Full Text Journal Articles by
Author Graham Fairfoul


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Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study.

Alex Iranzo, Graham Fairfoul, Anutra Chumbala Na Ayudhaya, Monica Serradell, Ellen Gelpi, Isabel Vilaseca, Raquel Sanchez-Valle, Carles Gaig, Joan Santamaria, Eduard Tolosa, Renata L Riha, Alison J E Green,

<h4>Background</h4>Isolated rapid-eye-movement (REM) sleep behaviour disorder (IRBD) can be part of the prodromal stage of the α-synucleinopathies Parkinson's disease and dementia with Lewy bodies. Real-time quaking-induced conversion (RT-QuIC) analysis of CSF has high sensitivity and specificity for the detection of misfolded α-synuclein in patients with Parkinson's disease and dementia with ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):203-212]

Cited: 0 times

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α-Synuclein real-time quaking-induced conversion in the cerebrospinal fluid of uncertain cases of parkinsonism.

Anouke van Rumund, Alison J E Green, Graham Fairfoul, Rianne A J Esselink, Bastiaan R Bloem, Marcel M Verbeek,

A reliable biomarker is needed for accurate and early differentiation between Parkinson disease and the various forms of atypical parkinsonism. We used a novel real-time quaking-induced conversion (RT-QuIC) assay to detect α-synuclein (α-syn) aggregates in cerebrospinal fluid (CSF) of 118 patients with parkinsonism of uncertain clinical etiology and 52 controls. ... Read more >>

Ann Neurol (Annals of neurology)
[2019, 85(5):777-781]

Cited: 12 times

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Comparative study of cerebrospinal fluid α-synuclein seeding aggregation assays for diagnosis of Parkinson's disease.

Un Jung Kang, Amelia K Boehme, Graham Fairfoul, Mohammad Shahnawaz, Thong Chi Ma, Samantha J Hutten, Alison Green, Claudio Soto,

<h4>Background</h4>PD diagnosis is based primarily on clinical criteria and can be inaccurate. Biological markers, such as α-synuclein aggregation, that reflect ongoing pathogenic processes may increase diagnosis accuracy and allow disease progression monitoring. Though α-synuclein aggregation assays have been published, reproducibility, standardization, and validation are key challenges for their development as ... Read more >>

Mov Disord (Movement disorders : official journal of the Movement Disorder Society)
[2019, 34(4):536-544]

Cited: 13 times

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α-synuclein RT-QuIC in cerebrospinal fluid of LRRK2-linked Parkinson's disease.

Alicia Garrido, Graham Fairfoul, Eduardo S Tolosa, Maria José Martí, Alison Green, ,

<h4>Background</h4>Leucine-rich kinase 2 (LRRK2)-linked Parkinson's disease (PD) is clinically indistinguishable from idiopathic PD (IPD). A pleiotropic neuropathology has been recognized but the majority of studies in LRRK2 p.G2019S patients reveal Lewy-type synucleinopathy as its principal histological substrate. To date no in vivo biomarkers of synucleinopathy have been found in LRRK2 mutation ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2019, 6(6):1024-1032]

Cited: 7 times

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Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies.

Graham Fairfoul, Lynne I McGuire, Suvankar Pal, James W Ironside, Juliane Neumann, Sharon Christie, Catherine Joachim, Margaret Esiri, Samuel G Evetts, Michal Rolinski, Fahd Baig, Claudio Ruffmann, Richard Wade-Martins, Michele T M Hu, Laura Parkkinen, Alison J E Green,

We have developed a novel real-time quaking-induced conversion RT-QuIC-based assay to detect alpha-synuclein aggregation in brain and cerebrospinal fluid from dementia with Lewy bodies and Parkinson's disease patients. This assay can detect alpha-synuclein aggregation in Dementia with Lewy bodies and Parkinson's disease cerebrospinal fluid with sensitivities of 92% and 95%, ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2016, 3(10):812-818]

Cited: 91 times

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Cerebrospinal fluid real-time quaking-induced conversion is a robust and reliable test for sporadic creutzfeldt-jakob disease: An international study.

Lynne I McGuire, Anna Poleggi, Ilaria Poggiolini, Silvia Suardi, Katarina Grznarova, Song Shi, Bart de Vil, Shannon Sarros, Katsuya Satoh, Keding Cheng, Maria Cramm, Graham Fairfoul, Matthias Schmitz, Inga Zerr, Patrick Cras, Michele Equestre, Fabrizio Tagliavini, Ryuichiro Atarashi, David Knox, Steven Collins, Stéphane Haïk, Piero Parchi, Maurizio Pocchiari, Alison Green,

Real-time quaking-induced conversion (RT-QuIC) has been proposed as a sensitive diagnostic test for sporadic Creutzfeldt-Jakob disease; however, before this assay can be introduced into clinical practice, its reliability and reproducibility need to be demonstrated. Two international ring trials were undertaken in which a set of 25 cerebrospinal fluid samples were ... Read more >>

Ann Neurol (Annals of neurology)
[2016, 80(1):160-165]

Cited: 43 times

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Atypical non-progressive pneumonia in goats.

Rosário Gonçalves, Isabel Mariano, Alejandro Núñez, Sandra Branco, Graham Fairfoul, Robin Nicholas,

An outbreak of severe respiratory disease in a goat herd was associated with Mycoplasma ovipneumoniae, Mycoplasma arginini, Mannheimia haemolytica and Pasteurella multocida with mortality rates exceeding 20% in kids. Post mortem features in affected kids included severe pleuropneumonia, lung consolidation, large quantities of pleural fluid and pericarditis. This is the ... Read more >>

Vet J (Veterinary journal (London, England : 1997))
[2010, 183(2):219-221]

Cited: 8 times

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