Full Text Journal Articles by
Author Glenn R Yamakawa

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Gut microbiome depletion and repetitive mild traumatic brain injury differentially modify bone development in male and female adolescent rats.

Ker Rui Wong, Marissa Sgro, Glenn R Yamakawa, Crystal Li, Stuart J McDonald, Mujun Sun, Sandy R Shultz, Rhys D Brady, Richelle Mychasiuk,

Dysregulation of the gut microbiome has been shown to disrupt both bone formation and bone resorption in several preclinical and clinical models. However, the role of microbiome in adolescent bone development remains poorly understood. This effect of disrupted bone development may be more pronounced during adolescence, when bone development is ... Read more >>

Bone Rep (Bone reports)
[2021, 15:101123]

Cited: 0 times

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Targeting the Cerebrovascular System: Next-Generation Biomarkers and Treatment for Mild Traumatic Brain Injury.

Tamara L Baker, Denes V Agoston, Rhys D Brady, Brendan Major, Stuart J McDonald, Richelle Mychasiuk, David K Wright, Glenn R Yamakawa, Mujun Sun, Sandy R Shultz,

The diagnosis, prognosis, and treatment of mild traumatic brain injuries (mTBIs), such as concussions, are significant unmet medical issues. The kinetic forces that occur in mTBI adversely affect the cerebral vasculature, making cerebrovascular injury (CVI) a pathophysiological hallmark of mTBI. Given the importance of a healthy cerebrovascular system in overall ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211012264]

Cited: 0 times

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Pain in the Developing Brain: Early Life Factors Alter Nociception and Neurobiological Function in Adolescent Rats.

Sabrina Salberg, Glenn R Yamakawa, Yannick Griep, Jesse Bain, Jaimie K Beveridge, Mujun Sun, Stuart J McDonald, Sandy R Shultz, Rhys D Brady, David K Wright, Melanie Noel, Richelle Mychasiuk,

Although adverse early experiences prime individuals to be at increased risk for chronic pain, little research has examined the trauma-pain relationship in early life or the underlying mechanisms that drive pathology over time. Given that early experiences can potentiate the nociceptive response, this study aimed to examine the effects of ... Read more >>

Cereb Cortex Commun (Cerebral cortex communications)
[2021, 2(2):tgab014]

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Temporal profile and utility of serum neurofilament light in a rat model of mild traumatic brain injury.

William T O'Brien, Louise Pham, Rhys D Brady, Jesse Bain, Glenn R Yamakawa, Mujun Sun, Richelle Mychasiuk, Terence J O'Brien, Mastura Monif, Sandy R Shultz, Stuart J McDonald,

There is a widely recognized need for blood biomarkers to assist clinical decisions surrounding mild traumatic brain injury (mTBI). Serum neurofilament light (NfL), an indicator of neuroaxonal damage, is one such candidate, with early mTBI clinical investigations demonstrating significant promise. To facilitate the translation of pre-clinical mTBI findings, clinically relevant ... Read more >>

Exp Neurol (Experimental neurology)
[2021, 341:113698]

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Examining changes in rodent temperament following repetitive mild traumatic brain injury in adolescence.

Ali Hazari, Sabrina Salberg, Yannick Griep, Glenn R Yamakawa, Richelle Mychasiuk,

Mild traumatic brain injuries are known to cause a host of symptoms, including headaches, nausea, and depression, that when persistent, are known as postconcussive syndrome. In addition to these overt symptomologies, individuals may experience changes in day-to-day behavior or temperament, which although not meeting criteria for postconcussive diagnosis, does cause ... Read more >>

Behav Neurosci (Behavioral neuroscience)
[2020, 134(5):384-393]

Cited: 0 times

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Is the glymphatic system the missing link between sleep impairments and neurological disorders? Examining the implications and uncertainties.

Jennaya Christensen, Glenn R Yamakawa, Sandy R Shultz, Richelle Mychasiuk,

Until recently, both the purpose of the biological need for sleep and the mechanism by which the central nervous system eliminated metabolic waste products were unknown. The glymphatic system is the recently discovered macroscopic waste clearance system for the CNS, which predominantly functions during sleep states. Important implications for the ... Read more >>

Prog Neurobiol (Progress in neurobiology)
[2021, 198:101917]

Cited: 3 times

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Experimental traumatic brain injury does not lead to lung infection.

Mujun Sun, Rhys D Brady, Brooke Wanrooy, Richelle Mychasiuk, Glenn R Yamakawa, Pablo M Casillas-Espinosa, Connie H Y Wong, Sandy R Shultz, Stuart J McDonald,

Traumatic brain injury (TBI) patients often experience post-traumatic infections, especially in the lung. Pulmonary infection is associated with unfavorable outcomes and increased mortality rates in TBI patients; however, our understanding of the underlying mechanisms is poor. Here we used a lateral fluid percussion injury (LFPI) model in rats to investigate ... Read more >>

J Neuroimmunol (Journal of neuroimmunology)
[2020, 343:577239]

Cited: 1 time

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Repetitive Mild Traumatic Brain Injury Alters Glymphatic Clearance Rates in Limbic Structures of Adolescent Female Rats.

Jennaya Christensen, David K Wright, Glenn R Yamakawa, Sandy R Shultz, Richelle Mychasiuk,

The glymphatic system is the macroscopic waste clearance system for the central nervous system. Glymphatic dysfunction has been linked to several neurological conditions, including traumatic brain injury (TBI). Adolescents are at particularly high risk for experiencing a TBI, particularly mild TBI (mTBI) and repetitive mTBI (RmTBI); however, glymphatic clearance, and ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):6254]

Cited: 3 times

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A novel rat model of heterotopic ossification after polytrauma with traumatic brain injury.

Rhys D Brady, Michael Z Zhao, Ker R Wong, Pablo M Casilla-Espinosa, Glenn R Yamakawa, Ryan C Wortman, Mujun Sun, Brian L Grills, Richelle Mychasiuk, Terence J O'Brien, Denes V Agoston, Peter V S Lee, Stuart J McDonald, Dale L Robinson, Sandy R Shultz,

Neurological heterotopic ossification (NHO) is characterized by abnormal bone growth in soft tissue and joints in response to injury to the central nervous system. The ectopic bone frequently causes pain, restricts mobility, and decreases the quality of life for those affected. NHO commonly develops in severe traumatic brain injury (TBI) ... Read more >>

Bone (Bone)
[2020, 133:115263]

Cited: 2 times

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Administration of diphenyl diselenide (PhSe)2 following repetitive mild traumatic brain injury exacerbates anxiety-like symptomology in a rat model.

Glenn R Yamakawa, Eric Eyolfson, Himanthri Weerawardhena, Richelle Mychasiuk,

Approximately 10-15 % of people that sustain mild traumatic brain injury (mTBI) develop post-concussive syndrome (PCS). PCS is a complex array of symptoms that can result in physical, cognitive and emotional impairments. Following mTBI, there are also complex changes in the oxidative stress system and engagement of the inflammatory system, ... Read more >>

Behav Brain Res (Behavioural brain research)
[2020, 382:112472]

Cited: 1 time

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The need to incorporate aged animals into the preclinical modeling of neurological conditions.

Mujun Sun, Stuart J McDonald, Rhys D Brady, Lyndsey Collins-Praino, Glenn R Yamakawa, Mastura Monif, Terence J O'Brien, Geoffrey C Cloud, Christopher G Sobey, Richelle Mychasiuk, David J Loane, Sandy R Shultz,

Neurological conditions such as traumatic brain injury, stroke, Parkinson's disease, epilepsy, multiple sclerosis, and Alzheimer's disease are serious clinical problems that affect millions of people worldwide. The majority of clinical trials for these common conditions have failed, and there is a critical need to understand why treatments in preclinical animal ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2020, 109:114-128]

Cited: 5 times

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Caffeine consumption during development alters spine density and recovery from repetitive mild traumatic brain injury in young adult rats.

Jennaya Christensen, Glenn R Yamakawa, Sabrina Salberg, Melinda Wang, Bryan Kolb, Richelle Mychasiuk,

Caffeine is the most commonly used psychostimulant throughout the world, with its consumption being especially prevalent among adolescents and young adults, as over 75% of this group consumes caffeine daily. Similarly, the adolescent and young adult age group exhibit the highest incidence of traumatic brain injury (TBI). Given that both ... Read more >>

Synapse (Synapse (New York, N.Y.))
[2020, 74(4):e22142]

Cited: 1 time

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Bone Health in Rats With Temporal Lobe Epilepsy in the Absence of Anti-Epileptic Drugs.

Rhys D Brady, Ker Rui Wong, Dale L Robinson, Richelle Mychasiuk, Stuart J McDonald, Ryan A D'Cunha, Glenn R Yamakawa, Mujun Sun, John D Wark, Peter Vee Sin Lee, Terence J O'Brien, Pablo M Casillas-Espinosa, Sandy R Shultz,

<b>Rationale:</b> Epilepsy patients often exhibit reduced bone mineral density and are at an increased risk of bone fracture. Whether these bone abnormalities are due to the use of anti-epileptic drugs (AED's) or the disease itself is unknown. For example, although decreased bone health in epilepsy patients is generally attributed to ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2019, 10:1278]

Cited: 0 times

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Investigating the Role of the Hypothalamus in Outcomes to Repetitive Mild Traumatic Brain Injury: Neonatal Monosodium Glutamate Does Not Exacerbate Deficits.

Glenn R Yamakawa, Himanthri Weerawardhena, Eric Eyolfson, Yannick Griep, Michael C Antle, Richelle Mychasiuk,

Repetitive mild traumatic brain injury (RmTBI) is a prevalent and costly head injury particularly among adolescents. These injuries may result in long-term consequences, especially during this critical period of development. Insomnia and sleeping difficulties are frequently reported following RmTBI and greatly impair recovery. We sought to develop an animal model ... Read more >>

Neuroscience (Neuroscience)
[2019, 413:264-278]

Cited: 2 times

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A Bump on the Head or Late to Bed: Behavioral and Pathophysiological Effects of Sleep Deprivation after Repetitive Mild Traumatic Brain Injury in Adolescent Rats.

Sabrina Salberg, Jennaya Christensen, Glenn R Yamakawa, Connor Lengkeek, Haris Malik, Jason Tabor, Ali Hazari, Richelle Mychasiuk,

An old wives' tale, and strongly held dogma, maintains that one should be kept awake after a mild traumatic brain injury (mTBI) to prevent a coma. This, however, conflicts with the known benefits of sleep: repair and restoration. We therefore sought to examine the effects of sleep deprivation (SD) in ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2018, 35(16):1895-1905]

Cited: 5 times

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Behavioral and pathophysiological outcomes associated with caffeine consumption and repetitive mild traumatic brain injury (RmTBI) in adolescent rats.

Glenn R Yamakawa, Connor Lengkeek, Sabrina Salberg, Simon C Spanswick, Richelle Mychasiuk,

Given that caffeine consumption is exponentially rising in adolescents and they are at increased risk for repetitive mild traumatic brain injury (RmTBI), we sought to examine the pathophysiological outcomes associated with early life caffeine consumption and RmTBI. Adolescent male and female Sprague Dawley rats received either caffeine in the drinking ... Read more >>

PLoS One (PloS one)
[2017, 12(11):e0187218]

Cited: 10 times

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Manipulating cognitive reserve: Pre-injury environmental conditions influence the severity of concussion symptomology, gene expression, and response to melatonin treatment in rats.

Glenn R Yamakawa, Sabrina Salberg, Karen M Barlow, Brian L Brooks, Michael J Esser, Keith Owen Yeates, Richelle Mychasiuk,

In an effort to understand the factors that contribute to heterogeneity in outcomes often associated with mTBI in youth, this study examined the role of premorbid differences in cognitive reserve on post-concussive symptoms (PCS), molecular markers, and treatment response. Male and female rats matured in one of three environmental conditions ... Read more >>

Exp Neurol (Experimental neurology)
[2017, 295:55-65]

Cited: 5 times

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The cholinergic forebrain arousal system acts directly on the circadian pacemaker.

Glenn R Yamakawa, Priyoneel Basu, Filomeno Cortese, Johanna MacDonnell, Danica Whalley, Victoria M Smith, Michael C Antle,

Sleep and wake states are regulated by a variety of mechanisms. One such important system is the circadian clock, which provides temporal structure to sleep and wake. Conversely, changes in behavioral state, such as sleep deprivation (SD) or arousal, can phase shift the circadian clock. Here we demonstrate that the ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2016, 113(47):13498-13503]

Cited: 15 times

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Phase delays to light and gastrin-releasing peptide require the protein kinase A pathway.

Roxanne Sterniczuk, Glenn R Yamakawa, Tara Pomeroy, Michael C Antle,

Daily photic resetting of the circadian system relies on the transmission of light information from the retina to retinorecipient cells within the ventrolateral suprachiasmatic nucleus (SCN) core, and subsequent activation of rhythmic clock cells in the dorsolateral region. Some neurochemicals such as gastrin-releasing peptide (GRP) mimic the phase shifting effects ... Read more >>

Neurosci Lett (Neuroscience letters)
[2014, 559:24-29]

Cited: 4 times

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Physiological responses of the circadian clock to acute light exposure at night.

Michael C Antle, Victoria M Smith, Roxanne Sterniczuk, Glenn R Yamakawa, Brooke D Rakai,

Circadian rhythms in physiological, endocrine and metabolic functioning are controlled by a neural clock located in the suprachiasmatic nucleus (SCN). This structure is endogenously rhythmic and the phase of this rhythm can be reset by light information from the eye. A key feature of the SCN is that while it ... Read more >>

Rev Endocr Metab Disord (Reviews in endocrine & metabolic disorders)
[2009, 10(4):279-291]

Cited: 36 times

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Phenotype and function of raphe projections to the suprachiasmatic nucleus.

Glenn R Yamakawa, Michael C Antle,

The circadian clock, located in the suprachiasmatic nucleus (SCN), receives a major afferent from the median raphe nucleus (MRN). In the Syrian hamster, only about 50% of the cells giving rise to this afferent contain serotonin. There is mixed evidence as to whether the serotonergic portion of this projection is ... Read more >>

Eur J Neurosci (The European journal of neuroscience)
[2010, 31(11):1974-1983]

Cited: 17 times

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The dorsomedial hypothalamic nucleus is not necessary for the expression of circadian food-anticipatory activity in rats.

Glenn J Landry, Glenn R Yamakawa, Ian C Webb, Rhiannon J Mear, Ralph E Mistlberger,

Restricted daytime feeding generates food-anticipatory activity (FAA) by entrainment of a circadian pacemaker separate from the light-entrainable pacemaker located in the SCN. The dorsomedial hypothalamic nucleus (DMH) has been proposed as the site of food-entrainable oscillators critical for the expression of FAA, but another study found no effects of complete ... Read more >>

J Biol Rhythms (Journal of biological rhythms)
[2007, 22(6):467-478]

Cited: 78 times

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