Full Text Journal Articles by
Author Grace Hsu

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Pediatric airway management.

Grace Hsu, Britta S von Ungern-Sternberg, Thomas Engelhardt,

<h4>Purpose of review</h4>Children are at risk of severe hypoxemia in the perioperative period owing to their unique anatomy and physiology. Safe and effective airway management strategies are therefore key to the practice of pediatric anesthesia. The goal of this review is to highlight recent publications (2019-2021) aimed to advance pediatric ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2021, 34(3):276-283]

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Reporting and design of randomized controlled trials for COVID-19: A systematic review.

Alison Dillman, Jay J H Park, Michael J Zoratti, Noor-E Zannat, Zelyn Lee, Louis Dron, Grace Hsu, Gerald Smith, Sahand Khakabimamaghani, Ofir Harari, Kristian Thorlund, Edward J Mills,

<h4>Background</h4>The novel coronavirus 2019 (COVID-19) pandemic has mobilized global research at an unprecedented scale. While challenges associated with the COVID-19 trial landscape have been discussed previously, no comprehensive reviews have been conducted to assess the reporting, design, and data sharing practices of randomized controlled trials (RCTs).<h4>Purpose</h4>The purpose of this review ... Read more >>

Contemp Clin Trials (Contemporary clinical trials)
[2021, 101:106239]

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The Landscape of Emerging Randomized Clinical Trial Evidence for COVID-19 Disease Stages: A Systematic Review of Global Trial Registries.

Alison Dillman, Michael J Zoratti, Jay J H Park, Grace Hsu, Louis Dron, Gerald Smith, Ofir Harari, Craig R Rayner, Noor-E Zannat, Alind Gupta, Eric Mackay, Paul Arora, Zelyn Lee, Edward J Mills,

<h4>Purpose</h4>A multitude of randomized controlled trials (RCTs) have emerged in response to the novel coronavirus disease (COVID-19) pandemic. Understanding the distribution of trials among various settings is important to guide future research priorities and efforts. The purpose of this review was to describe the emerging evidence base of COVID-19 RCTs ... Read more >>

Infect Drug Resist (Infection and drug resistance)
[2020, 13:4577-4587]

Cited: 1 time

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Utilizing Bayesian predictive power in clinical trial design.

Ofir Harari, Grace Hsu, Louis Dron, Jay J H Park, Kristian Thorlund, Edward J Mills,

The Bayesian paradigm provides an ideal platform to update uncertainties and carry them over into the future in the presence of data. Bayesian predictive power (BPP) reflects our belief in the eventual success of a clinical trial to meet its goals. In this paper we derive mathematical expressions for the ... Read more >>

Pharm Stat (Pharmaceutical statistics)
[2020, :]

Cited: 1 time

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A comparison of videolaryngoscopy using standard blades or non-standard blades in children in the Paediatric Difficult Intubation Registry.

James Peyton, Raymond Park, Steven J Staffa, Stefano Sabato, Thomas W Templeton, Mary Lyn Stein, Annery G Garcia-Marcinkiewicz, Edgar Kiss, John Edem Fiadjoe, Britta von Ungern-Sternberg, Franklin Chiao, Patrick Olomu, David Zurakowski, Pete G Kovatsis, ,

<h4>Background</h4>The design of a videolaryngoscope blade may affect its efficacy. We classified videolaryngoscope blades as standard and non-standard shapes to compare their efficacy performing tracheal intubation in children enrolled in the Paediatric Difficult Intubation Registry.<h4>Methods</h4>Cases entered in the Registry from March 2017 to January 2020 were analysed. We compared the ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, 126(1):331-339]

Cited: 1 time

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The Pediatric Difficult Airway: Updates and Innovations.

Grace Hsu, John E Fiadjoe,

Children have unique characteristics that make them particularly vulnerable to perioperative adverse events. Skilled airway management is a cornerstone of high-quality anesthetic management. The use of hybrid airway techniques is a critical tool for the pediatric anesthesiologist. Point-of-care ultrasonography has an expanding role in airway management, from preoperative assessment of ... Read more >>

Anesthesiol Clin (Anesthesiology clinics)
[2020, 38(3):459-475]

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Independent risk factors associated with higher mortality rates and recurrence of brain abscesses from head and neck sources.

Fugui Zhang, Grace Hsu, Somdipto Das, Youbai Chen, Meredith August,

<h4>Objective</h4>The aim of this study was to identify the features and independent risk factors associated with recurrence and mortality in patients with brain abscesses of head and neck origin.<h4>Study design</h4>We designed a retrospective study of patients diagnosed with a brain abscess at the Massachusetts General Hospital between 1980 and 2017. ... Read more >>

Oral Surg Oral Med Oral Pathol Oral Radiol (Oral surgery, oral medicine, oral pathology and oral radiology)
[2021, 131(2):173-179]

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How do I…Incorporate a two-sample blood type verification in a pediatric hospital?

Jorge Gálvez, Grace Hsu, Scott Dubow, Leslie Obermeier, Pamala Blair, David Friedman, Deborah Sesok-Pizzini,

<h4>Background</h4>The AABB (American Association of Blood Banks) and the College of American Pathologists (CAP) regulations call on blood banks to address the risk of misidentification of a patient's blood type, which can result in transfusion of a mismatched product. Transfusion of mismatched blood product is potentially fatal due to acute ... Read more >>

Transfusion (Transfusion)
[2020, 60(12):2787-2792]

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Do brain abscesses have a higher incidence of odontogenic origin than previously thought?

Grace Hsu, Jie Zhang, Firat Selvi, Neil Shady, Meredith August,

OBJECTIVE:The aim of this study was to answer the following clinical question: "In patients admitted to a tertiary care hospital with a diagnosis of brain abscess, how common is odontogenic etiology?" STUDY DESIGN:We designed a retrospective study of patients with brain abscesses diagnosed at the Massachusetts General Hospital between 1980 ... Read more >>

Oral Surg Oral Med Oral Pathol Oral Radiol (Oral surgery, oral medicine, oral pathology and oral radiology)
[2020, 130(1):10-17]

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Using 3D Animation to Visualize Hypotheses.

Shraddha Nayak, Hui Liu, Grace I Hsu, Janet H Iwasa,

Trends Biochem Sci (Trends in biochemical sciences)
[2020, 45(7):633-634]

Cited: 0 times

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A real-time dashboard of clinical trials for COVID-19.

Kristian Thorlund, Louis Dron, Jay Park, Grace Hsu, Jamie I Forrest, Edward J Mills,

Lancet Digit Health (The Lancet. Digital health)
[2020, 2(6):e286-e287]

Cited: 53 times

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Correction to: Exploratory data analysis for pre and post 24/7/365 attending radiologist coverage support in an emergency department: fundamentals of data science.

Sabeena Jalal, Marshall E Lloyd, Faisal Khosa, Grace I-Hsuan Hsu, Savvas Nicolaou,

The above article has an error in Figure 6 online (already correct in the PDF version) including the Graphical abstract figure. The original article has been corrected. ... Read more >>

Emerg Radiol (Emergency radiology)
[2020, 27(2):227]

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The applicability and efficacy of magnetic resonance-guided high intensity focused ultrasound system in the treatment of primary trigeminal neuralgia.

Yaping Ma, Grace Hsu, Fugui Zhang,

Primary trigeminal neuralgia is a common clinical refractory neuralgia characterized by an onset of excruciating pain that can severely affect patients' quality of life. Long-term suffering from this pain may lead to depression, anxiety, and suicide. Current treatments, however, are associated with high recurrent rates and severe complications. We hypothesize ... Read more >>

Med Hypotheses (Medical hypotheses)
[2020, 139:109688]

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Non-neural surface ectodermal rosette formation and F-actin dynamics drive mammalian neural tube closure.

Chengji J Zhou, Yu Ji, Kurt Reynolds, Moira McMahon, Michael A Garland, Shuwen Zhang, Bo Sun, Ran Gu, Mohammad Islam, Yue Liu, Tianyu Zhao, Grace Hsu, Janet Iwasa,

The mechanisms underlying mammalian neural tube closure remain poorly understood. We report a unique cellular process involving multicellular rosette formation, convergent cellular protrusions, and F-actin cable network of the non-neural surface ectodermal cells encircling the closure site of the posterior neuropore, which are demonstrated by scanning electron microscopy and genetic ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2020, 526(3):647-653]

Cited: 1 time

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An overview of precision oncology basket and umbrella trials for clinicians.

Jay J H Park, Grace Hsu, Ellie G Siden, Kristian Thorlund, Edward J Mills,

With advancements in biomarkers and momentum in precision medicine, biomarker-guided trials such as basket trials and umbrella trials have been developed under the master protocol framework. A master protocol refers to a single, overarching design developed to evaluate multiple hypotheses with the general goal of improving the efficiency of trial ... Read more >>

CA Cancer J Clin (CA: a cancer journal for clinicians)
[2020, 70(2):125-137]

Cited: 8 times

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Minimizing control group allocation in randomized trials using dynamic borrowing of external control data - An application to second line therapy for non-small cell lung cancer.

Louis Dron, Shirin Golchi, Grace Hsu, Kristian Thorlund,

<h4>Background</h4>Enrollment of participants to control arms in clinical trials can be challenging. This is particularly an issue in oncology trials where the standard-of-care is shifting rapidly and several promising experimental treatments are undergoing phase III testing. Novel methods for utilizing external control data may mitigate these challenges, but applied examples ... Read more >>

Contemp Clin Trials Commun (Contemporary clinical trials communications)
[2019, 16:100446]

Cited: 1 time

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Patient-centered design in developing a mobile application for oral anticancer medications.

Stephanie Y Crawford, Andrew D Boyd, Ashwin K Nayak, Neeta K Venepalli, Sandra Cuellar, Scott M Wirth, Grace I-Hsuan Hsu,

<h4>Objectives</h4>To develop and test the usability and feasibility of a customizable mobile application (app) designed to help educate patients about their oral anticancer medications (OAMs) and regimens.<h4>Setting</h4>Outpatient cancer center and oncology pharmacy for urban, Midwestern academic health system.<h4>Practice description</h4>Clinically-supervised educational intervention to support patients learning about OAMs.<h4>Practice innovation</h4>With input from ... Read more >>

J Am Pharm Assoc (2003) (Journal of the American Pharmacists Association : JAPhA)
[2019, 59(2S):S86-S95.e1]

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Technique Utilizing a Modified Oral Ring-Adair-Elwyn Tube to Provide Continuous Oxygen and Sevoflurane Delivery During Nasotracheal Intubation in an Infant With a Difficult Airway: A Case Report.

Janice Y Man, John E Fiadjoe, Grace Hsu,

Managing the airway of an infant with Pierre Robin sequence (PRS) is particularly challenging for anesthesiologists. Patients with PRS have the triad of micrognathia, glossoptosis, and airway obstruction that potentially and frequently leads to difficulty with both ventilation and intubation. Thus continuous oxygenation and spontaneous ventilation during intubation are essential. ... Read more >>

A A Pract (A&A practice)
[2018, 10(10):254-257]

Cited: 0 times

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Care Standardization Reduces Blood Donor Exposures and Transfusion in Complex Cranial Vault Reconstruction.

Wallis T Muhly, Jonathan M Tan, Grace Hsu, Deborah A Sesok-Pizzini, John E Fiadjoe, Jesse A Taylor, Scott P Bartlett, Paul A Stricker,

<h4>Background</h4>Complex cranial vault reconstruction (CCVR) often requires a large-volume transfusion of blood products. We implemented a series of improvement interventions to reduce blood donor exposures (BDE) and transfusion requirements in CCVR.<h4>Methods</h4>We implemented interventions over 4 epochs: (E1) reconstituted blood (1:1 ratio of donor-matched red blood cells and fresh-frozen plasma) for ... Read more >>

Hosp Pediatr (Hospital pediatrics)
[2018, 8(10):595-603]

Cited: 1 time

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Discussion: Assessing the Impact of Blood Loss in Cranial Vault Remodeling: A Risk Assessment Model Using the 2012 to 2013 Pediatric National Surgical Quality Improvement Program Data Sets.

Paul A Stricker, Grace Hsu,

Plast Reconstr Surg (Plastic and reconstructive surgery)
[2015, 136(6):1261-1263]

Cited: 0 times

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The complex relationship of race to outcomes in heart failure with preserved ejection fraction.

Jerry H Gurwitz, David J Magid, David H Smith, Grace Hsu, Sue Hee Sung, Larry A Allen, David D McManus, Robert J Goldberg, Alan S Go, ,

<h4>Background</h4>An improved understanding of racial differences in the natural history, clinical characteristics, and outcomes of heart failure will have important clinical and public health implications. We assessed how clinical characteristics and outcomes vary across racial groups (whites, blacks, and Asians) in adults with heart failure with preserved ejection fraction.<h4>Methods</h4>We identified ... Read more >>

Am J Med (The American journal of medicine)
[2015, 128(6):591-600]

Cited: 7 times

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Transient and reproducible loss of motor-evoked potential signals after intravenous levetiracetam in a child undergoing craniotomy for resection of astrocytoma.

Allan F Simpao, Luke S Janik, Grace Hsu, Alan Jay Schwartz, Gregory G Heuer, Andrew P Warrington, Mohamed A Rehman,

Transcranial electrical motor-evoked potential (tceMEP) monitoring is used in complex intracranial and spinal surgeries to detect and prevent neurological injury. We present a case of transient, reproducible loss of tceMEPs after an infusion of levetiracetam during craniotomy and tumor resection in a child. Cessation of the infusion resulted in restoration ... Read more >>

A A Case Rep (A & A case reports)
[2015, 4(2):26-28]

Cited: 0 times

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Hospital-level variation in use of cardiovascular testing for adults with incident heart failure: findings from the cardiovascular research network heart failure study.

Steven A Farmer, Justin Lenzo, David J Magid, Jerry H Gurwitz, David H Smith, Grace Hsu, Sue Hee Sung, Alan S Go,

<h4>Objectives</h4>This study aimed to characterize the use of cardiovascular testing for patients with incident heart failure (HF) hospitalization who participated in the National Heart, Lung, and Blood Institute sponsored Cardiovascular Research Network (CVRN) Heart Failure study.<h4>Background</h4>HF is a common cause of hospitalization, and testing and treatment patterns may differ substantially ... Read more >>

JACC Cardiovasc Imaging (JACC. Cardiovascular imaging)
[2014, 7(7):690-700]

Cited: 9 times

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Risk factors for adverse outcomes by left ventricular ejection fraction in a contemporary heart failure population.

Larry A Allen, David J Magid, Jerry H Gurwitz, David H Smith, Robert J Goldberg, Jane Saczynski, Micah L Thorp, Grace Hsu, Sue Hee Sung, Alan S Go,

<h4>Background</h4>Although heart failure (HF) is a syndrome with important differences in response to therapy by left ventricular ejection fraction (LVEF), existing risk stratification models typically group all HF patients together. The relative importance of common predictor variables for important clinical outcomes across strata of LVEF is relatively unknown.<h4>Methods and results</h4>We ... Read more >>

Circ Heart Fail (Circulation. Heart failure)
[2013, 6(4):635-646]

Cited: 17 times

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Contemporary prevalence and correlates of incident heart failure with preserved ejection fraction.

Jerry H Gurwitz, David J Magid, David H Smith, Robert J Goldberg, David D McManus, Larry A Allen, Jane S Saczynski, Micah L Thorp, Grace Hsu, Sue Hee Sung, Alan S Go,

<h4>Background</h4>We assessed the prevalence of preserved left ventricular ejection fraction in patients with incident heart failure and differences in the demographic and clinical characteristics that may differentiate patients presenting with heart failure with preserved versus reduced left ventricular ejection fraction.<h4>Methods</h4>We identified all patients with newly diagnosed heart failure between 2005 ... Read more >>

Am J Med (The American journal of medicine)
[2013, 126(5):393-400]

Cited: 35 times

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