Full Text Journal Articles by
Author Grant Stotts

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Prospective validation of Canadian TIA Score and comparison with ABCD2 and ABCD2i for subsequent stroke risk after transient ischaemic attack: multicentre prospective cohort study.

Jeffrey J Perry, Marco L A Sivilotti, Marcel Émond, Ian G Stiell, Grant Stotts, Jacques Lee, Andrew Worster, Judy Morris, Ka Wai Cheung, Albert Y Jin, Wieslaw J Oczkowski, Demetrios J Sahlas, Heather E Murray, Ariane Mackey, Steve Verreault, Marie-Christine Camden, Samuel Yip, Philip Teal, David J Gladstone, Mark I Boulos, Nicolas Chagnon, Elizabeth Shouldice, Clare Atzema, Tarik Slaoui, Jeanne Teitlebaum, Kasim Abdulaziz, Marie-Joe Nemnom, George A Wells, Mukul Sharma,

<h4>Objective</h4>To validate the previously derived Canadian TIA Score to stratify subsequent stroke risk in a new cohort of emergency department patients with transient ischaemic attack.<h4>Design</h4>Prospective cohort study.<h4>Setting</h4>13 Canadian emergency departments over five years.<h4>Participants</h4>7607 consecutively enrolled adult patients attending the emergency department with transient ischaemic attack or minor stroke.<h4>Main outcome measures</h4>The ... Read more >>

BMJ (BMJ (Clinical research ed.))
[2021, 372:n49]

Cited: 0 times

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Prevalence and the predictive performance of the dynamic CT-angiography spot sign in an observational cohort with intracerebral hemorrhage.

Dar Dowlatshahi, Hee Sahng Chung, Michael Reaume, Matthew J Hogan, Dylan Blacquiere, Grant Stotts, Michel Shamy, Franco Momoli, Richard Aviv, Andrew M Demchuk, Santanu Chakraborty,

The CT-angiography (CTA) spot sign is a predictor of hematoma expansion (HE). We have previously reported on the use of dynamic CTA (dCTA) to detect spot sign, and to study its formation over the acquisition period. In this study, we report the frequency of dCTA spot sign in acute intracerebral ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(47):e23278]

Cited: 1 time

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Diagnosis of Transient Ischemic Attack: Sex-Specific Differences From a Retrospective Cohort Study.

Sophia Gocan, Tess Fitzpatrick, Chu Qi Wang, Monica Taljaard, Wei Cheng, Aline Bourgoin, Dar Dowlatshahi, Grant Stotts, Michel Shamy,

<h4>Background and purpose</h4>Research suggests that women and men may present with different transient ischemic attack (TIA) and stroke symptoms. We aimed to explore symptoms and features associated with a definite TIA/stroke diagnosis and whether those associations differed by sex.<h4>Methods</h4>We completed a retrospective cohort study of patients referred to The Ottawa ... Read more >>

Stroke (Stroke)
[2020, 51(11):3371-3374]

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Distribution and predictive performance of the temporal phase of dynamic spot sign appearance in acute intracerebral hemorrhage.

Hee Sahng Chung, Santanu Chakraborty, Michael Reaume, Vignan Yogendrakumar, Matthew J Hogan, Dylan Blacquiere, Grant Stotts, Michel Shamy, Richard I Aviv, Dar Dowlatshahi,

<h4>Background</h4>Dynamic CT angiography (dCTA) contrast extravasation, known as the "dynamic spot sign", can predict hematoma expansion (HE) in intracerebral hemorrhage (ICH). Recent reports suggest the phase of spot sign appearance is related to the magnitude of HE. We used dCTA to explore the association between the phase of spot sign ... Read more >>

PLoS One (PloS one)
[2020, 15(8):e0236196]

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Decreased Stroke Presentation Rates at a Comprehensive Stroke Center during COVID-19.

Dar Dowlatshahi, Grant Stotts, Aline Bourgoin, Sophia Gocan, Laura Dunn, Jodi Powell, Frank L Silver, Greg Walker, Vignan Yogendrakumar, Robert Fahed, Dylan Blacquiere, Michel Shamy,

We reviewed stroke care delivery during the COVID-19 pandemic at our stroke center and provincial telestroke system. We counted referrals to our prevention clinic, code strokes, thrombolysis, endovascular thrombectomies, and activations of a provincial telestroke system from February to April of 2017-2020. In April 2020, there was 28% reduction in ... Read more >>

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2021, 48(1):118-121]

Cited: 1 time

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Early Dabigatran Treatment After Transient Ischemic Attack and Minor Ischemic Stroke Does Not Result in Hemorrhagic Transformation.

Anas Alrohimi, Kelvin Ng, Dar Dowlatshahi, Brian Buck, Grant Stotts, Sibi Thirunavukkarasu, Michel Shamy, Hayrapet Kalashyan, Leka Sivakumar, Ashfaq Shuaib, Mike Sharma, Ken Butcher,

<b>Objectives: </b>The optimal timing of anticoagulation after ischemic stroke in atrial fibrillation (AF) patients is unknown. Our aim was to demonstrate the feasibility and safety of initiating dabigatran therapy within 14 days of transient ischemic attack (TIA) or minor stroke in AF patients.<br><br><b>Patients and methods: </b>A prospective, multi-center registry (NCT02415855) ... Read more >>

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2020, 47(5):604-611]

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Can Emergency Physicians Perform Carotid Artery Point-of-Care Ultrasound to Detect Stenosis in Patients with TIA and Stroke? A Pilot Study.

Robert Suttie, Michael Y Woo, Lily Park, Marie-Joe Nemnom, Grant Stotts, Jeffrey J Perry,

INTRODUCTION:Patients with severe, symptomatic carotid stenosis can have their subsequent stroke risk reduced by surgical intervention if performed soon after a transient ischemic attack (TIA) or stroke. Patients presenting to an emergency department (ED) without computed tomography angiography (CTA) with TIA/stroke, may require transfer to another hospital for imaging to ... Read more >>

West J Emerg Med (The western journal of emergency medicine)
[2020, 21(3):626-632]

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Early vascular imaging and key system strategies expedite carotid revascularization after transient ischemic attack and stroke.

Sophia Gocan, Aline Bourgoin, Rany Shamloul, Brammiya Sivakumar, Dar Dowlatshahi, Grant Stotts,

<h4>Background</h4>International guidelines recommend carotid revascularization within 14 days for patients with a symptomatic transient ischemic attack (TIA) or stroke event. However, significant delays in care persist, with only 9% of outpatients and 36% of inpatients in Ontario meeting this target. The study objective was to explore the influence of health system ... Read more >>

J Vasc Surg (Journal of vascular surgery)
[2020, 72(5):1728-1734]

Cited: 0 times

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Clinical Reasoning: Recurrent strokes secondary to unknown vasculopathy.

Ronda Lun, Naomi Niznick, Ruth Padmore, Jonathan Mack, Michel Shamy, Grant Stotts, Dylan Blacquiere,

Neurology (Neurology)
[2020, 94(22):e2396-e2401]

Cited: 0 times

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Cohort Study of Features Used by Experts to Diagnose Transient Ischemic Attack.

Tess Fitzpatrick, Sophia Gocan, Chu Qi Wang, Aline Bourgoin, Monica Taljaard, Wei Cheng, Dar Dowlatshahi, Grant Stotts, Michel Shamy,

<h4>Background and purpose</h4>The diagnosis of transient ischemic attack (TIA) is largely dependent on a process of clinical decision-making that remains poorly characterized in the absence of a validated and accessible biomarker or imaging test. We performed a retrospective chart review to identify variables associated with a final neurologist diagnosis of ... Read more >>

Neurohospitalist (The Neurohospitalist)
[2020, 10(4):245-249]

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A Delayed Modified ICH Score Outperforms Baseline Scoring in Acute Intracerebral Hemorrhage.

Ronda Lun, Vignan Yogendrakumar, Dylan Blacquiere, Michel Shamy, Grant Stotts, Dar Dowlatshahi,

The Modified Intracerebral Hemorrhage (MICH) score is a simple tool created to provide prognostication in basal ganglia hemorrhages. Current prognostic scores, including the MICH, are based on the assessment of baseline patient characteristics, failing to account for significant developments, such as intraventricular extension and clinical deterioration, which may occur over ... Read more >>

Neurohospitalist (The Neurohospitalist)
[2020, 10(3):217-220]

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Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial.

Michael D Hill, Mayank Goyal, Bijoy K Menon, Raul G Nogueira, Ryan A McTaggart, Andrew M Demchuk, Alexandre Y Poppe, Brian H Buck, Thalia S Field, Dar Dowlatshahi, Brian A van Adel, Richard H Swartz, Ruchir A Shah, Eric Sauvageau, Charlotte Zerna, Johanna M Ospel, Manish Joshi, Mohammed A Almekhlafi, Karla J Ryckborst, Mark W Lowerison, Kathy Heard, David Garman, Diogo Haussen, Shawna M Cutting, Shelagh B Coutts, Daniel Roy, Jeremy L Rempel, Axel Cr Rohr, Daniela Iancu, Demetrios J Sahlas, Amy Y X Yu, Thomas G Devlin, Ricardo A Hanel, Volker Puetz, Frank L Silver, Bruce C V Campbell, René Chapot, Jeanne Teitelbaum, Jennifer L Mandzia, Timothy J Kleinig, David Turkel-Parrella, Donald Heck, Michael E Kelly, Aditya Bharatha, Oh Young Bang, Ashutosh Jadhav, Rishi Gupta, Donald F Frei, Jason W Tarpley, Cameron G McDougall, Staffan Holmin, Joung-Ho Rha, Ajit S Puri, Marie-Christine Camden, Götz Thomalla, Hana Choe, Stephen J Phillips, Joseph L Schindler, John Thornton, Simon Nagel, Ji Hoe Heo, Sung-Il Sohn, Marios-Nikos Psychogios, Ronald F Budzik, Sidney Starkman, Coleman O Martin, Paul A Burns, Seán Murphy, George A Lopez, Joey English, Michael Tymianski, ,

<h4>Background</h4>Nerinetide, an eicosapeptide that interferes with post-synaptic density protein 95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia-reperfusion. In this trial, we assessed the efficacy and safety of nerinetide in human ischaemia-reperfusion that occurs with rapid endovascular thrombectomy in patients who had an acute ischaemic stroke.<h4>Methods</h4>For ... Read more >>

Lancet (Lancet (London, England))
[2020, 395(10227):878-887]

Cited: 36 times

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Normal Systolic Blood Pressure at Presentation With Acute Ischemic Stroke Predicts Cardioembolic Etiology.

Margaret Moores, Vignan Yogendrakumar, Olena Bereznyakova, Walid Alesefir, Hailey Pettem, Grant Stotts, Dar Dowlatshahi, Michel Shamy,

Background Early insight into the possible etiology of ischemic stroke allows for early initiation of mechanism-specific secondary stroke prevention. Initial systolic blood pressure during acute ischemic stroke may relate to stroke etiology. We sought to determine whether normotension at presentation with acute ischemic stroke predicts cardioembolic etiology. Methods and Results ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(1):e014399]

Cited: 2 times

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RecoverNow: A mobile tablet-based therapy platform for early stroke rehabilitation.

Michael Pugliese, Tim Ramsay, Rany Shamloul, Karen Mallet, Lise Zakutney, Dale Corbett, Sean Dukelow, Grant Stotts, Michel Shamy, Kumanan Wilson, Julien Guerinet, Dar Dowlatshahi,

INTRODUCTION:Stroke survivors frequently experience a range of post-stroke deficits. Specialized stroke rehabilitation improves recovery, especially if it is started early post-stroke. However, resource limitations often preclude early rehabilitation. Mobile technologies may provide a platform for stroke survivors to begin recovery when they might not be able to otherwise. The study ... Read more >>

PLoS One (PloS one)
[2019, 14(1):e0210725]

Cited: 6 times

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How do neurologists diagnose transient ischemic attack: A systematic review.

Tess Fitzpatrick, Sophia Gocan, Chu Q Wang, Candyce Hamel, Aline Bourgoin, Dar Dowlatshahi, Grant Stotts, Michel Shamy,

<h4>Background</h4>Identifying and treating patients with transient ischemic attack is an effective means of preventing stroke. However, making this diagnosis can be challenging, and over a third of patients referred to stroke prevention clinic are ultimately found to have alternate diagnoses.<h4>Aims</h4>We performed a systematic review to determine how neurologists diagnose transient ... Read more >>

Int J Stroke (International journal of stroke : official journal of the International Stroke Society)
[2019, 14(2):115-124]

Cited: 6 times

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RecoverNow: A patient perspective on the delivery of mobile tablet-based stroke rehabilitation in the acute care setting.

Karen Mallet, Rany Shamloul, Michael Pugliese, Emma Power, Dale Corbett, Simon Hatcher, Michel Shamy, Grant Stotts, Lise Zakutney, Sean Dukelow, Dar Dowlatshahi,

<h4>Background/aim</h4>We previously reported the feasibility of RecoverNow (a mobile tablet-based post-stroke communication therapy in acute care). RecoverNow has since expanded to include fine motor and cognitive therapies. Our objectives were to gain a better understanding of patient experiences and recovery goals using mobile tablets.<h4>Methods</h4>Speech-language pathologists or occupational therapists identified patients ... Read more >>

Int J Stroke (International journal of stroke : official journal of the International Stroke Society)
[2019, 14(2):174-179]

Cited: 4 times

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[18F]-Fluorodeoxyglucose PET/CT imaging as a marker of carotid plaque inflammation: Comparison to immunohistology and relationship to acuity of events.

Myra S Cocker, J David Spence, Robert Hammond, Robert A deKemp, Cheemun Lum, George Wells, Jordan Bernick, Andrew Hill, Sudhir Nagpal, Grant Stotts, Murad Alturkustani, Adebayo Adeeko, Yulia Yerofeyeva, Katey Rayner, Joan Peterson, Ali R Khan, Ann C Naidas, Linda Garrard, Martin J Yaffe, Eugene Leung, Frank S Prato, Jean-Claude Tardif, Rob S B Beanlands, ,

<h4>Background</h4>[18F]-fluorodeoxyglucose (<sup>18</sup>FDG) uptake imaged with positron emission tomography (PET) and computed tomography (CT) may serve as a biomarker of plaque inflammation. This study evaluated the relationship between carotid plaque <sup>18</sup>FDG uptake and a) intraplaque expression of macrophage and macrophage-like cellular CD68 immunohistology; b) intraplaque inflammatory burden using leukocyte-sensitive CD45 immunohistology; ... Read more >>

Int J Cardiol (International journal of cardiology)
[2018, 271:378-386]

Cited: 9 times

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Diagnostic accuracy of whole-brain computed tomography perfusion for detection of ischemic stroke in patients with mild neurological symptoms.

Robert A Frank, Santanu Chakraborty, Trevor McGrath, Alexander Mungham, James Ross, Dar Dowlatshahi, Michel Shamy, Grant Stotts,

Mild and minor acute neurological symptoms may lead to diagnostic uncertainty, resulting in a heterogeneous group of patients with true ischemic events and stroke mimics with a potential for poor outcomes. More than half of ischemic stroke patients present as minor strokes (National Institutes of Health Stroke Scale score <6). ... Read more >>

Neuroradiol J (The neuroradiology journal)
[2018, 31(5):464-472]

Cited: 0 times

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Management of direct oral anticoagulant associated bleeding: Results of a multinational survey.

Joseph R Shaw, Lana Castellucci, Deborah Siegal, Ian Stiell, Summer Syed, Jacinthe Lampron, Paul Dorian, Harinder Dhaliwal, Grant Stotts, Philip S Wells, Marc Carrier,

Thromb Res (Thrombosis research)
[2018, 163:19-21]

Cited: 2 times

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Many randomized clinical trials may not be justified: a cross-sectional analysis of the ethics and science of randomized clinical trials.

Julie De Meulemeester, Mark Fedyk, Lucas Jurkovic, Michael Reaume, Dar Dowlatshahi, Grant Stotts, Michel Shamy,

<h4>Objective</h4>We have proposed that three scientific criteria are important for the ethical justification of randomized clinical trials (RCTs): (1) they should be designed around a clear hypothesis; (2) uncertainty should exist around that hypothesis; (3) that uncertainty should be as established through a systematic review. We hypothesized that the majority ... Read more >>

J Clin Epidemiol (Journal of clinical epidemiology)
[2018, 97:20-25]

Cited: 6 times

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Smoking cessation and outcome after ischemic stroke or TIA.

Katherine A Epstein, Catherine M Viscoli, J David Spence, Lawrence H Young, Silvio E Inzucchi, Mark Gorman, Brett Gerstenhaber, Peter D Guarino, Anand Dixit, Karen L Furie, Walter N Kernan, ,

<h4>Objective</h4>To assess whether smoking cessation after an ischemic stroke or TIA improves outcomes compared to continued smoking.<h4>Methods</h4>We conducted a prospective observational cohort study of 3,876 nondiabetic men and women enrolled in the Insulin Resistance Intervention After Stroke (IRIS) trial who were randomized to pioglitazone or placebo within 180 days of ... Read more >>

Neurology (Neurology)
[2017, 89(16):1723-1729]

Cited: 8 times

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Risk for Major Bleeding in Patients Receiving Ticagrelor Compared With Aspirin After Transient Ischemic Attack or Acute Ischemic Stroke in the SOCRATES Study (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes).

J Donald Easton, Maria Aunes, Gregory W Albers, Pierre Amarenco, Sara Bokelund-Singh, Hans Denison, Scott R Evans, Peter Held, Marianne Jahreskog, Jenny Jonasson, Kazuo Minematsu, Carlos A Molina, Yongjun Wang, K S Lawrence Wong, S Claiborne Johnston, ,

<h4>Background</h4>Patients with minor acute ischemic stroke or transient ischemic attack are at high risk for subsequent stroke, and more potent antiplatelet therapy in the acute setting is needed. However, the potential benefit of more intense antiplatelet therapy must be assessed in relation to the risk for major bleeding. The SOCRATES ... Read more >>

Circulation (Circulation)
[2017, 136(10):907-916]

Cited: 6 times

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Prevalence of Fabry Disease and Outcomes in Young Canadian Patients With Cryptogenic Ischemic Cerebrovascular Events.

Sylvain Lanthier, Gustavo Saposnik, Gerald Lebovic, Karen Pope, Daniel Selchen, David F Moore, ,

<h4>Background and purpose</h4>Previous studies reported Fabry disease in 0% to 4% of young patients with cryptogenic ischemic stroke (IS). We sought to determine the prevalence of Fabry and outcomes among young Canadians with cryptogenic IS or transient ischemic attack (TIA).<h4>Methods</h4>We prospectively enrolled individuals aged 18 to 55 with IS or ... Read more >>

Stroke (Stroke)
[2017, 48(7):1766-1772]

Cited: 8 times

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Neuroscience Intermediate-Level Care Units Staffed by Intensivists: Clinical Outcomes and Cost Analysis.

Kwadwo Kyeremanteng, Ariel Hendin, Kalpana Bhardwaj, Kednapa Thavorn, Dave Neilipovitz, Dalibour Kubelik, Gianni D'Egidio, Grant Stotts, Erin Rosenberg,

<h4>Introduction:</h4>With an aging population and increasing numbers of intensive care unit admissions, novel ways of providing quality care at reduced cost are required. Closed neurointensive care units improve outcomes for patients with critical neurological conditions, including decreased mortality and length of stay (LOS). Small studies have demonstrated the safety of ... Read more >>

J Intensive Care Med (Journal of intensive care medicine)
[2019, 34(2):109-114]

Cited: 2 times

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Calcified embolus mimics patent middle cerebral artery on CT angiogram.

Vignan Yogendrakumar, Satya Patro, Dar Dowlatshahi, Grant Stotts, Daniela Iancu,

Pract Neurol (Practical neurology)
[2017, 17(4):307-309]

Cited: 1 time

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