Full Text Journal Articles by
Author Grant W Waterer

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Antibiotic Stewardship in the Intensive Care Unit. An Official American Thoracic Society Workshop Report in Collaboration with the AACN, CHEST, CDC, and SCCM.

Richard G Wunderink, Arjun Srinivasan, Philip S Barie, Jean Chastre, Charles S Dela Cruz, Ivor S Douglas, Margaret Ecklund, Scott E Evans, Scott R Evans, Anthony T Gerlach, Lauri A Hicks, Michael Howell, Melissa L Hutchinson, Robert C Hyzy, Sandra L Kane-Gill, Erika D Lease, Mark L Metersky, Nancy Munro, Michael S Niederman, Marcos I Restrepo, Curtis N Sessler, Steven Q Simpson, Sandra M Swoboda, Christina Vazquez Guillamet, Grant W Waterer, Curtis H Weiss,

Intensive care units (ICUs) are an appropriate focus of antibiotic stewardship program efforts because a large proportion of any hospital's use of parenteral antibiotics, especially broad-spectrum, occurs in the ICU. Given the importance of antibiotic stewardship for critically ill patients and the importance of critical care practitioners as the front ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2020, 17(5):531-540]

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Update in adult community-acquired pneumonia: key points from the new American Thoracic Society/Infectious Diseases Society of America 2019 guideline.

Joshua P Metlay, Grant W Waterer,

PURPOSE OF REVIEW:The American Thoracic Society and Infectious Diseases Society of America recently released their joint guideline for the diagnosis and treatment of adults with community-acquired pneumonia (CAP). The co-chairs of the guideline committee provide a summary of the guideline process, key recommendations from the new guideline and future directions ... Read more >>

Curr Opin Pulm Med (Current opinion in pulmonary medicine)
[2020, 26(3):203-207]

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Reply to Huttner et al.: 2019 Community-acquired Pneumonia Treatment Guidelines: There Is a Need for a Change toward More Parsimonious Antibiotic Use.

Joshua P Metlay, Grant W Waterer,

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2020, 201(10):1316-1317]

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SARS-CoV-2: First Do No Harm.

Grant W Waterer, Jordi Rello, Richard G Wunderink,

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2020, :]

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Treatment of Community-Acquired Pneumonia During the Coronavirus Disease 2019 (COVID-19) Pandemic.

Joshua P Metlay, Grant W Waterer,

Ann. Intern. Med. (Annals of internal medicine)
[2020, :]

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Reply to Chahine, to Schuetz, and to Fabre et al.

Joshua P Metlay, Grant W Waterer,

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2020, 201(6):746-747]

Cited: 0 times

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Summary for Clinicians: Clinical Practice Guideline for the Diagnosis and Treatment of Community-acquired Pneumonia.

Barbara E Jones, Derrick D Herman, Charles S Dela Cruz, Grant W Waterer, Joshua P Metlay, Joseph K Ruminjo, Carey C Thomson,

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2020, 17(2):133-138]

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Invasive Pneumococcal and Meningococcal Disease.

Deirdre Fitzgerald, Grant W Waterer,

This review focuses on current knowledge of the epidemiology, prevention, and treatment of invasive pneumococcal (IPD) and meningococcal disease (IMD). IPD decreased significantly with the introduction of effective conjugate vaccines but is on the rise again. Effective antibiotic therapy of IPD includes the combination of a beta-lactam and a macrolide ... Read more >>

Infect. Dis. Clin. North Am. (Infectious disease clinics of North America)
[2019, 33(4):1125-1141]

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Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2018: the Influenza Complications Alert Network (FluCAN).

Allen C Cheng, Mark Holmes, Dominic E Dwyer, Sanjaya Senanayake, Louise Cooley, Louis B Irving, Graham Simpson, Tony Korman, Kristine Macartney, N Deborah Friedman, Peter Wark, Anna Howell, Christopher C Blyth, Nigel Crawford, Jim Buttery, Simon Bowler, John W Upham, Grant W Waterer, Tom Kotsimbos, Paul M Kelly,

The Influenza Complications Alert Network (FluCAN) is a sentinel hospital-based surveillance program that operates at sites in all jurisdictions in Australia. This report summarises the epidemiology of hospitalisations with laboratory-confirmed influenza during the 2018 influenza season. In this observational surveillance system, cases were defined as patients admitted to any of ... Read more >>

Commun Dis Intell (2018) (Communicable diseases intelligence (2018))
[2019, 43:]

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Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America.

Joshua P Metlay, Grant W Waterer, Ann C Long, Antonio Anzueto, Jan Brozek, Kristina Crothers, Laura A Cooley, Nathan C Dean, Michael J Fine, Scott A Flanders, Marie R Griffin, Mark L Metersky, Daniel M Musher, Marcos I Restrepo, Cynthia G Whitney,

Background: This document provides evidence-based clinical practice guidelines on the management of adult patients with community-acquired pneumonia.Methods: A multidisciplinary panel conducted pragmatic systematic reviews of the relevant research and applied Grading of Recommendations, Assessment, Development, and Evaluation methodology for clinical recommendations.Results: The panel addressed 16 specific areas for recommendations spanning ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2019, 200(7):e45-e67]

Cited: 4 times

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Steroid therapy and outcome of parapneumonic pleural effusions (STOPPE): Study protocol for a multicenter, double-blinded, placebo-controlled randomized clinical trial.

Deirdre B Fitzgerald, Grant W Waterer, Catherine A Read, Edward T Fysh, Ranjan Shrestha, Christopher Stanley, Sanjeevan Muruganandan, Norris S H Lan, Natalia D Popowicz, Carolyn J Peddle-McIntyre, Najib M Rahman, Seng Khee Gan, Kevin Murray, Yun Chor Gary Lee,

BACKGROUND:Community-acquired pneumonia (CAP) is a major global disease. Parapneumonic effusions often complicate CAP and range from uninfected (simple) to infected (complicated) parapneumonic effusions and empyema (pus). CAP patients who have a pleural effusion at presentation are more likely to require hospitalization, have a longer length of stay and higher mortality ... Read more >>

Medicine (Madr) (Medicine)
[2019, 98(43):e17397]

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Hot topics and current controversies in community-acquired pneumonia.

Diego Severiche-Bueno, Daniela Parra-Tanoux, Luis F Reyes, Grant W Waterer,

Community-acquired pneumonia (CAP) is one of the most common infectious diseases, as well as a major cause of death both in developed and developing countries, and it remains a challenge for physicians around the world. Several guidelines have been published to guide clinicians in how to diagnose and take care ... Read more >>

Breathe (Sheff) (Breathe (Sheffield, England))
[2019, 15(3):216-225]

Cited: 1 time

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Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2017: the Influenza Complications Alert Network (FluCAN).

Allen C Cheng, Mark Holmes, Dominic E Dwyer, Sanjaya Senanayake, Louise Cooley, Louis B Irving, Graham Simpson, Tony Korman, Kristine Macartney, N Deborah Friedman, Peter Wark, Anna Howell, Christopher C Blyth, Simon Bowler, John Upham, Grant W Waterer, Tom Kotsimbos, Paul M Kelly,

The Influenza Complications Alert Network (FluCAN) is a sentinel-hospital-based surveillance program that operates at sites in all jurisdictions in Australia. This report summarises the epidemiology of hospitalisations with laboratory-confirmed influenza during the 2017 influenza season. In this observational surveillance system, cases were defined as patients admitted to any of the ... Read more >>

Commun Dis Intell (2018) (Communicable diseases intelligence (2018))
[2019, 43:]

Cited: 0 times

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Potential antibiotic resistant pathogens in community-acquired pneumonia: playing it safe is anything but.

Grant W Waterer,

Eur. Respir. J. (The European respiratory journal)
[2019, 54(1):]

Cited: 0 times

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Pneumococcal and Legionella Urinary Antigen Tests in Community-acquired Pneumonia: Prospective Evaluation of Indications for Testing.

Shawna Bellew, Carlos G Grijalva, Derek J Williams, Evan J Anderson, Richard G Wunderink, Yuwei Zhu, Grant W Waterer, Anna M Bramley, Seema Jain, Kathryn M Edwards, Wesley H Self,

BACKGROUND:Adult, community-acquired pneumonia (CAP) guidelines from the Infectious Diseases Society of America (IDSA) and American Thoracic Society (ATS) include indications for urinary antigen tests (UATs) for Streptococcus pneumoniae (SP) and Legionella pneumophila (LP). These recommendations were based on expert opinions and have not been rigorously evaluated. METHODS:We used data from ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2019, 68(12):2026-2033]

Cited: 0 times

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Health Care-Associated Pneumonia: Is It Still a Useful Concept?

Grant W Waterer,

"Health care-associated pneumonia (HCAP) was introduced into guidelines because of concerns about the increasing prevalence of drug-resistant pathogens (DRPs) not covered by standard empirical therapy. We now know that DRPs are very localized phenomena with low rates in most sites. Although HCAP risk factors are associated with a higher mortality, ... Read more >>

Clin. Chest Med. (Clinics in chest medicine)
[2018, 39(4):765-773]

Cited: 1 time

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Streptococcus pneumoniae potently induces cell death in mesothelial cells.

Rabab Rashwan, Julius F Varano Della Vergiliana, Sally M Lansley, Hui Min Cheah, Natalia Popowicz, James C Paton, Grant W Waterer, Tiffany Townsend, Ian Kay, Jeremy S Brown, Y C Gary Lee,

Pleural infection/empyema is common and its incidence continues to rise. Streptococcus pneumoniae is the commonest bacterial cause of empyema in children and among the commonest in adults. The mesothelium represents the first line of defense against invading microorganisms, but mesothelial cell responses to common empyema pathogens, including S. pneumoniae, have ... Read more >>

PLoS ONE (PloS one)
[2018, 13(7):e0201530]

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In-Hospital Deaths Among Adults With Community-Acquired Pneumonia.

Grant W Waterer, Wesley H Self, D Mark Courtney, Carlos G Grijalva, Robert A Balk, Timothy D Girard, Sherene S Fakhran, Christopher Trabue, Paul McNabb, Evan J Anderson, Derek J Williams, Anna M Bramley, Seema Jain, Kathryn M Edwards, Richard G Wunderink,

BACKGROUND:Adults hospitalized with community-acquired pneumonia (CAP) are at high risk for short-term mortality. However, it is unclear whether improvements in in-hospital pneumonia care could substantially lower this risk. We extensively reviewed all in-hospital deaths in a large prospective CAP study to assess the cause of each death and assess the ... Read more >>

Chest (Chest)
[2018, 154(3):628-635]

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Response.

Wesley H Self, Cameron P Upchurch, Richard G Wunderink, Grant W Waterer, Carlos G Grijalva, Kathryn M Edwards,

Chest (Chest)
[2018, 153(3):763-764]

Cited: 0 times

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Human pleural fluid is a potent growth medium for Streptococcus pneumoniae.

Natalia D Popowicz, Sally M Lansley, Hui M Cheah, Ian D Kay, Christine F Carson, Grant W Waterer, James C Paton, Jeremy S Brown, Y C Gary Lee,

Empyema is defined by the presence of bacteria and/or pus in pleural effusions. However, the biology of bacteria within human pleural fluid has not been studied. Streptococcus pneumoniae is the most common cause of pediatric and frequent cause of adult empyema. We investigated whether S. pneumoniae can proliferate within human ... Read more >>

PLoS ONE (PloS one)
[2017, 12(11):e0188833]

Cited: 4 times

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Reply to Skowronski and Chambers.

Allen C Cheng, Kristine K Macartney, Grant W Waterer, Tom Kotsimbos, Paul M Kelly, Christopher C Blyth,

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2017, 65(2):355]

Cited: 0 times

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High endocan levels are associated with the need for mechanical ventilation among patients with severe sepsis.

Mandeep Mangat, Bravein Amalakuhan, Sheila Habib, Luis F Reyes, Cecilia A Hinojosa, Alejandro H Rodriguez, Nilam J Soni, Antonio Anzueto, Stephanie M Levine, Jay I Peters, Stefano Aliberti, Oriol Sibila, Jordi Rello, Martin Witzenrath, Grant W Waterer, Ignacio Martin-Loeches, Jose Blanquer, Francisco Sanz, Pedro J Marcos, Jordi Solé-Violán, James D Chalmers, Charles Feldman, Richard G Wunderink, Charles S Dela Cruz, Carlos J Orihuela, Marcos I Restrepo,

Eur. Respir. J. (The European respiratory journal)
[2017, 50(1):]

Cited: 1 time

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Antibiotic Prescribing for Adults Hospitalized in the Etiology of Pneumonia in the Community Study.

Sara Tomczyk, Seema Jain, Anna M Bramley, Wesley H Self, Evan J Anderson, Chris Trabue, D Mark Courtney, Carlos G Grijalva, Grant W Waterer, Kathryn M Edwards, Richard G Wunderink, Lauri A Hicks,

Community-acquired pneumonia (CAP) 2007 guidelines from the Infectious Diseases Society of America (IDSA)/American Thoracic Society (ATS) recommend a respiratory fluoroquinolone or beta-lactam plus macrolide as first-line antibiotics for adults hospitalized with CAP. Few studies have assessed guideline-concordant antibiotic use for patients hospitalized with CAP after the 2007 IDSA/ATS guidelines. We ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2017, 4(2):ofx088]

Cited: 3 times

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Severe Pneumococcal Pneumonia Causes Acute Cardiac Toxicity and Subsequent Cardiac Remodeling.

Luis F Reyes, Marcos I Restrepo, Cecilia A Hinojosa, Nilam J Soni, Antonio Anzueto, Bettina L Babu, Norberto Gonzalez-Juarbe, Alejandro H Rodriguez, Alejandro Jimenez, James D Chalmers, Stefano Aliberti, Oriol Sibila, Vicki T Winter, Jacqueline J Coalson, Luis D Giavedoni, Charles S Dela Cruz, Grant W Waterer, Martin Witzenrath, Norbert Suttorp, Peter H Dube, Carlos J Orihuela,

RATIONALE:Up to one-third of patients hospitalized with pneumococcal pneumonia experience major adverse cardiac events (MACE) during or after pneumonia. In mice, Streptococcus pneumoniae can invade the myocardium, induce cardiomyocyte death, and disrupt cardiac function following bacteremia, but it is unknown whether the same occurs in humans with severe pneumonia. OBJECTIVES:We ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2017, 196(5):609-620]

Cited: 26 times

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Community-Acquired Pneumonia Visualized on CT Scans but Not Chest Radiographs: Pathogens, Severity, and Clinical Outcomes.

Cameron P Upchurch, Carlos G Grijalva, Richard G Wunderink, Derek J Williams, Grant W Waterer, Evan J Anderson, Yuwei Zhu, Eric M Hart, Frank Carroll, Anna M Bramley, Seema Jain, Kathryn M Edwards, Wesley H Self,

BACKGROUND:The clinical significance of pneumonia visualized on CT scan in the setting of a normal chest radiograph is uncertain. METHODS:In a multicenter prospective surveillance study of adults hospitalized with community-acquired pneumonia (CAP), we compared the presenting clinical features, pathogens present, and outcomes of patients with pneumonia visualized on a CT ... Read more >>

Chest (Chest)
[2018, 153(3):601-610]

Cited: 7 times

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