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Author Giuseppe Lippi

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Red blood cell distribution width (RDW) in Hospitalized COVID-19 Patients

Preethi Ramachandran, Mahesh Gajendran, Abhilash Perisetti, Karim Osama Elkholy, Abhishek Chakraborti, Giuseppe Lippi, Hemant Goyal,

Introduction: Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is causing dramatic morbidity and mortality worldwide. The Red Blood Cell Distribution Width (RDW) has been strongly associated with increased morbidity and mortality in multiple diseases. Objective: To assess if elevated RDW is associated with unfavorable outcomes in ... Read more >>

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Further advices on measuring lipoprotein(a) for reducing the residual cardiovascular risk on statin therapy.

Giuseppe Lippi, Giovanni Targher,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(8):e144-e147]

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The need for accurate D‐dimer reporting in COVID‐19: Communication from the ISTH SSC on Fibrinolysis.

Jecko Thachil, Colin Longstaff, Emmanuel J. Favaloro, Giuseppe Lippi, Tetsumei Urano, Paul Y. Kim,

AbstractThe coronavirus disease 2019 (COVID‐19) pandemic continues to claim many lives across the world. In the attempts to identify a reliable prognostic indicator, marked elevation of D‐dimer has been a strong contender.1,2 In many studies, D‐dimers have consistently been shown to be the most significant marker for illness severity and ... Read more >>

J. Thromb. Haemost. (Journal of thrombosis and haemostasis : JTH)
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Do genetic polymorphisms in angiotensin converting enzyme 2 (ACE2) gene play a role in coronavirus disease 2019 (COVID-19)?

Giuseppe Lippi, Carl J Lavie, Brandon M Henry, Fabian Sanchis-Gomar,

Although some demographic, clinical and environmental factors have been associated with a higher risk of developing coronavirus disease 2019 (COVID-19) and progressing towards severe disease, altogether these variables do not completely account for the different clinical presentations observed in patients with comparable baseline risk, whereby some subjects may remain totally ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, :]

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Eosinophil count in severe coronavirus disease 2019.

G Lippi, B M Henry,

QJM (QJM : monthly journal of the Association of Physicians)
[2020, 113(7):511-512]

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Lower nasopharyngeal viral load during the latest phase of COVID-19 pandemic in a Northern Italy University Hospital.

Nicola Clementi, Roberto Ferrarese, Marco Tonelli, Virginia Amato, Sara Racca, Massimo Locatelli, Giuseppe Lippi, Guido Silvestri, Massimo Clementi, Nicasio Mancini,

Objectives A milder clinical course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been anecdotally reported over the latest phase of COVID-19 pandemic in Italy. Several factors may contribute to this observation, including the effect of lockdown, social distancing, lower humidity, lower air pollution, and potential changes in ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, :]

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A modern and pragmatic definition of Laboratory Medicine.

Giuseppe Lippi, Mario Plebani,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(8):1171]

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Diagnostic and clinical significance of "atypical" symptoms in coronavirus disease 2019.

Giuseppe Lippi, Camilla Mattiuzzi,

(Polish archives of internal medicine)
[2020, 130(6):478-480]

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GM1 as Adjuvant of Innovative Therapies for Cystic Fibrosis Disease.

Giulia Mancini, Nicoletta Loberto, Debora Olioso, Maria Cristina Dechecchi, Giulio Cabrini, Laura Mauri, Rosaria Bassi, Domitilla Schiumarini, Elena Chiricozzi, Giuseppe Lippi, Emanuela Pesce, Sandro Sonnino, Nicoletta Pedemonte, Anna Tamanini, Massimo Aureli,

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein is expressed at the apical plasma membrane (PM) of different epithelial cells. The most common mutation responsible for the onset of cystic fibrosis (CF), F508del, inhibits the biosynthesis and transport of the protein at PM, and also presents gating and stability defects of ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(12):]

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Statins and other drugs: Facing COVID-19 as a vascular disease.

Fabian Sanchis-Gomar, Carme Perez-Quilis, Emmanuel J Favaloro, Giuseppe Lippi,

Pharmacol. Res. (Pharmacological research)
[2020, 159:105033]

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Editorial Compilation VIII.

Emmanuel J Favaloro, Giuseppe Lippi,

Semin. Thromb. Hemost. (Seminars in thrombosis and hemostasis)
[2020, 46(4):393-397]

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Exact time of venous blood sample collection - an unresolved issue, on behalf of the European Federation for Clinical Chemistry and Laboratory Medicine (EFLM) Working Group for Preanalytical Phase (WG-PRE).

Alexander von Meyer, Giuseppe Lippi, Ana-Maria Simundic, Janne Cadamuro,

Objectives An accurate knowledge of blood collection times is crucial for verifying the stability of laboratory analytes. We therefore aimed to (i) assess if and how this information is collected throughout Europe and (ii) provide a list of potentially available solutions. Methods A survey was issued by the European Federation ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, :]

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Do sex-specific immunobiological factors and differences in angiotensin converting enzyme 2 (ACE2) expression explain increased severity and mortality of COVID-19 in males?

Jens Vikse, Giuseppe Lippi, Brandon Michael Henry,

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2), shares similarities with the former SARS outbreak, which was caused by SARS-CoV-1. SARS was characterized by severe lung injury due to virus-induced cytopathic effects and dysregulated hyperinflammatory state. COVID-19 has a higher mortality rate in men ... Read more >>

Diagnosis (Berl) (Diagnosis (Berlin, Germany))
[2020, :]

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Operational considerations and challenges of biochemistry laboratories during the COVID-19 outbreak: an IFCC global survey.

Tze Ping Loh, Andrea Rita Horvath, Cheng-Bin Wang, David Koch, Khosrow Adeli, Nicasio Mancini, Maurizio Ferrari, Robert Hawkins, Sunil Sethi, Giuseppe Lippi, ,

Objectives The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Task Force on COVID-19 conducted a global survey to understand how biochemistry laboratories manage the operational challenges during the coronavirus disease 2019 (COVID-19) pandemic. Materials and methods An electronic survey was distributed globally to record the operational considerations to ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, :]

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COVID-19: unravelling the clinical progression of nature's virtually perfect biological weapon.

Giuseppe Lippi, Fabian Sanchis-Gomar, Brandon M Henry,

Coronavirus disease 2019 (COVID-19) pandemic has shocked the world and caused morbidity and mortality on an unprecedented level in the era of modern medicine. Evidence generated to-date on the virulence and pathogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suggests that COVID-19 may be considered a perfect storm, caused ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2020, 8(11):693]

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Errors within the total laboratory testing process, from test selection to medical decision-making - A review of causes, consequences, surveillance and solutions.

Cornelia Mrazek, Giuseppe Lippi, Martin H Keppel, Thomas K Felder, Hannes Oberkofler, Elisabeth Haschke-Becher, Janne Cadamuro,

Laboratory analyses are crucial for diagnosis, follow-up and treatment decisions. Since mistakes in every step of the total testing process may potentially affect patient safety, a broad knowledge and systematic assessment of laboratory errors is essential for future improvement. In this review, we aim to discuss the types and frequencies ... Read more >>

Biochem Med (Zagreb) (Biochemia medica)
[2020, 30(2):020502]

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Headache is an important symptom in patients with coronavirus disease 2019 (COVID-19).

Giuseppe Lippi, Camilla Mattiuzzi, Chiara Bovo, Brandon Michael Henry,

Diagnosis (Berl) (Diagnosis (Berlin, Germany))
[2020, :]

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Laboratory abnormalities in children with novel coronavirus disease 2019.

Brandon Michael Henry, Giuseppe Lippi, Mario Plebani,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(7):1135-1138]

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Urinalysis parameters for predicting severity in coronavirus disease 2019 (COVID-19).

Graziella Bonetti, Filippo Manelli, Alessandra Bettinardi, Gianluca Borrelli, Gianfranco Fiordalisi, Antonio Marino, Annamaria Menolfi, Sara Saggini, Roberta Volpi, Riccardo Adamini, Giuseppe Lippi,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, :]

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Laboratory practices to mitigate biohazard risks during the COVID-19 outbreak: an IFCC global survey.

Tze Ping Loh, Andrea Rita Horvath, Cheng-Bin Wang, David Koch, Giuseppe Lippi, Nicasio Mancini, Maurizio Ferrari, Robert Hawkins, Sunil Sethi, Khosrow Adeli, ,

Objectives A global survey was conducted by the IFCC Task Force on COVID-19 to better understand how general biochemistry laboratories manage the pre-analytical, analytical and post-analytical processes to mitigate biohazard risks during the coronavirus disease 2019 (COVID-19) pandemic. Methods An electronic survey was developed to record the general characteristics of ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, :]

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Laboratory predictors of death from coronavirus disease 2019 (COVID-19) in the area of Valcamonica, Italy.

Graziella Bonetti, Filippo Manelli, Andrea Patroni, Alessandra Bettinardi, Gianluca Borrelli, Gianfranco Fiordalisi, Antonio Marino, Annamaria Menolfi, Sara Saggini, Roberta Volpi, Adriano Anesi, Giuseppe Lippi,

Background Comprehensive information has been published on laboratory tests which may predict worse outcome in Asian populations with coronavirus disease 2019 (COVID-19). The aim of this study is to describe laboratory findings in a group of Italian COVID-19 patients in the area of Valcamonica, and correlate abnormalities with disease severity. ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(7):1100-1105]

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Biosafety measures for preventing infection from COVID-19 in clinical laboratories: IFCC Taskforce Recommendations.

Giuseppe Lippi, Khosrow Adeli, Maurizio Ferrari, Andrea R Horvath, David Koch, Sunil Sethi, Cheng-Bin Wang,

Coronavirus disease 2019 (COVID-19) is the third coronavirus outbreak that has emerged in the past 20 years, after severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). One important aspect, highlighted by many global health organizations, is that this novel coronavirus outbreak may be especially hazardous to healthcare ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(7):1053-1062]

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Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research.

Behnood Bikdeli, Mahesh V Madhavan, Aakriti Gupta, David Jimenez, John R Burton, Caroline Der Nigoghossian, Taylor Chuich, Shayan Nabavi Nouri, Isaac Dreyfus, Elissa Driggin, Sanjum Sethi, Kartik Sehgal, Saurav Chatterjee, Walter Ageno, Mohammad Madjid, Yutao Guo, Liang V Tang, Yu Hu, Laurent Bertoletti, Jay Giri, Mary Cushman, Isabelle Quéré, Evangelos P Dimakakos, C Michael Gibson, Giuseppe Lippi, Emmanuel J Favaloro, Jawed Fareed, Alfonso J Tafur, Dominic P Francese, Jaya Batra, Anna Falanga, Kevin J Clerkin, Nir Uriel, Ajay Kirtane, Claire McLintock, Beverley J Hunt, Alex C Spyropoulos, Geoffrey D Barnes, John W Eikelboom, Ido Weinberg, Sam Schulman, Marc Carrier, Gregory Piazza, Joshua A Beckman, Martin B Leon, Gregg W Stone, Stephan Rosenkranz, Samuel Z Goldhaber, Sahil A Parikh, Manuel Monreal, Harlan M Krumholz, Stavros V Konstantinides, Jeffrey I Weitz, Gregory Y H Lip, ,

Coronavirus disease 2019 (COVID-19), currently a worldwide pandemic, is a viral illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The suspected contribution of thrombotic events to morbidity and mortality in COVID-19 patients has prompted a search for novel potential options for preventing COVID-19-associated thrombotic disease. In this ... Read more >>

Thromb. Haemost. (Thrombosis and haemostasis)
[2020, 120(7):1004-1024]

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Assessment of immune response to SARS-CoV-2 with fully automated MAGLUMI 2019-nCoV IgG and IgM chemiluminescence immunoassays.

Giuseppe Lippi, Gian Luca Salvagno, Manuela Pegoraro, Valentina Militello, Cecilia Caloi, Angelo Peretti, Stefania Gaino, Antonella Bassi, Chiara Bovo, Giuliana Lo Cascio,

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(7):1156-1159]

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Potential preanalytical and analytical vulnerabilities in the laboratory diagnosis of coronavirus disease 2019 (COVID-19).

Giuseppe Lippi, Ana-Maria Simundic, Mario Plebani,

A novel zoonotic coronavirus outbreak is spreading all over the world. This pandemic disease has now been defined as novel coronavirus disease 2019 (COVID-19), and is sustained by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As the current gold standard for the etiological diagnosis of SARS-CoV-2 infection is (real time) ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(7):1070-1076]

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