Full Text Journal Articles by
Author Glauco Issamu Miyahara

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Absence of human papillomavirus in cancer of the oral cavity and oropharynx in a Brazilian population.

Ingrid da Silva Santos, Lígia Lavezo Ferreira, Saygo Tomo, Sandra Helena Penha de Oliveira, Eder Ricardo Biasoli, Daniel Galera Bernabé, Luísa Lina Villa, Glauco Issamu Miyahara,

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2021, 30(4):350]

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Beta-adrenergic pathway activation enhances aggressiveness and inhibits stemness in head and neck cancer.

Gabriela Lopes-Santos, Daniel Galera Bernabé, Glauco Issamu Miyahara, Kellen Cristine Tjioe,

Chronic stress leads to the activation of the beta-adrenergic pathway. Its activation has been implicated in the progression of different types of cancer but its role on head and neck squamous cell carcinomas (HNSCCs) remains undefined. The aim of this study was to investigate the influence of the beta-adrenergic pathway ... Read more >>

Transl Oncol (Translational oncology)
[2021, 14(8):101117]

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Pleomorphic sarcoma of maxillary sinus: Clinical report of a patient initially diagnosed with denture-induced fibrous hyperplasia.

Vitor Bonetti Valente, Giseli Mitsuy Kayahara, Daniela Brito Bastos, Ingrid da Silva Santos, José Cândido Caldeira Xavier-Junior, Éder Ricardo Biasoli, Glauco Issamu Miyahara, Daniel Galera Bernabé,

Undifferentiated pleomorphic sarcoma is a high-grade soft-tissue malignant tumor that is rare in the head and neck region. A 74-year-old woman displayed a large nodular lesion in the maxillary alveolar mucosa, which was initially identified as denture-related fibrous hyperplasia. Although her prosthodontist has adjusted the maxillary complete denture to relieve ... Read more >>

J Prosthet Dent (The Journal of prosthetic dentistry)
[2021, :]

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Social isolation stress facilitates chemically induced oral carcinogenesis.

Flávia Alves Verza, Vitor Bonetti Valente, Lia Kobayashi Oliveira, Giseli Mitsuy Kayahara, Marcelo Macedo Crivelini, Cristiane Furuse, Éder Ricardo Biasoli, Glauco Issamu Miyahara, Sandra Helena Penha Oliveira, Daniel Galera Bernabé,

Social isolation has affected a large number of people and may lead to impairment of physical and mental health. Although stress resulting from social isolation may increase cancer progression, its interference on tumorigenesis is poorly known. In this study, we used a preclinical model to evaluate the effects of social ... Read more >>

PLoS One (PloS one)
[2021, 16(1):e0245190]

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Tongue Nodule as Primary Manifestation of American Cutaneous Leishmaniasis in an Immunocompetent Patient.

Maria Clara Bertolini Botelho, Lígia Lavezo Ferreira, Stelios Fikaris, Ana Carolina Prado-Ribeiro, Ana Maria Pires Soubhia, Eder Ricardo Biasoli, Glauco Issamu Miyahara, Daniel Galera Bernabé,

Leishmaniasis is a parasitic disease considered an endemic public health problem in developing countries, where it is a reportable disease. Isolated oral manifestation is rare, and its clinical manifestations are variable. In this paper we describe an unusual case of an immunocompetent patient, 57-year-old man with a painless reddish submucosal ... Read more >>

Head Neck Pathol (Head and neck pathology)
[2020, :]

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In situ melanoma of oral cavity: Diagnosis and treatment of a rare entity.

Diovana de Melo Cardoso, Daniela Brito Bastos, Daniela Micheline Dos Santos, Sebastião Conrado-Neto, Francisco Urbano Collado, Marcelo Macedo Crivelini, José Cândido Caldeira Xavier-Júnior, Éder Ricardo Biasoli, Glauco Issamu Miyahara, Daniel Galera Bernabé,

Oral melanoma is an extremely aggressive and rare tumor. Commonly, oral melanomas are diagnosed as invasive tumors, which considerably reduces the chances of cure. In situ oral melanomas being exceedingly rare, which makes its clinicopathological and prognostic characteristics poorly known. Herein, we report a case of 67-year-old non-white woman with ... Read more >>

Oral Oncol (Oral oncology)
[2021, 115:105116]

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Canalis sinuosus: An Anatomic Repair that May Prevent Success of Dental Implants in Anterior Maxilla.

Gabriela Lopes Dos Santos, Carla Renata Sanomiya Ikuta, Leda Maria Pescinini Salzedas, Glauco Issamu Miyahara, Kellen Cristine Tjioe,

Canalis sinuosus (CS) is a neurovascular canal that corresponds to a small branch of the infraorbital canal. It contains the anterior superior alveolar nerve and vessels, supplying the anterior maxilla. Despite having been described 81 years ago, CS is not recognized by many dental practitioners and may be the cause ... Read more >>

J Prosthodont (Journal of prosthodontics : official journal of the American College of Prosthodontists)
[2020, 29(9):751-755]

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Beta-adrenergic blocker inhibits oral carcinogenesis and reduces tumor invasion.

Heitor Pinhata Cecilio, Vitor Bonetti Valente, Karla Marcila Pereira, Giseli Mitsuy Kayahara, Cristiane Furuse, Éder Ricardo Biasoli, Glauco Issamu Miyahara, Sandra Helena Penha Oliveira, Daniel Galera Bernabé,

<h4>Purpose</h4>Beta-adrenergic signaling can influence cancer progression and the use of beta blockers as adjuvant drugs in oncologic patients has been suggested. However, the involvement of beta-adrenergic blockers in tumorigenesis is poorly understood. This study investigated the action of beta-adrenergic blocker propranolol on tumor onset using a preclinical model of chemically ... Read more >>

Cancer Chemother Pharmacol (Cancer chemotherapy and pharmacology)
[2020, 86(5):681-686]

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Fluorescence-guided surgical management of medication-related osteonecrosis of the jaws.

Saygo Tomo, Thiago Moreira da Cruz, Jéssica Araújo Figueira, John Lennon Silva Cunha, Glauco Issamu Miyahara, Luciana Estevam Simonato,

Medication-related osteonecrosis of the jaw (MRONJ) results in progressive destruction of the jawbones, and advanced cases demand surgical intervention. The total removal of necrotic bone is required to prevent recurrence and infection. However, determining the limits between necrotic and healthy bone is a challenge. The use of fluorescence to detect ... Read more >>

Photodiagnosis Photodyn Ther (Photodiagnosis and photodynamic therapy)
[2020, 32:102003]

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Oral mucositis in a SARS-CoV-2-infected patient: Secondary or truly associated condition?

Saygo Tomo, Glauco Issamu Miyahara, Luciana Estevam Simonato,

Oral Dis (Oral diseases)
[2020, :]

Cited: 6 times

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Diagnosis and Treatment of Oral Venous Malformation in a Child.

Vitor Bonetti Valente, Giseli Mitsuy Kayahara, Glauco Issamu Miyahara, Éder Ricardo Biasoli, Daniel Galera Bernabé,

Venous malformations (VMs) are congenital disorders that constitute about 40% of all vascular anomalies. These lesions do not regress spontaneously and may increase in size during childhood. The case of a 10-year-old girl with an extensive oral VM is reported. Intraoral examination revealed the presence of purplish nodules in the ... Read more >>

J Craniofac Surg (The Journal of craniofacial surgery)
[2020, 31(4):e393-e394]

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Granulomatous ulceration of the palate.

Tamara Fernandes de Castro, Saygo Tomo, Alan Roger Santos-Silva, Daniel Galera Bernabé, Éder Ricardo Biasoli, Marcelo Macedo Crivelini, Ana Cláudia Okamoto, Glauco Issamu Miyahara,

Oral Surg Oral Med Oral Pathol Oral Radiol (Oral surgery, oral medicine, oral pathology and oral radiology)
[2021, 131(4):390-394]

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High p16INK4a immunoexpression is not HPV dependent in oral leukoplakia.

Saygo Tomo, Stephanye Pinto Biss, Marcelo Macedo Crivelini, Sandra Helena Penha de Oliveira, Éder Ricardo Biasoli, Kellen Cristine Tjioe, Daniel Galera Bernabé, Luisa Lina Villa, Glauco Issamu Miyahara,

<h4>Objective</h4>To evaluate the prevalence of HPV DNA detection in fresh tissue from oral leukoplakia by Linear Array assay, and its correlation with p16<sup>INK4a</sup> immunoexpression in the northwest region of the São Paulo state, Brazil.<h4>Patients and methods</h4>Fifty patients diagnosed with oral leukoplakia were included in the study. Sociodemographic, clinicopathologic and lifestyle ... Read more >>

Arch Oral Biol (Archives of oral biology)
[2020, 115:104738]

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Pineal gland protects against chemically induced oral carcinogenesis and inhibits tumor progression in rats.

Giseli Mitsuy Kayahara, Vitor Bonetti Valente, Rosani Belzunces Pereira, Felipe Yudi Kabeya Lopes, Marcelo Macedo Crivelini, Glauco Issamu Miyahara, Éder Ricardo Biasoli, Sandra Helena Penha Oliveira, Daniel Galera Bernabé,

Clinical investigations suggest that melatonin suppression and circadian dysfunction may be related to cancer development in shift workers. Studies also show that melatonin suppression after pinealectomy increases cancer incidence in preclinical models. However, no study evaluated the influence of pinealectomy on oral cancer development. In the current study, we investigated ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(20):1816-1831]

Cited: 1 time

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Head and neck squamous cell carcinoma in young patients: a 26-year clinicopathologic retrospective study in a Brazilian specialized center.

S Tomo, S-C Neto, F-U Collado, M-L Sundefeld, D-G Bernabé, É-R Biasoli, G-I Miyahara,

BACKGROUND:To describe the clinicopathologic profile of young patients with head and neck squamous cell carcinoma (HNSCC) and compare to middle-aged and elderly adults. MATERIAL AND METHODS:Patients' individual records were reviewed for clinicopathologic data. Eighty-nine patients with age 18-45 years old met the inclusion criteria of the study. Two additional groups ... Read more >>

Med Oral Patol Oral Cir Bucal (Medicina oral, patologia oral y cirugia bucal)
[2020, 25(3):e416-e424]

Cited: 2 times

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Benign symmetric lipomatosis in the tongue: an uncommon case.

Daniela Brito Bastos, Jéssica Araújo Figueira, Cristiane Furuse, Éder Ricardo Biasoli, Glauco Issamu Miyahara, Daniel Galera Bernabé,

Symmetric lipomatosis of the tongue (SLT) is rare and characterized by diffuse growth and unencapsulated lipomas. An 87-year-old man was referred for evaluation of tongue lesions. Intraoral findings showed soft yellowish nodules with a smooth shiny surface diffusely on the lateral border of the tongue, bilaterally. Our clinical diagnosis was ... Read more >>

Dermatol Online J (Dermatology online journal)
[2020, 26(1):]

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Diagnosis and treatment of oral lichen sclerosus in a pediatric patient.

Luciana Estevam Simonato, Saygo Tomo, Débora Lima Pereira, Oslei Paes de Almeida, Pablo Agustin Vargas, Glauco Issamu Miyahara,

Lichen sclerosus is an uncommon chronic inflammatory disease, which rarely affects the oral mucosa. Here, we describe the occurrence of oral lichen sclerosus with gingival destruction in a 12-year-old female patient. After diagnostic confirmation by histopathology, intralesional injection of corticosteroid was performed, producing satisfactory remission of the lesion. ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2019, 36(6):978-979]

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History and future perspectives for the use of fluorescence visualization to detect oral squamous cell carcinoma and oral potentially malignant disorders.

Saygo Tomo, Glauco Issamu Miyahara, Luciana Estevam Simonato,

The early diagnosis of oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD) is challenging. The use of fluorescence visualization (FV) has been improved as an auxiliary method to early detect alterations in the oral mucosa suggestive of malignancy or pre-malignancy. However, perhaps due to some misinterpretation regarding ... Read more >>

Photodiagnosis Photodyn Ther (Photodiagnosis and photodynamic therapy)
[2019, 28:308-317]

Cited: 2 times

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Follow-Up of Non-Syndromic Oligodontia With Conservative Approach.

Saygo Tomo, Tamara Fernandes de Castro, Jéssica Araújo Figueria, Elisa Mattias Sartori, Glauco Issamu Miyahara, Luciana Estevam Simonato,

J Craniofac Surg (The Journal of craniofacial surgery)
[2019, 30(6):1926-1928]

Cited: 0 times

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Uncommon oral manifestation of lichen sclerosus: critical analysis of cases reported from 1957 to 2016.

S Tomo, I-S Santos, S-A de Queiroz, D-G Bernabé, L-E Simonato, G-I Miyahara,

<h4>Background</h4>Lichen sclerosus is a mucocutaneous autoimmune disease which might be initiated by infectious pathogens as Borrelia Bugrdorferi and HPV. This disease shows destructive potential and is rarely diagnosed in oral mucosa. The purpose of this paper is to evaluate the characteristics of cases described in literature from 1957 to 2016, ... Read more >>

Med Oral Patol Oral Cir Bucal (Medicina oral, patologia oral y cirugia bucal)
[2017, 22(4):e410-e416]

Cited: 2 times

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Stress hormones concentrations in the normal microenvironment predict risk for chemically induced cancer in rats.

Vitor Bonetti Valente, Flávia Alves Verza, Felipe Yudi Kabeya Lopes, Joana Zafalon Ferreira, Paulo Sérgio Patto Dos Santos, Maria Lúcia Marçal Mazza Sundefeld, Éder Ricardo Biasoli, Glauco Issamu Miyahara, Ana Maria Pires Soubhia, Mariza de Andrade, Sandra Helena Penha de Oliveira, Daniel Galera Bernabé,

Evidence show that stress hormones can influence cancer progression, but its role in carcinogenesis is poorly understood. In this study, we used a new method based on oral carcinogenesis model in rats to test the hypothesis that physiological levels of stress hormones in the normal tissue microenvironment would have significant ... Read more >>

Psychoneuroendocrinology (Psychoneuroendocrinology)
[2018, 89:229-238]

Cited: 6 times

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Uncommon Occurrence of Lip Squamous Cell Carcinoma in a Pediatric Patient.

Saygo Tomo, Ingrid da Silva Santos, Aline Reis Stefanini, Guilherme de Oliveira Cucolicchio, Glauco Issamu Miyahara, Luciana Estevam Simonato,

Although head and neck squamous cell carcinoma represents one of the most common cancers among adults, it is rare in pediatric patients. The purpose of this report is to discuss the case of a 15-year-old male patient referred by his dentist due to a three-month old ulcer in his lower ... Read more >>

J Dent Child (Chic) (Journal of dentistry for children (Chicago, Ill.))
[2017, 84(2):86-89]

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Plasma HPV DNA is detectable in oral leukoplakia patients.

Lígia Lavezo Ferreira, Éder Ricardo Biasoli, Daniel Galera Bernabé, Cáris Maroni Nunes, Glauco Issamu Miyahara,

<h4>Background</h4>Oral leukoplakia is considered a potentially malignant lesion for the development of squamous cell carcinoma, and various risk factors may be related to its development and malignant transformation, including the human papillomavirus (HPV). The aim of this case-control study was to detect the presence of HPV in fresh tissue, plasma ... Read more >>

Pathol Res Pract (Pathology, research and practice)
[2017, 213(7):759-765]

Cited: 3 times

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Extra-Gingival Pyogenic Granuloma Displacing Teeth.

Ketelin Juliane Dal Prá, Daniel Galera Bernabé, Glauco Issamu Miyahara, Eder Ricardo Biasoli, Marcelo Macedo Crivelini, Kellen Cristine Tjioe,

Pyogenic granuloma is a common cause of growth of soft tissue in the oral cavity, especially in the gingiva. It is mainly associated with local and chronic irritants besides hormonal changes during pregnancy. Here, the authors present an unusual patient of an extra-gingival pyogenic granuloma with large dimensions and displacing ... Read more >>

J Craniofac Surg (The Journal of craniofacial surgery)
[2017, 28(2):e185-e186]

Cited: 2 times

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Pemphigus Vulgaris: How to Perform an Oral Biopsy Properly?

Aneliza de Fatima Moraes da Silva, Daniel Galera Bernabé, Glauco Issamu Miyahara, Eder Ricardo Biasoli, Renata Callestini, Kellen Cristine Tjioe,

Oral biopsy of vesiculobullous diseases such as pemphigus vulgaris often raises questions due to some particularities involving this procedure. The adequate selection of the area to be biopsied defines if the final diagnosis will be reached, being the Achiles heel of the proper management of the patient. Here, the authors ... Read more >>

J Craniofac Surg (The Journal of craniofacial surgery)
[2016, 27(8):e768-e769]

Cited: 0 times

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