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The Evolution of Toolkits and Bundles to Improve the Care of Sepsis Patients.

Greg S Martin, Sandra L Kane-Gill, Vinay Nadkarni, Lauren R Sorce, Lewis J Kaplan, Maurizio Cecconi, Elie Azoulay, Jean-Louis Teboul, Lui Forni, Jozef Kesecioglu,

Crit Care Med (Critical care medicine)
[2021, 49(11):1849-1850]

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SCCM/ACCM Guideline and Toolkit Development Pathways.

Sandra L Kane-Gill, Julie Winkle, Lewis J Kaplan, Vinay Nadkarni, Lauren R Sorce, Lori Harmon, Greg S Martin,

Crit Care Med (Critical care medicine)
[2021, 49(11):1851-1854]

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The Epidemiology of Adult Tracheostomy in the United States 2002-2017: A Serial Cross-Sectional Study.

Maria K Abril, David M Berkowitz, Yunyun Chen, Lance A Waller, Greg S Martin, Jordan A Kempker,

Describe the longitudinal national epidemiology of tracheostomies performed in acute care hospitals and describe the annual rate of tracheostomy performed for patients with respiratory failure with invasive mechanical ventilation.<h4>Design</h4>Serial cross-sectional study.<h4>Setting</h4>The 2002-2014 and 2016-2017 Healthcare Utilization Project's National Inpatient Sample datasets.<h4>Patients</h4>Discharges greater than or equal to 18 years old, excluding ... Read more >>

Crit Care Explor (Critical care explorations)
[2021, 3(9):e0523]

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Defining Patient-Oriented Natural Language Processing: A New Paradigm for Research and Development to Facilitate Adoption and Use by Medical Experts.

Abeed Sarker, Mohammed Ali Al-Garadi, Yuan-Chi Yang, Jinho Choi, Arshed A Quyyumi, Greg S Martin,

The capabilities of natural language processing (NLP) methods have expanded significantly in recent years, and progress has been particularly driven by advances in data science and machine learning. However, NLP is still largely underused in patient-oriented clinical research and care (POCRC). A key reason behind this is that clinical NLP ... Read more >>

JMIR Med Inform (JMIR medical informatics)
[2021, 9(9):e18471]

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Surviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies.

Ignacio Martin-Loeches, Mark E Nunnally, Judith Hellman, Ishaq Lat, Greg S Martin, Sameer Jog, Jozef Kesecioglu, Daniel De Backer, Craig M Coopersmith,

Patients with infection can develop sepsis, and their mortality can be high. An important aspect in the treatment of sepsis is adequate management of the infection.<h4>Data sources</h4>Using a modified Delphi approach, the Surviving Sepsis Campaign research committee recently published a series of 26 priorities for sepsis and septic shock.<h4>Study selection</h4>Task ... Read more >>

Crit Care Explor (Critical care explorations)
[2021, 3(9):e0511]

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A scalable workflow to characterize the human exposome.

Xin Hu, Douglas I Walker, Yongliang Liang, Matthew Ryan Smith, Michael L Orr, Brian D Juran, Chunyu Ma, Karan Uppal, Michael Koval, Greg S Martin, David C Neujahr, Carmen J Marsit, Young-Mi Go, Kurt D Pennell, Gary W Miller, Konstantinos N Lazaridis, Dean P Jones,

Complementing the genome with an understanding of the human exposome is an important challenge for contemporary science and technology. Tens of thousands of chemicals are used in commerce, yet cost for targeted environmental chemical analysis limits surveillance to a few hundred known hazards. To overcome limitations which prevent scaling to ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):5575]

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The need for new test verification and regulatory support for innovative diagnostics.

John D Roback, Erika A Tyburski, David Alter, Saja Asakrah, Ann Chahroudi, Annette Esper, Sarah Farmer, Janet Figueroa, Jennifer K Frediani, Mark D Gonzalez, David S Gottfried, Jeannette Guarner, Nitika A Gupta, Stacy S Heilman, Charles E Hill, Robert Jerris, Russell R Kempker, Jessica Ingersoll, Joshua M Levy, Maud Mavigner, Carlos S Moreno, Claudia R Morris, Eric J Nehl, Andrew S Neish, Deniz Peker, Natia Saakadze, Paulina A Rebolledo, Christina A Rostad, Nils Schoof, Allie Suessmith, Julie Sullivan, Yun F Wayne Wang, Anna Wood, Miriam B Vos, Oliver Brand, Greg S Martin, Wilbur A Lam,

Nat Biotechnol (Nature biotechnology)
[2021, 39(9):1060-1062]

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eARDS: A multi-center validation of an interpretable machine learning algorithm of early onset Acute Respiratory Distress Syndrome (ARDS) among critically ill adults with COVID-19.

Lakshya Singhal, Yash Garg, Philip Yang, Azade Tabaie, A Ian Wong, Akram Mohammed, Lokesh Chinthala, Dipen Kadaria, Amik Sodhi, Andre L Holder, Annette Esper, James M Blum, Robert L Davis, Gari D Clifford, Greg S Martin, Rishikesan Kamaleswaran,

We present an interpretable machine learning algorithm called 'eARDS' for predicting ARDS in an ICU population comprising COVID-19 patients, up to 12-hours before satisfying the Berlin clinical criteria. The analysis was conducted on data collected from the Intensive care units (ICU) at Emory Healthcare, Atlanta, GA and University of Tennessee ... Read more >>

PLoS One (PloS one)
[2021, 16(9):e0257056]

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Single-amplicon, multiplex real-time RT-PCR with tiled probes to detect SARS-CoV-2 spike mutations associated with variants of concern.

Ahmed Babiker, Katherine Immergluck, Samuel D Stampfer, Anuradha Rao, Leda Bassit, Max Su, Vi Nguyen, Victoria Stittleburg, Jessica M Ingersoll, Heath L Bradley, Maud Mavigner, Nils Schoof, Colleen S Kraft, Ann Chahroudi, Raymond F Schinazi, Greg S Martin, Anne Piantadosi, Wilbur A Lam, Jesse J Waggoner,

To provide an accessible and inexpensive method to surveil for SARS-CoV-2 mutations, we developed a multiplex real-time RT-PCR (the Spike SNP assay) to detect specific mutations in the <i>spike</i> receptor binding domain. A single primer pair was designed to amplify a 348 bp region of <i>spike</i>, and probes were initially ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2021, :JCM0144621]

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Correlation of SARS-CoV-2 Subgenomic RNA with Antigen Detection in Nasal Midturbinate Swab Specimens.

Katherine Immergluck, Mark D Gonzalez, Jennifer K Frediani, Joshua M Levy, Janet Figueroa, Anna Wood, Beverly B Rogers, Jared O'Neal, Roger Elias-Marcellin, Allie Suessmith, Julie Sullivan, Raymond F Schinazi, Ahmed Babiker, Anne Piantadosi, Miriam B Vos, Greg S Martin, Wilbur A Lam, Jesse J Waggoner,

Among symptomatic outpatients, subgenomic RNA of severe acute respiratory syndrome coronavirus 2 in nasal midturbinate swab specimens was concordant with antigen detection but remained detectable in 13 (82.1%) of 16 nasopharyngeal swab specimens from antigen-negative persons. Subgenomic RNA in midturbinate swab specimens might be useful for routine diagnostics to identify ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2021, 27(11):]

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Impact of repeated nasal sampling on detection and quantification of SARS-CoV-2.

Joshua M Levy, Jennifer K Frediani, Erika A Tyburski, Anna Wood, Janet Figueroa, Russell R Kempker, Paulina A Rebolledo, Mark D Gonzalez, Julie Sullivan, Miriam B Vos, Jared O'Neal, Greg S Martin, Wilbur A Lam, Jesse J Waggoner,

The impact of repeated sample collection on COVID-19 test performance is unknown. The FDA and CDC currently recommend the primary collection of diagnostic samples to minimize the perceived risk of false-negative findings. We therefore evaluated the association between repeated sample collection and test performance among 325 symptomatic patients undergoing COVID-19 ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):14903]

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Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration.

Jennifer K Frediani, Joshua M Levy, Anuradha Rao, Leda Bassit, Janet Figueroa, Miriam B Vos, Anna Wood, Robert Jerris, Van Leung-Pineda, Mark D Gonzalez, Beverly B Rogers, Maud Mavigner, Raymond F Schinazi, Nils Schoof, Jesse J Waggoner, Russell R Kempker, Paulina A Rebolledo, Jared W O'Neal, Cheryl Stone, Ann Chahroudi, Claudia R Morris, Allie Suessmith, Julie Sullivan, Sarah Farmer, Amanda Foster, John D Roback, Thanuja Ramachandra, CaDeidre Washington, Kristie Le, Maria C Cordero, Annette Esper, Eric J Nehl, Yun F Wang, Erika A Tyburski, Greg S Martin, Wilbur A Lam,

While there has been significant progress in the development of rapid COVID-19 diagnostics, as the pandemic unfolds, new challenges have emerged, including whether these technologies can reliably detect the more infectious variants of concern and be viably deployed in non-clinical settings as "self-tests". Multidisciplinary evaluation of the Abbott BinaxNOW COVID-19 ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):14604]

Cited: 5 times

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The Surviving Sepsis Campaign: research priorities for the administration, epidemiology, scoring and identification of sepsis.

Mark E Nunnally, Ricard Ferrer, Greg S Martin, Ignacio Martin-Loeches, Flavia R Machado, Daniel De Backer, Craig M Coopersmith, Clifford S Deutschman, ,

<h4>Objective</h4>To identify priorities for administrative, epidemiologic and diagnostic research in sepsis.<h4>Design</h4>As a follow-up to a previous consensus statement about sepsis research, members of the Surviving Sepsis Campaign Research Committee, representing the European Society of Intensive Care Medicine and the Society of Critical Care Medicine addressed six questions regarding care delivery, ... Read more >>

Intensive Care Med Exp (Intensive care medicine experimental)
[2021, 9(1):34]

Cited: 1 time

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Developing Treatment Guidelines During a Pandemic Health Crisis: Lessons Learned From COVID-19.

Safia Kuriakose, Kanal Singh, Alice K Pau, Eric Daar, Rajesh Gandhi, Pablo Tebas, Laura Evans, Roy M Gulick, H Clifford Lane, Henry Masur, , Judith A Aberg, Adaora A Adimora, Jason Baker, Lisa Baumann Kreuziger, Roger Bedimo, Pamela S Belperio, Stephen V Cantrill, Craig M Coopersmith, Susan L Davis, Amy L Dzierba, John J Gallagher, David V Glidden, Birgit Grund, Erica J Hardy, Carl Hinkson, Brenna L Hughes, Steven Johnson, Marla J Keller, Arthur Y Kim, Jeffrey L Lennox, Mitchell M Levy, Jonathan Z Li, Greg S Martin, Susanna Naggie, Andrew T Pavia, Nitin Seam, Steven Q Simpson, Susan Swindells, Phyllis Tien, Alpana A Waghmare, Kevin C Wilson, Jinoos Yazdany, Philip Zachariah, Danielle M Campbell, Carly Harrison, Timothy Burgess, Joseph Francis, Virginia Sheikh, Timothy M Uyeki, Robert Walker, John T Brooks, Laura Bosque Ortiz, Richard T Davey, Laurie K Doepel, Robert W Eisinger, Alison Han, Elizabeth S Higgs, Martha C Nason, Page Crew, Andrea M Lerner, Claire Lund, Christopher Worthington,

The development of the National Institutes of Health (NIH) COVID-19 Treatment Guidelines began in March 2020 in response to a request from the White House Coronavirus Task Force. Within 4 days of the request, the NIH COVID-19 Treatment Guidelines Panel was established and the first meeting took place (virtually-as did ... Read more >>

Ann Intern Med (Annals of internal medicine)
[2021, 174(8):1151-1158]

Cited: 1 time

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Plasma high-resolution metabolomic phenotyping of lean mass in a United States adult cohort.

Moriah P Bellissimo, Dean P Jones, Greg S Martin, Jessica A Alvarez, Thomas R Ziegler,

<h4>Background</h4>Rapid loss of lean mass during catabolic states is associated with impaired convalescence and increased mortality rates. An understanding of metabolic pathways related to lean mass is needed to enable future interventions designed to combat malnutrition. This study assessed the plasma metabolome in relation to lean mass in clinically stable ... Read more >>

JPEN J Parenter Enteral Nutr (JPEN. Journal of parenteral and enteral nutrition)
[2021, :]

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Variation in Early Management Practices in Moderate-to-Severe ARDS in the United States: The Severe ARDS: Generating Evidence Study.

Nida Qadir, Raquel R Bartz, Mary L Cooter, Catherine L Hough, Michael J Lanspa, Valerie M Banner-Goodspeed, Jen-Ting Chen, Shewit Giovanni, Dina Gomaa, Michael W Sjoding, Negin Hajizadeh, Jordan Komisarow, Abhijit Duggal, Ashish K Khanna, Rahul Kashyap, Akram Khan, Steven Y Chang, Joseph E Tonna, Harry L Anderson, Janice M Liebler, Jarrod M Mosier, Peter E Morris, Alissa Genthon, Irene K Louh, Mark Tidswell, R Scott Stephens, Annette M Esper, David J Dries, Anthony Martinez, Kraftin E Schreyer, William Bender, Anupama Tiwari, Pramod K Guru, Sinan Hanna, Michelle N Gong, Pauline K Park, , ,

<h4>Background</h4>Although specific interventions previously demonstrated benefit in patients with ARDS, use of these interventions is inconsistent, and patient mortality remains high. The impact of variability in center management practices on ARDS mortality rates remains unknown.<h4>Research question</h4>What is the impact of treatment variability on mortality in patients with moderate to severe ... Read more >>

Chest (Chest)
[2021, 160(4):1304-1315]

Cited: 2 times

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Society of Critical Care Medicine Presidential Address-50th Annual Congress, February 2021.

Greg S Martin,

Crit Care Med (Critical care medicine)
[2021, 49(5):723-727]

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Future potential of Rapid Acceleration of Diagnostics (RADx Tech) in molecular diagnostics.

Steven C Schachter, Denise R Dunlap, Wilbur A Lam, Yukari C Manabe, Greg S Martin, Sally M McFall,

Expert Rev Mol Diagn (Expert review of molecular diagnostics)
[2021, 21(3):251-253]

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How the COVID-19 pandemic will change the future of critical care.

Yaseen M Arabi, Elie Azoulay, Hasan M Al-Dorzi, Jason Phua, Jorge Salluh, Alexandra Binnie, Carol Hodgson, Derek C Angus, Maurizio Cecconi, Bin Du, Rob Fowler, Charles D Gomersall, Peter Horby, Nicole P Juffermans, Jozef Kesecioglu, Ruth M Kleinpell, Flavia R Machado, Greg S Martin, Geert Meyfroidt, Andrew Rhodes, Kathryn Rowan, Jean-François Timsit, Jean-Louis Vincent, Giuseppe Citerio,

Coronavirus disease 19 (COVID-19) has posed unprecedented healthcare system challenges, some of which will lead to transformative change. It is obvious to healthcare workers and policymakers alike that an effective critical care surge response must be nested within the overall care delivery model. The COVID-19 pandemic has highlighted key elements ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(3):282-291]

Cited: 7 times

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Relationships between plasma apelin and adiponectin with normal weight obesity, body composition, and cardiorespiratory fitness in working adults.

Moriah P Bellissimo, Emory Hsu, Li Hao, Kirk Easley, Greg S Martin, Thomas R Ziegler, Jessica A Alvarez,

<h4>Background</h4>A significant proportion of adults have normal weight obesity (NWO), defined as a normal body mass index (BMI) but disproportionately high body fat percentage. Individuals with NWO may have increased risk of cardiometabolic disorders and lower exercise tolerance, but it is unclear if this obesity phenotype is linked with dysregulated ... Read more >>

J Clin Transl Endocrinol (Journal of clinical & translational endocrinology)
[2021, 24:100257]

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Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update.

Waleed Alhazzani, Laura Evans, Fayez Alshamsi, Morten Hylander Møller, Marlies Ostermann, Hallie C Prescott, Yaseen M Arabi, Mark Loeb, Michelle Ng Gong, Eddy Fan, Simon Oczkowski, Mitchell M Levy, Lennie Derde, Amy Dzierba, Bin Du, Flavia Machado, Hannah Wunsch, Mark Crowther, Maurizio Cecconi, Younsuck Koh, Lisa Burry, Daniel S Chertow, Wojciech Szczeklik, Emilie Belley-Cote, Massimiliano Greco, Malgorzata Bala, Ryan Zarychanski, Jozef Kesecioglu, Allison McGeer, Leonard Mermel, Manoj J Mammen, Sheila Nainan Myatra, Amy Arrington, Ruth Kleinpell, Giuseppe Citerio, Kimberley Lewis, Elizabeth Bridges, Ziad A Memish, Naomi Hammond, Frederick G Hayden, Muhammed Alshahrani, Zainab Al Duhailib, Greg S Martin, Lewis J Kaplan, Craig M Coopersmith, Massimo Antonelli, Andrew Rhodes,

<h4>Background</h4>The coronavirus disease 2019 pandemic continues to affect millions worldwide. Given the rapidly growing evidence base, we implemented a living guideline model to provide guidance on the management of patients with severe or critical coronavirus disease 2019 in the ICU.<h4>Methods</h4>The Surviving Sepsis Campaign Coronavirus Disease 2019 panel has expanded to ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(3):e219-e234]

Cited: 37 times

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Outcomes of Patients With Coronavirus Disease 2019 Receiving Organ Support Therapies: The International Viral Infection and Respiratory Illness Universal Study Registry.

Juan Pablo Domecq, Amos Lal, Christopher R Sheldrick, Vishakha K Kumar, Karen Boman, Scott Bolesta, Vikas Bansal, Michael O Harhay, Michael A Garcia, Margit Kaufman, Valerie Danesh, Sreekanth Cheruku, Valerie M Banner-Goodspeed, Harry L Anderson, Patrick S Milligan, Joshua L Denson, Catherine A St Hill, Kenneth W Dodd, Greg S Martin, Ognjen Gajic, Allan J Walkey, Rahul Kashyap, ,

<h4>Objectives</h4>To describe the outcomes of hospitalized patients in a multicenter, international coronavirus disease 2019 registry.<h4>Design</h4>Cross-sectional observational study including coronavirus disease 2019 patients hospitalized with laboratory-confirmed severe acute respiratory syndrome coronavirus-2 infection between February 15, 2020, and November 30, 2020, according to age and type of organ support therapies.<h4>Setting</h4>About 168 hospitals ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(3):437-448]

Cited: 5 times

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COVID-19: What we've done well and what we could or should have done better-the 4 Ps.

Jean-Louis Vincent, Julia Wendon, Greg S Martin, Nicole P Juffermans, Jacques Creteur, Maurizio Cecconi,

The current coronavirus pandemic has impacted heavily on ICUs worldwide. Although many hospitals and healthcare systems had plans in place to manage multiple casualties as a result of major natural disasters or accidents, there was insufficient preparation for the sudden, massive influx of severely ill patients with COVID-19. As a ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):40]

Cited: 1 time

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Remote Continuous Glucose Monitoring With a Computerized Insulin Infusion Protocol for Critically Ill Patients in a COVID-19 Medical ICU: Proof of Concept.

Georgia M Davis, Eileen Faulds, Tara Walker, Debbie Vigliotti, Marina Rabinovich, Joi Hester, Limin Peng, Barbara McLean, Patricia Hannon, Norma Poindexter, Petrena Saunders, Citlalli Perez-Guzman, Seema S Tekwani, Greg S Martin, Guillermo Umpierrez, Shivani Agarwal, Kathleen Dungan, Francisco J Pasquel,

<h4>Objective</h4>The use of remote real-time continuous glucose monitoring (CGM) in the hospital has rapidly emerged to preserve personal protective equipment and reduce potential exposures during coronavirus disease 2019 (COVID-19).<h4>Research design and methods</h4>We linked a hybrid CGM and point-of-care (POC) glucose testing protocol to a computerized decision support system for continuous ... Read more >>

Diabetes Care (Diabetes care)
[2021, 44(4):1055-1058]

Cited: 3 times

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Covid-19 will not "magically disappear": Why access to widespread testing is paramount.

Paul E George, Claire L Stokes, Leda C Bassit, Ann Chahroudi, Janet Figueroa, Mark A Griffiths, Stacy Heilman, David N Ku, Eric J Nehl, Traci Leong, Joshua M Levy, Russell Kempker, Robert G Mannino, Maud Mavigner, Sunita I Park, Anuradha Rao, Paulina A Rebolledo, John D Roback, Beverly B Rogers, Raymond F Schinazi, Julie Sullivan, Erika A Tyburski, Miriam B Vos, Jesse J Waggoner, Yun F Wang, Jen Madsen, Daniel S Wechsler, Clinton H Joiner, Greg S Martin, Wilbur A Lam,

Am J Hematol (American journal of hematology)
[2021, 96(2):174-178]

Cited: 1 time

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