Full Text Journal Articles by
Author Grace Protasiewicz

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The Role of Toll-Like Receptor 2 and 4 Innate Immunity Pathways in Intracortical Microelectrode-Induced Neuroinflammation.

John K Hermann, Shushen Lin, Arielle Soffer, Chun Wong, Vishnupriya Srivastava, Jeremy Chang, Smrithi Sunil, Shruti Sudhakar, William H Tomaszewski, Grace Protasiewicz, Stephen M Selkirk, Robert H Miller, Jeffrey R Capadona,

We have recently demonstrated that partial inhibition of the cluster of differentiation 14 (CD14) innate immunity co-receptor pathway improves the long-term performance of intracortical microelectrodes better than complete inhibition. We hypothesized that partial activation of the CD14 pathway was critical to a neuroprotective response to the injury associated with initial ... Read more >>

Front Bioeng Biotechnol (Frontiers in bioengineering and biotechnology)
[2018, 6:113]

Cited: 6 times

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Inhibition of the cluster of differentiation 14 innate immunity pathway with IAXO-101 improves chronic microelectrode performance.

John K Hermann, Madhumitha Ravikumar, Andrew J Shoffstall, Evon S Ereifej, Kyle M Kovach, Jeremy Chang, Arielle Soffer, Chun Wong, Vishnupriya Srivastava, Patrick Smith, Grace Protasiewicz, Jingle Jiang, Stephen M Selkirk, Robert H Miller, Steven Sidik, Nicholas P Ziats, Dawn M Taylor, Jeffrey R Capadona,

OBJECTIVE:Neuroinflammatory mechanisms are hypothesized to contribute to intracortical microelectrode failures. The cluster of differentiation 14 (CD14) molecule is an innate immunity receptor involved in the recognition of pathogens and tissue damage to promote inflammation. The goal of the study was to investigate the effect of CD14 inhibition on intracortical microelectrode ... Read more >>

J Neural Eng (Journal of neural engineering)
[2018, 15(2):025002]

Cited: 17 times

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