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Author Giuseppe Mancia

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Highlights of the December issue.

Giuseppe Mancia,

J. Hypertens. (Journal of hypertension)
[2019, 37(12):2305-2306]

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Impact of ESH and AAP hypertension guidelines for children and adolescents on office and ambulatory blood pressure-based classifications.

Empar Lurbe, Isabel Torró, Julio Álvarez, Francisco Aguilar, Giuseppe Mancia, Josep Redon, Pau Redon,

BACKGROUND:The objective was to assess the differences between the 2016 European Society of Hypertension (ESH) and the 2017 American Academy of Pediatrics (AAP) hypertension (HTN) guidelines in the distribution of office blood pressure (BP) categories as well as in the office and ambulatory BP mismatches. MATERIAL AND METHODS:The study included ... Read more >>

J. Hypertens. (Journal of hypertension)
[2019, 37(12):2414-2421]

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Do reverse dippers have the highest risk of right ventricular remodeling?

Marijana Tadic, Cesare Cuspidi, Aleksandra Sljivic, Biljana Pencic, Giuseppe Mancia, Michele Bombelli, Guido Grassi, Maurizio Galderisi, Vesna Kocijancic, Vera Celic,

We aimed to evaluate right ventricular (RV) deformation in recently diagnosed untreated hypertensive patients with different 24-h blood pressure (BP) patterns (dipping, nondipping, extreme dipping and reverse dipping). This cross-sectional study involved 190 untreated hypertensive patients who underwent 24-h ambulatory BP monitoring and a detailed two-dimensional echocardiographic examination, including the ... Read more >>

Hypertens. Res. (Hypertension research : official journal of the Japanese Society of Hypertension)
[2019, :]

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Hypertension in aortic stenosis: relationship with revealed symptoms and functional measures on treadmill exercise.

Sahrai Saeed, Giuseppe Mancia, Ronak Rajani, Denise Parkin, John B Chambers,

BACKGROUND:The impact of hypertension on symptoms and functional capacity during exercise treadmill test (ETT) in apparently asymptomatic patients with aortic stenosis is poorly understood. METHODS:A total of 314 patients (age 65 ± 12 years, 68% men) with moderate or severe asymptomatic aortic stenosis underwent baseline echocardiography and ETT. Hypertension was defined as ... Read more >>

J. Hypertens. (Journal of hypertension)
[2019, 37(11):2209-2215]

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Real-world efficacy and safety of nebivolol in Korean patients with hypertension from the BENEFIT KOREA study.

Jinho Shin, Yu Jeong Choi, Geu-Ru Hong, Dong Woon Jeon, Dae-Hyeok Kim, Young Youp Koh, Giuseppe Mancia, Athanasios J Manolis, Hyuck-Jun Yoon, Sang Won Park,

OBJECTIVE:The efficacy and safety of nebivolol in patients with hypertension is well established, but its effect in Asian patients with essential hypertension in the real world has not been studied. METHODS:Adult South Korean patients with essential hypertension, with or without comorbidities, were enrolled to participate in this prospective, single-arm, open, ... Read more >>

J. Hypertens. (Journal of hypertension)
[2019, :]

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Highlights of the November issue.

Giuseppe Mancia,

J. Hypertens. (Journal of hypertension)
[2019, 37(11):2113-2115]

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Polygenic risk scores predict diabetic complications and their response to therapy

Johanne Tremblay, Mounsif Haloui, Francois Harvey, Ramzan Tahir, Francois-Christophe Marois-Blanchet, Carole Long, Redha Attaoua, Paul Simon, Lara Santucci, Candan Hizel, John Chalmers, Michel Marre, Stephen Harrap, Renata Cifkova, Alena Krajcoviechova, David Matthews, Bryan Williams, Neil Poulter, Sophia Zoungas, Stephen Colagiuri, Giuseppe Mancia, Diederick Grobbee, Anthony Rodgers, Lisheng Liu, Mawusse Agbessi, Vanessa Bruat, Marie-Julie Fave, Michelle Harwood, Philip Awadalla, Mark Woodward, Pavel Hamet,

Type 2 diabetes increases the risk of cardiovascular and renal complications, but early risk prediction can lead to timely intervention and better outcomes. Through summary statistics of meta-analyses of published genome-wide association studies performed in over 1.2 million of individuals, we combined 9 PRS gathering genomic variants associated to cardiovascular ... Read more >>

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Inhibition of the renin-angiotensin system in the cardiorenal syndrome with anaemia: a double-edged sword.

Demetrios V Vlahakos, Costas Tsioufis, Athanasios Manolis, Gerasimos Filippatos, Katerina P Marathias, Vasilios Papademetriou, Giuseppe Mancia,

: The term 'cardiorenal syndrome' (CRS) was introduced to describe problems related to the simultaneous existence of heart and renal insufficiency. The prevalence of anaemia in CRS is high and increases the risk of hospitalizations and death. Renin-angiotensin system (RAS) inhibition is the cornerstone therapy in cardiovascular and renal medicine. ... Read more >>

J. Hypertens. (Journal of hypertension)
[2019, 37(11):2145-2153]

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Effects of renal denervation on kidney function and long-term outcomes: 3-year follow-up from the Global SYMPLICITY Registry.

Felix Mahfoud, Michael Böhm, Roland Schmieder, Krzysztof Narkiewicz, Sebastian Ewen, Luis Ruilope, Markus Schlaich, Bryan Williams, Martin Fahy, Giuseppe Mancia,

AIMS:Several studies and registries have demonstrated sustained reductions in blood pressure (BP) after renal denervation (RDN). The long-term safety and efficacy after RDN in real-world patients with uncontrolled hypertension, however, remains unknown. The objective of this study was to assess the long-term safety and efficacy of RDN, including its effects ... Read more >>

Eur. Heart J. (European heart journal)
[2019, 40(42):3474-3482]

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Evaluation, risk stratification and management of hypertensive patients in the perioperative period.

Maria Koutsaki, Dimitrios Patoulias, Pavlos Tsinivizov, Michael Doumas, Manolis Kallistratos, Costas Thomopoulos, Leonidas Poulimenos, Giancarlo Agnelli, Giuseppe Mancia, Athanasios Manolis,

Uncontrolled hypertension represents an important cause for postponing a non-cardiac surgery. Perioperative management of hypertensive patients should focus on cardiovascular risk stratification, evaluation of blood pressure levels and hypertension control, registration of the ongoing antihypertensive regimen and counseling about clinical decisions related to the expected perioperative blood pressure fluctuations. To ... Read more >>

Eur. J. Intern. Med. (European journal of internal medicine)
[2019, 69:1-7]

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Highlights of the October issue.

Giuseppe Mancia,

J. Hypertens. (Journal of hypertension)
[2019, 37(10):1915-1916]

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Extreme dipping: is the cardiovascular risk increased? An unsolved issue.

Cesare Cuspidi, Marijana Tadic, Carla Sala, Elisa Gherbesi, Guido Grassi, Giuseppe Mancia,

: Extreme dipping (i.e. a marked blood pressure fall during night-time period) is an alteration of circadian blood pressure (BP) rhythm frequently observed in the setting of systemic hypertension as well as in the general population. Some reports have suggested that cardiovascular prognosis in extreme dippers (ED) is similar as ... Read more >>

J. Hypertens. (Journal of hypertension)
[2019, 37(10):1917-1926]

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Pheochromocytoma as a Clinical Model of Peripheral Sympathetic Overdrive: Old and New Findings.

Guido Grassi, Fosca Quarti Trevano, Raffaella Dell'Oro, Gino Seravalle, Giuseppe Mancia,

PURPOSE OF REVIEW:The present paper will review the results of experimental and clinical studies aimed at defining the functional behavior of the central and peripheral nervous system in adrenal pheochromocytoma. RECENT FINDINGS:The contribution of sympathetic neural influences to the development of high blood pressure values in pheochromocytoma is complex. Studies ... Read more >>

Curr. Hypertens. Rep. (Current hypertension reports)
[2019, 21(11):90]

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Limited reproducibility of MUCH and WUCH: evidence from the ELSA study.

Giuseppe Mancia, Rita Facchetti, Cesare Cuspidi, Michele Bombelli, Giovanni Corrao, Guido Grassi,

AIMS:To evaluate the long-term reproducibility of masked (MUCH) and white-coat uncontrolled hypertension (WUCH), an information crucial for determining the long-term prognostic impact of these conditions. METHODS AND RESULTS:Reproducibility of MUCH and WUCH was assessed in 1664 hypertensive patients recruited for the European Lacidipine Study on Atherosclerosis and treated with atenolol ... Read more >>

Eur. Heart J. (European heart journal)
[2019, :]

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Target blood pressure values in the US and European Guidelines. Are they truly similar?

Giuseppe Mancia,

J Clin Hypertens (Greenwich) (Journal of clinical hypertension (Greenwich, Conn.))
[2019, 21(10):1602-1603]

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Antihypertensive treatment with calcium channel blockers in patients with moderate or severe aortic stenosis: Relationship with all-cause mortality.

Sahrai Saeed, Giuseppe Mancia, Ronak Rajani, Denise Parkin, John B Chambers,

BACKGROUND:Hypertension is common in patients with aortic stenosis (AS) and optimal blood pressure (BP) control is advised to reduce arterial load and cardiovascular events. Whether calcium channel blockers (CCB) are safe is not known. METHODS:This was a retrospective analysis of 314 patients (age 65 ± 12 years, 68% men) with moderate or severe ... Read more >>

Int. J. Cardiol. (International journal of cardiology)
[2019, :]

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The impact of systolic and diastolic blood pressure variability on mortality is age dependent: Data from the Dublin Outcome Study.

Grzegorz Bilo, Eamon Dolan, Eoin O'Brien, Rita Facchetti, Davide Soranna, Antonella Zambon, Giuseppe Mancia, Gianfranco Parati,

BACKGROUND:Twenty-four-hour blood pressure variability (BPV) is independently related to cardiovascular outcomes, but limited and conflicting evidence is available on the relative prognostic importance of systolic and diastolic BPV. The aim of this study was to verify the hypothesis that the association of systolic and diastolic blood pressure variability over 24 h ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2019, :2047487319872572]

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Blood Pressure Non-Dipping and Obstructive Sleep Apnea Syndrome: A Meta-Analysis.

Cesare Cuspidi, Marijana Tadic, Carla Sala, Elisa Gherbesi, Guido Grassi, Giuseppe Mancia,

AIM:We examined the reduced blood pressure (BP) nocturnal fall in patients with obstructive sleep apnea (OSA) by a meta-analysis including studies that provided data on prevalence rates of non-dipping (ND) pattern during 24-h ambulatory blood pressure monitoring (ABPM). DESIGN:The PubMed, OVID-MEDLINE, and Cochrane CENTRAL literature databases were searched for appropriate ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(9):]

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The association between 24-h blood pressure patterns and left ventricular mechanics.

Marijana Tadic, Cesare Cuspidi, Anka Majstorovic, Biljana Pencic, Giuseppe Mancia, Michele Bombelli, Guido Grassi, Vesna Kocijancic, Vladimir Djukic, Vera Celic,

OBJECTIVE:We sought to investigate left ventricular (LV) mechanics in the recently diagnosed hypertensive patients with different 24-h blood pressure (BP) patterns (dipping, nondipping, extreme dipping and reverse dipping). METHODS:The current cross-sectional study included 209 hypertensive patients who underwent 24-h ambulatory BP monitoring and comprehensive two-dimensional echocardiographic examination including multilayer strain ... Read more >>

J. Hypertens. (Journal of hypertension)
[2019, :]

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Women discontinue antihypertensive drug therapy more than men. Evidence from an Italian population-based study.

Federico Rea, Marta Mella, Matteo Monzio Compagnoni, Anna Cantarutti, Luca Merlino, Giuseppe Mancia, Giovanni Corrao,

OBJECTIVE:Several factors affect adherence to antihypertensive drug treatment, but whether these factors include a sex difference is unclear. Aim of the study was to compare persistence with antihypertensive drug therapy between men and women in a large cohort of patients. METHODS:The 60 526 residents of the Italian Lombardy Region aged 40-80 ... Read more >>

J. Hypertens. (Journal of hypertension)
[2019, :]

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Effectiveness of two-drug therapy versus monotherapy as initial regimen in hypertension: A propensity score-matched cohort study in the UK Clinical Practice Research Datalink.

Karine Marinier, Pauline Macouillard, Martine de Champvallins, Nicolas Deltour, Neil Poulter, Giuseppe Mancia,

PURPOSE:To compare the effectiveness on blood pressure (BP) of initial two-drug therapy versus monotherapy in hypertensive patients. METHODS:Using the Clinical Practice Research Datalink, linked with Hospital Episode Statistics and Office for National Statistics, we identified a cohort of adults with uncontrolled hypertension, initiating one or two antihypertensive drug classes between ... Read more >>

Pharmacoepidemiol Drug Saf (Pharmacoepidemiology and drug safety)
[2019, :]

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Sympathetic neural overdrive in congestive heart failure and its correlates: systematic reviews and meta-analysis.

Guido Grassi, Graziella D'Arrigo, Anna Pisano, Davide Bolignano, Francesca Mallamaci, Raffaella Dell'Oro, Fosca Quarti-Trevano, Gino Seravalle, Giuseppe Mancia, Carmine Zoccali,

BACKGROUND AND OBJECTIVES:Sympathetic neural activation occurs in congestive heart failure (CHF). However, the small sample size of the microneurographic studies, heterogeneity of the patients examined, presence of comorbidities as well as confounders (including treatment) represented major weaknesses not allowing to identify the major features of the phoenomenon, particularly in mild ... Read more >>

J. Hypertens. (Journal of hypertension)
[2019, 37(9):1746-1756]

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Intensive glucose-lowering and the risk of vascular events and premature death in patients with decreased kidney function: The ADVANCE trial.

Toshiaki Ohkuma, Sophia Zoungas, Min Jun, Liu Lisheng, Giuseppe Mancia, Michel Marre, Anthony Rodgers, Bryan Williams, Mark Woodward, John Chalmers, ,

To assess the effects of intensive glucose control on the risk of major clinical outcomes according to estimated glomerular filtration rate (eGFR) levels in people with type 2 diabetes. Of 11 140 ADVANCE trial participants, 11 096 with baseline eGFR measurements were included, and classified into three eGFR groups: ≥90 mL/min/1.73 m2 ; 60 ... Read more >>

Diabetes Obes Metab (Diabetes, obesity & metabolism)
[2019, :]

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Highlights of the September issue.

Giuseppe Mancia,

J. Hypertens. (Journal of hypertension)
[2019, 37(9):1735-1736]

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Initial combination treatment in the 2018 ESC/ESH hypertension guidelines.

Giuseppe Mancia,

Anatol J Cardiol (Anatolian journal of cardiology)
[2019, 22(3):100-101]

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