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Author Giuseppe Rizzo

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Letter to Editor with regard to the article "Hybrid simulation for obstetrics training: A systematic review".

Bianca Masturzo, Tullio Ghi, Giuseppe Rizzo,

Eur. J. Obstet. Gynecol. Reprod. Biol. (European journal of obstetrics, gynecology, and reproductive biology)
[2020, :]

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Outcome of Coronavirus spectrum infections (SARS, MERS, COVID 1 -19) during pregnancy: a systematic review and meta-analysis.

Daniele Di Mascio, Asma Khalil, Gabriele Saccone, Giuseppe Rizzo, Danilo Buca, Marco Liberati, Jacopo Vecchiet, Luigi Nappi, Giovanni Scambia, Vincenzo Berghella, Francesco D'Antonio,

Objective:The aim of this systematic review was to report pregnancy and perinatal outcomes of Coronavirus (CoV) spectrum infections, and particularly COVID-19 disease due to SARS-COV-2 infection during pregnancy. Data sources:Medline, Embase, Cinahl and Clinicaltrials.gov databases were searched electronically utilizing combinations of word variants for "coronavirus" or "severe acute respiratory syndrome" ... Read more >>

Am J Obstet Gynecol MFM (American journal of obstetrics & gynecology MFM)
[2020, :100107]

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Prenatal risk factors for urgent atrial septostomy at birth in fetuses with transposition of the great arteries: a systematic review and meta-analysis.

Danilo Buca, Per Winberg, Giuseppe Rizzo, Asma Khalil, Marco Liberati, Alexander Makatsariya, Francesca Greco, Luigi Nappi, Ganesh Acharya, Francesco D'Antonio,

Purpose of the article. To explore the role of fetal echocardiography in predicting the risk of urgent balloon atrial septostomy (BAS) at birth in fetuses diagnosed with transposition of the great arteries (TGA).Material and methods: Medline, Embase, and Cochrane databases were searched. The primary aim was to explore the differences ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, :1-9]

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Single-cell transcriptomic profiling maps monocyte/macrophage transitions after myocardial infarction in mice

Giuseppe Rizzo, Ehsan Vafadarnejad, Panagiota Arampatzi, Jean-Sébastien Silvestre, Alma Zernecke, Antoine-Emmanuel Saliba, Clément Cochain,

Abstract Rationale Monocytes and macrophages have a critical and dual role in post-ischemic cardiac repair, as they can foster both tissue healing and damage. To decipher how monocytes/macrophages acquire heterogeneous functional phenotypes in the ischemic myocardium, we profiled the gene expression dynamics at the single-cell level in circulating and cardiac ... Read more >>

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Identification of large-for-gestational age fetuses using antenatal customized fetal growth charts: Can we improve the prediction of abnormal labor course?

Andrea Dall'Asta, Giuseppe Rizzo, Ariane Kiener, Nicola Volpe, Elvira Di Pasquo, Enrica Roletti, Ilenia Mappa, Alexander Makatsariya, Giuseppe Maria Maruotti, Gabriele Saccone, Laura Sarno, Marta Papaccio, Anna Fichera, Federico Prefumo, Chiara Ottaviani, Tamara Stampalija, Tiziana Frusca, Tullio Ghi,

INTRODUCTION:Fetal overgrowth is an acknowledged risk factor for abnormal labor course and maternal and perinatal complications. The objective of this study was to evaluate whether the use of antenatal ultrasound-based customized fetal growth charts in fetuses at risk for large-for-gestational age (LGA) allows a better identification of cases undergoing caesarean ... Read more >>

Eur. J. Obstet. Gynecol. Reprod. Biol. (European journal of obstetrics, gynecology, and reproductive biology)
[2020, 248:81-88]

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Pre- and postnatal brain hemodynamics in pregnancies at term: correlation with Doppler ultrasound, birthweight, and adverse perinatal outcome.

Danilo Buca, Marco Liberati, Giuseppe Rizzo, Diego Gazzolo, Francesco Chiarelli, Cosimo Giannini, Luciano Di Tizio, Ebe D'Adamo, Luigi Nappi, Giovanni Scambia, Francesco D'Antonio,

Purpose: To elucidate the correlation between pre- and postnatal cerebral Doppler in pregnancies close to term and to explore whether they are associated with perinatal outcome.Materials and methods: Prospective study on singleton pregnancies at 36-37 weeks of gestation. The primary outcome was a composite score of perinatal morbidity, while secondary outcomes ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, :1-7]

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Weight discordance and perinatal mortality in monoamniotic twin pregnancy: analysis of MONOMONO, NorSTAMP and STORK multiple-pregnancy cohorts.

G Saccone, A Khalil, B Thilaganathan, S V Glinianaia, V Berghella, F D'Antonio, ,

OBJECTIVES:The primary objective was to quantify the risk of perinatal mortality in non-anomalous monochorionic monoamniotic (MCMA) twin pregnancies complicated by birth-weight (BW) discordance. The secondary objectives were to investigate the effect of inpatient vs outpatient fetal monitoring on the risk of mortality in weight-discordant MCMA twin pregnancies, and to explore ... Read more >>

Ultrasound Obstet Gynecol (Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology)
[2020, 55(3):332-338]

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Diagnostic Accuracy of Doppler Ultrasound in Predicting Perinatal Outcome in Appropriate for Gestational Age Fetuses: A Prospective Study.

Danilo Buca, Giuseppe Rizzo, Sarah Gustapane, Ilenia Mappa, Martina Leombroni, Francesca Bascietto, Maria Elena Flacco, Cecilia Acuti Martellucci, Lamberto Manzoli, Luigi Nappi, Alessandra Familiari, Giovanni Scambia, Marco Liberati, Francesco D'Antonio,

OBJECTIVE: To elucidate the role of Doppler ultrasound in predicting perinatal outcome in appropriate for gestational age (AGA) fetuses at term. MATERIAL AND METHODS: Prospective study carried out in a dedicated research ultrasound clinic. The inclusion criterion was AGA fetuses, defined as those with an estimated fetal weight between the 10th and ... Read more >>

Ultraschall Med (Ultraschall in der Medizin (Stuttgart, Germany : 1980))
[2020, :]

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Hypoplastic left heart syndrome with prenatally diagnosed foramen ovale restriction: diagnosis, management and outcome.

Anna Jadczak, Maria Respondek-Liberska, Łukasz Sokołowski, Jędrzej Chrzanowski, Giuseppe Rizzo, Edward Araujo Júnior, Nathalie Jeanne Bravo-Valenzuela, Roland Axt-Fliedner, Maciej Słodki, ,

Objective: Despite advances in prenatal diagnosis and postnatal intervention/surgery methods, patients with Hypoplastic Left Heart Syndrome (HLHS) and coexisting foramen oval restriction still achieve high mortality rates. Our objective was to determine survival predictors and to find answers to, why restriction develops in some, but not others.Methods: We performed a ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, :1-8]

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Splenic Ly6Chi monocytes are critical players in dystrophic muscle injury and repair.

Giuseppe Rizzo, Rosanna Di Maggio, Anna Benedetti, Jacopo Morroni, Marina Bouche, Biliana Lozanoska-Ochser,

Dystrophic muscle is characterized by chronic injury and a steady recruitment of inflammatory Ly6Chi monocytes. Recent studies have identified the spleen as the dominant reservoir of these cells during chronic inflammation. Here, we investigated the contribution of splenic Ly6Chi monocytes to dystrophic muscle pathology. Using the mdx mouse model of ... Read more >>

JCI Insight (JCI insight)
[2020, 5(2):]

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Prenatal imaging features and postnatal outcomes of isolated fetal duplex renal collecting system: A systematic review and meta-analysis.

Francesca Bascietto, Asma Khalil, Giuseppe Rizzo, Alexander Makatsariya, Danilo Buca, Claudia Silvi, Matteo Ucci, Marco Liberati, Alessandra Familiari, Francesco D'Antonio,

OBJECTIVES:To perform a systematic review of studies reporting the outcome of fetuses with a prenatal diagnosis of isolated duplex collecting system (DCS). METHODS:Inclusion criteria were studies reporting the outcome of fetuses with a prenatal diagnosis of isolated DCS, defined as DCS not associated with other major structural anomalies at the ... Read more >>

Prenat. Diagn. (Prenatal diagnosis)
[2020, 40(4):424-431]

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Outcome of fetal echogenic bowel: a systematic review and meta-analysis.

Alice D'Amico, Danilo Buca, Giuseppe Rizzo, Asma Khalil, Claudia Silvi, Alexander Makatsariya, Luigi Nappi, Marco Liberati, Francesco D'Antonio,

The main aim of this systematic review was to explore the outcome of fetuses with isolated echogenic bowel (EB) on antenatal ultrasound. Inclusion criteria were singleton pregnancies with isolated EB no associated major structural anomalies at the time of diagnosis. The outcomes observed were: chromosomal anomalies, cystic fibrosis, associated structural ... Read more >>

Prenat. Diagn. (Prenatal diagnosis)
[2020, :]

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First trimester detection of fetal open spina bifida using BS/BSOB ratio.

Angelo Sirico, Antonio Raffone, Antonio Lanzone, Gabriele Saccone, Antonio Travaglino, Laura Sarno, Giuseppe Rizzo, Fulvio Zullo, Giuseppe Maria Maruotti,

BACKGROUND:Despite the well-known second trimester ultrasound signs, current possibilities of in utero surgical repair of open spina bifida require a timely detection of the spine defect. OBJECTIVE:To evaluate the diagnostic accuracy of the ratio between brain stem (BS) diameter and its distance to the occipital bone (BSOB) (BS/BSOB ratio) in ... Read more >>

Arch. Gynecol. Obstet. (Archives of gynecology and obstetrics)
[2020, 301(2):333-340]

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Role of prenatal magnetic resonance imaging in fetuses with isolated mild or moderate ventriculomegaly in the era of neurosonography: a multicenter study.

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OBJECTIVES:To assess the role of fetal magnetic resonance imaging (MRI) in detecting associated anomalies in fetuses presenting with mild and moderate isolated ventriculomegaly (VM) undergoing multiplanar ultrasound (US) evaluation of fetal brain. METHODS:Multicenter, retrospective, cohort study involving 15 referral fetal medicine centers in Italy, United Kingdom, and Spain. Inclusion criteria ... Read more >>

Ultrasound Obstet Gynecol (Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology)
[2020, :]

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Antepartum ultrasound prediction of failed vacuum-assisted operative delivery: a prospective cohort study.

Giuseppe Rizzo, Cecilia Mattioli, Ilenia Mappa, Viktoriya Bitsadze, Jamilya Khizroeva, Alexander Makatsariya, Francesco D'Antonio,

Background: Failed vacuum-assisted delivery (VD) is associated with increased risk of maternal perineal trauma and neonatal morbidity. Knowledge of the risk factors related to failed VD is essential in the clinical decision-making.Objective: To elucidate the strength of association and the predictive accuracy of different ante-partum ultrasound parameters in predicting the ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2019, :1-7]

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Diagnostic accuracy of Doppler ultrasound in predicting perinatal outcome in pregnancies at term: A prospective longitudinal study.

Francesco D'Antonio, Giuseppe Rizzo, Sarah Gustapane, Danilo Buca, Maria Elena Flacco, Cecilia Martellucci, Lamberto Manzoli, Alexander Makatsariya, Luigi Nappi, Giorgio Pagani, Marco Liberati,

INTRODUCTION:To explore the strength of association and the diagnostic accuracy of umbilical (UA), middle cerebral (MCA), uterine arteries pulsatility index (PI) and the cerebroplacental ratio in predicting an adverse outcome when applied to singleton pregnancies at term. MATERIAL AND METHODS:Prospective study carried out in a dedicated research ultrasound clinic. Attended ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2020, 99(1):42-47]

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Role of first-trimester umbilical vein flow in predicting fetal macrosomia: a matched case-control study.

Giuseppe Rizzo, Ilenia Mappa, Victoria Bitsadze, Maciej Słodki, Jamilya Khizroeva, Alexander Makatsarya, Francesco D'Antonio,

OBJECTIVE:To describe umbilical vein (UV) hemodynamic in macrosomic fetuses at 11+0 13+6 weeks of gestation and to build a multiparametric prediction model including pregnancy and ultrasound characteristics able to detect fetal macrosomia in the first trimester. METHODS:Matched case-control study including pregnancies who underwent ultrasound examination at 11+0 to 13+6 weeks ... Read more >>

Ultrasound Obstet Gynecol (Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology)
[2019, :]

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The role of first trimester fetal heart rate in the prediction of gestational diabetes: A multicenter study.

Angelo Sirico, Antonio Lanzone, Ilenia Mappa, Laura Sarno, Maciej Słodki, Dario Pitocco, Fulvio Zullo, Giuseppe Maria Maruotti, Giuseppe Rizzo,

OBJECTIVE:Early pregnancy models for prediction of GDM have been proposed, mostly using anamnestic and biochemical parameters. The aim of our study was to evaluate the strength of association of first trimester fetal heart rate (FHR) in predicting the development of gestational diabetes (GDM). STUDY DESIGN:We considered in our analysis singleton ... Read more >>

Eur. J. Obstet. Gynecol. Reprod. Biol. (European journal of obstetrics, gynecology, and reproductive biology)
[2019, 243:158-161]

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Core outcome set for studies investigating management of selective fetal growth restriction in twins.

R Townsend, J M N Duffy, F Sileo, H Perry, W Ganzevoort, K Reed, A A Baschat, J Deprest, E Gratacos, K Hecher, L Lewi, E Lopriore, D Oepkes, A Papageorghiou, S J Gordijn, A Khalil, ,

OBJECTIVE:Selective fetal growth restriction (sFGR) occurs in monochorionic twin pregnancies when unequal placental sharing leads to restriction in the growth of just one twin. Management options include laser separation of the fetal circulations, selective reduction or expectant management, but what constitutes the best treatment is not yet known. New trials ... Read more >>

Ultrasound Obstet Gynecol (Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology)
[2020, 55(5):652-660]

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Emotional Stability Interacts with Cortisol Levels Before fMRI on Brain Processing of Fearful Faces.

Antonio Rampino, Silvia Torretta, Giuseppe Rizzo, Giovanna Viscanti, Tiziana Quarto, Barbara Gelao, Leonardo Fazio, Maria Teresa Attrotto, Rita Masellis, Giulio Pergola, Alessandro Bertolino, Giuseppe Blasi,

Functional-Magnetic-Imaging (fMRI) is widely adopted to investigate neurophysiological correlates of emotion processing (EP). However, studies have reported that scanning procedures in neuroimaging protocols may increase or cause anxiety and psychological distress related with the scanning, thus inducing peripheral cortisol release. These phenomena may in turn impact on brain EP. Additionally, ... Read more >>

Neuroscience (Neuroscience)
[2019, 416:190-197]

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Hemodynamic factors associated with fetal cardiac remodeling in late fetal growth restriction: a prospective study.

Giuseppe Rizzo, Cecilia Mattioli, Ilenia Mappa, Victoria Bitsadze, Jamilya Khizroeva, Maciej Słodki, Alexander Makatsarya, Francesco D'Antonio,

Background Altered cardiac geometry affects a proportion of fetuses with growth restriction (FGR). The aim of this study was to explore the hemodynamic factors associated with cardiac remodeling in late FGR. Methods This was a prospective study of singleton pregnancies complicated by late-onset FGR undergoing assessment of left (LV) and ... Read more >>

J Perinat Med (Journal of perinatal medicine)
[2019, 47(7):683-688]

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The use of a hybrid mannequin for the modern high-fidelity simulation in the labor ward: the Italian experience of the Ecografia Gestione Emergenze Ostetriche (EGEO) group.

Tullio Ghi, Giuseppe Rizzo, ,

Regular training in the management of intrapartum emergencies has been demonstrated to yield measurable benefits in terms of maternal and perinatal outcomes. Thanks to technologic advances, computerized, full-body mannequins have been created and made available for high-fidelity simulation in obstetrics. The technical skills subjected to training are conventionally represented by ... Read more >>

Am. J. Obstet. Gynecol. (American journal of obstetrics and gynecology)
[2020, 222(1):41-47]

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Time-resolved single-cell transcriptomics uncovers dynamics of cardiac neutrophil diversity in murine myocardial infarction

Ehsan Vafadarnejad, Giuseppe Rizzo, Laura Krampert, Panagiota Arampatzi, Vallery Audy Nugroho, Dirk Schulz, Melanie Roesch, Paul Alayrac, Jose Vilar, Jean-Sébastien Silvestre, Alma Zernecke, Antoine-Emmanuel Saliba, Clément Cochain,

Abstract Objective After myocardial infarction, neutrophils rapidly and massively infiltrate the heart, where they can promote both tissue healing and damage. Here, we investigated the dynamics of cardiac neutrophil heterogeneity after infarction. Methods and results We employed single-cell transcriptomics (scRNA-seq) to investigate temporal neutrophil heterogeneity in the heart after murine ... Read more >>

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Outcome of isolated fetal talipes: A systematic review and meta-analysis.

Daniele Di Mascio, Danilo Buca, Asma Khalil, Giuseppe Rizzo, Alexander Makatsariya, Filomena Sileo, Marco Liberati, Pierluigi Benedetti Panici, Ganesh Acharya, Francesco D'Antonio,

INTRODUCTION:The aim of this systematic review was to explore the outcome of fetuses with a prenatal diagnosis of isolated talipes. MATERIAL AND METHODS:Medline, Embase, Cinahl, and Clinicaltrials.gov databases were searched. The outcomes explored were: associated anomalies detected at follow-up ultrasound examination; fetal magnetic resonance imaging (MRI) and birth; chromosomal abnormalities ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2019, 98(11):1367-1377]

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Ultrasound assessment of the cervix in predicting successful membrane sweeping: a prospective observational study.

Giuseppe Rizzo, Filomena Aloisio, Marylene Yacoub, Viktoriya Bitsadze, Maciej Słodki, Alexander Makatsariya, Francesco D'Antonio,

Objective: Membrane sweeping has been shown to potentially reduce the need for formal induction of labor. The primary aim of this study was to elucidate the role of ultrasound assessment of the cervix in predicting successful membrane sweeping in singleton pregnancies at term; the secondary aim was to build a ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2019, :1-7]

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