Full Text Journal Articles by
Author Gordana Supic

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An insight into osteoarthritis susceptibility: Integration of immunological and genetic background.

Debora Stefik, Vladimir Vranic, Nemanja Ivkovic, Dzihan Abazovic, Dusan Maric, Danilo Vojvodic, Gordana Supic,

Osteoarthritis (OA) is a progressive degenerative disease that affects all synovial joints, causing the disability of the main locomotor diarthrodial joints. OA pathogenesis is caused by a complex interplay between a number of genetic and environmental risk factors, involved in the early onset and progression of this chronic inflammatory joint ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

Cited: 0 times

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Expression of SIRT1, SIRT3 and SIRT6 Genes for Predicting Survival in Triple-Negative and Hormone Receptor-Positive Subtypes of Breast Cancer.

Bojana Uzelac, Ana Krivokuca, Mirjana Brankovic-Magic, Zvonko Magic, Snezana Susnjar, Zorka Milovanovic, Gordana Supic,

Triple-negative breast cancer (TNBC) is characterized by aggressive phenotype and a poorer prognosis compared to the estrogen and progesterone receptor positive, Her2 negative (ER + PR + Her2-) breast cancer. Increasing evidence suggests that sirtuins, a family of histone deacetylases, could have an important role in aggressiveness of TNBC's. The current study evaluated the ... Read more >>

Pathol. Oncol. Res. (Pathology oncology research : POR)
[2020, 26(4):2723-2731]

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DNMT1 and DNMT3B genetic polymorphisms affect the clinical course and outcome of melanoma patients.

Helena Maric, Gordana Supic, Lidija Kandolf-Sekulovic, Veljko Maric, Zeljko Mijuskovic, Tatjana Radevic, Milica Rajovic, Zvonko Magic,

The aberrant DNA methylation plays a critical role in a number of different malignancies, including melanoma. DNA methylation is catalyzed by DNA methyltransferases (DNMTs), involved in methylation maintenance (DNMT1) and de novo DNA methylation (DNMT3A and DNMT3B). The current study investigated the association of genetic variants in the DNMT1 and ... Read more >>

Melanoma Res. (Melanoma research)
[2019, 29(6):596-602]

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Hedgehog signaling pathway and vitamin D receptor gene variants as potential risk factors in odontogenic cystic lesions.

Marko Magic, Katarina Zeljic, Stevo Jovandic, Jelena Stepic, Marko Pejovic, Snjezana Colic, Zvonko Magic, Gordana Supic,

OBJECTIVES:Genetic variants in the hedgehog signaling pathway and VDR gene are involved in inflammatory responses and neoplastic transformation. Current study investigated whether single-nucleotide polymorphisms in the hedgehog pathway genes PTCH1, GLI1, SMO, and VDR contribute to susceptibility to odontogenic cystic lesions, odontogenic keratocysts, or inflammatory radicular cysts. MATERIAL AND METHODS:Current ... Read more >>

Clin Oral Investig (Clinical oral investigations)
[2019, 23(6):2675-2684]

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Pulp Sensitivity: Influence of Sex, Psychosocial Variables, COMT Gene, and Chronic Facial Pain.

Irena Mladenovic, Jelena Krunic, Gordana Supic, Ruzica Kozomara, Dejan Bokonjic, Nikola Stojanovic, Zvonko Magic,

INTRODUCTION:The purpose of this study was to evaluate the associations of variability in pulp sensitivity with sex, psychosocial variables, the gene that encodes for the enzyme catechol-O-methyltransferase (COMT), and chronic painful conditions (temporomandibular disorders [TMDs]). METHODS:The study was composed of 97 subjects (68 women and 29 men aged 20-44 years). ... Read more >>

J Endod (Journal of endodontics)
[2018, 44(5):717-721.e1]

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Promoter hypermethylation of p16, BRCA1 and RASSF1A genes in triple-negative breast cancer patients from Serbia.

Zoran Kozomara, Gordana Supic, Ana Krivokuca, Zvonko Magic, Radan Dzodic, Zorka Milovanovic, Mirjana Brankovic-Magic,

PURPOSE:In order to investigate if aberrant promoter methylation of p16, BRCA1 and RASSF1A genes contributes to biological behavior of triple-negative breast cancer (TNBC), marked as the most aggressive phenotype of breast cancer, we compared the hypermethylation pattern between TNBC and ER+PR+Her2- breast cancer. METHODS:131 patients with histologically confirmed breast cancers ... Read more >>

J BUON (Journal of B.U.ON. : official journal of the Balkan Union of Oncology)
[2018, 23(3):684-691]

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MicroRNA meta-signature of oral cancer: evidence from a meta-analysis.

Katarina Zeljic, Ivan Jovanovic, Jasmina Jovanovic, Zvonko Magic, Aleksandra Stankovic, Gordana Supic,

AIM:It was the aim of the study to identify commonly deregulated miRNAs in oral cancer patients by performing a meta-analysis of previously published miRNA expression profiles in cancer and matched normal non-cancerous tissue in such patients. MATERIAL AND METHODS:Meta-analysis included seven independent studies analyzed by a vote-counting method followed by ... Read more >>

Ups. J. Med. Sci. (Upsala journal of medical sciences)
[2018, 123(1):43-49]

Cited: 9 times

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miR-183 and miR-21 expression as biomarkers of progression and survival in tongue carcinoma patients.

Gordana Supic, Katarina Zeljic, Aleksandra Divac Rankov, Ruzica Kozomara, Aleksandra Nikolic, Dragica Radojkovic, Zvonko Magic,

Micro RNAs (miRNAs) have a major role in human cancerogenesis.The current study investigated the prognostic significance of miR-183 and miR-21 expression in tongue carcinoma patients.For qPCR of miR-183 and miR-21 expression, total RNA isolated from 60 fresh-frozen tissue of tongue carcinomas was converted into cDNA by TaqMan MicroRNA Reverse Transcription ... Read more >>

Clin Oral Investig (Clinical oral investigations)
[2018, 22(1):401-409]

Cited: 7 times

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New insights into vitamin D anticancer properties: focus on miRNA modulation.

Katarina Zeljic, Gordana Supic, Zvonko Magic,

Vitamin D anticancer properties are well known and have been demonstrated in many in vitro and in vivo studies. Mechanistic insights have given an explanation on how vitamin D exerts antineoplastic functions, which are mainly conducted via the canonical vitamin D receptor (VDR)-vitamin D response elements (VDRE) pathway. Numerous findings ... Read more >>

Mol. Genet. Genomics (Molecular genetics and genomics : MGG)
[2017, 292(3):511-524]

Cited: 14 times

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Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain.

Irena Mladenovic, Gordana Supic, Ruzica Kozomara, Slobodan Dodic, Nedeljka Ivkovic, Bojana Milicevic, Ivana Simic, Zvonko Magic,

To evaluate the association between catechol-O-methyltransferase (COMT) gene polymorphisms and temporomandibular disorders (TMD), TMD pain, psychosocial impairment related to TMD, and postoperative pain.A total of 90 patients with a diagnosis of painful TMD and 92 matched controls were investigated for the presence of TMD, TMD pain, and psychosocial variables by ... Read more >>

J Oral Facial Pain Headache (Journal of oral & facial pain and headache)
[2016, 30(4):302-310]

Cited: 3 times

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Prognostic value of the DNMTs mRNA expression and genetic polymorphisms on the clinical outcome in oral cancer patients.

Gordana Supic, Ruzica Kozomara, Katarina Zeljic, Nebojsa Jovic, Zvonko Magic,

Although the importance of the epigenetic changes in tumors, including oral squamous cell carcinomas (OSCCs), is now becoming apparent, the mechanisms that trigger or cause aberrant DNA methylation in cancer are still unrevealed. DNA methylation is regulated by a family of enzymes, DNA methyltransferases (DNMTs). DNMT gene expression analysis, as ... Read more >>

Clin Oral Investig (Clinical oral investigations)
[2017, 21(1):173-182]

Cited: 6 times

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Association of vdr, cyp27b1, cyp24a1 and mthfr gene polymorphisms with oral lichen planus risk.

Bojan Kujundzic, Katarina Zeljic, Gordana Supic, Marko Magic, Dragan Stanimirovic, Vesna Ilic, Barbara Jovanovic, Zvonko Magic,

The current study investigated the association between VDR EcoRV (rs4516035), FokI (rs2228570), ApaI (rs7975232) and TaqI (rs731236), CYP27B1 (rs4646536), CYP24A1 (rs2296241), and MTHFR (rs1801133) gene polymorphisms and risk of oral lichen planus (OLP) occurrence.The study group consisted of 65 oral lichen planus patients and 100 healthy blood donors in the ... Read more >>

Clin Oral Investig (Clinical oral investigations)
[2016, 20(4):781-789]

Cited: 5 times

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Melanoma risk is associated with vitamin D receptor gene polymorphisms.

Katarina Zeljic, Lidija Kandolf-Sekulovic, Gordana Supic, Janko Pejovic, Marijan Novakovic, Zeljko Mijuskovic, Zvonko Magic,

Previous studies have reported that vitamin D receptor (VDR) gene polymorphisms are associated with the occurrence of various cancers, including melanoma. The aim of the current study was to investigate the association of VDR gene polymorphisms with melanoma risk, clinicopathological characteristics, and vitamin D levels. The study group included 117 ... Read more >>

Melanoma Res. (Melanoma research)
[2014, 24(3):273-279]

Cited: 13 times

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The nobel prize in physiology or medicine 2013.

Gordana Supic,

Vojnosanit Pregl (Vojnosanitetski pregled)
[2013, 70(11):991-992]

Cited: 0 times

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Next-generation sequencing identifies microRNAs that associate with pathogenic autoimmune neuroinflammation in rats.

Petra Bergman, Tojo James, Lara Kular, Sabrina Ruhrmann, Tatiana Kramarova, Anders Kvist, Gordana Supic, Alan Gillett, Andor Pivarcsi, Maja Jagodic,

MicroRNAs (miRNAs) are known to regulate most biological processes and have been found dysregulated in a variety of diseases, including multiple sclerosis (MS). In this study, we characterized miRNAs that associate with susceptibility to develop experimental autoimmune encephalomyelitis (EAE) in rats, a well-established animal model of MS. Using Illumina next-generation ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2013, 190(8):4066-4075]

Cited: 16 times

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Epigenetics: a new link between nutrition and cancer.

Gordana Supic, Maja Jagodic, Zvonko Magic,

Emerging studies suggest that dietary components can affect gene expression through epigenetic mechanisms. Epigenetic modifications are heritable and potentially reversible changes in gene expression that do not require changes in the DNA sequence. The main mechanisms of epigenetic control in mammals are DNA methylation, histone modifications, and RNA silencing. The ... Read more >>

Nutr Cancer (Nutrition and cancer)
[2013, 65(6):781-792]

Cited: 29 times

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Vitamin D receptor, CYP27B1 and CYP24A1 genes polymorphisms association with oral cancer risk and survival.

Katarina Zeljic, Gordana Supic, Marina Stamenkovic Radak, Nebojsa Jovic, Ruzica Kozomara, Zvonko Magic,

Genetic polymorphisms of vitamin D receptor gene (VDR) and genes involved in vitamin D metabolism pathway, CYP27B1 and CYP24B1, may affect individual susceptibility to oral squamous cell carcinoma. The purpose of this study was to evaluate the associations between VDR, CYP27B1 and CYP24A1 gene polymorphisms with oral cancer risk and ... Read more >>

J. Oral Pathol. Med. (Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology)
[2012, 41(10):779-787]

Cited: 29 times

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Association of VEGF-A genetic polymorphisms with cancer risk and survival in advanced-stage oral squamous cell carcinoma patients.

Gordana Supic, Nebojsa Jovic, Katarina Zeljic, Ruzica Kozomara, Zvonko Magic,

BACKGROUND: Vascular endothelial growth factor (VEGF), a key mediator of angiogenesis, is overexpressed in a wide variety of human cancers, including oral squamous cell carcinoma (OSCC). In this study, we examined whether individual polymorphisms within VEGF-A gene, rs699947 (-2578C/A), rs1570360 (-1154G/A), rs2010963 (-634G/C), rs3025039 (+936C/T) or their haplotypes are associated ... Read more >>

Oral Oncol. (Oral oncology)
[2012, 48(11):1171-1177]

Cited: 19 times

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Prognostic significance of tumor-related genes hypermethylation detected in cancer-free surgical margins of oral squamous cell carcinomas.

Gordana Supic, Ruzica Kozomara, Nebojsa Jovic, Katarina Zeljic, Zvonko Magic,

Oral squamous cell carcinoma (OSCC) is characterized by high mortality rates. High incidence of local recurrences in the normal-appearing surgical margins of OSCC patients indicates the existence molecular alterations, including DNA methylation, which could not be detectable by histopathologic analysis. The objective of our study was to determine correlation of ... Read more >>

Oral Oncol. (Oral oncology)
[2011, 47(8):702-708]

Cited: 40 times

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Genetic polymorphisms of ADH1C and CYP2E1 and risk of oral squamous cell carcinoma.

Miroslav Brocic, Gordana Supic, Katarina Zeljic, Nebojsa Jovic, Ruzica Kozomara, Sladjana Zagorac, Milica Zlatkovic, Zvonko Magic,

OBJECTIVE: Several studies have suggested that the metabolism of alcohol is modulated by the polymorphisms in genes encoding ethanol-metabolizing enzymes, including alcohol dehydrogenase 1C, ADH1C, and cytochrome P450-dependent monooxygenase, CYP2E1. Genetic polymorphisms of ethanol-metabolizing enzymes may affect individual susceptibility to oral cancer. The purpose of this study was to investigate ... Read more >>

Otolaryngol Head Neck Surg (Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery)
[2011, 145(4):586-593]

Cited: 10 times

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Immunomodulatory properties of mesenchymal stem cells derived from dental pulp and dental follicle are susceptible to activation by toll-like receptor agonists.

Sergej Tomic, Jelena Djokic, Sasa Vasilijic, Dragana Vucevic, Vera Todorovic, Gordana Supic, Miodrag Colic,

Adult mesenchymal stem cells (MSCs) have recently become a potent tool in regenerative medicine. Due to certain shortcomings of obtaining bone marrow MSCs, alternate sources of MSCs have been sought. In this work, we studied MSCs from dental pulp (DP-MSCs) and dental follicle (DF-MSCs), isolated from the same tooth/donor, to ... Read more >>

Stem Cells Dev. (Stem cells and development)
[2011, 20(4):695-708]

Cited: 65 times

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Gene hypermethylation in tumor tissue of advanced oral squamous cell carcinoma patients.

Gordana Supić, Ruzica Kozomara, Mirjana Branković-Magić, Nebojsa Jović, Zvonko Magić,

Oral squamous cell carcinoma (OSCC) is characterized by high mortality rate and rising incidence. The aim of this study was to examine the methylation of particular tumor suppressor genes promoters in OSCC and to correlate the methylation status with the tumor-host features and patients survival. The genes selected for our ... Read more >>

Oral Oncol. (Oral oncology)
[2009, 45(12):1051-1057]

Cited: 35 times

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Increased nitric oxide formation followed by increased arginase activity induces relative lack of arginine at the wound site and alters whole nutritional status in rats almost within the early healing period.

Gordana Zunić, Gordana Supić, Zvonko Magić, Biljana Drasković, Milijana Vasiljevska,

Nitric oxide (NO) production and free amino acid fluxes at the wound side during the first 3 days following cutaneous wound were investigated. Experiments were performed on Albino Oxford rats (n=18) underwent cutaneous implantation of polyvinyl sponges. Intact animals (n=6) were controls. Nitrites, nitrates, free amino acids and urea were ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2009, 20(4):253-258]

Cited: 12 times

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