Full Text Journal Articles by
Author Giuseppe Crisafulli

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Direct drug provocation test for the diagnosis of self-reported, mild and immediate drug hypersensitivity reaction in children and adolescents: our real-life experience.

Daniela Nisticò, Stefano Passanisi, Erminia M Oppedisano, Lucia Caminiti, Alessandra Marino, Paolo Ruggeri, Giuseppe Crisafulli, Giovanni B Pajno,

BACKGROUND:Approximately 10% of the parents report suspected drug hypersensitivity reactions to at least one drug in their children, but most of these reactions are not confirmed after an adequate diagnostic work-up. The diagnosis of drugs hypersensitivity is frequently laborious and based on anamnesis, skin tests, serum-specific IgE research and drug ... Read more >>

Minerva Pediatr. (Minerva pediatrica)
[2020, :]

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Hypersensitivity Reactions to Monoclonal Antibodies in Children.

Francesca Mori, Francesca Saretta, Annamaria Bianchi, Giuseppe Crisafulli, Silvia Caimmi, Lucia Liotti, Paolo Bottau, Fabrizio Franceschini, Claudia Paglialunga, Giampaolo Ricci, Angelica Santoro, Carlo Caffarelli,

Biologic drugs are widely used in pediatric medicine. Monoclonal antibodies (mAbs) in particular are a therapeutic option for rheumatic, autoinflammatory and oncologic diseases. Adverse drug reactions and hypersensitivity reactions (HSR) to mAbs may occur in children. Clinical presentation of HSRs to mAbs can be classified according to phenotypes in infusion-related ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2020, 56(5):]

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Omalizumab for treatment of refractory severe atopic dermatitis. A pediatric perspective.

Mauro Iannelli, Lucia Caminiti, Mario Vaccaro, Ilenia Marafioti, Antonietta Spinuzza, Ilenia Panasiti, Andrea Barbalace, Giuseppe Crisafulli, Giovanni B Pajno,

Omalizumab is a monoclonal antibody, targeting Fc receptor of IgE, approved for the treatment of allergic asthma and chronic spontaneous urticaria. Its utility in atopic dermatitis appears controversial from data in literature since the molecule is well tolerated but it seems less effective than other medications used in adult patients ... Read more >>

Dermatol Ther (Dermatologic therapy)
[2020, :e13519]

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Omalizumab in children and adolescents with chronic spontaneous urticaria: Case series and review of the literature.

Stefano Passanisi, Stefania Arasi, Lucia Caminiti, Giuseppe Crisafulli, Giuseppina Salzano, Giovanni B Pajno,

The recent EAACI/GA2 LEN/EDF/WAO guidelines recommend omalizumab (anti-IgE) for the management of patients aged ≥12 years with chronic urticaria unresponsive to high-doses second-generation H1 -antihistamines (antiH1 ). However, there is little published information on the success of omalizumab for such a treatment in children. We reported our experience of six patients ... Read more >>

Dermatol Ther (Dermatologic therapy)
[2020, :e13489]

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Allergic contact dermatitis in pediatric patients with type 1 diabetes: An emerging issue.

Fortunato Lombardo, Giuseppina Salzano, Giuseppe Crisafulli, Ilenia Panasiti, Angela Alibrandi, Maria Francesca Messina, Giovanni Battista Pajno, Lucia Caminiti, Stefano Passanisi,

AIMS:Aim of our observational study was to assess the prevalence of allergic contact dermatitis among children and adolescents with type 1 diabetes who use technological devices for diabetes treatment and its management. Secondary outcome was to identify possible clinical and/or demographic variables that could be associated to contact dermatitis. METHODS:Among ... Read more >>

Diabetes Res. Clin. Pract. (Diabetes Research and Clinical Practice)
[2020, 162:108089]

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Advances in Management of Food Allergy in Children.

Fernanda Chiera, Lucia Caminiti, Giuseppe Crisafulli, Giovanni Battista Pajno,

Food allergy is a potentially life-threatening medical condition and a significant public health concern worldwide. The current management consists of strict avoidance of the culprit food and treating any adverse reactions from unintended food ingestion. The increasing prevalence of food allergy encouraged research and clinical trials in the field of ... Read more >>

Curr Pediatr Rev (Current pediatric reviews)
[2020, 16(2):123-128]

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Thyrotropin serum levels and coexistence with Hashimoto's thyroiditis as predictors of malignancy in children with thyroid nodules.

Giuseppina Zirilli, Giuseppina Salzano, Domenico Corica, Giovanni Battista Pajno, Cristina Mignosa, Giorgia Pepe, Filippo De Luca, Giuseppe Crisafulli,

Thyroid cancer (TC) in childhood is a rare disease characterized by an excellent prognosis. Thyroid nodules in children, although less common than in adults, have a greater risk of malignancies, particularly in those cases associated with anamnestic, clinical and ultrasonographic risk factors.Among the factors, which have been found to be ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2019, 45(1):96]

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Mechanisms of hypersensitivity reactions induced by drugs.

Fabrizio Franceschini, Paolo Bottau, Silvia Caimmi, Fabio Cardinale, Giuseppe Crisafulli, Lucia Liotti, Francesca Saretta, Roberto Bernardini, Francesca Mori, Carlo Caffarelli,

Adverse drug reactions include drug hypersensitivity reactions (DHRs), which can be immunologically mediated or non-immunologically mediated. The high number of DHRs unconfirmed and/or self-reported is a frequent problem in daily clinical practice, with considerable impact on future prescription choices and patient health. It is important to distinguish between hypersensitivity and ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):44-51]

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Subclinical Hypothyroidism in Children: When a Replacement Hormonal Treatment Might Be Advisable.

Giuseppe Crisafulli, Tommaso Aversa, Giuseppina Zirilli, Giovanni Battista Pajno, Domenico Corica, Filippo De Luca, Malgorzata Wasniewska,

Aim of this mini review was to analyze the main variables which should be taken into account when the decision regarding a possible treatment with L-T4 has to be considered for a child with subclinical hypothyroidism (SH). The indications of periodical monitoring and vigilance have been also discussed. It was ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2019, 10:109]

Cited: 4 times

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Pediatric drug hypersensitivity: which diagnostic tests?

Francesca Saretta, Francesca Mori, Fabio Cardinale, Lucia Liotti, Fabrizio Franceschini, Giuseppe Crisafulli, Silvia Caimmi, Paolo Bottau, Roberto Bernardini, Carlo Caffarelli,

Along with the anamnesis and clinical evaluation, diagnostic tests are one of the mainstream key points in the evaluation and management of drug hypersensitivity reactions (DHR). A wide knowledge gap, both in diagnosis and management of pediatric DHR, must be filled.  Only a few published studies evaluated sensitivity and specificity ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):94-107]

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Clinical features, outcomes and treatment in children with drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis.

Lucia Liotti, Silvia Caimmi, Paolo Bottau, Roberto Bernardini, Fabio Cardinale, Francesca Saretta, Francesca Mori, Giuseppe Crisafulli, Fabrizio Franceschini, Carlo Caffarelli,

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which can be considered a late-onset allergic reaction, can cause serious long-term sequelae. SJS/TEN are considered a spectrum of life-threatening adverse drug reactions. They have the same clinical manifestations and the only difference is in the extent of epidermal detachment. These conditions ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):52-60]

Cited: 1 time

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A practical management of children with antibiotic allergy.

Elisabetta Calamelli, Carlo Caffarelli, Fabrizio Franceschini, Francesca Saretta, Fabio Cardinale, Roberto Bernardini, Lucia Liotti, Francesca Mori, Giuseppe Crisafulli, Silvia Caimmi, Paolo Bottau,

About 10% of the parents reported that their children are allergic to one drug and the betalactam antibiotics are the most frequently suspected. Even if most of the adverse events following antibiotic prescriptions to children are considered allergic, after a full allergy work-up only a few of the suspected reactions ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):11-19]

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Anaphylaxis to cutaneous exposure to bovine colostrum based cream.

Federica Porcaro, Lucia Caminiti, Giuseppe Crisafulli, Francesco Guglielmo, Giovanni Battista Pajno,

Children who are highly sensitive to milk may also have severe allergic reactions after exposure to cow's milk proteins(CMP) through a different administration route than the oral one. We describe the case of a 16-year-old Caucasian boy with a clinical history of persistent cow's milk allergy (CMA), who developed one ... Read more >>

Asian Pac. J. Allergy Immunol. (Asian Pacific journal of allergy and immunology)
[2019, 37(1):9-11]

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Chronic urticaria and drug hypersensitivity in children.

Carlo Mastrorilli, Roberto Bernardini, Lucia Liotti, Fabrizio Franceschini, Giuseppe Crisafulli, Silvia Caimmi, Paolo Bottau, Francesca Mori, Fabio Cardinale, Francesca Saretta, Giovanni Simeone, Marcello Bergamini, Carlo Caffarelli,

The cause of chronic urticaria remains often elusive. The association between chronic urticaria and intake of medications have been reported in children. However, the causative role of drugs has been rarely ascertained by onset of symptoms on drug provocation test. Chronic urticaria can be mediated by immunologic and nonimmunologic mechanisms. ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):61-65]

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Drug desensitization in allergic children.

Silvia Caimmi, Carlo Caffarelli, Francesca Saretta, Lucia Liotti, Giuseppe Crisafulli, Fabio Cardinale, Paolo Bottau, Francesca Mori, Fabrizio Franceschini, Roberto Bernardini, Gian Luigi Marseglia,

Drug allergy is an increasing problem worldwide, affecting all populations and races, children and adults, and for which diagnosis and treatment are not well standardized yet. Besides classical treatments, new drugs have been developed, especially for patients suffering from malignancies and chronic inflammatory diseases, that specifically target the cause of ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):20-29]

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Mild cutaneous reactions to drugs.

Giuseppe Crisafulli, Fabrizio Franceschini, Silvia Caimmi, Paolo Bottau, Lucia Liotti, Francesca Saretta, Roberto Bernardini, Fabio Cardinale, Francesca Mori, Carlo Caffarelli,

Adverse reactions to drugs are not frequent in childhood. Cutaneous reactions are the most frequent in this age group. Mild cutaneous reactions are immediate or delayed adverse reactions that do not seriously compromise the clinical condition of children. The patients usually early improve and recover the state of health. Although ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):36-43]

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The safety of oral immunotherapy for food allergy during maintenance phase: Effect of counselling on adverse reactions.

Stefania Arasi, Lucia Caminiti, Giuseppe Crisafulli, Ilenia Panasiti, Andrea Barbalace, Giovanni Passalacqua, Giovanni Battista Pajno,

World Allergy Organ J (The World Allergy Organization journal)
[2019, 12(1):100010]

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Management of the child with allergy to non-antibiotic drugs.

Roberto Bernardini, Fabio Cardinale, Francesca Mori, Francesca Saretta, Lucia Liotti, Fabrizio Franceschini, Giuseppe Crisafulli, Silvia Caimmi, Paolo Bottau, Carlo Caffarelli,

Non-steroidal anti-inflammatory drugs, perioperative drugs, radio contrast media and chemotherapeutics drugs are, after the non-antibiotic drugs, the drugs most commonly responsible for allergic reactions in children. Management is different depending on the drug involved. ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):5-10]

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Omalizumab in children with severe allergic disease: a case series.

Giuseppe Crisafulli, Lucia Caminiti, Fernanda Chiera, Stefania Arasi, Giuseppina Salzano, Ilenia Panasiti, Andrea Barbalace, Giovanni Battista Pajno,

BACKGROUND:Currently, severe allergic asthma and food allergy in children represent an important public health problem with medical, psychosocial and economic impacts. Omalizumab is a humanized monoclonal anti-IgE antibody, approved for refractory allergic asthma and chronic urticaria. It has been widely used in clinical practice as add-on therapy in patients with ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2019, 45(1):13]

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Drug-induced anaphylaxis in children.

Fabio Cardinale, Doriana Amato, Maria Felicia Mastrototaro, Carlo Caffarelli, Giuseppe Crisafulli, Fabrizio Franceschini, Lucia Liotti, Silvia Caimmi, Paolo Bottau, Francesca Saretta, Francesca Mori, Roberto Bernardini,

Anaphylaxis represents one of the most frequent medical emergencies in childhood. However, as compared to adults, drugs are less common triggers of anaphylaxis in children, with a frequency which is increasing  from infancy to adolescence. Deaths seldom occur, maybe because of the paucity of comorbidities in children.  Antibiotics and non-steroidal ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):30-35]

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Drug reaction with eosinophilia and systemic symptoms (DRESS) in children.

Francesca Mori, Carlo Caffarelli, Silvia Caimmi, Paolo Bottau, Lucia Liotti, Fabrizio Franceschini, Fabio Cardinale, Roberto Bernardini, Giuseppe Crisafulli, Francesca Saretta, Elio Novembre,

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a severe reaction to drugs. Incidence of DRESS in children is not well known and the mortality rate seems to be lower than 10%. Anticonvulsants are the main drugs involved both in adults and in children. The treatment of choice is ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):66-79]

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SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children.

Carlo Caffarelli, Fabrizio Franceschini, Davide Caimmi, Francesca Mori, Lucia Diaferio, Dora Di Mauro, Carla Mastrorilli, Stefania Arasi, Simona Barni, Paolo Bottau, Silvia Caimmi, Fabio Cardinale, Pasquale Comberiati, Giuseppe Crisafulli, Lucia Liotti, Umberto Pelosi, Francesca Saretta, Gianluigi Marseglia, Marzia Duse, Francesco Paravati,

Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs). Laboratory tests for identifying children who are allergic to drugs have low diagnostic accuracy and predictive value. The gold standard to diagnose DHR is represented by the drug provocation test (DPT), ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2018, 44(1):147]

Cited: 9 times

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A general strategy for de novo immunotherapy design: the active treatment of food allergy.

Stefania Arasi, Lucia Caminiti, Giuseppe Crisafulli, Giovanni Battista Pajno,

INTRODUCTION:IgE-mediated food allergy (FA) has been emerging as a public health priority. It is a potentially life-threatening condition with negative impact on the quality of life of patients and their family and its prevalence is increasing in westernized countries in the recent two decades. The current standard approach to FA ... Read more >>

Expert Rev Clin Immunol (Expert review of clinical immunology)
[2018, 14(8):665-671]

Cited: 1 time

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Allergic contact dermatitis and diabetes medical devices: 2 clinical cases.

Stefano Passanisi, Fortunato Lombardo, Andrea Barbalace, Lucia Caminiti, Ilenia Panasiti, Giuseppe Crisafulli, Giuseppina Salzano, Giovanni B Pajno,

Contact Derm. (Contact dermatitis)
[2018, 79(2):115-117]

Cited: 1 time

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Evaluating children with suspected allergic reactions to vaccines for infectious diseases.

Fabrizio Franceschini, Paolo Bottau, Silvia Caimmi, Fabio Cardinale, Giuseppe Crisafulli, Lucia Liotti, Guido Pellegrini, Diego Peroni, Francesca Saretta, Carla Mastrorilli, Carlo Caffarelli,

BACKGROUND:Vaccines often contain potentially allergenic material in addition to pathogen-specific immunogens that may induce allergic reactions. Parents and physicians often suspect that adverse reactions to vaccines are allergic in etiology. The concern that some of the substances contained in vaccines may trigger an anaphylactic reaction may lead to a low ... Read more >>

Allergy Asthma Proc (Allergy and asthma proceedings)
[2018, 39(3):177-183]

Cited: 4 times

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