Full Text Journal Articles by
Author Gordon J Lithgow

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Caenorhabditis Intervention Testing Program: the herbicide diuron does not robustly extend lifespan in nematodes.

Hadley C Osman, Christine A Sedore, E Grace Jackson, Elena T Battistoni, David Hall, Anna Foulger, Mark Lucanic, Max Guo, Monica Driscoll, Patrick Phillips, Gordon J Lithgow,

MicroPubl Biol (microPublication biology)
[2021, 2021:]

Cited: 0 times

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Swimming exercise reduces native ⍺-synuclein protein species in a transgenic C. elegans model of Parkinson's disease.

Minna Y Schmidt, Manish Chamoli, Gordon J Lithgow, Julie K Andersen,

Exercise has been historically recommended to prevent many disease conditions. Intense exercise in particular, has been shown to be beneficial for Parkinson's disease (PD) - stopping and even reversing symptoms in some patients. Recent research in mammalian animal models of Parkinson's have shown that exercise affects ⍺-synuclein aggregate species, considered ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

Cited: 0 times

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Kavain suppresses human Aβ-induced paralysis in C. elegans.

Manish Chamoli, Shankar J Chinta, Julie K Andersen, Gordon J Lithgow,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

Cited: 0 times

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Caenorhabditis Intervention Testing Program: the creatine analog β-guanidinopropionic acid does not extend lifespan in nematodes.

Anna L Coleman-Hulbert, Erik Johnson, Christine A Sedore, Stephen A Banse, Max Guo, Monica Driscoll, Gordon J Lithgow, Patrick C Phillips,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

Cited: 3 times

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Caenorhabditis Intervention Testing Program: the tyrosine kinase inhibitor imatinib mesylate does not extend lifespan in nematodes.

Anna L Coleman-Hulbert, Erik Johnson, Christine A Sedore, Stephen A Banse, Max Guo, Monica Driscoll, Gordon J Lithgow, Patrick C Phillips,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 3 times

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University of Southern California and buck institute nathan shock center: multidimensional models of aging.

Sean P Curran, Gordon J Lithgow, Eric Verdin, Cohen P,

The USC-Buck Nathan Shock Center of Excellence in the Biology of Aging is a new and fully integrated multi-institutional center focused on training the next generation of geroscientists and providing access to cutting-edge geroscience technologies to investigators across the nation. The USC-Buck NSC is devoted to forging a deeper understanding ... Read more >>

Geroscience (GeroScience)
[2021, :]

Cited: 0 times

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Moving geroscience from the bench to clinical care and health policy.

Felipe Sierra, Avshalom Caspi, Richard H Fortinsky, Laura Haynes, Gordon J Lithgow, Terrie E Moffitt, S Jay Olshansky, Daniel Perry, Eric Verdin, George A Kuchel,

Geriatricians and others must embrace the emerging field of geroscience. Until recently geroscience research was pursued in laboratory animals, but now this field requires specialized expertise in the care of vulnerable older patients with multiple chronic diseases and geriatric syndromes, the population likely to benefit the most from emerging therapies. ... Read more >>

J Am Geriatr Soc (Journal of the American Geriatrics Society)
[2021, 69(9):2455-2463]

Cited: 0 times

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Career Retrospective: Tom Johnson-Genetics, Genomics, Stress, Stochastic Variation, and Aging.

Alexander R Mendenhall, Gordon J Lithgow, Stuart Kim, David Friedman, Breanne L Newell-Stamper, Thomas E Johnson,

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2021, 76(7):e85-e91]

Cited: 0 times

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Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs.

Daniel S Evans, Monique N O'Leary, Ryan Murphy, Minna Schmidt, Kristin Koenig, Michael Presley, Brittany Garrett, Ha-Neui Kim, Li Han, Emmeline C Academia, Matt J Laye, Daniel Edgar, Christopher A Zambataro, Tracey Barhydt, Colleen M Dewey, Jarrott Mayfield, Joy Wilson, Silvestre Alavez, Mark Lucanic, Brian K Kennedy, Maria Almeida, Julie K Andersen, Pankaj Kapahi, Gordon J Lithgow, Simon Melov,

Aging is characterized by systemic declines in tissue and organ functions. Interventions that slow these declines represent promising therapeutics to protect against age-related disease and improve the quality of life. In this study, several interventions associated with lifespan extension in invertebrates or improvement of age-related disease were tested in mouse ... Read more >>

JBMR Plus (JBMR plus)
[2021, 5(3):e10466]

Cited: 0 times

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A simplified design for the C. elegans lifespan machine.

Mark Abbott, Stephen A Banse, Ilija Melentijevic, Cody M Jarrett, Jonathan St Ange, Christine A Sedore, Ron Falkowski, Benjamin W Blue, Anna L Coleman-Hulbert, Erik Johnson, Max Guo, Gordon J Lithgow, Patrick C Phillips, Monica Driscoll,

<i>Caenorhabditis elegans</i> (<i>C. elegans</i>) lifespan assays constitute a broadly used approach for investigating the fundamental biology of longevity. Traditional <i>C. elegans</i> lifespan assays require labor-intensive microscopic monitoring of individual animals to evaluate life/death over a period of weeks, making large-scale high throughput studies impractical. The lifespan machine developed by Stroustrup ... Read more >>

J Biol Methods (Journal of biological methods)
[2020, 7(4):e137]

Cited: 0 times

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Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice.

Azar Asadi Shahmirzadi, Daniel Edgar, Chen-Yu Liao, Yueh-Mei Hsu, Mark Lucanic, Arash Asadi Shahmirzadi, Christopher D Wiley, Garbo Gan, Dong Eun Kim, Herbert G Kasler, Chisaka Kuehnemann, Brian Kaplowitz, Dipa Bhaumik, Rebeccah R Riley, Brian K Kennedy, Gordon J Lithgow,

Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here, we investigate the effect of alpha-ketoglutarate (delivered in the form of a calcium salt, CaAKG) on healthspan and lifespan in C57BL/6 mice. To ... Read more >>

Cell Metab (Cell metabolism)
[2020, 32(3):447-456.e6]

Cited: 19 times

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Dysregulated iron metabolism in C. elegans catp-6/ATP13A2 mutant impairs mitochondrial function.

Nikhita Anand, Angelina Holcom, Michael Broussalian, Minna Schmidt, Shankar J Chinta, Gordon J Lithgow, Julie K Andersen, Manish Chamoli,

Mutations in the human ATP13A2 gene are associated with an early-onset form of Parkinson's disease (PD) known as Kufor Rakeb Syndrome (KRS). Patients with KRS show increased iron deposition in the basal ganglia, suggesting iron toxicity-induced neurodegeneration as a potential pathogenesis associated with the ATP13A2 mutation. Previously we demonstrated that ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2020, 139:104786]

Cited: 7 times

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Automated lifespan determination across Caenorhabditis strains and species reveals assay-specific effects of chemical interventions.

Stephen A Banse, Mark Lucanic, Christine A Sedore, Anna L Coleman-Hulbert, W Todd Plummer, Esteban Chen, Jason L Kish, David Hall, Brian Onken, Michael P Presley, E Grace Jones, Benjamin W Blue, Theo Garrett, Mark Abbott, Jian Xue, Suzhen Guo, Erik Johnson, Anna C Foulger, Manish Chamoli, Ron Falkowski, Ilija Melentijevic, Girish Harinath, Phu Huynh, Shobhna Patel, Daniel Edgar, Cody M Jarrett, Max Guo, Pankaj Kapahi, Gordon J Lithgow, Monica Driscoll, Patrick C Phillips,

The goal of the Caenorhabditis Intervention Testing Program is to identify robust and reproducible pro-longevity interventions that are efficacious across genetically diverse cohorts in the Caenorhabditis genus. The project design features multiple experimental replicates collected by three different laboratories. Our initial effort employed fully manual survival assays. With an interest ... Read more >>

Geroscience (GeroScience)
[2019, 41(6):945-960]

Cited: 4 times

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From discoveries in ageing research to therapeutics for healthy ageing.

Judith Campisi, Pankaj Kapahi, Gordon J Lithgow, Simon Melov, John C Newman, Eric Verdin,

For several decades, understanding ageing and the processes that limit lifespan have challenged biologists. Thirty years ago, the biology of ageing gained unprecedented scientific credibility through the identification of gene variants that extend the lifespan of multicellular model organisms. Here we summarize the milestones that mark this scientific triumph, discuss different ... Read more >>

Nature (Nature)
[2019, 571(7764):183-192]

Cited: 103 times

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Acarbose improves health and lifespan in aging HET3 mice.

David E Harrison, Randy Strong, Silvestre Alavez, Clinton Michael Astle, John DiGiovanni, Elizabeth Fernandez, Kevin Flurkey, Michael Garratt, Jonathan A L Gelfond, Martin A Javors, Moshe Levi, Gordon J Lithgow, Francesca Macchiarini, James F Nelson, Stacey J Sukoff Rizzo, Thomas J Slaga, Tim Stearns, John Erby Wilkinson, Richard A Miller,

To follow-up on our previous report that acarbose (ACA), a drug that blocks postprandial glucose spikes, increases mouse lifespan, we studied ACA at three doses: 400, 1,000 (the original dose), and 2,500 ppm, using genetically heterogeneous mice at three sites. Each dose led to a significant change (by log-rank test) in ... Read more >>

Aging Cell (Aging cell)
[2019, 18(2):e12898]

Cited: 21 times

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Natural Genetic Variation in Yeast Reveals That NEDD4 Is a Conserved Modifier of Mutant Polyglutamine Aggregation.

Theodore W Peters, Christopher S Nelson, Akos A Gerencser, Kathleen J Dumas, Brandon Tavshanjian, Kyu Chul Chang, Gordon J Lithgow, Robert E Hughes,

A feature common to late onset proteinopathic disorders is an accumulation of toxic protein conformers and aggregates in affected tissues. In the search for potential drug targets, many studies used high-throughput screens to find genes that modify the cytotoxicity of misfolded proteins. A complement to this approach is to focus ... Read more >>

G3 (Bethesda) (G3 (Bethesda, Md.))
[2018, 8(11):3421-3431]

Cited: 2 times

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A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans.

Mark Lucanic, Theo Garrett, Matthew S Gill, Gordon J Lithgow,

Caenorhabditis elegans is a useful organism for testing chemical effects on physiology. Whole organism small molecule screens offer significant advantages for identifying biologically active chemical structures that can modify complex phenotypes such as lifespan. Described here is a simple protocol for producing hundreds of 96-well culture plates with fairly consistent ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2018, (133):]

Cited: 5 times

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A long journey to reproducible results.

Gordon J Lithgow, Monica Driscoll, Patrick Phillips,

Nature (Nature)
[2017, 548(7668):387-388]

Cited: 41 times

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Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects.

Mark Lucanic, W Todd Plummer, Esteban Chen, Jailynn Harke, Anna C Foulger, Brian Onken, Anna L Coleman-Hulbert, Kathleen J Dumas, Suzhen Guo, Erik Johnson, Dipa Bhaumik, Jian Xue, Anna B Crist, Michael P Presley, Girish Harinath, Christine A Sedore, Manish Chamoli, Shaunak Kamat, Michelle K Chen, Suzanne Angeli, Christina Chang, John H Willis, Daniel Edgar, Mary Anne Royal, Elizabeth A Chao, Shobhna Patel, Theo Garrett, Carolina Ibanez-Ventoso, June Hope, Jason L Kish, Max Guo, Gordon J Lithgow, Monica Driscoll, Patrick C Phillips,

Limiting the debilitating consequences of ageing is a major medical challenge of our time. Robust pharmacological interventions that promote healthy ageing across diverse genetic backgrounds may engage conserved longevity pathways. Here we report results from the Caenorhabditis Intervention Testing Program in assessing longevity variation across 22 Caenorhabditis strains spanning 3 ... Read more >>

Nat Commun (Nature communications)
[2017, 8:14256]

Cited: 36 times

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Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson's Disease.

Dmitri Leonoudakis, Anand Rane, Suzanne Angeli, Gordon J Lithgow, Julie K Andersen, Shankar J Chinta,

Glial activation and subsequent release of neurotoxic proinflammatory factors are believed to play an important role in the pathogenesis of several neurological disorders including Parkinson's disease (PD). Inhibition of glial activation and inflammatory processes may represent a therapeutic target to alleviate neurodegeneration. Securinine, a major natural alkaloid product from the ... Read more >>

Mediators Inflamm (Mediators of inflammation)
[2017, 2017:8302636]

Cited: 12 times

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Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1.

Karla A Mark, Kathleen J Dumas, Dipa Bhaumik, Birgit Schilling, Sonnet Davis, Tal Ronnen Oron, Dylan J Sorensen, Mark Lucanic, Rachel B Brem, Simon Melov, Arvind Ramanathan, Bradford W Gibson, Gordon J Lithgow,

Vitamin D has multiple roles, including the regulation of bone and calcium homeostasis. Deficiency of 25-hydroxyvitamin D, the major circulating form of vitamin D, is associated with an increased risk of age-related chronic diseases, including Alzheimer's disease, Parkinson's disease, cognitive impairment, and cancer. In this study, we utilized Caenorhabditis elegans to ... Read more >>

Cell Rep (Cell reports)
[2016, 17(5):1227-1237]

Cited: 21 times

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A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification.

Jyotiska Chaudhuri, Neelanjan Bose, Jianke Gong, David Hall, Alexander Rifkind, Dipa Bhaumik, T Harshani Peiris, Manish Chamoli, Catherine H Le, Jianfeng Liu, Gordon J Lithgow, Arvind Ramanathan, X Z Shawn Xu, Pankaj Kapahi,

Reactive α-dicarbonyls (α-DCs), like methylglyoxal (MGO), accumulate with age and have been implicated in aging and various age-associated pathologies, such as diabetic complications and neurodegenerative disorders like Alzheimer's and Parkinson's diseases. Evolutionarily conserved glyoxalases are responsible for α-DC detoxification; however, their core biochemical regulation has remained unclear. We have established ... Read more >>

Curr Biol (Current biology : CB)
[2016, 26(22):3014-3025]

Cited: 17 times

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Chemical activation of a food deprivation signal extends lifespan.

Mark Lucanic, Theo Garrett, Ivan Yu, Fernando Calahorro, Azar Asadi Shahmirzadi, Aaron Miller, Matthew S Gill, Robert E Hughes, Lindy Holden-Dye, Gordon J Lithgow,

Model organisms subject to dietary restriction (DR) generally live longer. Accompanying this lifespan extension are improvements in overall health, based on multiple metrics. This indicates that pharmacological treatments that mimic the effects of DR could improve health in humans. To find new chemical structures that extend lifespan, we screened 30 000 ... Read more >>

Aging Cell (Aging cell)
[2016, 15(5):832-841]

Cited: 14 times

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Zinc Levels Modulate Lifespan through Multiple Longevity Pathways in Caenorhabditis elegans.

Jitendra Kumar, Tracy Barhydt, Anjali Awasthi, Gordon J Lithgow, David W Killilea, Pankaj Kapahi,

Zinc is an essential trace metal that has integral roles in numerous biological processes, including enzymatic function, protein structure, and cell signaling pathways. Both excess and deficiency of zinc can lead to detrimental effects on development and metabolism, resulting in abnormalities and disease. We altered the zinc balance within Caenorhabditis ... Read more >>

PLoS One (PloS one)
[2016, 11(4):e0153513]

Cited: 13 times

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Long live FOXO: unraveling the role of FOXO proteins in aging and longevity.

Rute Martins, Gordon J Lithgow, Wolfgang Link,

Aging constitutes the key risk factor for age-related diseases such as cancer and cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are complex phenotypes influenced by both environmental and genetic factors. The fact that genetic contribution to lifespan strongly increases with greater age provides basis for research on which ... Read more >>

Aging Cell (Aging cell)
[2016, 15(2):196-207]

Cited: 209 times

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