Full Text Journal Articles by
Author Gopal Potti

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Stability of isoniazid injection in i.v. solutions.

Jun H Lee, Brad Moriyama, Stacey A Henning, Robert L Danner, Thomas J Walsh, Scott R Penzak, George J Grimes, Gopal K Potti,

PURPOSE:Results of an assessment of the chemical stability of isoniazid injection in 0.9% sodium chloride injection and 5% dextrose injection are reported. METHODS:Triplicate solutions of isoniazid (0.5 and 6.0 mg/mL) in the 2 diluents were prepared in ethylene and propylene copolymer i.v. containers and stored under light protection at room ... Read more >>

Am J Health Syst Pharm (American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists)
[2018, 75(10):622-626]

Cited: 0 times

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Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate.

Kara S Hughan, Stacy Gelhaus Wendell, Meghan Delmastro-Greenwood, Nicole Helbling, Catherine Corey, Landon Bellavia, Gopal Potti, George Grimes, Bret Goodpaster, Daniel B Kim-Shapiro, Sruti Shiva, Bruce A Freeman, Mark T Gladwin,

Dietary NO3- (nitrate) and NO2- (nitrite) support ˙NO (nitric oxide) generation and downstream vascular signaling responses. These nitrogen oxides also generate secondary nitrosating and nitrating species that react with low molecular weight thiols, heme centers, proteins, and unsaturated fatty acids. To explore the kinetics of NO3-and NO2-metabolism and the impact ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2017, 70(3):634-644]

Cited: 7 times

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Dose-escalation study of octanoic acid in patients with essential tremor.

Bernhard Voller, Emily Lines, Gayle McCrossin, Sule Tinaz, Codrin Lungu, George Grimes, Judith Starling, Gopal Potti, Peter Buchwald, Dietrich Haubenberger, Mark Hallett,

Recently, 1-octanol has been shown to have efficacy in treating patients with essential tremor (ET). The primary metabolite of 1-octanol is octanoic acid (OA), which is now thought to be the active substance that mediates tremor suppression. Our aim was to describe the maximum tolerated dose (MTD) of oral OA ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2016, 126(4):1451-1457]

Cited: 5 times

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Assays for biological agents--author's reply.

Justin T Goldspiel, Barry R Goldspiel, George Grimes, Peng Yuan, Gopal Potti,

Am J Health Syst Pharm (American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists)
[2013, 70(13):1102]

Cited: 0 times

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Octanoic acid in alcohol-responsive essential tremor: a randomized controlled study.

Dietrich Haubenberger, Gayle McCrossin, Codrin Lungu, Elaine Considine, Camilo Toro, Fatta B Nahab, Sungyoung Auh, Peter Buchwald, George J Grimes, Judith Starling, Gopal Potti, Linda Scheider, Daniel Kalowitz, Daniel Bowen, Andrea Carnie, Mark Hallett,

To assess safety and efficacy of an oral, single, low dose of octanoic acid (OA) in subjects with alcohol-responsive essential tremor (ET).We conducted a double-blind, placebo-controlled, crossover, phase I/II clinical trial evaluating the effect of 4 mg/kg OA in 19 subjects with ET. The primary outcome was accelerometric postural tremor ... Read more >>

Neurology (Neurology)
[2013, 80(10):933-940]

Cited: 15 times

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Safety and pharmacokinetics of a preservative-free triamcinolone acetonide formulation for intravitreal administration.

Hyuncheol Kim, Karl G Csaky, Luisa Gravlin, Peng Yuan, Robert J Lutz, Peter M Bungay, Ginger Tansey, Francisco DE Monasterio, Gopal K Potti, George Grimes, Michael R Robinson,

PURPOSE:The safety and pharmacokinetics of a triamcinolone acetonide (TA) preservative-free (TA-PF) formulation were investigated after intravitreal administration in rabbits. METHODS:A TA-PF formulation was prepared as a sterile 40-mg/mL or 160-mg/mL suspension in single-use vials by adding TA powder to 0.5% hydroxypropyl methylcellulose in normal saline. TA-PF (4-mg and 16-mg doses) ... Read more >>

Retina (Philadelphia, Pa.) (Retina (Philadelphia, Pa.))
[2006, 26(5):523-530]

Cited: 36 times

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Injectable formulation of disodium 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO), an ultrafast nitric oxide donor prodrug.

David J Waterhouse, Joseph E Saavedra, Keith M Davies, Michael L Citro, Xia Xu, Douglas A Powell, George J Grimes, Gopal K Potti, Larry K Keefer,

PROLI/NO is an agent of structure XN(O)==NONa (X = L-prolyl) whose 2-s half-life for nitric oxide (NO) release at physiological pH makes it an excellent prodrug for localizing NO's therapeutic effects at the site of application, but a difficult one to formulate and certify as pure. Despite its extraordinary thermal ... Read more >>

J Pharm Sci (Journal of pharmaceutical sciences)
[2006, 95(1):108-115]

Cited: 9 times

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Oral delivery of replication-competent adenovirus vectors is well tolerated by SIV- and SHIV-infected rhesus macaques.

V Raúl Gómez-Román, George J Grimes, Gopal K Potti, Bo Peng, Thorsten Demberg, Luisa Gravlin, James Treece, Ranajit Pal, Eun Mi Lee, W Gregory Alvord, Phillip D Markham, Marjorie Robert-Guroff,

Although replication-competent adenovirus (Ad) vectors are promising in AIDS vaccine design, their safety in immune compromised hosts is unknown. To initially address this question, enteric-coated tablets containing a replicating Ad vector were orally administered to SHIV- and SIV-infected rhesus macaques with normal, intermediate or low CD4 T cell counts and ... Read more >>

Vaccine (Vaccine)
[2006, 24(23):5064-5072]

Cited: 18 times

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