Full Text Journal Articles by
Author Glen E Leverson

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A Comparison of Rates and Severity of Chronic Kidney Disease in Deceased Donor and Living Donor Liver Transplant Recipients. Times matter.

YÜcel Yankol, Emily Bugeaud, Tiffany Zens, Michael Rizzari, Nesİmİ Mecİt, Glen E Leverson, David Foley, Joshua D Mezrich, Turan Kanmaz, Oya MÜnevver AndaÇoĞlu, Anthony M D'Alessandro, Koray Sadik Acarli, MÜncİ KalayoĞlu, Luis A Fernandez,

Background/ Aim: The progression of chronic kidney disease (CKD) in recipients of living donor liver transplant (LDLT) compared to deceased donor liver transplant (DDLT) has not been studied in the literature. We hypothesize that CKD stage progression in LDLT recipients is reduced compared to their DDLT counterparts. MATERIAL AND METHODS:A ... Read more >>

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

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Pre-transplant bariatric surgery is associated with increased fungal infection after liver transplant.

Margaret R Jorgenson, Adam S Gracon, Bret Hanlon, Glen E Leverson, Sandesh Parajuli, Jeannina A Smith, David P Al-Adra,

AIM:The impact of pre-transplant (pre-TXP) bariatric surgery (BS) on outcomes after liver transplant (LTX) has not been completely elucidated. Roux-en Y gastric bypass (RYGB) is one of the most common BS procedures. The primary objective of this study was to identify the risk of infection in LTX recipients with pre-TXP ... Read more >>

Transpl Infect Dis (Transplant infectious disease : an official journal of the Transplantation Society)
[2020, :e13484]

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Association of Personality and Thinking Style With Effective Surgical Coaching.

Kara A Vande Walle, Sudha R Pavuluri Quamme, Glen E Leverson, Tedi Engler, Janet C Dombrowski, Douglas A Wiegmann, Justin B Dimick, Caprice C Greenberg,

Importance:While interest in surgical coaching programs is rising, there is no objective method for selecting effective surgical coaches. Objective:To identify a quantitative measure to determine who will be an effective surgical coach. Design, Setting, and Participants:This prospective cohort study included coaches and coachees from 2 statewide peer surgical coaching programs: ... Read more >>

JAMA Surg (JAMA surgery)
[2020, 155(6):480-485]

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Summary perioperative risk metrics within the electronic medical record predict patient-level cost variation in pancreaticoduodenectomy.

Christopher C Stahl, Patrick B Schwartz, Glen E Leverson, James R Barrett, Taylor Aiken, Alexandra W Acher, Sean M Ronnekleiv-Kelly, Rebecca M Minter, Sharon M Weber, Daniel E Abbott,

BACKGROUND:Automated data extraction from the electronic medical record is fast, scalable, and inexpensive compared with manual abstraction. However, concerns regarding data quality and control for underlying patient variation when performing retrospective analyses exist. This study assesses the ability of summary electronic medical record metrics to control for patient-level variation in ... Read more >>

Surgery (Surgery)
[2020, 168(2):274-279]

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Development and Assessment of the Wisconsin Surgical Coaching Rubric.

Kara A Vande Walle, Sudha R Pavuluri Quamme, Heather L Beasley, Glen E Leverson, Hala N Ghousseini, Janet C Dombrowski, Brian T Fry, Justin B Dimick, Douglas A Wiegmann, Caprice C Greenberg,

Importance:Surgical coaching continues to gain momentum as an innovative method for continuous professional development. A tool to measure the performance of a surgical coach is needed to provide formative feedback to coaches for continued skill development and to assess the fidelity of a coaching intervention for future research and dissemination. ... Read more >>

JAMA Surg (JAMA surgery)
[2020, 155(6):486-492]

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The Optimal Ileal Pouch: Physiologic Parameters Significantly Correlate with Overall Pouch Function.

Joseph C Melvin, Bruce A Harms, Charles P Heise, Glen E Leverson, Evie H Carchman,

BACKGROUND:Ileal pouch function is affected by several patient factors and pouch physiology. The significance of pouch physiology on optimal pouch function has not been well characterized. The purpose of this study was to examine specific post-ileal pouch anal anastomosis (IPAA) physiologic parameters to determine impact on pouch function and quality ... Read more >>

J. Gastrointest. Surg. (Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract)
[2020, :]

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Kidney After Liver Transplantation Matched-pair Analysis: Are Kidneys Allocated to Appropriate Patients to Maximize Their Survival?

Michael J Eerhart, José A Reyes, Glen E Leverson, Juan S Danobeitia, Casi L Blanton, Laura J Zitur, Peter J Chlebeck, Luis A Fernandez,

BACKGROUND:Kidney after liver transplantation (KALT) is the best therapeutic option for patients with end-stage renal disease after orthotopic liver transplantation (OLT). New allocation policies prioritize kidneys to patients in renal failure within the first year following OLT. There is little data on how kidney quality, measured by kidney donor profile ... Read more >>

Transplantation (Transplantation)
[2020, 104(4):804-812]

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Alemtuzumab induction for retransplantation after primary transplant with alemtuzumab induction
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Jillian L Descourouez, Margaret R Jorgenson, Sandesh Parajuli, Didier A Mandelbrot, Glen E Leverson, Jon S Odorico, Robert R Redfield,

BACKGROUND:Lymphocyte-depleting induction with alemtuzumab (ALEM) or rabbit antithymocyte-globulin (rATG) is commonly used at retransplantation. It is unknown which agent is preferable, particularly when ALEM was used at primary transplant. OBJECTIVE:Evaluate outcomes after ALEM at retransplant following primary transplant with ALEM induction (ALEM-ALEM) as compared to retransplant with rATG (ALEM-rATG). MATERIALS ... Read more >>

Clin. Nephrol. (Clinical nephrology)
[2020, 93(2):77-84]

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A targeted fungal prophylaxis protocol with static dosed fluconazole significantly reduces invasive fungal infection after liver transplantation.

Margaret R Jorgenson, Jillian L Descourouez, Nicholas A Marka, Glen E Leverson, Jeannina A Smith, David R Andes, Luis A Fernandez, David P Foley,

BACKGROUND:Invasive fungal infection (IFI) after liver transplant (LTx) is associated with extensive morbidity and mortality. Targeted prophylaxis reduces risk, but qualifying criteria, drug of choice and regimen are unclear and compliance is inconsistent. OBJECTIVE:Assess the impact of a risk factor-based fungal prophylaxis protocol (FPP) after LTx on fungal infection rates, ... Read more >>

Transpl Infect Dis (Transplant infectious disease : an official journal of the Transplantation Society)
[2019, 21(5):e13156]

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Evaluation of infectious risk and outcomes in the hmong renal transplant population.

Margaret R Jorgenson, Brianna Cardinale, Jillian L Descourouez, Dou-Yan Yang, Glen E Leverson, Sandesh Parajuli, Jeannina A Smith, Robert R Redfield,

BACKGROUND:Hmong ethnicity has been associated with infection, particularly fungal. The risk of infection after transplant in the Hmong population is unknown. METHODS:Observational study of adult renal transplant (RTX) recipients between 1/1/1994 and 12/31/2015. Primary objective was to identify infectious risk in the Hmong RTX population as compared to non-Hispanic whites ... Read more >>

Transpl Infect Dis (Transplant infectious disease : an official journal of the Transplantation Society)
[2019, 21(5):e13142]

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Prostate Transition Zone Fibrosis is Associated with Clinical Progression in the MTOPS Study.

Jill A Macoska, Kristen S Uchtmann, Glen E Leverson, Kevin T McVary, William A Ricke,

PURPOSE:Medications targeting androgen receptor activity (eg finasteride) or smooth muscle contractility (eg doxazosin) do not resolve lower urinary tract symptoms indicative of lower urinary tract dysfunction in an important subgroup of men. Recently fibrosis has been implicated as another pathobiology contributing to male lower urinary tract symptoms but to our ... Read more >>

J Urol (The Journal of urology)
[2019, 202(6):1240-1247]

Cited: 1 time

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Safety of Antithymocyte Globulin in Patients Undergoing Liver Transplantation With Livers From Donation After Circulatory Death Donors.

Margaret R Jorgenson, Jillian L Descourouez, Daniel C Felix, Bret M Hanlon, Glen E Leverson, David P Foley,

Background: Studies suggest that rabbit-antithymocyte globulin (rATG) decreases biliary complications (BCs) after donation-after-circulatory-death-donor liver transplantation (DCD LTx), but safety data are lacking. Objective: Our aim was to assess the safety of rATG for this indication. The secondary end point was efficacy of rATG for this indication. Methods: Adult recipients of ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2019, 53(10):981-990]

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Epidemiology, Risk Factors, and Outcomes After Early Posttransplant Clostridiodes difficile Infection in Renal Transplant Recipients.

Margaret R Jorgenson, Jillian L Descourouez, Dou-Yan Yang, Glen E Leverson, Christopher M Saddler, Jeannina A Smith, Nasia Safdar, Didier A Mandlebrot, Robert R Redfield,

BACKGROUND:Modifiable risk-factors associated with Clostridioides difficile infection (CDI) in renal-transplant (RTX) have not been clearly established and peri-transplant risk has not been described. OBJECTIVE:Evaluate epidemiology, risk-factors and outcomes after CDI occurring in the first 90 days after RTX (CDI-90).Methods: Observational cohort study/survival analysis of adult RTX recipients from 1/1/2012-12/31/2015. Primary ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2019, 53(10):1020-1025]

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Comparison of risk factors and outcomes of daptomycin-susceptible and -nonsusceptible vancomycin-resistant enterococcus faecium infections in liver transplant recipients; A reply to Lewis et al.

Margaret R Jorgenson, Jillian L Descourouez, Glen E Leverson, Warren E Rose, Jeannina A Smith, Luis A Fernandez,

Transpl Infect Dis (Transplant infectious disease : an official journal of the Transplantation Society)
[2018, 20(6):e13004]

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Ipsilateral versus contralateral placement of the pancreas allograft in pancreas after kidney transplant recipients.

Hang Yin, Emre Arpali, Glen E Leverson, Hans W Sollinger, Dixon B Kaufman, Jon S Odorico,

BACKGROUND:In a diabetic, uremic kidney transplant recipient that may receive a future pancreas after kidney (PAK) transplant, the kidney is typically implanted on the left side in anticipation of the subsequent pancreas transplant on the right side. In this study, we sought to determine if ipsilateral PAK (iPAK) is as ... Read more >>

Clin Transplant (Clinical transplantation)
[2018, 32(8):e13337]

Cited: 1 time

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Endocrine disruptor bisphenol A is implicated in urinary voiding dysfunction in male mice.

Tristan M Nicholson, Jalissa L Nguyen, Glen E Leverson, Julia A Taylor, Frederick S Vom Saal, Ronald W Wood, William A Ricke,

Estrogens, acting synergistically with androgens, are known from animal experiments to be important in lower urinary tract symptoms (LUTS) and benign prostate enlargement. Human exposure to environmental estrogens occurs throughout the life span, but the urologic health risks in men are largely unknown. Bisphenol A (BPA) is an endocrine disruptor ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2018, 315(5):F1208-F1216]

Cited: 3 times

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The Impact of Hospital Neoadjuvant Therapy Utilization on Survival Outcomes for Pancreatic Cancer.

Alexander V Fisher, Daniel E Abbott, Manasa Venkatesh, Glen E Leverson, Stephanie A Campbell-Flohr, Sean M Ronnekleiv-Kelly, Caprice C Greenberg, Emily R Winslow, Sharon M Weber,

BACKGROUND:Many surgeons advocate the use of neoadjuvant treatment for resectable pancreatic cancer, however little is known about variation in the utilization of neoadjuvant therapy (NAT) at the hospital level. METHODS:The National Cancer Data Base was used to identify patients undergoing resection for pancreatic cancer between 2006 and 2014 at high-volume ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2018, 25(9):2661-2668]

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Impact of High-Dose Acyclovir Cytomegalovirus Prophylaxis Failure in Abdominal Solid Organ Transplant Recipients.

Magdalena Siodlak, Margaret R Jorgenson, Jillian L Descourouez, Glen E Leverson, Didier A Mandelbrot, Jeannina A Smith, Robert R Redfield,

To evaluate the clinical course and long-term impact of high-dose acyclovir (HD-A, 800 mg 4 times/day) cytomegalovirus (CMV) prophylaxis failure in a CMV-seropositive abdominal solid organ transplant population.Retrospective cohort study.Tertiary academic medical center.A total of 691 adults who received solid organ transplants between January 1, 2008, and June 30, 2013, ... Read more >>

Pharmacotherapy (Pharmacotherapy)
[2018, :]

Cited: 0 times

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Race, insurance status, and traumatic brain injury outcomes before and after enactment of the Affordable Care Act.

Eric W Moffet, Tiffany J Zens, Krista L Haines, Megan V Beems, Kaitlyn M McQuistion, Glen E Leverson, Suresh K Agarwal,

The Affordable Care Act aims to improve patient outcomes. Race/ethnicity and insurance status impact outcomes after traumatic brain injury. We sought to gauge the Affordable Care Act's effect on outcomes after traumatic brain injury, as graded by race/ethnicity and insurance status.The National Trauma Data Bank was utilized to identify traumatic ... Read more >>

Surgery (Surgery)
[2018, 163(2):251-258]

Cited: 1 time

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Vancomycin Prophylaxis for Prevention of Clostridium difficile Infection Recurrence in Renal Transplant Patients.

Lindsey E Splinter, Luiza Kerstenetzky, Margaret R Jorgenson, Jillian L Descourouez, Glen E Leverson, Christopher M Saddler, Jeannina A Smith, Nasia Safdar, Robert R Redfield,

BACKGROUND:Incidence of primary and recurrent Clostridium difficile infection (CDI) is higher in solid-organ transplant recipients than in the average hospitalized patient. Strategies for preventing recurrent CDI are limited. Prophylaxis with oral vancomycin (VPPx) for preventing recurrent CDI may be beneficial, but there is limited evidence supporting its use. OBJECTIVE:To examine ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2018, 52(2):113-119]

Cited: 5 times

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High-Dose Acyclovir for Cytomegalovirus Prophylaxis in Seropositive Abdominal Transplant Recipients.

Margaret R Jorgenson, Jillian L Descourouez, Glen E Leverson, Erin K McCreary, Michael R Lucey, Jeannina A Smith, Robert R Redfield,

Following abdominal solid organ transplant (aSOT), valganciclovir (VGC) is recommended for cytomegalovirus (CMV) prophylaxis. This agent is associated with efficacy concerns, toxicity, and emergence of ganciclovir resistance.To evaluate the incidence of high-dose acyclovir (HD-A) prophylaxis failure in seropositive aSOT recipients (R+).This was a retrospective, single-center study of R+ transplanted without ... Read more >>

Ann Pharmacother (The Annals of pharmacotherapy)
[2018, 52(1):5-10]

Cited: 1 time

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Fosfomycin for the Treatment of Cystitis in the Abdominal Solid Organ Transplant Population.

Ashley A Loethen, Luiza Kerstenetzky, Jillian L Descourouez, Glen E Leverson, Jeannina A Smith, Margaret R Jorgenson,

To evaluate the use of fosfomycin (FOS) at the single-dose regimen approved by the U.S. Food and Drug Administration as well as off-label multidose regimens for the treatment of cystitis after abdominal solid organ transplant (aSOT).Retrospective study.Tertiary academic medical center.Adult inpatients with history of aSOT receiving FOS between January 1, ... Read more >>

Pharmacotherapy (Pharmacotherapy)
[2017, 37(5):599-606]

Cited: 1 time

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An Institutional Change in Continuous Renal Replacement Therapy: Nutrition Support Team Resolves Resultant Severe Hypophosphatemia.

Rebecca A Busch, Caitlin S Curtis, Cassandra E Kight, Glen E Leverson, Yue Ma, Laura Maursetter, Kenneth A Kudsk,

BACKGROUND:Critically ill patients with acute kidney injury may require parenteral nutrition (PN) and continuous renal replacement therapy (CRRT). Introduction of a phosphate-free premixed renal replacement fluid without system-wide education in May 2011 resulted in increased incidence of hypophosphatemia, necessitating change in practice. Changes included (1) maximizing phosphate in PN, (2) ... Read more >>

Nutr Clin Pract (Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition)
[2017, 32(2):245-251]

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Trends in the presentation, treatment, and survival of patients with medullary thyroid cancer over the past 30 years.

Reese W Randle, Courtney J Balentine, Glen E Leverson, Jeffrey A Havlena, Rebecca S Sippel, David F Schneider, Susan C Pitt,

The impact of recent medical advances on disease presentation, extent of operation, and disease-specific survival for patients with medullary thyroid cancer is unclear.We used the Surveillance, Epidemiology, and End Results registry to compare trends over 3 time periods, 1983-1992, 1993-2002, and 2003-2012.There were 2,940 patients diagnosed with medullary thyroid cancer ... Read more >>

Surgery (Surgery)
[2017, 161(1):137-146]

Cited: 25 times

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Minimally Invasive Resection of Adrenocortical Carcinoma: a Multi-Institutional Study of 201 Patients.

Christina W Lee, Ahmed I Salem, David F Schneider, Glen E Leverson, Thuy B Tran, George A Poultsides, Lauren M Postlewait, Shishir K Maithel, Tracy S Wang, Ioannis Hatzaras, Rivfka Shenoy, John E Phay, Lawrence Shirley, Ryan C Fields, Linda X Jin, Timothy M Pawlik, Jason D Prescott, Jason K Sicklick, Shady Gad, Adam C Yopp, John C Mansour, Quan-Yang Duh, Natalie Seiser, Carmen C Solorzano, Colleen M Kiernan, Konstantinos I Votanopoulos, Edward A Levine, Sharon M Weber,

Minimally invasive surgery for adrenocortical carcinoma (ACC) is controversial. We sought to evaluate the perioperative and long-term outcomes following minimally invasive (MIS) and open resection (OA) of ACC in patients treated with curative intent surgery.Retrospective data from patients who underwent adrenalectomy for primary ACC at 13 tertiary care cancer centers ... Read more >>

J Gastrointest Surg (Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract)
[2017, 21(2):352-362]

Cited: 5 times

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