Full Text Journal Articles by
Author Graciela M Nogueras Gonzalez

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Progression of Disease after BCG Therapy: Refining Patient Selection for Neoadjuvant Chemotherapy before Radical Cystectomy.

Patrick J Hensley, Kelly K Bree, Matthew T Campbell, Omar Alhalabi, Andrea Kokorovic, Tanner Miest, Graciela M Nogueras-Gonzalez, Jianjun Gao, Arlene O Siefker-Radtke, Charles C Guo, Neema Navai, Colin P Dinney, Ashish M Kamat,

<h4>Purpose</h4>Data from the pre-neoadjuvant chemotherapy (NAC) era suggests patients who progress on BCG to muscle-invasive bladder cancer (P-MIBC) exhibit worse outcomes compared to <i>de novo</i> MIBC (D-MIBC). Herein, we investigate whether P-MIBC is an independent poor risk factor in the setting of contemporary NAC use.<h4>Materials and methods</h4>A review of patients ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001943]

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Impact of sex on response to BCG in non-muscle invasive bladder cancer patients: a contemporary review from a tertiary care center.

Kelly K Bree, Patrick J Hensley, Nathan Brooks, Justin Matulay, Graciela M Nogueras-Gonzalez, Neema Navai, Colin P Dinney, Ashish M Kamat,

<h4>Purpose</h4>Female sex has been implicated with higher stage at diagnosis and as a negative prognostic factor amongst patients with non-muscle invasive bladder cancer (NMIBC). Whether this holds true with contemporary management paradigms is unknown. We analyzed a cohort of patients treated with adequate bacillus Calmette-Guerin (BCG) for NMIBC in an ... Read more >>

World J Urol (World journal of urology)
[2021, :]

Cited: 1 time

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Long-Term Outcomes of Whole Gland Salvage Cryotherapy for Locally Recurrent Prostate Cancer following Radiation Therapy: A Combined Analysis of Two Centers.

Joseph L Chin, Arnon Lavi, Michael J Metcalfe, Khuram Siddiqui, Malcolm Dewar, Firas G Petros, Roger Li, Graciela M Nogueras González, Xuemei Wang, Shiva M Nair, John F Ward, Louis Pisters,

<h4>Purpose</h4>Radiation refractory prostate cancer (RRPCa) is common and salvage cryotherapy for RRPCa is emerging as a viable local treatment option. However, there is a paucity of long-term data. The purpose of this study is to determine long-term outcomes following salvage cryotherapy for RRPca.<h4>Materials and methods</h4>Patients undergoing salvage cryotherapy for biopsy-proven, ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001831]

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Development of an Objective Scoring System for Endoscopic Assessment of Radiation-Induced Upper Gastrointestinal Toxicity.

Daniel Lin, Shalini Moningi, Joseph Abi Jaoude, Ben S Singh, Irina M Cazacu, Ramez Kouzy, Graciela M Nogueras Gonzalez, Phonthep Angsuwatcharakon, Joseph M Herman, Manoop S Bhutani, Cullen M Taniguchi,

We developed and implemented an objective toxicity scoring system to be used during endoscopic evaluation of the upper gastrointestinal (GI) tract in order to directly assess changes in toxicity during the radiation treatment of pancreatic cancer. We assessed and validated the upper GI toxicity of 19 locally advanced pancreatic cancer ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(9):]

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Preclinical Development and First-in-Human Study of KA2507, a Selective and Potent Inhibitor of Histone Deacetylase 6, for Patients with Refractory Solid Tumors.

Apostolia M Tsimberidou, Philip A Beer, Carrie A Cartwright, Cara Haymaker, Henry H Vo, Simin Kiany, Alexander R L Cecil, James Dow, Kemal Haque, Franck A Silva, Lucy Coe, Helen Berryman, Elisabeth A Bone, Graciela M Nogueras-Gonzalez, David Vining, Hilary McElwaine-Johnn, Ignacio I Wistuba,

<h4>Purpose</h4>Inhibition of histone deacetylase 6 (HDAC6) is predicted to deliver both direct antitumor activity and modulation of the antitumor immune response. This study describes the development of a novel HDAC6 inhibitor.<h4>Patients and methods</h4>KA2507 was characterized in HDAC biochemical and cellular target engagement assays and in preclinical efficacy models of melanoma ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2021, 27(13):3584-3594]

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Contemporary Rates of Gynecologic Organ Involvement in Females with Muscle Invasive Bladder Cancer: A Retrospective Review of Women Undergoing Radical Cystectomy following Neoadjuvant Chemotherapy.

Kelly K Bree, Patrick J Hensley, Mary E Westerman, Andrea Kokorovic, Graciela M Nogueras Gonzalez, Colin P Dinney, Ashish M Kamat, Neema Navai,

<h4>Purpose</h4>According to the American Urological Association/American Society of Clinical Oncology/American Society for Radiation Oncology/Society of Urologic Oncology Guideline on treatment of nonmetastatic muscle invasive bladder cancer (MIBC), females requiring radical cystectomy (RC) should undergo concomitant anterior pelvic exenteration despite low rates of malignant involvement of gynecologic organs. We present the ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001784]

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Implications of Guideline-based, Risk-stratified Restaging Transurethral Resection of High-grade Ta Urothelial Carcinoma on Bacillus Calmette-Guérin Therapy Outcomes.

Patrick J Hensley, Kelly K Bree, Nathan Brooks, Justin Matulay, Roger Li, Graciela M Nogueras-Gonzalez, Supriya Nagaraju, Neema Navai, H Barton Grossman, Colin P Dinney, Ashish M Kamat,

<h4>Background</h4>Guideline indications for restaging transurethral resection (reTUR) for high-grade (HG) Ta bladder tumors vary due to a paucity of data.<h4>Objective</h4>To investigate guideline-based, risk-adapted approaches to reTUR for HG Ta lesions.<h4>Design, setting, and participants</h4>An institutional review of HG Ta patients who received adequate bacillus Calmette-Guérin (BCG) from 2000 to 2019 was ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, :]

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Time interval from transurethral resection of bladder tumour to bacille Calmette-Guérin induction does not impact therapeutic response.

Patrick J Hensley, Kelly K Bree, Nathan Brooks, Justin Matulay, Roger Li, Graciela M Nogueras González, Neema Navai, Herbert B Grossman, Colin P Dinney, Ashish M Kamat,

<h4>Objectives</h4>To investigate bacille Calmette-Guérin (BCG) tolerability and response with respect to the timing of BCG administration after transurethral resection of bladder tumour (TURBT) in patients with non-muscle-invasive bladder cancer (NMIBC).<h4>Patients and methods</h4>A review of patients with NMIBC at our institution managed with at least 'adequate BCG' (defined by the United ... Read more >>

BJU Int (BJU international)
[2021, :]

Cited: 1 time

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Impact of upper tract urothelial carcinoma on response to BCG in patients with non-muscle-invasive bladder cancer.

Kelly K Bree, Patrick J Hensley, Nathan A Brooks, Justin Matulay, Roger Li, Graciela M Nogueras Gonzalez, Neema Navai, Herbert Barton Grossman, Surena F Matin, Colin P N Dinney, Ashish M Kamat,

<h4>Objective</h4>To evaluate the impact of upper tract urothelial carcinoma (UTUC) on bacillus Calmette-Guerin (BCG) response and progression in patients with non-muscle-invasive bladder cancer (NMIBC).<h4>Patients and methods</h4>We performed an institutional review board-approved review of patients with NMIBC treated with adequate intravesical BCG, as defined by the US Food and Drug Administration, ... Read more >>

BJU Int (BJU international)
[2021, :]

Cited: 1 time

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Prospective trial of regional (hockey-stick) prostate cryoablation: oncologic and quality of life outcomes.

Justin R Gregg, Leonardo D Borregales, Haesun Choi, Marisa Lozano, Stephen E McRae, Aradhana M Venkatesan, John W Davis, Graciela M Nogueras-Gonzalez, Louis L Pisters, John F Ward,

<h4>Purpose</h4>To report long-term follow-up of the efficacy of subtotal prostate ablation using a "hockey-stick" template, including oncologic control and quality of life (QoL) impact.<h4>Methods</h4>We performed a prospective controlled trial to evaluate the efficacy of subtotal prostate ablation in selected men with baseline and confirmatory biopsy showing grade group (GG) 1-2 ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Prevalence of medication related osteonecrosis of the jaw in patients treated with sequential antiresorptive drugs: systematic review and meta-analysis.

Akanksha Srivastava, Graciela M Nogueras Gonzalez, Yimin Geng, Alexander M Won, Maria E Cabanillas, Aung Naing, Jeffrey N Myers, Yisheng Li, Mark S Chambers,

<h4>Background</h4>Antiresorptive drugs (ARD) are associated with a known serious adverse event, known as medication-related osteonecrosis of the jaws (MRONJ). Transition from one ARD to another has become common clinical practice with the advent of more potent or safer agents; however, the influence of sequential antiresorptive therapy as a risk factor ... Read more >>

Support Care Cancer (Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer)
[2021, 29(5):2305-2317]

Cited: 2 times

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An international study of interobserver variability of "string sign" of pancreatic cysts among experienced endosonographers.

Seifeldin Hakim, Emmanuel Coronel, Graciela M Nogueras González, Philip S Ge, Suresh T Chari, Nirav Thosani, Srinivas Ramireddy, Ricardo Badillo, Tomas DaVee, Marc F Catalano, Robert J Sealock, Sreeram Parupudi, Lyndon V Hernandez, Virendra Joshi, Atsushi Irisawa, Surinder Rana, Sundeep Lakhtakia, Peter Vilmann, Adrian Saftoiu, Siyu Sun, Marc Giovannini, Matthew H Katz, Michael P Kim, Manoop S Bhutani,

<h4>Background and objectives</h4>No single optimal test reliably determines the pancreatic cyst subtype. Following EUS-FNA, the "string sign" test can differentiate mucinous from nonmucinous cysts. However, the interobserver variability of string sign results has not been studied.<h4>Methods</h4>An experienced endosonographer performed EUS-FNA of pancreatic cysts on different patients and was recorded on ... Read more >>

Endosc Ultrasound (Endoscopic ultrasound)
[2021, 10(1):39-50]

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The effects of zinc on radiation-induced dysgeusia: a systematic review and meta-analysis.

Woo J Chi, Jeffrey N Myers, Steven J Frank, Ruth A Aponte-Wesson, Adegbenga O Otun, Graciela M Nogueras-González, Yisheng Li, Yimin Geng, Mark S Chambers,

<h4>Purpose</h4>Many head and neck cancer patients who receive radiation therapy experience radiation-induced dysgeusia (RID), which has no standard treatment. The only supplement controlled clinical trials have evaluated for the treatment of RID is zinc. However, the results of these and other studies investigating the use of zinc for RID have ... Read more >>

Support Care Cancer (Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer)
[2020, 28(12):1-12]

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Altered T-cell subset repertoire affects treatment outcome of patients with myelofibrosis.

Ivo Veletic, Sanja Prijic, Taghi Manshouri, Graciela M Nogueras-Gonzalez, Srdan Verstovsek, Zeev Estrov,

Phenotypic characterization of T cells in myelofibrosis (MF) is intriguing owing to increased inflammation, markedly elevated pro-inflammatory cytokines, and altered distribution of T-cell subsets. Constitutive activation of Janus kinase-2 (JAK2) in the majority of MF patients contributes to the expression of the programmed cell death protein-1 (PD1) and T-cell exhaustion. ... Read more >>

Haematologica (Haematologica)
[2020, :]

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Comparing confirmatory biopsy outcomes between MRI-targeted biopsy and standard systematic biopsy among men being enrolled in prostate cancer active surveillance.

Daniel D Shapiro, Justin R Gregg, Amy H Lim, Graciela M Nogueras-González, Haesun Choi, Hyunseon C Kang, Irene A Inguillo, Brian F Chapin, John W Davis, John F Ward,

<h4>Objectives</h4>To evaluate the ability of magnetic resonance imaging (MRI)-targeted biopsy combined with systematic biopsy (MRI-biopsy) to reduce negative biopsies and detect clinically significant prostate cancer compared to systematic biopsy (SB) alone in the confirmatory biopsy setting using matched cohorts.<h4>Patients and methods</h4>Patients were identified from an active surveillance database who had ... Read more >>

BJU Int (BJU international)
[2021, 127(3):340-348]

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Efficacy of Three-Drug Induction Chemotherapy Followed by Preoperative Chemoradiation in Patients with Localized Gastric Adenocarcinoma.

Dilsa Mizrak Kaya, Graciela M Nogueras González, Kazuto Harada, Mariela A Blum Murphy, Jeffrey H Lee, Manoop S Bhutani, Brian Weston, Irene Thomas, Jane E Rogers, Prajnan Das, Brian D Badgwell, Jaffer A Ajani,

<h4>Background</h4>Preoperative induction chemotherapy followed by chemoradiation yields better R0 resection rates, pathologic complete response (pCR) rates and improved survival for localized gastric adenocarcinoma (GAC). We report the effect of three-drug induction chemotherapy on a large cohort of localized GAC patients.<h4>Methods</h4>We identified 97 patients with localized GAC who received three-drug induction ... Read more >>

Oncology (Oncology)
[2020, 98(8):542-548]

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The clinical impact of time to response in de novo accelerated-phase chronic myeloid leukemia.

Maro Ohanian, Hagop M Kantarjian, Mahran Shoukier, Sara Dellasala, Arine Musaelyan, Graciela M Nogueras Gonzalez, Elias Jabbour, Lynne Abruzzo, Srdan Verstovsek, Gautam Borthakur, Farhad Ravandi, Guillermo Garcia-Manero, Gevorg Tamamyan, Richard Champlin, Sherry Pierce, Alessandra Ferrajoli, Tapan Kadia, Jorge E Cortes,

We aimed to describe the impact of time to response on the outcomes of 75 patients with accelerated-phase chronic myeloid leukemia (CML-AP) at diagnosis. Patients had at least 1 feature of AP: blasts ≥15% (n = 2), basophils ≥20% (n = 19), platelets <100 × 10<sup>9</sup> /L (n = 7), cytogenetic clonal ... Read more >>

Am J Hematol (American journal of hematology)
[2020, :]

Cited: 1 time

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A Phase II Study of Cabozantinib and Androgen Ablation in Patients with Hormone-Naïve Metastatic Prostate Cancer.

Paul G Corn, Miao Zhang, Graciela M Nogueras-Gonzalez, Lianchun Xiao, Amado J Zurita, Sumit K Subudhi, Shi-Ming Tu, Ana M Aparicio, Cristian Coarfa, Kimal Rajapakshe, Shixia Huang, Nora M Navone, Sue-Hwa Lin, Guocan Wang, Sumankalai Ramachandran, Mark A Titus, Theocharis Panaretakis, Gary E Gallick, Eleni Efstathiou, Patricia Troncoso, Christopher Logothetis,

<h4>Purpose</h4>Cabozantinib, an oral inhibitor of c-MET/VEGFR2 signaling, improved progression-free survival (mPFS) but not overall survival (OS) in metastatic castrate-resistant prostate cancer. We evaluated cabozantinib plus androgen deprivation therapy (ADT) in hormone-naïve metastatic prostate cancer (HNMPCa).<h4>Patients and methods</h4>Patients received ADT plus cabozantinib starting at 60 mg daily. The primary endpoint was ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2020, 26(5):990-999]

Cited: 0 times

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Clinical Characteristics and Adverse Impact of Hepatotoxicity due to Immune Checkpoint Inhibitors.

Ethan D Miller, Hamzah Abu-Sbeih, Brett Styskel, Graciela M Nogueras Gonzalez, Boris Blechacz, Aung Naing, Naga Chalasani,

<h4>Introduction</h4>We conducted this study to characterize the incidence, clinical features, treatment, and outcomes of immune checkpoint inhibitor (ICI) hepatotoxicity.<h4>Methods</h4>Patients who received ICIs (with either single-agent or combination regimens) from January 1, 2010, to March 31, 2018, were identified. Hepatotoxicity was defined as alanine aminotransferase (ALT) >5 times the upper limit ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2020, 115(2):251-261]

Cited: 4 times

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Long-term results of a phase 2 trial of nilotinib 400 mg twice daily in newly diagnosed patients with chronic-phase chronic myeloid leukemia.

Lucia Masarova, Jorge E Cortes, Keyur P Patel, Susan O'Brien, Graciela M Nogueras-Gonzalez, Marina Konopleva, Srdan Verstovsek, Guillermo Garcia-Manero, Alessandra Ferrajoli, Tapan M Kadia, Farhad Ravandi-Kashani, Gautam Borthakur, Sara DellaSala, Zeev Estrov, Elias J Jabbour, Hagop M Kantarjian,

<h4>Background</h4>Nilotinib is a potent, second-generation inhibitor of BCR-ABL1 tyrosine kinase and has been approved as frontline and salvage therapy for patients with chronic-phase chronic myeloid leukemia (CP-CML).<h4>Methods</h4>In this single-institution, phase 2 study, 122 patients with newly diagnosed CP-CML received nilotinib 400 mg twice daily. The median follow-up on study was 78.3 months ... Read more >>

Cancer (Cancer)
[2020, 126(7):1448-1459]

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Long-term overall survival and prognostic score predicting survival: the IMPACT study in precision medicine.

Apostolia-Maria Tsimberidou, David S Hong, Jennifer J Wheler, Gerald S Falchook, Filip Janku, Aung Naing, Siqing Fu, Sarina Piha-Paul, Carrie Cartwright, Russell R Broaddus, Graciela M Nogueras Gonzalez, Patrick Hwu, Razelle Kurzrock,

BACKGROUND:In 2007, we initiated IMPACT, a precision medicine program for patients referred for participation in early-phase clinical trials. We assessed the correlation of factors, including genomically matched therapy, with overall survival (OS). PATIENTS AND METHODS:We performed molecular profiling (Clinical Laboratory Improvement Amendments) (genes ≤ 182) for patients with lethal/refractory advanced cancers ... Read more >>

J Hematol Oncol (Journal of hematology & oncology)
[2019, 12(1):145]

Cited: 5 times

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Long-term results of frontline dasatinib in chronic myeloid leukemia.

Abhishek Maiti, Jorge E Cortes, Keyur P Patel, Lucia Masarova, Gautam Borthakur, Farhad Ravandi, Srdan Verstovsek, Alessandra Ferrajoli, Zeev Estrov, Guillermo Garcia-Manero, Tapan M Kadia, Graciela M Nogueras-González, Jeffrey Skinner, Rebecca Poku, Sara DellaSala, Rajyalakshmi Luthra, Elias J Jabbour, Susan O'Brien, Hagop M Kantarjian,

<h4>Background</h4>Dasatinib is a second-generation tyrosine kinase inhibitor that, when used as frontline therapy, produces more and faster cytogenetic and molecular responses compared with imatinib. The authors report the long-term follow-up from the first study using dasatinib as initial therapy for chronic-phase chronic myeloid leukemia.<h4>Methods</h4>Between November 2005 and August 2014, patients ... Read more >>

Cancer (Cancer)
[2020, 126(7):1502-1511]

Cited: 2 times

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Temsirolimus versus Pazopanib (TemPa) in Patients with Advanced Clear-cell Renal Cell Carcinoma and Poor-risk Features: A Randomized Phase II Trial.

Nizar M Tannir, Pavlos Msaouel, Jeremy A Ross, Catherine E Devine, Anuradha Chandramohan, Graciela M Nogueras Gonzalez, Xuemei Wang, Jennifer Wang, Paul G Corn, Zita D Lim, Lisa Pruitt, Jose A Karam, Christopher G Wood, Amado J Zurita,

<h4>Background</h4>Temsirolimus has level 1 evidence for initial treatment of poor-risk patients with advanced renal cell carcinoma (mRCC), but its efficacy has not been directly compared with an antiangiogenic tyrosine kinase inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor [VEGFR TKi]) in this setting.<h4>Objective</h4>To evaluate temsirolimus versus pazopanib as first-line ... Read more >>

Eur Urol Oncol (European urology oncology)
[2020, 3(5):687-694]

Cited: 1 time

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The role of metastatic burden in cytoreductive/consolidative radical cystectomy.

Roger Li, Janet E Baack Kukreja, Mohamed A Seif, Firas G Petros, Matthew T Campbell, Justin V Nguyen, Graciela M Nogueras González, Ashish M Kamat, Louis L Pisters, Colin P Dinney, Neema Navai,

<h4>Purpose</h4>To describe our institutional experience with cytoreductive/consolidative radical cystectomy (CCRC) for metastatic urothelial carcinoma (UC) and to investigate clinicopathologic features predicting prolonged cancer specific survival (CSS) following CCRC.<h4>Methods</h4>We performed IRB-approved review of our cystectomy database, and identified 43 patients with metastatic UC who underwent CCRC. Baseline demographics, chemotherapy regimen, clinicopathologic ... Read more >>

World J Urol (World journal of urology)
[2019, 37(12):2691-2698]

Cited: 2 times

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Significance of Cancer Cells at the Vein Edge in Patients with Pancreatic Adenocarcinoma Following Pancreatectomy with Vein Resection.

Laura R Prakash, Huamin Wang, Jun Zhao, Graciela M Nogueras-Gonzalez, Jordan M Cloyd, Ching-Wei D Tzeng, Michael P Kim, Jeffrey E Lee, Matthew H G Katz,

<h4>Background</h4>Resection of the superior mesenteric and/or portal vein (SMV-PV) is increasingly performed with pancreatectomy for adenocarcinoma. We sought to analyze the impact of cancer at the transected edge(s) of the vein wall.<h4>Methods</h4>Patients who underwent pancreatectomy with vein resection between 2003 and 2015 at a single center were evaluated. R1 resection ... Read more >>

J Gastrointest Surg (Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract)
[2020, 24(2):368-379]

Cited: 3 times

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