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Author Giuseppe Cosentino

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Isolated bulbar palsy after SARS-CoV-2 infection.

Massimiliano Todisco, Enrico Alfonsi, Sebastiano Arceri, Giulia Bertino, Carlo Robotti, Michele Albergati, Matteo Gastaldi, Cristina Tassorelli, Giuseppe Cosentino,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):169-170]

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Electrophysiological features of acute inflammatory demyelinating polyneuropathy associated with SARS-CoV-2 infection

Antonino Uncini, Camillo Foresti, Barbara Frigeni, Storti Benedetta, Maria Cristina Servalli, Stefano Gazzina, Giuseppe Cosentino, Francesca Bianchi, Ubaldo Del Carro, Enrico Alfonsi, Stefano Cotti Piccinelli, Giovanni De Maria, Alessandro Padovani, Massimiliano Filosto, Luigi Ippoliti,

<h4>Objective</h4> To assess whether patients with acute inflammatory demyelinating polyneuropathy (AIDP) associated with SARS-CoV-2 show characteristic electrophysiological features. <h4>Methods</h4> Clinical and electrophysiological findings of 24 patients with SARS-CoV-2 infection and AIDP (S-AIDP) and of 48 control AIDP (C-AIDP) without SARS-CoV-2 infection were compared. <h4>Results</h4> S-AIDP patients more frequently developed respiratory ... Read more >>

Neurophysiol Clin (Neurophysiologie clinique = Clinical neurophysiology)
[2021, :]

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Guillain-Barré syndrome and COVID-19: an observational multicentre study from two Italian hotspot regions.

Massimiliano Filosto, Stefano Cotti Piccinelli, Stefano Gazzina, Camillo Foresti, Barbara Frigeni, Maria Cristina Servalli, Maria Sessa, Giuseppe Cosentino, Enrico Marchioni, Sabrina Ravaglia, Chiara Briani, Francesca Castellani, Gabriella Zara, Francesca Bianchi, Ubaldo Del Carro, Raffaella Fazio, Massimo Filippi, Eugenio Magni, Giuseppe Natalini, Francesco Palmerini, Anna Maria Perotti, Andrea Bellomo, Maurizio Osio, Giuseppe Scopelliti, Marinella Carpo, Andrea Rasera, Giovanna Squintani, Pietro Emiliano Doneddu, Valeria Bertasi, Maria Sofia Cotelli, Laura Bertolasi, Gian Maria Fabrizi, Sergio Ferrari, Federico Ranieri, Francesca Caprioli, Elena Grappa, Laura Broglio, Giovanni De Maria, Ugo Leggio, Loris Poli, Frank Rasulo, Nicola Latronico, Eduardo Nobile-Orazio, Alessandro Padovani, Antonino Uncini,

<h4>Objective</h4>Single cases and small series of Guillain-Barré syndrome (GBS) have been reported during the SARS-CoV-2 outbreak worldwide. We evaluated incidence and clinical features of GBS in a cohort of patients from two regions of northern Italy with the highest number of patients with COVID-19.<h4>Methods</h4>GBS cases diagnosed in 12 referral hospitals ... Read more >>

J Neurol Neurosurg Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2020, :]

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A Rare Syndrome Causing Neurogenic Dysphagia.

Antonio Zito, Paola Bini, Massimiliano Todisco, Giuseppe Cosentino, Simone Mauramati, Matteo Paoletti, Vincenzo Marasco, Enrico Marchioni, Enrico Alfonsi,

Dysphagia (Dysphagia)
[2020, :]

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Chronic inflammatory demyelinating polyradiculoneuropathy: can a diagnosis be made in patients not fulfilling electrodiagnostic criteria?

G Liberatore, F Manganelli, P E Doneddu, D Cocito, R Fazio, C Briani, M Filosto, L Benedetti, A Mazzeo, G Antonini, G Cosentino, S Jann, A Cortese, G A Marfia, A M Clerici, G Siciliano, M Carpo, M Luigetti, G Lauria, T Rosso, G Cavaletti, L Santoro, E Peci, S Tronci, M Ruiz, S Cotti Piccinelli, A Schenone, L Leonardi, A Toscano, G Mataluni, E Spina, L Gentile, E Nobile-Orazio, ,

<h4>Background and purpose</h4>The aim was to identify the clinical and diagnostic investigations that may help to support a diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in patients not fulfilling the European Federation of Neurological Societies and Peripheral Nerve Society (EFNS/PNS) electrodiagnostic criteria.<h4>Methods</h4>The data from patients with a clinical diagnosis of ... Read more >>

Eur J Neurol (European journal of neurology)
[2021, 28(2):620-629]

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Severe breathlessness in Stiff person syndrome (SPS). Looking under the bonnet.

Grazia Crescimanno, Margherita Algeri, Maria Canino, Marcello Romano, Giuseppe Cosentino, Oreste Marrone,

J Neurol Sci (Journal of the neurological sciences)
[2020, 418:117144]

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Mutation in RNF170 causes sensory ataxic neuropathy with vestibular areflexia: a CANVAS mimic.

Andrea Cortese, Ilaria Callegari, Riccardo Currò, Elisa Vegezzi, Silvia Colnaghi, Maurizio Versino, Enrico Alfonsi, Giuseppe Cosentino, Enzamaria Valente, Simone Gana, Cristina Tassorelli, Anna Pichiecchio, Alexander M Rossor, Enrico Bugiardini, Antonio Biroli, Daniela Di Capua, Henry Houlden, Mary M Reilly,

J Neurol Neurosurg Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2020, 91(11):1237-1238]

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Frequency of diabetes and other comorbidities in chronic inflammatory demyelinating polyradiculoneuropathy and their impact on clinical presentation and response to therapy.

Pietro Emiliano Doneddu, Dario Cocito, Fiore Manganelli, Raffaella Fazio, Chiara Briani, Massimiliano Filosto, Luana Benedetti, Elisa Bianchi, Stefano Jann, Anna Mazzeo, Giovanni Antonini, Giuseppe Cosentino, Girolama Alessandra Marfia, Andrea Cortese, Angelo Maurizio Clerici, Marinella Carpo, Angelo Schenone, Gabriele Siciliano, Marco Luigetti, Giuseppe Lauria, Tiziana Rosso, Guido Cavaletti, Ettore Beghi, Giuseppe Liberatore, Lucio Santoro, Emanuele Spina, Erdita Peci, Stefano Tronci, Marta Ruiz, Stefano Cotti Piccinelli, Elena Pinuccia Verrengia, Luca Gentile, Luca Leonardi, Giorgia Mataluni, Laura Piccolo, Eduardo Nobile-Orazio, ,

<h4>Objectives</h4>To determine the prevalence of different comorbidities in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), and their impact on outcome, treatment choice and response.<h4>Methods</h4>Using a structured questionnaire, we collected information on comorbidities from 393 patients with CIDP fulfilling the European Federation of Neurological Societies and Peripheral Nerve Society criteria included in the ... Read more >>

J Neurol Neurosurg Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2020, 91(10):1092-1099]

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KCTD17-related myoclonus-dystonia syndrome: clinical and electrophysiological findings of a patient with atypical late onset.

Massimiliano Todisco, Simone Gana, Giuseppe Cosentino, Edoardo Errichiello, Sebastiano Arceri, Micol Avenali, Enza Maria Valente, Enrico Alfonsi,

<h4>Introduction</h4>Myoclonus-dystonia is a rare syndrome typically occurring during childhood or adolescence, mainly due to SGCE pathogenic variants. Early-onset, atypical presentations of myoclonus-dystonia have recently been associated with KCTD17 variants. In these cases, laryngeal involvement was reported in the advanced stages.<h4>Methods</h4>We evaluated a 52-year-old man with myoclonus-dystonia and positive family history. ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2020, 78:129-133]

Cited: 1 time

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Reply to: "Anodal transcranial direct current stimulation and intermittent theta burst stimulation improve deglutition and swallowing reproducibility in elderly patients with dysphagia: A methodological issue to avoid misinterpretation".

Giuseppe Cosentino, Massimiliano Todisco, Enrico Alfonsi,

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2020, 32(8):e13933]

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Reproducibility and reaction time of swallowing as markers of dysphagia in parkinsonian syndromes.

Giuseppe Cosentino, Cristina Tassorelli, Paolo Prunetti, Massimiliano Todisco, Roberto De Icco, Micol Avenali, Brigida Minafra, Roberta Zangaglia, Francesca Valentino, Claudio Pacchetti, Giulia Bertino, Simone Mauramati, Mauro Fresia, Enrico Alfonsi,

<h4>Objective</h4>To investigate reproducibility and reaction time of oropharyngeal swallowing in patients with Parkinson's disease (PD) and atypical parkinsonisms (APs).<h4>Methods</h4>We enrolled 19 patients with PD, 30 with APs, and 20 healthy subjects. Presence and severity of dysphagia were assessed with clinical and fiberoptic endoscopic evaluations of swallowing. Reproducibility of the oral ... Read more >>

Clin Neurophysiol (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology)
[2020, 131(9):2200-2208]

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Intranasal midazolam for treating acute respiratory crises in a woman with stiff person syndrome.

Giuseppe Cosentino, Marcello Romano, Margherita Algeri, Filippo Brighina, Enrico Alfonsi, Cristina Tassorelli, Grazia Crescimanno,

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(4):]

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Sensitivity and specificity of a commercial ELISA test for anti-MAG antibodies in patients with neuropathy.

Giuseppe Liberatore, Claudia Giannotta, Blesson Punnen Sajeev, Emanuela Morenghi, Fabrizia Terenghi, Francesca Gallia, Pietro Emiliano Doneddu, Fiore Manganelli, Dario Cocito, Massimiliano Filosto, Giovanni Antonini, Giuseppe Cosentino, Girolama Alessandra Marfia, Angelo Maurizio Clerici, Giuseppe Lauria, Tiziana Rosso, Guido Cavaletti, Eduardo Nobile-Orazio,

For the diagnosis of anti-MAG polyneuropathy the commercial ELISA manufacturer currently recommends a cut-off of 1000 Bühlmann Titer Units (BTU). We analyzed sera from 80 anti-MAG neuropathy patients and 383 controls (with other neuropathies or healthy controls) to assess the ELISA sensitivity and specificity at different thresholds. A better combination ... Read more >>

J Neuroimmunol (Journal of neuroimmunology)
[2020, 345:577288]

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RELEVANCE OF DIAGNOSTIC INVESTIGATIONS IN CHRONIC INFLAMMATORY DEMYELINATING POLIRADICULONEUROPATHY: DATA FROM THE ITALIAN CIDP DATABASE.

Giuseppe Liberatore, Fiore Manganelli, Fiore Manganelli, Dario Cocito, Raffaella Fazio, Chiara Briani, Massimiliano Filosto, Luana Benedetti, Giovanni Antonini, Giuseppe Cosentino, Stefano Jann, Anna Mazzeo, Andrea Cortese, Girolama Alessandra Marfia, Angelo Maurizio Clerici, Gabriele Siciliano, Marinella Carpo, Mario Sabatelli, Giuseppe Lauria, Tiziana Rosso, Eduardo Nobile Orazio, ,

Background and aims to report the clinical features and the relevance of diagnostic investigations in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We retrospectively reviewed data from patients with a clinical diagnosis of CIDP included in a national database. Among the 500 included patients with a clinical diagnosis of CIDP, ... Read more >>

J Peripher Nerv Syst (Journal of the peripheral nervous system : JPNS)
[2020, :]

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Is Transcranial Magnetic Resonance Imaging-Guided Focused Ultrasound a Repeatable Treatment Option? Case Report of a Retreated Patient With Tremor Combined With Parkinsonism.

Francesca Valentino, Giuseppe Cosentino, Rosario Maugeri, Roberto Giammalva, Gerardo Domenico Iacopino, Maurizio Marrale, Tommaso Vincenzo Bartolotta, Cesare Gagliardo,

<h4>Introduction</h4>In recent years, transcranial Magnetic Resonance Imaging-guided Focused Ultrasound (tcMRgFUS) treatments for functional neurological disorders are giving a new thrust to the field of therapeutic brain lesioning.<h4>Objective</h4>To present the case of a patient affected by tremor combined with Parkinsonism who underwent a second tcMRgFUS thalamotomy because of relapsing tremor after ... Read more >>

Oper Neurosurg (Hagerstown) (Operative neurosurgery (Hagerstown, Md.))
[2020, 18(6):577-582]

Cited: 1 time

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Impact of environmental factors and physical activity on disability and quality of life in CIDP.

Pietro Emiliano Doneddu, Elisa Bianchi, Dario Cocito, Fiore Manganelli, Raffaella Fazio, Massimiliano Filosto, Ettore Beghi, Anna Mazzeo, Giuseppe Cosentino, Andrea Cortese, Stefano Jann, Angelo Maurizio Clerici, Giovanni Antonini, Gabriele Siciliano, Girolama Alessandra Marfia, Chiara Briani, Giuseppe Lauria, Tiziana Rosso, Guido Cavaletti, Marinella Carpo, Luana Benedetti, Angelo Schenone, Giuseppe Liberatore, Erdita Peci, Emanuele Spina, Stefano Tronci, Stefano Cotti Piccinelli, Antonio Toscano, Luca Gentile, Laura Piccolo, Luca Leonardi, Giorgia Mataluni, Marta Ruiz, Mario Sabatelli, Lucio Santoro, Eduardo Nobile-Orazio, ,

A few observational studies and randomized trials suggest that exercise and rehabilitation may improve activity limitation and quality of life (QoL) in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), but the impact of other modifiable factors on the severity of the disease is not well understood. Using a structured questionnaire, ... Read more >>

J Neurol (Journal of neurology)
[2020, 267(9):2683-2691]

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Experimentally induced spinal nociceptive sensitization increases with migraine frequency: a single-blind controlled study.

Roberto De Icco, Armando Perrotta, Valentina Grillo, Giuseppe Cosentino, Grazia Sances, Giorgio Sandrini, Cristina Tassorelli,

The nitric-oxide donor nitroglycerin (NTG) administration induces a facilitation of nociceptive pathways in episodic migraine. This study aims to test the hypothesis that induced spinal sensitization could be more pronounced in patients affected by high-frequency migraine (HF-MIG) with respect to low-frequency migraine (LF-MIG). We enrolled 28 patients with LF-MIG (1-5 ... Read more >>

Pain (Pain)
[2020, 161(2):429-438]

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Anodal transcranial direct current stimulation and intermittent theta-burst stimulation improve deglutition and swallowing reproducibility in elderly patients with dysphagia.

Giuseppe Cosentino, Cristina Tassorelli, Paolo Prunetti, Giulia Bertino, Roberto De Icco, Massimiliano Todisco, Salvatore Di Marco, Filippo Brighina, Antonio Schindler, Mariangela Rondanelli, Mauro Fresia, Luca Mainardi, Domenico A Restivo, Alberto Priori, Giorgio Sandrini, Enrico Alfonsi,

BACKGROUND:Dysphagia in the elderly, known as presbydysphagia, has become a relevant public health problem in several countries. Swallowing disorders may be a consequence of different neurological disorders (secondary presbydysphagia) or the expression of the aging process itself (primary presbydysphagia). We aimed to test the therapeutic potential of two different non-invasive ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2020, 32(5):e13791]

Cited: 0 times

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Multisensorial Perception in Chronic Migraine and the Role of Medication Overuse.

Simona Maccora, Nadia Bolognini, Giuseppe Cosentino, Roberta Baschi, Giuseppe Vallar, Brigida Fierro, Filippo Brighina,

Multisensory processing can be assessed by measuring susceptibility to crossmodal illusions such as the Sound-Induced Flash Illusion (SIFI). When a single flash is accompanied by 2 or more beeps, it is perceived as multiple flashes (fission illusion); conversely, a fusion illusion is experienced when more flashes are matched with a ... Read more >>

J Pain (The journal of pain)
[2020, 21(7-8):919-929]

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Antibodies to neurofascin, contactin-1, and contactin-associated protein 1 in CIDP: Clinical relevance of IgG isotype.

Andrea Cortese, Raffaella Lombardi, Chiara Briani, Ilaria Callegari, Luana Benedetti, Fiore Manganelli, Marco Luigetti, Sergio Ferrari, Angelo M Clerici, Girolama Alessandra Marfia, Andrea Rigamonti, Marinella Carpo, Raffaella Fazio, Massimo Corbo, Anna Mazzeo, Fabio Giannini, Giuseppe Cosentino, Elisabetta Zardini, Riccardo Currò, Matteo Gastaldi, Elisa Vegezzi, Enrico Alfonsi, Angela Berardinelli, Ludivine Kouton, Constance Manso, Claudia Giannotta, Pietro Doneddu, Patrizia Dacci, Laura Piccolo, Marta Ruiz, Alessandro Salvalaggio, Chiara De Michelis, Emanuele Spina, Antonietta Topa, Giulia Bisogni, Angela Romano, Sara Mariotto, Giorgia Mataluni, Federica Cerri, Claudia Stancanelli, Mario Sabatelli, Angelo Schenone, Enrico Marchioni, Giuseppe Lauria, Eduardo Nobile-Orazio, Jérôme Devaux, Diego Franciotta,

<h4>Objective</h4>To assess the prevalence and isotypes of anti-nodal/paranodal antibodies to nodal/paranodal proteins in a large chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) cohort, compare clinical features in seronegative vs seropositive patients, and gather evidence of their isotype-specific pathogenic role.<h4>Methods</h4>Antibodies to neurofascin-155 (Nfasc155), neurofascin-140/186 (Nfasc140/186), contactin-1 (CNTN1), and contactin-associated protein 1 (Caspr1) were ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(1):]

Cited: 7 times

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Vocal cord electromyographic correlates of stridor in multiple system atrophy phenotypes.

Massimiliano Todisco, Enrico Alfonsi, Ioannis Ugo Isaias, Roberta Zangaglia, Brigida Minafra, Giuseppe Cosentino, Michele Terzaghi, Nicoló Gabriele Pozzi, Raffaele Manni, Claudio Pacchetti,

<h4>Introduction</h4>Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by dysautonomia in combination with parkinsonian and cerebellar signs. Stridor may also occur and it is associated with life-threatening events and poor prognosis. The pathophysiology of stridor in MSA is still debated.<h4>Objective</h4>To define correlations between diurnal electromyographic (EMG) abnormalities of vocal ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2020, 70:31-35]

Cited: 2 times

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Application of tRNS to improve multiple sclerosis fatigue: a pilot, single-blind, sham-controlled study.

Giuseppe Salemi, Giulia Vazzoler, Paolo Ragonese, Alessia Bianchi, Giuseppe Cosentino, Giuseppe Croce, Massimo Gangitano, Erika Portera, Sabrina Realmuto, Brigida Fierro, Filippo Brighina,

We evaluated the effects of transcranial random noise stimulation (tRNS) on fatigue in 17 subjects with relapsing-remitting multiple sclerosis with low physical disability. Two different patient groups underwent real or sham stimulation for 10 days, targeting the primary motor cortex of the dominant side or contralateral to the most compromised limb. ... Read more >>

J Neural Transm (Vienna) (Journal of neural transmission (Vienna, Austria : 1996))
[2019, 126(6):795-799]

Cited: 2 times

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Cathodal Occipital tDCS Is Unable to Modulate the Sound Induced Flash Illusion in Migraine.

Simona Maccora, Giuseppe Giglia, Nadia Bolognini, Giuseppe Cosentino, Massimo Gangitano, Giuseppe Salemi, Filippo Brighina,

Migraine is a highly disabling disease characterized by recurrent pain. Despite an intensive effort, mechanisms of migraine pathophysiology still represent an unsolved issue. Evidence from both animal and human studies suggests that migraine is characterized by hyperresponsivity or hyperexcitability of sensory cortices, especially the visual cortex. This phenomenon, in turn, ... Read more >>

Front Hum Neurosci (Frontiers in human neuroscience)
[2019, 13:247]

Cited: 0 times

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Brain Modulation by Electric Currents in Fibromyalgia: A Structured Review on Non-invasive Approach With Transcranial Electrical Stimulation.

Filippo Brighina, Massimiliano Curatolo, Giuseppe Cosentino, Marina De Tommaso, Giuseppe Battaglia, Pier Carlo Sarzi-Puttini, Giuliana Guggino, Brigida Fierro,

Fibromyalgia syndrome (FMS) is a complex disorder where widespread musculoskeletal pain is associated with many heterogenous symptoms ranging from affective disturbances to cognitive dysfunction and central fatigue. FMS is currently underdiagnosed and often very poorly responsive to pharmacological treatment. Pathophysiology of the disease remains still obscure even if in the ... Read more >>

Front Hum Neurosci (Frontiers in human neuroscience)
[2019, 13:40]

Cited: 5 times

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Intracortical facilitation within the migraine motor cortex depends on the stimulation intensity. A paired-pulse TMS study.

Giuseppe Cosentino, Salvatore Di Marco, Salvatore Ferlisi, Francesca Valentino, Walter M Capitano, Brigida Fierro, Filippo Brighina,

<h4>Introduction</h4>Connectivity within the primary motor cortex can be measured using the paired-pulse transcranial magnetic stimulation (TMS) paradigm. This evaluates the effect of a first conditioning stimulus on the motor evoked potential (MEP) elicited by a second test stimulus when different interstimulus intervals are used. Aim of the present study was ... Read more >>

J Headache Pain (The journal of headache and pain)
[2018, 19(1):65]

Cited: 2 times

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