Full Text Journal Articles by
Author Gordon D Rubenfeld

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Reflections on Critical Care's Past, Present, and Future.

Manu Shankar-Hari, Hannah Wunsch, Kathy Rowan, Mervyn Singer, Gordon D Rubenfeld, Derek C Angus,

Crit Care Med (Critical care medicine)
[2021, 49(11):1855-1865]

Cited: 0 times

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What Can Simulations Tell Us About Triage Protocols in a Real Pandemic?

Abhinay Sathya, Gordon D Rubenfeld, Rob Fowler,

Chest (Chest)
[2021, 160(2):398-399]

Cited: 0 times

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Structural Racism and JAMA Network Open.

Frederick P Rivara, Steven M Bradley, Daniel V Catenacci, Angel N Desai, Ishani Ganguli, Sebastien J P A Haneuse, Sharon K Inouye, Elizabeth A Jacobs, Kristin Kan, Howard S Kim, Arden M Morris, Olugbenga Ogedegbe, Eli N Perencevich, Roy H Perlis, Elizabeth Powell, Gordon D Rubenfeld, Lawrence N Shulman, N Seth Trueger, Stephan D Fihn,

JAMA Netw Open (JAMA network open)
[2021, 4(6):e2120269]

Cited: 2 times

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Risk Factors for Cytomegalovirus Reactivation and Association With Outcomes in Critically Ill Adults With Sepsis: A Pooled Analysis of Prospective Studies.

Hannah Imlay, Sayan Dasgupta, Michael Boeckh, Renee D Stapleton, Gordon D Rubenfeld, Ying Chen, Ajit P Limaye,

We performed multivariable analysis of potential risk factors (including cytomegalovirus [CMV] reactivation) for clinical outcomes by day 28 (death or continued hospitalization, ventilator-free days, intensive care unit (ICU)-free days, hospital-free days) from pooled cohorts of 2 previous prospective studies of CMV-seropositive adults with sepsis. CMV reactivation at any level, >100 ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2021, 223(12):2108-2112]

Cited: 0 times

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Reporting Clinical Studies Affected by the COVID-19 Pandemic: Guidelines for Authors.

Roy H Perlis, Sebastien J P A Haneuse, Gordon D Rubenfeld, Stephan D Fihn, Frederick P Rivara,

JAMA Netw Open (JAMA network open)
[2021, 4(1):e2036155]

Cited: 0 times

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Prevalence of Clostridioides difficile Infection in Critically Ill Patients with Extreme Leukocytosis and Diarrhea.

Bijan Teja, Nafeesa Alibhai, Gordon D Rubenfeld, Linda R Taggart, Naheed Jivraj, Sameer A Hirji, Brian P O'Gara, Shahzad Shaefi,

While early empiric antibiotic therapy is beneficial for patients presenting with sepsis, the presentation of sepsis from <i>Clostridioides difficile</i> (formerly <i>Clostridium difficile</i>) infection (CDI) has not been well studied in large cohorts. We sought to determine whether the combination of extreme leukocytosis and diarrhea was strongly predictive of CDI in ... Read more >>

Infect Dis Rep (Infectious disease reports)
[2021, 13(1):18-22]

Cited: 0 times

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Identifying Subjects at Risk for Diaphragm Atrophy During Mechanical Ventilation Using Routinely Available Clinical Data.

Martin Urner, Nicholas Mitsakakis, Stefannie Vorona, Lu Chen, Michael C Sklar, Martin Dres, Gordon D Rubenfeld, Laurent J Brochard, Niall D Ferguson, Eddy Fan, Ewan C Goligher,

<h4>Background</h4>Diaphragmatic respiratory effort during mechanical ventilation is an important determinant of patient outcome, but direct measurement of diaphragmatic contractility requires specialized instrumentation and technical expertise. We sought to determine whether routinely collected clinical variables can predict diaphragmatic contractility and stratify the risk of diaphragm atrophy.<h4>Methods</h4>We conducted a secondary analysis of ... Read more >>

Respir Care (Respiratory care)
[2021, 66(4):551-558]

Cited: 0 times

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Barriers and Facilitators to Early Rehabilitation in the ICU: A Theory Driven Delphi Study.

Brian H Cuthbertson, Shannon L Goddard, Fabiana Lorencatto, Ellen Koo, Louise Rose, Eddy Fan, Michelle E Kho, Dale M Needham, Gordon D Rubenfeld, Jill J Francis,

<h4>Objectives</h4>There is conflicting evidence for the effectiveness of early rehabilitation in the intensive care and marked variation in rates of implementation in practice. We aimed to identify barriers and facilitators to early rehabilitation in mechanically ventilated patients and their relevance to practice, as perceived by key ICU clinicians across North ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(12):e1171-e1178]

Cited: 1 time

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Anesthesiologist to Patient Communication: A Systematic Review.

Michael J Tylee, Gordon D Rubenfeld, Duminda Wijeysundera, Michael C Sklar, Sajid Hussain, Neill K J Adhikari,

<h4>Importance</h4>Many patients are admitted to the intensive care unit following surgery, and some of them will experience incomplete recovery. For patients in this situation, preoperative discussions regarding patient values and preferences may direct care decisions. Existing literature shows that it is uncommon for surgeons to have these conversations preoperatively; it ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(11):e2023503]

Cited: 0 times

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Development, Validation, and Clinical Utility Assessment of a Prognostic Score for 1-Year Unplanned Rehospitalization or Death of Adult Sepsis Survivors.

Manu Shankar-Hari, Gordon D Rubenfeld, Paloma Ferrando-Vivas, David A Harrison, Kathryn Rowan,

<h4>Importance</h4>The longer-term risk of rehospitalizations and death of adult sepsis survivors is associated with index sepsis illness characteristics.<h4>Objective</h4>To derive and validate a parsimonious prognostic score for unplanned rehospitalizations or death in the first year after hospital discharge of adult sepsis survivors.<h4>Design, setting, and participants</h4>This cohort study used data from the ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(9):e2013580]

Cited: 0 times

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Sleep Fragmentation and Cognitive Trajectories After Critical Illness.

Mary Elizabeth Wilcox, Mary Pat McAndrews, Julie Van, James C Jackson, Ruxandra Pinto, Sandra E Black, Andrew S Lim, Jan O Friedrich, Gordon D Rubenfeld,

<h4>Background</h4>ICU survivors can experience both cognitive dysfunction and persistent sleep disturbances after hospitalization. Sleep disturbances have been linked with cognitive impairment in various patient populations, and the apolipoprotein E (APOE) genotype has been linked to sleep-related impairments in cognition.<h4>Research question</h4>Is there an association between sleep, long-term cognition, and APOE status ... Read more >>

Chest (Chest)
[2021, 159(1):366-381]

Cited: 2 times

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Standardized Management for Hypoxemic Respiratory Failure and ARDS: Systematic Review and Meta-analysis.

Ken Kuljit S Parhar, Henry T Stelfox, Kirsten M Fiest, Gordon D Rubenfeld, Danny J Zuege, Gwen Knight, Helen Lee Robertson, Andrea Soo, Christopher J Doig, Daniel J Niven,

<h4>Background</h4>Treatment of hypoxemic respiratory failure (HRF) and ARDS is complex. Standardized management of HRF and ARDS may improve adherence to evidence-informed practice and improve outcomes.<h4>Research question</h4>What is the effect of standardized treatment compared with usual care on survival of patients with HRF and ARDS?<h4>Study design and methods</h4>MEDLINE, EMBASE, Cochrane, CINAHL, ... Read more >>

Chest (Chest)
[2020, 158(6):2358-2369]

Cited: 2 times

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Association of Low Baseline Diaphragm Muscle Mass With Prolonged Mechanical Ventilation and Mortality Among Critically Ill Adults.

Michael C Sklar, Martin Dres, Eddy Fan, Gordon D Rubenfeld, Damon C Scales, Margaret S Herridge, Nuttapol Rittayamai, Michael O Harhay, W Darlene Reid, George Tomlinson, Dmitry Rozenberg, William McClelland, Stephen Riegler, Arthur S Slutsky, Laurent Brochard, Niall D Ferguson, Ewan C Goligher,

Importance:Low diaphragm muscle mass at the outset of mechanical ventilation may predispose critically ill patients to poor clinical outcomes. Objective:To determine whether lower baseline diaphragm thickness (Tdi) is associated with delayed liberation from mechanical ventilation and complications of acute respiratory failure (reintubation, tracheostomy, prolonged ventilation >14 days, or death in ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(2):e1921520]

Cited: 5 times

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Rate and risk factors for rehospitalisation in sepsis survivors: systematic review and meta-analysis.

Manu Shankar-Hari, Rohit Saha, Julie Wilson, Hallie C Prescott, David Harrison, Kathryn Rowan, Gordon D Rubenfeld, Neill K J Adhikari,

<h4>Purpose</h4>Sepsis survivors have a higher risk of rehospitalisation and of long-term mortality. We assessed the rate, diagnosis, and independent predictors for rehospitalisation in adult sepsis survivors.<h4>Methods</h4>We searched for non-randomized studies and randomized clinical trials in MEDLINE, Cochrane Library, Web of Science, and EMBASE (OVID interface, 1992-October 2019). The search strategy ... Read more >>

Intensive Care Med (Intensive care medicine)
[2020, 46(4):619-636]

Cited: 5 times

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2307. Risk factors for Cytomegalovirus (CMV) reactivation and Association with Clinical Outcomes in Critically Ill Adults with Sepsis: A Pooled Analysis of Prospective Studies

Hannah Imlay, Sayan Dasgupta, Michael Boeckh, Renee D Stapleton, Gordon D Rubenfeld, Ying Chen, Ajit P Limaye,

Abstract <h4>Background</h4> CMV reactivation in seropositive, non-immunosuppressed adults with sepsis has been associated with worse clinical outcomes. To inform rational design of interventional trials determining whether CMV prevention improves outcomes, it is critical to identify the independence and strength of the association of CMV reactivation measures with clinically-relevant endpoints. Identification ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S791-S791]

Cited: 0 times

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Population enrichment for critical care trials: phenotypes and differential outcomes.

Manu Shankar-Hari, Gordon D Rubenfeld,

<h4>Purpose of review</h4>Sepsis and acute respiratory distress syndrome (ARDS) are two heterogenous acute illnesses where numerous RCTs have indeterminate results. We present a narrative review on the recent developments in enriching patient populations for future sepsis and ARDS trials.<h4>Recent findings</h4>Many researchers are actively pursuing enrichment strategies to reduce heterogeneity to ... Read more >>

Curr Opin Crit Care (Current opinion in critical care)
[2019, 25(5):489-497]

Cited: 10 times

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Actigraphic measures of sleep on the wards after ICU discharge.

M Elizabeth Wilcox, Gordon D Rubenfeld, Karolina D Walczak, Sandra E Black, Mary Pat McAndrews, Andrew S Lim,

<h4>Background</h4>The purpose of this study was to use an objective measure to evaluate sleep quality on the ward after ICU discharge in survivors of critical illness.<h4>Materials and methods</h4>This was a prospective cohort study of 94 patients admitted to a multidisciplinary intensive care unit (ICU) between December 2013 and June 2017. ... Read more >>

J Crit Care (Journal of critical care)
[2019, 54:163-169]

Cited: 1 time

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Risk Factors at Index Hospitalization Associated With Longer-term Mortality in Adult Sepsis Survivors.

Manu Shankar-Hari, David A Harrison, Paloma Ferrando-Vivas, Gordon D Rubenfeld, Kathryn Rowan,

<h4>Importance</h4>Sepsis survivors, defined as adult patients who survived to hospital discharge following a critical care unit admission for sepsis, are at increased risk of long-term mortality. Identifying factors independently associated with long-term mortality, known during critical care admission for sepsis, could inform targeted strategies to reduce this risk.<h4>Objective</h4>To assess, in ... Read more >>

JAMA Netw Open (JAMA network open)
[2019, 2(5):e194900]

Cited: 12 times

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Trends in site of death and health care utilization at the end of life: a population-based cohort study.

Andrea D Hill, Therese A Stukel, Longdi Fu, Damon C Scales, Andreas Laupacis, Gordon D Rubenfeld, Hannah Wunsch, James Downar, Kenneth Rockwood, Daren K Heyland, Samir K Sinha, Camilla Zimmermann, Sonal Gandhi, Jeff Myers, Heather J Ross, Jean F Kozak, Scott Berry, Shelly P Dev, Ignazio La Delfa, Robert A Fowler,

<h4>Background</h4>High rates of health care utilization at the end of life may be a marker of care that does not align with patient-stated preferences. We sought to describe trends in end-of-life care and factors associated with dying in hospital.<h4>Methods</h4>We conducted a population-level retrospective cohort study of adult decedents in Ontario ... Read more >>

CMAJ Open (CMAJ open)
[2019, 7(2):E306-E315]

Cited: 7 times

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Diaphragmatic myotrauma: a mediator of prolonged ventilation and poor patient outcomes in acute respiratory failure.

Ewan C Goligher, Laurent J Brochard, W Darlene Reid, Eddy Fan, Olli Saarela, Arthur S Slutsky, Brian P Kavanagh, Gordon D Rubenfeld, Niall D Ferguson,

Several mechanisms of diaphragm muscle injury (myotrauma) can result in ventilator-induced diaphragm dysfunction, including ventilator over-assistance, under-assistance, eccentric contractions, and end-expiratory shortening. In this Personal View, we summarise the evidence for the clinical relevance of these mechanisms, and present new data based on mediation analysis supporting the hypothesis that myotrauma ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2019, 7(1):90-98]

Cited: 29 times

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Lessons From ARDS for Non-ARDS Research: Remembrance of Trials Past.

Gordon D Rubenfeld, Manu Shankar-Hari,

JAMA (JAMA)
[2018, 320(18):1863-1865]

Cited: 6 times

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Trends in Use of Daily Chest Radiographs Among US Adults Receiving Mechanical Ventilation.

Hayley B Gershengorn, Hannah Wunsch, Damon C Scales, Gordon D Rubenfeld,

<h4>Importance</h4>Guidelines from December 2011 recommended against obtaining daily chest radiographs (CXRs) for patients requiring mechanical ventilation (MV). Daily CXR use for patients receiving MV in US hospitals is unknown and, if high, may represent an opportunity to reduce low-value care and unnecessary radiation.<h4>Objectives</h4>To determine frequency of daily CXR use for ... Read more >>

JAMA Netw Open (JAMA network open)
[2018, 1(4):e181119]

Cited: 3 times

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Competing and conflicting interests in the care of critically ill patients.

Alison E Turnbull, Sarina K Sahetya, E Lee Daugherty Biddison, Christiane S Hartog, Gordon D Rubenfeld, Dominique D Benoit, Bertrand Guidet, Rik T Gerritsen, Mark R Tonelli, J Randall Curtis,

Medical professionals are expected to prioritize patient interests, and most patients trust physicians to act in their best interest. However, a single patient is never a physician's sole concern. The competing interests of other patients, clinicians, family members, hospital administrators, regulators, insurers, and trainees are omnipresent. While prioritizing patient interests ... Read more >>

Intensive Care Med (Intensive care medicine)
[2018, 44(10):1628-1637]

Cited: 0 times

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Impact of ICU Structure and Processes of Care on Outcomes After Severe Traumatic Brain Injury: A Multicenter Cohort Study.

Victoria A McCredie, Aziz S Alali, Damon C Scales, Gordon D Rubenfeld, Brian H Cuthbertson, Avery B Nathens,

OBJECTIVES:It is uncertain whether dedicated neurocritical care units are associated with improved outcomes for critically ill neurologically injured patients in the era of collaborative protocol-driven care. We examined the association between dedicated neurocritical care units and mortality and the effects of standardized management protocols for severe traumatic brain injury. DESIGN:We ... Read more >>

Crit Care Med (Critical care medicine)
[2018, 46(7):1139-1149]

Cited: 9 times

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Sleep on the ward in intensive care unit survivors: a case series of polysomnography.

Mary Elizabeth Wilcox, Andrew S Lim, Ruxandra Pinto, Sandra E Black, Mary Pat McAndrews, Gordon D Rubenfeld,

<h4>Background</h4>Few studies have investigated sleep in patients after intensive care despite the possibility that inadequate sleep might further complicate an acute illness impeding recovery.<h4>Aims</h4>To assess the quality and quantity of a patient's sleep on the ward by polysomnography (PSG) within a week of intensive care unit (ICU) discharge and to ... Read more >>

Intern Med J (Internal medicine journal)
[2018, 48(7):795-802]

Cited: 2 times

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