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Author Giuseppe Indolfi

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Letter: universal screening for hepatitis C in pregnancy, children and adolescents-authors' reply.

Giuseppe Indolfi, Ersilia Lucenteforte,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(7):979-980]

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The decrease of Kawasaki syndrome during the second COVID-19 wave: a potential, unexpected effect of social distancing.

Maria Vincenza Mastrolia, Rino Agostiniani, Chiara Azzari, Roberto Bernardini, Ugo Bottone, Giovanni Battista Calabri, Flavio Civitelli, Rita Consolini, Roberto Danieli, Rosalia Di Silvio, Susanna Falorni, Luigi Gagliardi, Salvatore Grosso, Giuseppe Indolfi, Manuela L'Erario, Marco Martini, Graziano Memmini, Diego Peroni, Marco Pezzati, Giovanni Suriano, Luca Tafi, Sandra Trapani, Angelina Vaccaro, Pier Luigi Vasarri, Simonini Gabriele,

Clin Exp Rheumatol (Clinical and experimental rheumatology)
[2021, :]

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Spontaneous Clearance of Vertically Acquired Hepatitis C Infection: Implications for Testing and Treatment

Ades, Fabiana Gordon, Karen Scott, Jeannie Collins, Claire Thorne, Lucy Pembrey, Elizabeth Chappell, Eugènia Mariné-Barjoan, Karina Butler, Giuseppe Indolfi, Diana Gibb, Ali Judd,

<h4>Background</h4> Current guidelines recommend that infants born to women with hepatitis C (HCV) viremia are screened for HCV antibody at age 18 months, and if positive, referred for RNA testing at 3 years to confirm chronic infection. This policy is based in part on analyses suggesting 25%-40% of vertically acquired ... Read more >>

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Overall vertical transmission of HCV, transmission net of clearance, and timing of transmission

Ades, Fabiana Gordon, Karen Scott, Jeannie Collins, Claire Thorne, Lucy Pembrey, Elizabeth Chappell, Eugènia Mariné-Barjoan, Karina Butler, Giuseppe Indolfi, Diana Gibb, Ali Judd,

<h4>Background</h4> It is widely accepted that the risk of HCV vertical transmission (VT) is 5-6% in mono-infected women, and that 25-40% of HCV infection clears spontaneously within 5 years. However, VT and clearance rates have not been estimated from the same datasets, and there is a lack of information on ... Read more >>

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Gastrointestinal, hepatic and pancreatic manifestations of COVID-19 in children.

Francesco Pegoraro, Sandra Trapani, Giuseppe Indolfi,

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a well-established respiratory tract pathogen. Recent studies in adults and children have shown an increasing number of patients reporting gastrointestinal manifestations of SARS-CoV-2 infection such as diarrhoea, nausea, vomiting and abdominal pain. SARS-CoV-2 RNA can be detected in faeces for an extended period, ... Read more >>

Clin Res Hepatol Gastroenterol (Clinics and research in hepatology and gastroenterology)
[2021, :101818]

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Sofosbuvir/velpatasvir for the treatment of hepatitis C in pediatric patients.

Chiara Rubino, Sandra Trapani, Giuseppe Indolfi,

<b>Introduction</b>: Sofosbuvir/velpatasvir is a combination of direct-acting antivirals with pangenotypic activity for treatment of chronic hepatitis C virus infection. It was approved in 2020 for use in children aged 6-17 years and in June 2021 by the United States Food and Drug Administration for the age group 3-5 years.<b>Areas covered</b>: A literature ... Read more >>

Expert Rev Gastroenterol Hepatol (Expert review of gastroenterology & hepatology)
[2021, 15(10):1097-1105]

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Case Report: Perioperative Kounis Syndrome in an Adolescent With Congenital Glaucoma.

Guglielmo Capponi, Mattia Giovannini, Ioanna Koniari, Francesca Mori, Chiara Rubino, Gaia Spaziani, Giovanni Battista Calabri, Silvia Favilli, Elio Novembre, Giuseppe Indolfi, Luciano De Simone, Sandra Trapani,

A 12-year-old male patient suffering from congenital glaucoma developed bradycardia, left ventricular failure, and hypotension after induction of anesthesia. Electrocardiography and echocardiography revealed a complete normalization of ECG and a complete spontaneous recovery in the cardiac function 72 hours from the beginning of the clinical manifestations, while cardiac Magnetic Resonance ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2021, 8:676188]

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NBAS Variants Are Associated with Quantitative and Qualitative NK and B Cell Deficiency.

Dominic Lenz, Jens Pahl, Fabian Hauck, Seham Alameer, Meena Balasubramanian, Ivo Baric, Nikolas Boy, Joseph A Church, Ellen Crushell, Anke Dick, Felix Distelmaier, Jidnyasa Gujar, Giuseppe Indolfi, Eberhard Lurz, Bianca Peters, Tobias Schwerd, Daniele Serranti, Stefan Kölker, Christoph Klein, Georg F Hoffmann, Holger Prokisch, Johann Greil, Adelheid Cerwenka, Thomas Giese, Christian Staufner,

<h4>Purpose</h4>Biallelic pathogenic NBAS variants manifest as a multisystem disorder with heterogeneous clinical phenotypes such as recurrent acute liver failure, growth retardation, and susceptibility to infections. This study explores how NBAS-associated disease affects cells of the innate and adaptive immune system.<h4>Methods</h4>Clinical and laboratory parameters were combined with functional multi-parametric immunophenotyping methods ... Read more >>

J Clin Immunol (Journal of clinical immunology)
[2021, :]

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Surveillance on Healthcare Workers During the First Wave of SARS-CoV-2 Pandemic in Italy: The Experience of a Tertiary Care Pediatric Hospital.

Valentina Guarnieri, Maria Moriondo, Mattia Giovannini, Lorenzo Lodi, Silvia Ricci, Laura Pisano, Paola Barbacci, Costanza Bini, Giuseppe Indolfi, Alberto Zanobini, Chiara Azzari,

Healthcare workers (HCWs) play a central role in handling the ongoing coronavirus disease 2019 (COVID-19) pandemic. Monitoring HCWs, both symptomatic and asymptomatic, through screening programs, are critical to avoid the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the hospital environment to rapidly identify and isolate infected ... Read more >>

Front Public Health (Frontiers in public health)
[2021, 9:644702]

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Gastrointestinal involvement in IgA vasculitis: a single-center 11-year study on a cohort of 118 children.

Chiara Rubino, Costanza Monacelli, Edoardo Marrani, Monica Paci, Giuseppe Indolfi, Gabriele Simonini, Sandra Trapani,

<h4>Introduction and objectives</h4>Immunoglobulin A vasculitis (IgAV), the most common childhood vasculitis, is associated with gastrointestinal (GI) involvement in 50-75% of cases. The aim of this study was to describe the characteristics of GI involvement in a cohort of hospitalized children with IgAV.<h4>Methods</h4>We retrospectively evaluated patients hospitalized for IgAV at Meyer ... Read more >>

Clin Rheumatol (Clinical rheumatology)
[2021, :]

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Real-time polymerase chain reaction on filter paper spotted samples: a gateway to molecular diagnosis of invasive bacterial diseases for rural areas in low-income countries.

Elisa De Vitis, Silvia Ricci, Francesco Nieddu, Maria Moriondo, Martina Cortimiglia, Arianna Casini, Lorenzo Lodi, Giuseppe Indolfi, Chiara Azzari,

<h4>Background</h4>Bacterial culture is the gold standard for the diagnosis of invasive bacterial diseases (IBDs) but molecular methods are more specific and sensitive. Fresh liquid samples (FLSs) show patent limitations for shipping and storage. We aimed to evaluate the sensitivity and specificity of real-time polymerase chain reaction (PCR) performed on dried ... Read more >>

Trans R Soc Trop Med Hyg (Transactions of the Royal Society of Tropical Medicine and Hygiene)
[2021, :]

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Effective and Safe Daclatasvir Drug Exposures Predicted in Children Using Adult Formulations.

Tim R Cressey, Maggie Abbassi, Marc Lallemant, Giuseppe Indolfi, Mogeb Al-Nahari, Samar Farid, Martina Penazzato, Philippa Easterbrook, Manal H El-Sayed,

<h4>Background</h4>Sofosbuvir (SOF)/daclatasvir (DCV) is the direct-acting antiviral regimen of choice in many low- and middle-income countries for curative treatment of chronic hepatitis C virus (HCV) infection in adults, but data on the use of DCV in children are lacking. We performed a population pharmacokinetic (PK) analysis to predict DCV exposure ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, :]

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Chronic asymptomatic SARS-CoV-2 infection in the immunocompromised patient: new challenges and urgent needs.

Lorenzo Lodi, Maria Moriondo, Alessandra Pucci, Laura Pisano, Silvia Ricci, Giuseppe Indolfi, Chiara Azzari,

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, :]

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Impact of SARS-CoV-2 Pandemic and Strategies for Resumption of Activities During the Second Wave of the Pandemic: A Report From Eight Paediatric Hospitals From the ECHO Network.

Giuseppe Indolfi, Micol Stivala, Matteo Lenge, Ruben Diaz Naderi, Jennifer McIntosh, Ricard Casadevall Llandrich, Joe Gannon, Kathleen S McGreevy, Sandra Trapani, Päivi Miettinen, Pekka Lahdenne, Louisa Desborough, Jana Pavare, Annemarie van Rossum, Dagmara Zyska, Massimo Resti, Alberto Zanobini,

The Severe Acute Respiratory Syndrome CoronaVirus type 2 (SARS-CoV-2) pandemic impacted the organization of paediatric hospitals. This study aimed to evaluate the preparedness for the pandemic among a European network of children's hospitals and to explore the strategies to restart health care services. A cross-sectional, web-based survey was distributed in ... Read more >>

Front Public Health (Frontiers in public health)
[2021, 9:630168]

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SNPs of the IFNL favour spontaneous clearance of HCV infection in children.

Giusi Mangone, Daniele Serranti, Elisa Bartolini, Veronica Vigna, Greta Mastrangelo, Silvia Ricci, Sandra Trapani, Chiara Azzari, Massimo Resti, Giuseppe Indolfi,

<h4>Background</h4>Both spontaneous and treatment-induced clearance of hepatitis C virus (HCV) in adults have been associated with genetic polymorphisms in the interferon-λ genes. The aim of the present study was to confirm the association between the rs12979860 and evaluate the association between the rs368234815 and the rs4803217 single-nucleotide polymorphisms (SNPs) of ... Read more >>

Pediatr Res (Pediatric research)
[2021, :]

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Parent-Collected Nasal Swab for Severe Acute Respiratory Syndrome Coronavirus 2 Testing in Children.

Lorenzo Lodi, Chiara Rubino, Maria Moriondo, Laura Pisano, Valeria Astorino, Francesco Citera, Mattia Giovannini, Sandra Trapani, Massimo Resti, Silvia Ricci, Giuseppe Indolfi, Chiara Azzari,

This cross-sectional study, including children hospitalized for severe acute respiratory syndrome coronavirus 2 infection, demonstrates for the first time that nonhealthcare worker parents perform similarly to healthcare workers in the administration to their children of an unsupervised nasal swab for severe acute respiratory syndrome coronavirus 2 detection by following written ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(5):e202-e204]

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Netherton Syndrome in Children: Management and Future Perspectives.

Federica Barbati, Mattia Giovannini, Teresa Oranges, Lorenzo Lodi, Simona Barni, Elio Novembre, Ermanno Baldo, Mario Cristofolini, Stefano Stagi, Silvia Ricci, Francesca Mori, Cesare Filippeschi, Chiara Azzari, Giuseppe Indolfi,

Netherton syndrome (NS) is a genetic, multisystemic disease classically distinguished by a triad of clinical manifestations: congenital ichthyosiform erythroderma, hair shaft abnormalities, and immune dysregulation. Due to the complex pathogenesis of the disease, there are no specific therapies currently accessible for patients with NS. An early diagnosis is crucial to ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:645259]

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How home anterior self-collected nasal swab simplifies SARS-CoV-2 testing: new surveillance horizons in public health and beyond.

Silvia Ricci, Lorenzo Lodi, Francesco Citera, Francesco Nieddu, Maria Moriondo, Valentina Guarnieri, Mattia Giovannini, Giuseppe Indolfi, Massimo Resti, Alberto Zanobini, Chiara Azzari,

The sample collection procedure for SARS-CoV-2 has a strong impact on diagnostic capability, contact tracing approach, ultimately affecting the infection containment performance. This study demonstrates that self-collected nasal-swab has shown to be a valid and well tolerated procedure to SARS-CoV-2 surveillance in a healthcare system. More significantly, no performance adequacy ... Read more >>

Virol J (Virology journal)
[2021, 18(1):59]

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Molecular typing of group B Neisseria meningitidis'subcapsular antigens directly on biological samples demonstrates epidemiological congruence between culture-positive and -negative cases: A surveillance study of invasive disease over a 13-year period.

Lorenzo Lodi, Maria Moriondo, Francesco Nieddu, Silvia Ricci, Sara Guiducci, Francesca Lippi, Clementina Canessa, Elisa Calistri, Francesco Citera, Mattia Giovannini, Giuseppe Indolfi, Massimo Resti, Chiara Azzari,

<h4>Background</h4>Surveillance of serogroup B Neisseria meningitidis (MenB) subcapsular antigen variant distribution in invasive disease (IMD) is fundamental for multicomponent vaccine coverage prediction. IMD incidence in Tuscany in 2018 was 0.37/100,000 inhabitants, with MenB representing 57% of cases. More than 50% of MenB responsible for IMD cannot be grown in culture, ... Read more >>

J Infect (The Journal of infection)
[2021, 82(4):28-36]

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Gastrointestinal and hepatic involvement in paediatric systemic lupus erythematosus.

Sandra Trapani, Chiara Rubino, Gabriele Simonini, Giuseppe Indolfi,

Systemic lupus erythematosus (SLE) is a multisystemic, autoimmune, inflammatory disease. Gastrointestinal (GI) involvement, extensively described in adults, is less characterised in paediatric-onset SLE (pSLE). The aim of the present narrative review was to provide a comprehensive summary and update on GI involvement in pSLE. A literature search on PubMed and ... Read more >>

Clin Exp Rheumatol (Clinical and experimental rheumatology)
[2021, 39(4):899-906]

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Recurrent Bilateral Salpingitis in a Sexually Inactive Adolescent: Don't Forget about the Appendix.

Chiara Rubino, Federica Barbati, Marta Regoli, Erica Bencini, Alberto Mattei, Francesca Fierro, Ilaria Brizzi, Giuseppe Indolfi,

<h4>Background</h4>Salpingitis is an acute inflammation of the fallopian tubes and is extremely uncommon in patients who are sexually inactive or premenarchal.<h4>Case</h4>We describe a 15-year-old sexually inactive patient with recurrent bilateral salpingitis. After the second episode, she underwent an exploratory laparoscopy and was diagnosed with chronic appendicitis.<h4>Summary and conclusion</h4>Appendicular involvement should ... Read more >>

J Pediatr Adolesc Gynecol (Journal of pediatric and adolescent gynecology)
[2021, 34(2):217-219]

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How Home Anterior Self-collected Nasal Swab Simplifies SARS-CoV2 Testing: New Surveillance Horizons in Public Health and Beyond.

Silvia Ricci, Lorenzo Lodi, Francesco Citera, Francesco Nieddu, Maria Moriondo, Valentina Guarnieri, Mattia Giovannini, Giuseppe Indolfi, Massimo Resti, Alberto Zanobini, Chiara Azzari,

The sample collection procedure for SARS-Co-V2 identification has a strong impact on diagnostic capability, contact tracing approach, ultimately affecting the infection containment performance. This study demonstrates that self-collected nasal-swab has shown to be a valid and well tolerated procedure to Sars-CoV-2 surveillance in a healthcare system. More significantly, no performance ... Read more >>

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Efficacy of Sofosbuvir/Ledipasvir in Adolescents With Chronic Hepatitis C Genotypes 1, 3, and 4: A Real-world Study.

Daniele Serranti, Gabriella Nebbia, Mara Cananzi, Emanuele Nicastro, Fabiola Di Dato, Federica Nuti, Silvia Garazzino, Erika Silvestro, Vania Giacomet, Federica Forlanini, Michele Pinon, Pier Luigi Calvo, Silvia Riva, Icilio Dodi, Antonina Marta Cangelosi, Roberto Antonucci, Silvia Ricci, Elisa Bartolini, Greta Mastrangelo, Sandra Trapani, Matteo Lenge, Paola Gaio, Pietro Vajro, Raffaele Iorio, Lorenzo D'Antiga, Giuseppe Indolfi,

<h4>Objectives</h4>Sofosbuvir/Ledipasvir (SOF/LDV) has been approved by the European Medicine Agency (EMA) for the treatment of children and adolescents (at least 3 years of age) with chronic hepatitis C (CHC) genotype 1, 3, and 4 infection. The aim of this study was to evaluate the efficacy and safety of SOF/LDV in ... Read more >>

J Pediatr Gastroenterol Nutr (Journal of pediatric gastroenterology and nutrition)
[2021, 72(1):95-100]

Cited: 2 times

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Leopard-like retinopathy and severe early-onset portal hypertension expand the phenotype of KARS1-related syndrome: a case report.

Francesca Peluso, Viviana Palazzo, Giuseppe Indolfi, Francesco Mari, Roberta Pasqualetti, Elena Procopio, Claudia Nesti, Renzo Guerrini, Filippo Santorelli, Sabrina Giglio,

<h4>Background</h4>Mutations in lysyl-tRNA synthetase (KARS1), an enzyme that charges tRNA with the amino acid lysine in both the cytoplasm and mitochondria, have been associated thus far with autosomal recessive Charcot-Marie-Tooth type CMTRIB, hearing loss type DFNB89, and mitochondrial encephalohepatopathy (MEH) featuring neurodevelopmental disorders with microcephaly, white matter changes, and cardiac ... Read more >>

BMC Med Genomics (BMC medical genomics)
[2021, 14(1):25]

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Criteria for referral of pediatric SARS-CoV-2 infection: a real-life experience in the pandemic era.

Carlotta Montagnani, Elisabetta Venturini, Manuela L'Erario, Chiara Tersigni, Barbara Bortone, Leila Bianchi, Francesca Menegazzo, Giuseppe Indolfi, Elena Chiappini, Luisa Galli,

A practical guidance on the management of children with COVID-19 to insure homogeneous criteria for referral to a higher-level facility, according to the disease severity, is pivotal in the pandemic era. A panel of experts in pediatric infectious diseases and intensive care at the tertiary-care Meyer Children's University Hospital, Florence, ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):181]

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