, Ashley Benner, Fatima S Alwan, Gregory J Beilman,

<h4>Objectives</h4>This study aimed to quantify the prevalence of venous thromboembolic (VTE) events in patients with pancreatitis requiring hospitalization and its impact on outcomes.<h4>Methods</h4>Adult patients admitted from 2011 to 2018 for pancreatitis were identified. Every admission for pancreatitis in the first year after diagnosis was evaluated for a VTE (pulmonary embolism, ... Read more >>

Pancreas (Pancreas)
[2021, 50(5):751-755]

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Atypical Hepatic Steatosis Patterns on MRI After Total Pancreatectomy With Islet Autotransplant.

Alexandria J Robbins, Stephen Ritter, Matthew Markese, Mariya E Skube, Kendall R McEachron, Melena D Bellin, Mark J Stice, Gregory J Beilman, Robben Schat, Benjamin Spilseth,

<b>OBJECTIVE.</b> The purpose of this retrospective study was to investigate the prevalence and patterns of hepatic steatosis after total pancreatectomy with islet autotransplant (TPIAT) and to determine if the unique patterns of steatosis seen in this study correlated with islet graft function. <b>MATERIALS AND METHODS.</b> Fifty-two subjects who had undergone ... Read more >>

AJR Am J Roentgenol (AJR. American journal of roentgenology)
[2021, 217(1):100-106]

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Hemodynamic Parameters in the Assessment of Fluid Status in a Porcine Hemorrhage and Resuscitation Model.

Eric S Wise, Kyle M Hocking, Monica E Polcz, Gregory J Beilman, Colleen M Brophy, Jenna H Sobey, Philip J Leisy, Roy K Kiberenge, Bret D Alvis,

<h4>Background</h4>Measuring fluid status during intraoperative hemorrhage is challenging, but detection and quantification of fluid overload is far more difficult. Using a porcine model of hemorrhage and over-resuscitation, it is hypothesized that centrally obtained hemodynamic parameters will predict volume status more accurately than peripherally obtained vital signs.<h4>Methods</h4>Eight anesthetized female pigs were ... Read more >>

Anesthesiology (Anesthesiology)
[2021, 134(4):607-616]

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Metabolic measures before surgery and long-term diabetes outcomes in recipients of total pancreatectomy and islet autotransplantation.

Yoshihide Nanno, Solvejg Wastvedt, Martin L Freeman, Guru Trikudanathan, Sarah J Schwarzenberg, Elissa M Downs, Varvara A Kirchner, Timothy L Pruett, Gregory J Beilman, Srinath Chinnakotla, Bernhard J Hering, Melena D Bellin,

In this single-center, retrospective cohort study, we aimed to elucidate simple metabolic markers or surrogate indices of β-cell function that best predict long-term insulin independence and goal glycemic HbA1c control (HbA1c ≤ 6.5%) after total pancreatectomy with islet autotransplantation (TP-IAT). Patients who underwent TP-IAT (n = 371) were reviewed for metabolic measures before TP-IAT ... Read more >>

Am J Transplant (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2021, 21(10):3411-3420]

Cited: 1 time

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Factors Associated With Morbidity Following Total Pancreatectomy and Islet Autotransplantation: A NSQIP Analysis.

John T Butterfield, Victor R Vakayil, Keaton Joppru, Melena D Bellin, Gregory J Beilman, James V Harmon,

<h4>Background</h4>Total pancreatectomy with islet autotransplantation is a therapeutic surgical option for patients with chronic pancreatitis leading to significant reduction in pain, improvement in quality of life, and potential for preservation of partial to full endocrine function. Data on the factors associated with short-term morbidities are limited.<h4>Methods</h4>We queried the American College ... Read more >>

Transplant Proc (Transplantation proceedings)
[2021, 53(2):705-711]

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Portal Vein Thrombosis may Be More Strongly Associated With Islet Infusion Than Extreme Thrombocytosis After Total Pancreatectomy With Islet Autotransplantation.

Alexander A Boucher, Solvejg Wastvedt, James S Hodges, Gregory J Beilman, Varvara A Kirchner, Timothy L Pruett, Bernhard J Hering, Sarah J Schwarzenberg, Elissa Downs, Martin Freeman, Guru Trikudanathan, Srinath Chinnakotla, Melena D Bellin,

<h4>Background</h4>Total pancreatectomy with islet autotransplantation (TPIAT) involves pancreatectomy, splenectomy, and reinjection of the patient's pancreatic islets into the portal vein. This process triggers a local inflammatory reaction and increase in portal pressure, threatening islet survival and potentially causing portal vein thrombosis. Recent research has highlighted a high frequency of extreme ... Read more >>

Transplantation (Transplantation)
[2021, :]

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Early use of continuous glucose monitoring in children and adolescents after total pancreatectomy with islet autotransplantation.

Kendall R McEachron, Neha Potlapalli, Arpana Rayannavar, Elissa M Downs, Sarah J Schwarzenberg, Varvara A Kirchner, Gregory J Beilman, Srinath Chinnakotla, Melena D Bellin,

<h4>Background</h4>Children undergoing total pancreatectomy with islet autotransplantation (TPIAT) for chronic pancreatitis require intensive insulin therapy early after TPIAT with narrow glycemic targets, which can a present significant care burden. Outpatient use of continuous glucose monitoring (CGM) systems by children and caregivers early after TPIAT is inadequately studied.<h4>Methods</h4>In this open-label study, ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2021, 22(3):434-438]

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Body Composition is Associated With Islet Function After Pancreatectomy and Islet Autotransplantation for Pancreatitis.

Tasma Harindhanavudhi, Yi Yang, James S Hodges, Timothy L Pruett, Varvara Kirchner, Gregory J Beilman, Melena D Bellin,

<h4>Context</h4>Body composition in total pancreatectomy with islet autotransplantation (TPIAT) has never been studied.<h4>Objective</h4>Determine whether presurgical body composition is associated with islet function and insulin sensitivity after TPIAT.<h4>Methods</h4>In 88 adults undergoing TPIAT (median age 41.0 years, IQR 32.8-48.0), beta-cell function and insulin sensitivity were assessed using mixed meal tolerance test and ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2021, 106(2):e496-e506]

Cited: 1 time

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Preoperative ERCP has no impact on islet yield following total pancreatectomy and islet autotransplantation (TPIAT): Results from the Prospective Observational Study of TPIAT (POST) cohort.

Guru Trikudanathan, B Joseph Elmunzer, Yi Yang, Maisam Abu-El-Haija, David Adams, Syed Ahmad, Appakalai N Balamurugan, Gregory J Beilman, Srinath Chinnakotla, Darwin L Conwell, Martin L Freeman, Timothy B Gardner, Betul Hatipoglu, James S Hodges, Varvara Kirchner, Luis F Lara, Leslie Long-Simpson, Rebecca Mitchell, Katherine Morgan, Jaimie D Nathan, Bashoo Naziruddin, Andrew Posselt, Timothy L Pruett, Sarah J Schwarzenberg, Vikesh K Singh, Kerrington Smith, Martin Wijkstrom, Piotr Witkowski, Melena D Bellin,

<h4>Background and aims</h4>Many patients undergoing total pancreatectomy with islet autotransplant (TPIAT) for severe, refractory chronic pancreatitis or recurrent acute pancreatitis have a history of endoscopic retrograde cholangiopancreatography (ERCP). Using data from the multicenter POST (Prospective Observational Study of TPIAT) cohort, we aimed to determine clinical characteristics associated with ERCP and ... Read more >>

Pancreatology (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.])
[2021, 21(1):275-281]

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Type 1 diabetes mellitus in patients with recurrent acute and chronic pancreatitis: A case series.

Harmeet K Kharoud, Tetyana Mettler, Martin L Freeman, Guru Trikudanathan, Gregory J Beilman, Srinath Chinnakotla, Elissa Downs, Sarah J Schwarzenberg, Melena D Bellin,

<h4>Background/objectives</h4>Pancreatogenic diabetes mellitus has been assumed to result from non-immune beta cell destruction when the pancreas is replaced by fibrotic tissue secondary to acute and chronic pancreatitis. We hypothesize that recurrent episodes of pancreatic inflammation may increase the risk for developing β-cell autoimmunity in susceptible individuals.<h4>Methods</h4>We describe 11 patients who ... Read more >>

Pancreatology (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.])
[2021, 21(1):95-97]

Cited: 1 time

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Propensity score adjusted comparison of three-factor versus four-factor prothrombin complex concentrate for emergent warfarin reversal: a retrospective cohort study.

David J Margraf, Scott Seaburg, Gregory J Beilman, Julian Wolfson, Jonathan C Gipson, Scott A Chapman,

<h4>Background</h4>Prothrombin Complex Concentrates (PCC) are prescribed for emergent warfarin reversal (EWR). The comparative effectiveness and safety among PCC products are not fully understood.<h4>Methods</h4>Patients in an academic level one trauma center who received PCC3 or PCC4 for EWR were identified. Patient characteristics, PCC dose and time of dose, pre- and post-INR ... Read more >>

BMC Emerg Med (BMC emergency medicine)
[2020, 20(1):93]

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Performance of modified Igls criteria to evaluate islet autograft function after total pancreatectomy with islet autotransplantation - a retrospective study.

Kendall R McEachron, Yi Yang, James S Hodges, Gregory J Beilman, Varvara A Kirchner, Timothy L Pruett, Srinath Chinnakotla, Bernhard J Hering, Melena D Bellin,

The Igls criteria assess islet function after islet allotransplant, based on C-peptide, insulin use, hemoglobin A1c, and severe hypoglycemia. However, these criteria as currently defined cannot be applied to total pancreatectomy islet autotransplant (TPIAT) patients. We tested modified criteria for assessing islet function in a large cohort of TPIAT patients ... Read more >>

Transpl Int (Transplant international : official journal of the European Society for Organ Transplantation)
[2021, 34(1):87-96]

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The histopathology of SPINK1-associated chronic pancreatitis.

Terrell E Jones, Melena D Bellin, Dhiraj Yadav, Martin L Freeman, Sarah J Schwarzenberg, Adam Slivka, Jennifer S Chennat, Gregory J Beilman, Srinath Chinnakotla, Timothy L Pruett, Varvara Kirchner, Abhinav Humar, Martin Wijkstrom, Amer H Zureikat, Marina N Nikiforova, Abigail I Wald, David C Whitcomb, Aatur D Singhi,

<h4>Background</h4>The identification of genetic risk factors for chronic pancreatitis, such as PRSS1, CFTR and SPINK1, provides the opportunity to define key pathologic hallmarks and etiologic-specific changes. For example, pancreata from PRSS1 and CFTR patients exhibit progressive lipomatous atrophy without significant fibrosis. Considering the pathology of SPINK1-associated pancreatitis is ill-defined, we ... Read more >>

Pancreatology (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.])
[2020, 20(8):1648-1655]

Cited: 2 times

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Gene Expression Profiling of the Pancreas in Patients Undergoing Total Pancreatectomy With Islet Autotransplant Suggests Unique Features of Alcoholic, Idiopathic, and Hereditary Pancreatitis.

Brandon M Blobner, Melena D Bellin, Gregory J Beilman, Celeste A Shelton, Hyung Jung Park, David C Whitcomb,

<h4>Objectives</h4>To determine if RNA collected from pancreatic tissue, without the use of RNAlater, is useful for RNA sequencing (RNA-seq) despite degradation, and if so, then, via RNA-seq analysis, how does gene expression vary between pancreatitis etiologies.<h4>Methods</h4>Data were assessed in 2 dimensions, based on RNA-seq signal shape assessed by RSeQC v.2.6.4 ... Read more >>

Pancreas (Pancreas)
[2020, 49(8):1037-1043]

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Transforming a Long-Term Acute Care Hospital into a COVID-19-Designated Hospital.

Alexandria Robbins, Gregory J Beilman, Brian Amdahl, Mark Welton, Christopher Tignanelli, Andrew P J Olson, Jeffrey G Chipman,

Surg Infect (Larchmt) (Surgical infections)
[2020, 21(9):729-731]

Cited: 4 times

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Combination of pancreas volume and HbA1c level predicts islet yield in patients undergoing total pancreatectomy and islet autotransplantation.

Yoshihide Nanno, Joshua J Wilhelm, David Heller, Robben Schat, Martin L Freeman, Guru Trikudanathan, Varvara A Kirchner, Timothy L Pruett, Gregory J Beilman, Bernhard J Hering, Melena D Bellin,

Islet yield is an important predictor of acceptable glucose control after total pancreatectomy with islet autotransplantation (TP-IAT). We assessed if pancreas volume calculated with preoperative MRI could assess islet yield and postoperative outcomes. We reviewed dynamic MRI studies from 154 adult TP-IAT patients (2009-2016), and associations between calculated volumes and ... Read more >>

Clin Transplant (Clinical transplantation)
[2020, 34(8):e14008]

Cited: 1 time

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